LOCUS       NM_008011               3146 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus fibroblast growth factor receptor 4 (Fgfr4), mRNA.
ACCESSION   NM_008011
VERSION     NM_008011.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3146)
  AUTHORS   Shen,L., Wang,C., Ren,R., Liu,X., Zhou,D., Chen,Y., Zhou,Y.,
            Lei,J., Xiao,Y., Zhang,N., Zhao,H. and Li,Y.
  TITLE     Fibroblast growth factor receptor 4 deficiency in macrophages
            aggravates experimental colitis by promoting M1-polarization
  JOURNAL   Inflamm Res 73 (9), 1493-1510 (2024)
   PUBMED   38981913
  REMARK    GeneRIF: Fibroblast growth factor receptor 4 deficiency in
            macrophages aggravates experimental colitis by promoting
            M1-polarization.
REFERENCE   2  (bases 1 to 3146)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3146)
  AUTHORS   Soutto,M., Zhang,X., Bhat,N., Chen,Z., Zhu,S., Maacha,S.,
            Genoula,M., El-Gazzaz,O., Peng,D., Lu,H., McDonald,O.G., Chen,X.S.,
            Cao,L., Xu,Z. and El-Rifai,W.
  TITLE     Fibroblast growth factor receptor-4 mediates activation of Nuclear
            Factor Erythroid 2-Related Factor-2 in gastric tumorigenesis
  JOURNAL   Redox Biol 69, 102998 (2024)
   PUBMED   38154380
  REMARK    GeneRIF: Fibroblast growth factor receptor-4 mediates activation of
            Nuclear Factor Erythroid 2-Related Factor-2 in gastric
            tumorigenesis.
REFERENCE   4  (bases 1 to 3146)
  AUTHORS   Zhou,C., Pan,X., Huang,L., Wu,T., Zhao,T., Qi,J., Wu,J.,
            Mukondiwa,A.V., Tang,Y., Luo,Y., Tu,Q., Huang,Z. and Niu,J.
  TITLE     Fibroblast growth factor 21 ameliorates cholestatic liver injury
            via a hepatic FGFR4-JNK pathway
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166870 (2024)
   PUBMED   37696161
REFERENCE   5  (bases 1 to 3146)
  AUTHORS   Kobayashi,K., Iwasa,K., Azuma-Suzuki,R., Kawauchi,T. and
            Nabeshima,Y.I.
  TITLE     Feto-maternal cholesterol transport regulated by beta-Klotho-FGF15
            axis is essential for fetal growth
  JOURNAL   Life Sci Alliance 6 (10), e202301916 (2023)
   PUBMED   37541847
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3146)
  AUTHORS   Johnson,K.R., Cook,S.A. and Davisson,M.T.
  TITLE     Identification and genetic mapping of 151 dispersed members of 16
            ribosomal protein multigene families in the mouse
  JOURNAL   Mamm Genome 5 (11), 670-687 (1994)
   PUBMED   7873877
REFERENCE   7  (bases 1 to 3146)
  AUTHORS   Gilardi-Hebenstreit,P., Nieto,M.A., Frain,M., Mattei,M.G.,
            Chestier,A., Wilkinson,D.G. and Charnay,P.
  TITLE     An Eph-related receptor protein tyrosine kinase gene segmentally
            expressed in the developing mouse hindbrain
  JOURNAL   Oncogene 7 (12), 2499-2506 (1992)
   PUBMED   1281307
  REMARK    Erratum:[Oncogene. 1993 Apr;8(4):1103.. PMID: 8455939]
REFERENCE   8  (bases 1 to 3146)
  AUTHORS   Korhonen,J., Partanen,J. and Alitalo,K.
  TITLE     Expression of FGFR-4 mRNA in developing mouse tissues
  JOURNAL   Int J Dev Biol 36 (2), 323-329 (1992)
   PUBMED   1326315
REFERENCE   9  (bases 1 to 3146)
  AUTHORS   Stark,K.L., McMahon,J.A. and McMahon,A.P.
  TITLE     FGFR-4, a new member of the fibroblast growth factor receptor
            family, expressed in the definitive endoderm and skeletal muscle
            lineages of the mouse
  JOURNAL   Development 113 (2), 641-651 (1991)
   PUBMED   1723680
REFERENCE   10 (bases 1 to 3146)
  AUTHORS   Bottaro,D.P., Rubin,J.S., Ron,D., Finch,P.W., Florio,C. and
            Aaronson,S.A.
  TITLE     Characterization of the receptor for keratinocyte growth factor.
            Evidence for multiple fibroblast growth factor receptors
  JOURNAL   J Biol Chem 265 (22), 12767-12770 (1990)
   PUBMED   2165484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK084850.1.
            
            On Aug 15, 2006 this sequence version replaced NM_008011.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK084850.1, BC033313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3146              AK084850.1         1-3146
FEATURES             Location/Qualifiers
     source          1..3146
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 29.8 cM"
     gene            1..3146
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /note="fibroblast growth factor receptor 4"
                     /db_xref="GeneID:14186"
                     /db_xref="MGI:MGI:95525"
     exon            1..110
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /inference="alignment:Splign:2.1.0"
     exon            111..244
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /inference="alignment:Splign:2.1.0"
     exon            245..508
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /inference="alignment:Splign:2.1.0"
     exon            509..589
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /inference="alignment:Splign:2.1.0"
     exon            590..756
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /inference="alignment:Splign:2.1.0"
     exon            757..880
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1071
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1210
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1404
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1550
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1672
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1783
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1974
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2097
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2168
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2306
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2412
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..3146
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3122..3127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /note="hexamer: AATAAA"
     polyA_site      3127
                     /gene="Fgfr4"
                     /gene_synonym="Fgfr-4"
                     /note="major polyA site"
ORIGIN      
        1 gacattcctg gctcttcggc ccggggcgga ggagctccgg gcgggtgagt gtgccagccc
       61 tgccgggatc gtgacccgcg cgcgcgggag ccgggcggcg gaggagccag gaaggtggtc
      121 agtgggaagt ctggccctga tcctgagatc agctggaagg aaatgtggct gctcttggcc
      181 ctgttgagca tctttcaggg gacaccagct ttgtcccttg aggcctctga ggaaatggag
      241 caggagccct gcctagcccc aatcctggag cagcaagagc aggtgttgac ggtggccctg
      301 gggcagcctg tgaggctgtg ctgtgggcgc accgagcgtg gtcgtcactg gtacaaagag
      361 ggcagccgcc tagcatctgc tgggcgagta cggggttgga gaggccgcct ggagatcgcc
      421 agcttccttc ctgaggatgc tggccgatac ctctgcctgg cccgtggctc catgaccgtc
      481 gtacacaatc ttacgttgct tatggatgac tccttaacct ccatcagtaa tgatgaagac
      541 cccaagacac tcagcagctc ctcgagtggt catgtctacc cacagcaagc accctactgg
      601 acacaccccc aacgcatgga gaagaaactg catgcagtgc ctgccgggaa tactgtcaaa
      661 ttccgctgtc cagctgcagg gaaccccatg cctaccatcc actggctcaa ggatggacag
      721 gccttccacg gggagaatcg tattggaggc attcggctgc gccaccaaca ctggagcctg
      781 gtgatggaaa gtgtggtacc ctcggaccgt ggcacataca catgccttgt ggagaactct
      841 ctgggtagca ttcgctacag ctatctcctg gatgtgctgg agcggtcccc gcaccggccc
      901 atcctgcagg cggggctccc agccaacacc acagctgtgg ttggcagcga tgtggagcta
      961 ctctgcaagg tgtacagcga cgcccagccc cacatacagt ggctgaaaca cgtcgtcatc
     1021 aacggcagca gcttcggcgc cgacggtttc ccctacgtac aagtcctgaa gacaacagac
     1081 atcaatagct cggaggtaga ggtcttgtat ctgaggaacg tgtccgctga ggatgcagga
     1141 gagtatacct gtctggcggg caactccatc ggcctttcct accagtcagc gtggctcacg
     1201 gtgctgccag aggaagacct cacgtggaca acagcaaccc ctgaggccag atacacagat
     1261 atcatcctgt atgtatcagg ctcactggtt ctgcttgtgc tcctgctgct ggccggggtg
     1321 tatcatcggc aagtcatccg tggccactac tctcgccagc ctgtcactat acaaaagctg
     1381 tcccgtttcc ctttggcccg acagttctct ttggagtcga ggtcctctgg caagtcaagt
     1441 ttgtccctgg tgcgaggtgt ccgtctctcc tccagcggcc cgcccttgct cacgggcctt
     1501 gtgaatctag acctgcctct cgatccgctt tgggaattcc cccgggacag gttggtgctc
     1561 ggaaagcccc tgggtgaggg ctgctttggg caagtggttc gtgcagaggc ctttggtatg
     1621 gatccctccc ggcccgacca aaccagcacc gtggctgtga agatgctgaa agacaatgcc
     1681 tccgacaagg atttggcaga cctggtctcc gagatggagg tgatgaagct aatcggaaga
     1741 cacaagaaca tcatcaacct gctgggtgtc tgcactcagg aagggcccct gtacgtgatt
     1801 gtggaatgtg ccgccaaggg aaaccttcgg gaattcctcc gtgcccggcg ccccccaggc
     1861 cctgatctca gccctgatgg acctcggagc agcgaaggac cactctcctt cccggcccta
     1921 gtctcctgtg cctaccaggt ggcccgaggc atgcagtatc tggagtctcg gaagtgcatc
     1981 caccgggacc tggctgcccg aaatgtgctg gtgaccgagg atgatgtgat gaagatcgct
     2041 gactttgggc tggcacgtgg tgtccaccac attgactact ataagaaaac cagcaacggc
     2101 cgcctgccag tcaaatggat ggctccagag gcattgttcg accgcgtgta cacacaccag
     2161 agtgacgtgt ggtctttcgg gatcctgctg tgggaaatct tcaccctcgg gggctcccca
     2221 taccctggca ttccggtgga ggagctcttc tcactgctgc gagaggggca caggatggag
     2281 cggcccccaa actgcccctc agagctgtat gggctaatga gggagtgctg gcacgcagcc
     2341 ccatctcaga ggcctacttt taagcagctg gtggaagctc tggacaaggt cctgctggct
     2401 gtctctgaag agtaccttga cctccgcctg acctttggac ccttttctcc ctccaatggg
     2461 gatgccagca gcacctgctc ctccagtgac tcggttttca gccacgaccc tttgcccctc
     2521 gagccaagcc ccttcccttt ctctgactcg cagacgacat gagccgggga gcagcaatgt
     2581 tgtatgggct acgcggccca tggccgtggg tctcctcgct gagctgcaac ctgatgcatc
     2641 gacatttaat gttggcagtg tcaggcctct gacttgagac tactgctgtc gcagatcctc
     2701 tctctggccc tgttttgggg agggccattc ttggtcctaa ggttcatagt tgaggccttc
     2761 tgttccagcc ttatgctccc atctcagagt tcaactctca tctcaagatc atggccttgc
     2821 ccttggactc atcctcagag aagttaagca ttaaggcctt ggcacgcagc ctccgtctcc
     2881 ggggctctcc gggactagct gcaaaactta tgctctaaac atttctagtt cccccaaaca
     2941 acctagaggc cttgggactt cacatccccc agcacacaag cctcaccacc ccctgccatc
     3001 ccccctccat tgcttgttcc agcatcttgg tgaaaggggc atcagctctg gtgtccctga
     3061 gagacgagaa gcctgtggga acgacagaag aacatggcat ttttataaat tatttttttg
     3121 aaataaatct ctgtgtgcct ggtggc
//
