LOCUS       NM_008010               4219 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus fibroblast growth factor receptor 3 (Fgfr3),
            transcript variant 1, mRNA.
ACCESSION   NM_008010
VERSION     NM_008010.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4219)
  AUTHORS   Almubarak,A., Zhang,Q., Zhang,C.H., Abdelwahab,N., Kume,T.,
            Lassar,A.B. and Berry,F.B.
  TITLE     FOXC1 and FOXC2 regulate growth plate chondrocyte maturation
            towards hypertrophy in the embryonic mouse limb skeleton
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39012257
REFERENCE   2  (bases 1 to 4219)
  AUTHORS   Kim,D.K., Suh,K., Park,J., Lee,S.E., Han,J., Chang,S., Kim,Y. and
            Mook-Jung,I.
  TITLE     FGFR3 drives Abeta-induced tau uptake
  JOURNAL   Exp Mol Med 56 (7), 1631-1642 (2024)
   PUBMED   38951140
  REMARK    GeneRIF: FGFR3 drives Abeta-induced tau uptake.
REFERENCE   3  (bases 1 to 4219)
  AUTHORS   Sun,M., Gao,Y., Li,Z., Yang,L., Liu,G., Xu,Z., Guo,R., You,Y. and
            Yang,Z.
  TITLE     ERK signaling expands mammalian cortical radial glial cells and
            extends the neurogenic period
  JOURNAL   Proc Natl Acad Sci U S A 121 (13), e2314802121 (2024)
   PUBMED   38498715
REFERENCE   4  (bases 1 to 4219)
  AUTHORS   Twigg,S.R., Healy,C., Babbs,C., Sharpe,J.A., Wood,W.G.,
            Sharpe,P.T., Morriss-Kay,G.M. and Wilkie,A.O.
  TITLE     Skeletal analysis of the Fgfr3(P244R) mouse, a genetic model for
            the Muenke craniosynostosis syndrome
  JOURNAL   Dev Dyn 238 (2), 331-342 (2009)
   PUBMED   19086028
REFERENCE   5  (bases 1 to 4219)
  AUTHORS   Wang,Y., Spatz,M.K., Kannan,K., Hayk,H., Avivi,A., Gorivodsky,M.,
            Pines,M., Yayon,A., Lonai,P. and Givol,D.
  TITLE     A mouse model for achondroplasia produced by targeting fibroblast
            growth factor receptor 3
  JOURNAL   Proc Natl Acad Sci U S A 96 (8), 4455-4460 (1999)
   PUBMED   10200283
REFERENCE   6  (bases 1 to 4219)
  AUTHORS   Perez-Castro,A.V., Wilson,J. and Altherr,M.R.
  TITLE     Genomic organization of the mouse fibroblast growth factor receptor
            3 (Fgfr3) gene
  JOURNAL   Genomics 30 (2), 157-162 (1995)
   PUBMED   8586414
REFERENCE   7  (bases 1 to 4219)
  AUTHORS   Bellus,G.A., McIntosh,I., Smith,E.A., Aylsworth,A.S., Kaitila,I.,
            Horton,W.A., Greenhaw,G.A., Hecht,J.T. and Francomano,C.A.
  TITLE     A recurrent mutation in the tyrosine kinase domain of fibroblast
            growth factor receptor 3 causes hypochondroplasia
  JOURNAL   Nat Genet 10 (3), 357-359 (1995)
   PUBMED   7670477
REFERENCE   8  (bases 1 to 4219)
  AUTHORS   Chellaiah,A.T., McEwen,D.G., Werner,S., Xu,J. and Ornitz,D.M.
  TITLE     Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in
            immunoglobulin-like domain III creates a receptor highly specific
            for acidic FGF/FGF-1
  JOURNAL   J Biol Chem 269 (15), 11620-11627 (1994)
   PUBMED   7512569
REFERENCE   9  (bases 1 to 4219)
  AUTHORS   Ornitz,D.M. and Leder,P.
  TITLE     Ligand specificity and heparin dependence of fibroblast growth
            factor receptors 1 and 3
  JOURNAL   J Biol Chem 267 (23), 16305-16311 (1992)
   PUBMED   1379594
REFERENCE   10 (bases 1 to 4219)
  AUTHORS   Avivi,A., Zimmer,Y., Yayon,A., Yarden,Y. and Givol,D.
  TITLE     Flg-2, a new member of the family of fibroblast growth factor
            receptors
  JOURNAL   Oncogene 6 (6), 1089-1092 (1991)
   PUBMED   1648703
  REMARK    Erratum:[Oncogene 1992 Apr;7(4):823]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD349897.1, BC053056.1 and
            AC162898.10.
            
            On Apr 12, 2011 this sequence version replaced NM_008010.4.
            
            Summary: This gene encodes a member of the fibroblast growth factor
            receptor family. Members of this family are highly conserved
            proteins that differ from one another in their ligand affinities
            and tissue distribution. A representative protein consists of an
            extracellular region composed of three immunoglobulin-like domains,
            a single hydrophobic membrane-spanning segment, and a cytoplasmic
            tyrosine kinase domain. The extracellular portion of the protein
            interacts with fibroblast growth factors, setting in motion a
            cascade of downstream signals, ultimately influencing mitogenesis
            and differentiation. This family member binds acidic and basic
            fibroblast growth hormone and plays a role in bone development and
            maintenance. Mutations in this gene may be associated with
            craniosynostosis and multiple types of skeletal dysplasia. A
            pseudogene of this gene is located on chromosome 1. Alternatively
            spliced transcript variants encoding multiple isoforms have been
            observed for this gene. [provided by RefSeq, Apr 2011].
            
            Transcript Variant: This variant (1) encodes isoform 1, also known
            as IIIc, which includes the IIIc-type C-terminal half of the IgIII
            domain. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053056.1, SRR7974084.25339.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                CD349897.1         1-90
            91-4011             BC053056.1         1-3921
            4012-4219           AC162898.10        113202-113409
FEATURES             Location/Qualifiers
     source          1..4219
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.83 cM"
     gene            1..4219
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /note="fibroblast growth factor receptor 3"
                     /db_xref="GeneID:14184"
                     /db_xref="MGI:MGI:95524"
     exon            1..205
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            206..411
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..2711
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; heparin-binding growth factor receptor"
                     /codon_start=1
                     /product="fibroblast growth factor receptor 3 isoform 1
                     precursor"
                     /protein_id="NP_032036.2"
                     /db_xref="CCDS:CCDS51465.1"
                     /db_xref="GeneID:14184"
                     /db_xref="MGI:MGI:95524"
                     /translation="MVVPACVLVFCVAVVAGATSEPPGPEQRVVRRAAEVPGPEPSQQ
                     EQVAFGSGDTVELSCHPPGGAPTGPTVWAKDGTGLVASHRILVGPQRLQVLNASHEDA
                     GVYSCQHRLTRRVLCHFSVRVTDAPSSGDDEDGEDVAEDTGAPYWTRPERMDKKLLAV
                     PAANTVRFRCPAAGNPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRG
                     NYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAILGSDVEFHCKVYSDAQ
                     PHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCL
                     AGNSIGFSHHSAWLVVLPAEEELMETDEAGSVYAGVLSYGVVFFLFILVVAAVILCRL
                     RSPPKKGLGSPTVHKVSRFPLKRQVSLESNSSMNSNTPLVRIARLSSGEGPVLANVSE
                     LELPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDA
                     TDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRP
                     PGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNV
                     MKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIF
                     TLGGSPYPGIPVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVE
                     DLDRILTVTSTDEYLDLSVPFEQYSPGGQDTPSSSSSGDDSVFTHDLLPPGPPSNGGP
                     RT"
     exon            412..681
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            682..735
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            736..905
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1029
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1220
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1365
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1556
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1702
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1824
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1935
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2126
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2249
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2320
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2458
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2564
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..4219
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4194..4199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /note="hexamer: AATAAA"
     polyA_site      4215
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /note="major polyA site"
ORIGIN      
        1 tcggggcgtg gcgggagcac cccccaaccc ccgcccgggc tgctgcgcgc cgggcagccc
       61 cagttcagtg cactgtggca gcgggggtgg cgggagcagc tggcgccgtg cgatccactc
      121 cggcgggggg actcagtggt gggcggccgg ccactgggac agaggagacc ctggaaaagc
      181 gggccgagag acggagccgc gcgtgtctcc acagaggcgt tctcccaccg gcgccggagc
      241 cgggcgtggg gggttgcagc atgcccgcgc gcgctgcttg aggacgccgc ggcccccgct
      301 ctggagccat ggtagtcccg gcctgcgtgc tagtgttctg cgtggcggtc gtggctggag
      361 ctacttccga gcctcctggt ccagagcagc gagttgtgcg gagagcggca gaggttccag
      421 ggcctgaacc tagccagcag gagcaggtgg ccttcggcag tggggacacc gtggagctga
      481 gctgccatcc tcctggaggt gcccccacag ggcccacggt ctgggctaag gatggtacag
      541 gtctggtggc ctcccaccgc atcctggtgg ggcctcagag gctgcaagtg ctaaatgcct
      601 cccacgaaga tgcaggggtc tacagctgcc agcaccggct cactcggcgt gtgctgtgcc
      661 acttcagtgt gcgtgtaaca gatgctccat cctcaggaga tgacgaagat ggggaggacg
      721 tggctgaaga cacaggggct ccttattgga ctcgcccgga gcgaatggat aagaaactgc
      781 tggctgtgcc agccgcaaac actgtccgct tccgctgccc agctgctggc aaccctaccc
      841 cctccatctc ctggctgaag aatggcaaag aattccgagg ggagcatcgc attgggggca
      901 tcaagctccg gcaccagcag tggagcttgg tcatggaaag tgtggtaccc tccgatcgtg
      961 gcaactatac ctgtgtagtt gagaacaagt ttggcagcat ccggcagaca tacacactgg
     1021 atgtgctgga gcgctcccca caccggccca tcctgcaggc tgggctgccg gccaaccaga
     1081 cagccattct aggcagtgac gtggagttcc actgcaaggt gtacagcgat gcacagccac
     1141 acatccagtg gctgaagcac gtggaagtga acggcagcaa ggtgggccct gacggcacgc
     1201 cctacgtcac tgtactcaag actgcaggcg ctaacaccac cgacaaggag ctagaggttc
     1261 tgtccttgca caatgtcacc tttgaggacg cgggggagta cacctgcctg gcgggcaatt
     1321 ctattgggtt ttcccatcac tctgcgtggc tggtggtgct gccagctgag gaggagctga
     1381 tggaaactga tgaggctggc agcgtgtacg caggcgtcct cagctacggg gtggtcttct
     1441 tcctcttcat cctggtggtg gcagctgtga tactctgccg cctgcgcagt cccccaaaga
     1501 agggcttggg ctcgcccacc gtgcacaagg tctctcgctt cccgcttaag cgacaggtgt
     1561 ccttggaatc taactcctct atgaactcca acacacccct tgtccggatt gcccggctgt
     1621 cctcaggaga aggtcctgtt ctggccaatg tttctgaact tgagctgcct gctgacccca
     1681 agtgggagct atccaggacc cggctgacac ttggtaagcc tcttggagaa ggctgctttg
     1741 gacaggtggt catggcagaa gctattggca tcgacaagga ccgtactgcc aagcctgtca
     1801 ccgtggccgt gaagatgctg aaagatgatg cgactgacaa ggacctgtcg gacctggtat
     1861 ctgagatgga gatgatgaaa atgattggca agcacaagaa catcattaac ctgctggggg
     1921 cgtgcacaca gggtgggccc ctgtatgtgc tggtggagta cgcagccaag ggcaatctcc
     1981 gggagttcct tcgggcgcgg cggcctccag gcatggacta ctcctttgat gcctgcaggc
     2041 tgccagagga acagctcacc tgcaaggatc tagtgtcctg tgcctaccag gtggcacggg
     2101 gcatggaata cttggcttct cagaagtgta ttcacagaga cttggctgcc agaaacgtcc
     2161 tggtgaccga ggacaatgtg atgaagattg cggactttgg cctggctcga gatgtgcaca
     2221 acctggacta ctacaagaag accacaaatg gccggctacc tgtgaagtgg atggcaccag
     2281 aggccctttt tgaccgagtc tacacccacc agagtgatgt ttggtctttt ggtgtcctcc
     2341 tctgggagat ctttacgctg gggggctcac cgtatcctgg catcccagtg gaagagcttt
     2401 tcaagctgtt gaaagagggc caccgcatgg acaagccagc cagctgcaca catgacctgt
     2461 acatgatcat gcgggaatgt tggcatgcgg tgccttcaca gaggcccacc ttcaagcagt
     2521 tggtagagga tttagaccgc atcctcactg tgacatcaac cgacgagtac ttggacctct
     2581 ccgtgccgtt tgagcagtac tcgccaggtg gccaggacac gcctagctcc agctcgtccg
     2641 gagatgactc ggtgttcacc catgacctgc tacccccagg tccacccagt aacgggggac
     2701 ctcggacgtg aagggccaac agtcccacag accaagcccc aggcaatgtt tacgcggacc
     2761 ctagcccgcc ctgctactgc tggtgtgcag tggaccctag ccagcccagt gcaatgggcc
     2821 aacagtagac aagacttcct gcgtgtttat ccttggctcc tgggtgcaga ggccccttgg
     2881 gaacatgcac tgctgtagag taatctcctg actggccagg gccaggagca ccaaacaaga
     2941 atgtaagagg cccaccctgt gcaaccctgg ggttctggcc ctctcatttc ccactgctac
     3001 cttccaggga ccattgtgga gagggctaga ctccatgtcc agagtgggcc ttggccttct
     3061 tggtgcccca agctgagcct acagggaggc tctgctctgt gtggcaaacc tctctcctac
     3121 atggcacctt gtgcctgggg gtgtcatagc tcgacatctc caggctgcct gctttccacc
     3181 ctgcccctca gagacaaatt acgggtacct gaaggggggg cataatgtct atcagaaagg
     3241 tttattccag aggaaaatgt acatttatat aaatagatgt tgtgtatgat ataaatatat
     3301 acatacatat atataagaat atctatatgg aaaaaggcaa agttgaggcc caagggagca
     3361 agatactcca tgggtctcac taggaaactg gcaagagcag gctgagaagc aaggggcttt
     3421 tctggcacgg cagttttgtt tgtactggac ctgtatattt gtaaagctat ttatcaaccc
     3481 ccagagcgcc agtccccgac cccaggttca tagcgtttag tcccagggta ttgcagccat
     3541 cttaagttgt aacttattaa cagcggaaga ggttcatgct ggatttaggg aattgctgag
     3601 aacgtgcgtc tggcctccac caggctggcc gtggcccctt ggcgcttgaa tggctctcct
     3661 agtcagagct ggctccaggg agcattttct gttgcctttg gccctctttt gtgggggatt
     3721 agatttatat aggaactttc tttaggagat gtttaaaaat tttaaggtga actggtattt
     3781 ttcatacaga ttattctaat tgctatgtat tccaggcagg agcctgtgcc cagggaaggg
     3841 ctggccctgc aagaaggttc agatgttaat agttatctgt tacaagttta tctatctata
     3901 atttattgag tttttacaag ttgttttgct gtaggcttaa cacttcctat gcagtgcttc
     3961 tagactttta tagcctagac tgctaccttt caaagcttgg gagacagtgg tgaatgcaat
     4021 tttgttactt ttgtactgtc actgggccct aggcttgggt ggctgtccct tgcctgtcaa
     4081 ccagcagggt caggacagtg gctcagggtg actttcttgg ggcctagcac atggtttgtc
     4141 agcccacact ggcagatgtg gttttgttaa cacaaccaac ttactttcca aaaaataaag
     4201 agataactgg ttccatgag
//
