LOCUS       NM_001205270            4222 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus fibroblast growth factor receptor 3 (Fgfr3),
            transcript variant 5, mRNA.
ACCESSION   NM_001205270
VERSION     NM_001205270.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4222)
  AUTHORS   Almubarak,A., Zhang,Q., Zhang,C.H., Abdelwahab,N., Kume,T.,
            Lassar,A.B. and Berry,F.B.
  TITLE     FOXC1 and FOXC2 regulate growth plate chondrocyte maturation
            towards hypertrophy in the embryonic mouse limb skeleton
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39012257
REFERENCE   2  (bases 1 to 4222)
  AUTHORS   Kim,D.K., Suh,K., Park,J., Lee,S.E., Han,J., Chang,S., Kim,Y. and
            Mook-Jung,I.
  TITLE     FGFR3 drives Abeta-induced tau uptake
  JOURNAL   Exp Mol Med 56 (7), 1631-1642 (2024)
   PUBMED   38951140
  REMARK    GeneRIF: FGFR3 drives Abeta-induced tau uptake.
REFERENCE   3  (bases 1 to 4222)
  AUTHORS   Sun,M., Gao,Y., Li,Z., Yang,L., Liu,G., Xu,Z., Guo,R., You,Y. and
            Yang,Z.
  TITLE     ERK signaling expands mammalian cortical radial glial cells and
            extends the neurogenic period
  JOURNAL   Proc Natl Acad Sci U S A 121 (13), e2314802121 (2024)
   PUBMED   38498715
REFERENCE   4  (bases 1 to 4222)
  AUTHORS   Twigg,S.R., Healy,C., Babbs,C., Sharpe,J.A., Wood,W.G.,
            Sharpe,P.T., Morriss-Kay,G.M. and Wilkie,A.O.
  TITLE     Skeletal analysis of the Fgfr3(P244R) mouse, a genetic model for
            the Muenke craniosynostosis syndrome
  JOURNAL   Dev Dyn 238 (2), 331-342 (2009)
   PUBMED   19086028
REFERENCE   5  (bases 1 to 4222)
  AUTHORS   Wang,Y., Spatz,M.K., Kannan,K., Hayk,H., Avivi,A., Gorivodsky,M.,
            Pines,M., Yayon,A., Lonai,P. and Givol,D.
  TITLE     A mouse model for achondroplasia produced by targeting fibroblast
            growth factor receptor 3
  JOURNAL   Proc Natl Acad Sci U S A 96 (8), 4455-4460 (1999)
   PUBMED   10200283
REFERENCE   6  (bases 1 to 4222)
  AUTHORS   Perez-Castro,A.V., Wilson,J. and Altherr,M.R.
  TITLE     Genomic organization of the mouse fibroblast growth factor receptor
            3 (Fgfr3) gene
  JOURNAL   Genomics 30 (2), 157-162 (1995)
   PUBMED   8586414
REFERENCE   7  (bases 1 to 4222)
  AUTHORS   Bellus,G.A., McIntosh,I., Smith,E.A., Aylsworth,A.S., Kaitila,I.,
            Horton,W.A., Greenhaw,G.A., Hecht,J.T. and Francomano,C.A.
  TITLE     A recurrent mutation in the tyrosine kinase domain of fibroblast
            growth factor receptor 3 causes hypochondroplasia
  JOURNAL   Nat Genet 10 (3), 357-359 (1995)
   PUBMED   7670477
REFERENCE   8  (bases 1 to 4222)
  AUTHORS   Chellaiah,A.T., McEwen,D.G., Werner,S., Xu,J. and Ornitz,D.M.
  TITLE     Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in
            immunoglobulin-like domain III creates a receptor highly specific
            for acidic FGF/FGF-1
  JOURNAL   J Biol Chem 269 (15), 11620-11627 (1994)
   PUBMED   7512569
REFERENCE   9  (bases 1 to 4222)
  AUTHORS   Ornitz,D.M. and Leder,P.
  TITLE     Ligand specificity and heparin dependence of fibroblast growth
            factor receptors 1 and 3
  JOURNAL   J Biol Chem 267 (23), 16305-16311 (1992)
   PUBMED   1379594
REFERENCE   10 (bases 1 to 4222)
  AUTHORS   Avivi,A., Zimmer,Y., Yayon,A., Yarden,Y. and Givol,D.
  TITLE     Flg-2, a new member of the family of fibroblast growth factor
            receptors
  JOURNAL   Oncogene 6 (6), 1089-1092 (1991)
   PUBMED   1648703
  REMARK    Erratum:[Oncogene 1992 Apr;7(4):823]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC162898.10.
            
            Summary: This gene encodes a member of the fibroblast growth factor
            receptor family. Members of this family are highly conserved
            proteins that differ from one another in their ligand affinities
            and tissue distribution. A representative protein consists of an
            extracellular region composed of three immunoglobulin-like domains,
            a single hydrophobic membrane-spanning segment, and a cytoplasmic
            tyrosine kinase domain. The extracellular portion of the protein
            interacts with fibroblast growth factors, setting in motion a
            cascade of downstream signals, ultimately influencing mitogenesis
            and differentiation. This family member binds acidic and basic
            fibroblast growth hormone and plays a role in bone development and
            maintenance. Mutations in this gene may be associated with
            craniosynostosis and multiple types of skeletal dysplasia. A
            pseudogene of this gene is located on chromosome 1. Alternatively
            spliced transcript variants encoding multiple isoforms have been
            observed for this gene. [provided by RefSeq, Apr 2011].
            
            Transcript Variant: This variant (5) uses an alternate in-frame
            splice site in the coding region, compared to variant 1. The
            encoded isoform (4) is longer than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143592.1, SRR1660817.93994.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC162898.10        98065-98269
            206-411             AC162898.10        98647-98852
            412-681             AC162898.10        103988-104257
            682-735             AC162898.10        104533-104586
            736-905             AC162898.10        106022-106191
            906-1029            AC162898.10        106277-106400
            1030-1220           AC162898.10        106485-106675
            1221-1365           AC162898.10        108458-108602
            1366-1556           AC162898.10        109063-109253
            1557-1705           AC162898.10        109595-109743
            1706-1827           AC162898.10        110001-110122
            1828-1938           AC162898.10        110197-110307
            1939-2129           AC162898.10        110388-110578
            2130-2252           AC162898.10        110688-110810
            2253-2323           AC162898.10        110894-110964
            2324-2461           AC162898.10        111192-111329
            2462-2567           AC162898.10        111474-111579
            2568-4222           AC162898.10        111755-113409
FEATURES             Location/Qualifiers
     source          1..4222
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.83 cM"
     gene            1..4222
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /note="fibroblast growth factor receptor 3"
                     /db_xref="GeneID:14184"
                     /db_xref="MGI:MGI:95524"
     exon            1..205
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            206..411
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..2714
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /EC_number="2.7.10.1"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 5; heparin-binding growth factor receptor"
                     /codon_start=1
                     /product="fibroblast growth factor receptor 3 isoform 4
                     precursor"
                     /protein_id="NP_001192199.1"
                     /db_xref="CCDS:CCDS57335.1"
                     /db_xref="GeneID:14184"
                     /db_xref="MGI:MGI:95524"
                     /translation="MVVPACVLVFCVAVVAGATSEPPGPEQRVVRRAAEVPGPEPSQQ
                     EQVAFGSGDTVELSCHPPGGAPTGPTVWAKDGTGLVASHRILVGPQRLQVLNASHEDA
                     GVYSCQHRLTRRVLCHFSVRVTDAPSSGDDEDGEDVAEDTGAPYWTRPERMDKKLLAV
                     PAANTVRFRCPAAGNPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRG
                     NYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAILGSDVEFHCKVYSDAQ
                     PHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCL
                     AGNSIGFSHHSAWLVVLPAEEELMETDEAGSVYAGVLSYGVVFFLFILVVAAVILCRL
                     RSPPKKGLGSPTVHKVSRFPLKRQQVSLESNSSMNSNTPLVRIARLSSGEGPVLANVS
                     ELELPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDD
                     ATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARR
                     PPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDN
                     VMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI
                     FTLGGSPYPGIPVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLV
                     EDLDRILTVTSTDEYLDLSVPFEQYSPGGQDTPSSSSSGDDSVFTHDLLPPGPPSNGG
                     PRT"
     exon            412..681
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            682..735
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            736..905
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1029
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1220
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1365
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1556
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1705
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1827
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1938
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2129
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2252
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2323
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2461
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2567
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..4222
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4197..4202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /note="hexamer: AATAAA"
     polyA_site      4218
                     /gene="Fgfr3"
                     /gene_synonym="CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3;
                     sam3"
                     /note="major polyA site"
ORIGIN      
        1 tcggggcgtg gcgggagcac cccccaaccc ccgcccgggc tgctgcgcgc cgggcagccc
       61 cagttcagtg cactgtggca gcgggggtgg cgggagcagc tggcgccgtg cgatccactc
      121 cggcgggggg actcagtggt gggcggccgg ccactgggac agaggagacc ctggaaaagc
      181 gggccgagag acggagccgc gcgtgtctcc acagaggcgt tctcccaccg gcgccggagc
      241 cgggcgtggg gggttgcagc atgcccgcgc gcgctgcttg aggacgccgc ggcccccgct
      301 ctggagccat ggtagtcccg gcctgcgtgc tagtgttctg cgtggcggtc gtggctggag
      361 ctacttccga gcctcctggt ccagagcagc gagttgtgcg gagagcggca gaggttccag
      421 ggcctgaacc tagccagcag gagcaggtgg ccttcggcag tggggacacc gtggagctga
      481 gctgccatcc tcctggaggt gcccccacag ggcccacggt ctgggctaag gatggtacag
      541 gtctggtggc ctcccaccgc atcctggtgg ggcctcagag gctgcaagtg ctaaatgcct
      601 cccacgaaga tgcaggggtc tacagctgcc agcaccggct cactcggcgt gtgctgtgcc
      661 acttcagtgt gcgtgtaaca gatgctccat cctcaggaga tgacgaagat ggggaggacg
      721 tggctgaaga cacaggggct ccttattgga ctcgcccgga gcgaatggat aagaaactgc
      781 tggctgtgcc agccgcaaac actgtccgct tccgctgccc agctgctggc aaccctaccc
      841 cctccatctc ctggctgaag aatggcaaag aattccgagg ggagcatcgc attgggggca
      901 tcaagctccg gcaccagcag tggagcttgg tcatggaaag tgtggtaccc tccgatcgtg
      961 gcaactatac ctgtgtagtt gagaacaagt ttggcagcat ccggcagaca tacacactgg
     1021 atgtgctgga gcgctcccca caccggccca tcctgcaggc tgggctgccg gccaaccaga
     1081 cagccattct aggcagtgac gtggagttcc actgcaaggt gtacagcgat gcacagccac
     1141 acatccagtg gctgaagcac gtggaagtga acggcagcaa ggtgggccct gacggcacgc
     1201 cctacgtcac tgtactcaag actgcaggcg ctaacaccac cgacaaggag ctagaggttc
     1261 tgtccttgca caatgtcacc tttgaggacg cgggggagta cacctgcctg gcgggcaatt
     1321 ctattgggtt ttcccatcac tctgcgtggc tggtggtgct gccagctgag gaggagctga
     1381 tggaaactga tgaggctggc agcgtgtacg caggcgtcct cagctacggg gtggtcttct
     1441 tcctcttcat cctggtggtg gcagctgtga tactctgccg cctgcgcagt cccccaaaga
     1501 agggcttggg ctcgcccacc gtgcacaagg tctctcgctt cccgcttaag cgacagcagg
     1561 tgtccttgga atctaactcc tctatgaact ccaacacacc ccttgtccgg attgcccggc
     1621 tgtcctcagg agaaggtcct gttctggcca atgtttctga acttgagctg cctgctgacc
     1681 ccaagtggga gctatccagg acccggctga cacttggtaa gcctcttgga gaaggctgct
     1741 ttggacaggt ggtcatggca gaagctattg gcatcgacaa ggaccgtact gccaagcctg
     1801 tcaccgtggc cgtgaagatg ctgaaagatg atgcgactga caaggacctg tcggacctgg
     1861 tatctgagat ggagatgatg aaaatgattg gcaagcacaa gaacatcatt aacctgctgg
     1921 gggcgtgcac acagggtggg cccctgtatg tgctggtgga gtacgcagcc aagggcaatc
     1981 tccgggagtt ccttcgggcg cggcggcctc caggcatgga ctactccttt gatgcctgca
     2041 ggctgccaga ggaacagctc acctgcaagg atctagtgtc ctgtgcctac caggtggcac
     2101 ggggcatgga atacttggct tctcagaagt gtattcacag agacttggct gccagaaacg
     2161 tcctggtgac cgaggacaat gtgatgaaga ttgcggactt tggcctggct cgagatgtgc
     2221 acaacctgga ctactacaag aagaccacaa atggccggct acctgtgaag tggatggcac
     2281 cagaggccct ttttgaccga gtctacaccc accagagtga tgtttggtct tttggtgtcc
     2341 tcctctggga gatctttacg ctggggggct caccgtatcc tggcatccca gtggaagagc
     2401 ttttcaagct gttgaaagag ggccaccgca tggacaagcc agccagctgc acacatgacc
     2461 tgtacatgat catgcgggaa tgttggcatg cggtgccttc acagaggccc accttcaagc
     2521 agttggtaga ggatttagac cgcatcctca ctgtgacatc aaccgacgag tacttggacc
     2581 tctccgtgcc gtttgagcag tactcgccag gtggccagga cacgcctagc tccagctcgt
     2641 ccggagatga ctcggtgttc acccatgacc tgctaccccc aggtccaccc agtaacgggg
     2701 gacctcggac gtgaagggcc aacagtccca cagaccaagc cccaggcaat gtttacgcgg
     2761 accctagccc gccctgctac tgctggtgtg cagtggaccc tagccagccc agtgcaatgg
     2821 gccaacagta gacaagactt cctgcgtgtt tatccttggc tcctgggtgc agaggcccct
     2881 tgggaacatg cactgctgta gagtaatctc ctgactggcc agggccagga gcaccaaaca
     2941 agaatgtaag aggcccaccc tgtgcaaccc tggggttctg gccctctcat ttcccactgc
     3001 taccttccag ggaccattgt ggagagggct agactccatg tccagagtgg gccttggcct
     3061 tcttggtgcc ccaagctgag cctacaggga ggctctgctc tgtgtggcaa acctctctcc
     3121 tacatggcac cttgtgcctg ggggtgtcat agctcgacat ctccaggctg cctgctttcc
     3181 accctgcccc tcagagacaa attacgggta cctgaagggg gggcataatg tctatcagaa
     3241 aggtttattc cagaggaaaa tgtacattta tataaataga tgttgtgtat gatataaata
     3301 tatacataca tatatataag aatatctata tggaaaaagg caaagttgag gcccaaggga
     3361 gcaagatact ccatgggtct cactaggaaa ctggcaagag caggctgaga agcaaggggc
     3421 ttttctggca cggcagtttt gtttgtactg gacctgtata tttgtaaagc tatttatcaa
     3481 cccccagagc gccagtcccc gaccccaggt tcatagcgtt tagtcccagg gtattgcagc
     3541 catcttaagt tgtaacttat taacagcgga agaggttcat gctggattta gggaattgct
     3601 gagaacgtgc gtctggcctc caccaggctg gccgtggccc cttggcgctt gaatggctct
     3661 cctagtcaga gctggctcca gggagcattt tctgttgcct ttggccctct tttgtggggg
     3721 attagattta tataggaact ttctttagga gatgtttaaa aattttaagg tgaactggta
     3781 tttttcatac agattattct aattgctatg tattccaggc aggagcctgt gcccagggaa
     3841 gggctggccc tgcaagaagg ttcagatgtt aatagttatc tgttacaagt ttatctatct
     3901 ataatttatt gagtttttac aagttgtttt gctgtaggct taacacttcc tatgcagtgc
     3961 ttctagactt ttatagccta gactgctacc tttcaaagct tgggagacag tggtgaatgc
     4021 aattttgtta cttttgtact gtcactgggc cctaggcttg ggtggctgtc ccttgcctgt
     4081 caaccagcag ggtcaggaca gtggctcagg gtgactttct tggggcctag cacatggttt
     4141 gtcagcccac actggcagat gtggttttgt taacacaacc aacttacttt ccaaaaaata
     4201 aagagataac tggttccatg ag
//
