LOCUS       NM_026218               2828 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus FGFR1 oncogene partner 2 (Fgfr1op2), transcript
            variant 1, mRNA.
ACCESSION   NM_026218
VERSION     NM_026218.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2828)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2828)
  AUTHORS   Qin,H., Wu,Q., Cowell,J.K. and Ren,M.
  TITLE     FGFR1OP2-FGFR1 induced myeloid leukemia and T-cell lymphoma in a
            mouse model
  JOURNAL   Haematologica 101 (3), e91-e94 (2016)
   PUBMED   26589915
  REMARK    GeneRIF: FGFR1OP2-FGFR1 fusion in hematopoietic stem cells induced
            myeloid leukemia and T-cell lymphoma in a mouse model.
REFERENCE   3  (bases 1 to 2828)
  AUTHORS   Patra,D., DeLassus,E., Liang,G. and Sandell,L.J.
  TITLE     Cartilage-specific ablation of site-1 protease in mice results in
            the endoplasmic reticulum entrapment of type IIb procollagen and
            down-regulation of cholesterol and lipid homeostasis
  JOURNAL   PLoS One 9 (8), e105674 (2014)
   PUBMED   25147951
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2828)
  AUTHORS   Lin,A., Hokugo,A., Choi,J. and Nishimura,I.
  TITLE     Small cytoskeleton-associated molecule, fibroblast growth factor
            receptor 1 oncogene partner 2/wound inducible transcript-3.0
            (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure
  JOURNAL   Am J Pathol 176 (1), 108-121 (2010)
   PUBMED   19959814
  REMARK    GeneRIF: FGFR1OP2/wit3.0 may regulate cell motility and stimulate
            wound closure.
REFERENCE   5  (bases 1 to 2828)
  AUTHORS   Kenney-Hunt,J.P., Vaughn,T.T., Pletscher,L.S., Peripato,A.,
            Routman,E., Cothran,K., Durand,D., Norgard,E., Perel,C. and
            Cheverud,J.M.
  TITLE     Quantitative trait loci for body size components in mice
  JOURNAL   Mamm Genome 17 (6), 526-537 (2006)
   PUBMED   16783635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050102.1, AK004662.1, AK005320.1 and AK159805.1.
            
            On Dec 2, 2006 this sequence version replaced NM_026218.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050102.1, AK005320.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AK050102.1         1-17
            18-2678             AK004662.1         2-2662
            2679-2820           AK005320.1         2656-2797
            2821-2828           AK159805.1         2774-2781
FEATURES             Location/Qualifiers
     source          1..2828
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.7 cM"
     gene            1..2828
                     /gene="Fgfr1op2"
                     /gene_synonym="1500031J01Rik"
                     /note="FGFR1 oncogene partner 2"
                     /db_xref="GeneID:67529"
                     /db_xref="MGI:MGI:1914779"
     exon            1..298
                     /gene="Fgfr1op2"
                     /gene_synonym="1500031J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            299..435
                     /gene="Fgfr1op2"
                     /gene_synonym="1500031J01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1062
                     /gene="Fgfr1op2"
                     /gene_synonym="1500031J01Rik"
                     /note="isoform 1 is encoded by transcript variant 1; FGFR1
                     oncogene partner 2 homolog"
                     /codon_start=1
                     /product="FGFR1 oncogene partner 2 homolog isoform 1"
                     /protein_id="NP_080494.1"
                     /db_xref="CCDS:CCDS39711.1"
                     /db_xref="GeneID:67529"
                     /db_xref="MGI:MGI:1914779"
                     /translation="MSCTIEKALADAKALVERLRDHDDAAESLIEQTTALSKRVEAMK
                     QYQEEIQELNEVARHRPRSTLVMGIQQENRQIRELQQENKELRTSLEEHQSALELIMS
                     KYREQMFRLLMASKKDDPGIIMKLKEQHSKIDMVHRNSCEGFFLDASRHILEAPQHGL
                     ERRHLEANQNELQAHVDQITEMAAVMRKAIEIDEQQGCKEQERIFQLEQENKGLREIL
                     QITRESFLNLRKDDASESTSLSALVTNSDLSLRKS"
     exon            436..553
                     /gene="Fgfr1op2"
                     /gene_synonym="1500031J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            554..696
                     /gene="Fgfr1op2"
                     /gene_synonym="1500031J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            697..810
                     /gene="Fgfr1op2"
                     /gene_synonym="1500031J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            811..924
                     /gene="Fgfr1op2"
                     /gene_synonym="1500031J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            925..2828
                     /gene="Fgfr1op2"
                     /gene_synonym="1500031J01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1347..1352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgfr1op2"
                     /gene_synonym="1500031J01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1385
                     /gene="Fgfr1op2"
                     /gene_synonym="1500031J01Rik"
                     /note="major polyA site"
     regulatory      2748..2753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgfr1op2"
                     /gene_synonym="1500031J01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2767
                     /gene="Fgfr1op2"
                     /gene_synonym="1500031J01Rik"
                     /note="major polyA site"
     regulatory      2804..2809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgfr1op2"
                     /gene_synonym="1500031J01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2827
                     /gene="Fgfr1op2"
                     /gene_synonym="1500031J01Rik"
ORIGIN      
        1 gaagtctcgc gaggcttgtc gctcagcggc tgcgggtcgc ggaggttctg gtccgcccgg
       61 gatggggccg agacgagtgg gtttcccgta cgtcccgccg ctgtgtgagc aggactgtgc
      121 gtccgctcgc tgagcaggcg cagcgagggc gcggagacca ctccgtgggc actccacctc
      181 gcgggtggtc gtcgccccag ggggactgaa gcgcagtgga ataactacac gcgtgggcga
      241 gcctctgagc cgggcttcct ctctccgtgc tctccctgag gtcctgccgg gaactgagaa
      301 atgagctgca ccattgagaa ggcacttgct gacgctaaag cccttgttga aaggttgaga
      361 gatcatgatg atgcagcaga gtctctcatc gagcagacca ctgccctcag caagcgagtg
      421 gaagcgatga agcagtatca ggaggaaatc caagaactta atgaagtagc aagacatcgg
      481 ccacgatcca cactagttat gggaatccag caagaaaaca gacaaatcag agaattacaa
      541 caagaaaaca aagaactgcg gacatccctg gaagagcacc agtctgccct ggaactgata
      601 atgagcaagt accgagagca gatgttcaga ctgctcatgg ccagcaagaa agatgaccca
      661 ggtataataa tgaagttaaa agagcaacac tcaaagattg acatggtaca tcgtaacagc
      721 tgcgaaggat tcttcctgga tgcatctcgg cacatccttg aagcacctca gcacggactg
      781 gagaggaggc acttggaggc aaatcagaat gagttgcaag cacatgttga ccaaatcacc
      841 gagatggcag cagtaatgag aaaagctatt gaaattgacg agcagcaggg ttgcaaggaa
      901 caggagcgga tatttcaact tgaacaagaa aataaaggct tgagagagat ccttcagata
      961 actcgagaat cctttttgaa ccttcggaag gatgatgcgt cagagagtac gtctctatct
     1021 gccttagtga ctaacagtga cctgagtctg aggaagagct gagtggcttt ctgtgcggtc
     1081 actagaatgg gcccagaagt gagtggatga gtgaacataa agcccaactt cagtcagcct
     1141 tttccgtctg gtatgtacag ggacactggc aaagagacgg cagcagaatg tataaccagt
     1201 ggtcataaac tagatcccag tcacagtcag aaaggagacg ctgagccaca gagtgaacag
     1261 cgagtcttca aggtgctgct gagcactgca gtttcagaag tgctgttggc ttcttagatg
     1321 ctacatagat caccctgaat actcctaata aatgttggaa agcctaaatt atcacaattt
     1381 taaaagtaag gttggtgtgg ttttctgaat ggaagacttt gttctaagtc ttaccttcct
     1441 gttcagtgtc agagttggca tagcttgtgt acataaagct gctgagttgg tgctcacctg
     1501 cccatttgct cggccctcat caaaggcagt tcatgtttaa agactatagg aatacgtcac
     1561 ttgcatcaca aacagaagga acatacttac acctaattcc cataactctt agctagcagt
     1621 tattcacgac ttgcttaagt gtatgcatct caggaaagaa agacaaagaa tatactttct
     1681 aagaaagaca gccatatata gacacattta gtaggttgaa ctactttgaa agattatgtt
     1741 ttggttctct gttaacaatg aacctggttc ttcctcctct tttcatcatg tttaaggata
     1801 caagacagtt caccaataga caagagttga caatttaatg taatgagata ggtatggtca
     1861 tttccaagtt aatttggaat tcctttattg ttatttaaga aattactctt catacactta
     1921 caaagtagat acaggttcca aaaatcaaag ttctgagtct gagtctaagc ctcatctagt
     1981 tcttataacc tgtgaggttt ttcctacaac ctgtgactca gaaactggca gtgaagtgtg
     2041 gacacaaagg gattgtgctt tgcactttaa aaaaaaaaaa agcttcttaa ggccacagga
     2101 tacagaagtg tgctttcata ccaactgcaa cctaaacttt tctgtagtga taagaataaa
     2161 agattatgag atatggctga aaatacacta tacttgtatc tgaagtccat actgaaatta
     2221 gcacagacag aaagttagac ttttcaatat atcatttgtt aagtacatat tactttgcag
     2281 tgtaatttta tgtgtaattt catgtattgg caaaattaaa aggacttttc actccagaac
     2341 ctttcattct gaagtttgag gtgagtgggg tcataggtca gttaggaaag ggccagttcc
     2401 ccagatgtta aaccgttctc atgcagaggc cttaatattt tatatataag tgaatttact
     2461 tttaagattt ttctattgtt ttttggaaag taacccttaa tttaatggta ctttctttca
     2521 tgtagttttg tcccaggcca gaattttaaa aagaagaaaa gcggcacaga cgagatgagt
     2581 cagatcgatg tattgagcag gtctattgtg aaacgttatt tgagaagtaa ttatttttat
     2641 aaaaaattat ttatcctttg ttttcttgga tataatttta aggttgtgaa tattgaaaga
     2701 catttgcttt gtttttagca agttttccac cccaccccca tccccaaaat aaacagcttt
     2761 aagcttacat atgagagtgt gctgaagagg agcctatttt gtcaataaag atgagtgttt
     2821 aaaactgg
//
