LOCUS       NM_010206               7077 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus fibroblast growth factor receptor 1 (Fgfr1),
            transcript variant 1, mRNA.
ACCESSION   NM_010206
VERSION     NM_010206.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7077)
  AUTHORS   De Vincenti,A.P., Bonafina,A., Ledda,F. and Paratcha,G.
  TITLE     Lrig1 regulates cell fate specification of glutamatergic neurons
            via FGF-driven Jak2/Stat3 signaling in cortical progenitors
  JOURNAL   Development 151 (17) (2024)
   PUBMED   39250533
REFERENCE   2  (bases 1 to 7077)
  AUTHORS   Esteve,N.A., Rogers,D.J., Stagray,J.A., Mayeux,H., Nora,G.,
            Huval,L. and Smith,K.M.
  TITLE     Tanycyte radial morphology and proliferation are influenced by
            fibroblast growth factor receptor 1 and high-fat diet
  JOURNAL   Eur J Neurosci 60 (5), 5000-5018 (2024)
   PUBMED   39087621
  REMARK    GeneRIF: Tanycyte radial morphology and proliferation are
            influenced by fibroblast growth factor receptor 1 and high-fat
            diet.
REFERENCE   3  (bases 1 to 7077)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7077)
  AUTHORS   de Jaime-Soguero,A., Hattemer,J., Bufe,A., Haas,A., van den
            Berg,J., van Batenburg,V., Das,B., di Marco,B., Androulaki,S.,
            Bohly,N., Landry,J.J.M., Schoell,B., Rosa,V.S., Villacorta,L.,
            Baskan,Y., Trapp,M., Benes,V., Chabes,A., Shahbazi,M., Jauch,A.,
            Engel,U., Patrizi,A., Sotillo,R., van Oudenaarden,A., Bageritz,J.,
            Alfonso,J., Bastians,H. and Acebron,S.P.
  TITLE     Developmental signals control chromosome segregation fidelity
            during pluripotency and neurogenesis by modulating replicative
            stress
  JOURNAL   Nat Commun 15 (1), 7404 (2024)
   PUBMED   39191776
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7077)
  AUTHORS   Almubarak,A., Zhang,Q., Zhang,C.H., Abdelwahab,N., Kume,T.,
            Lassar,A.B. and Berry,F.B.
  TITLE     FOXC1 and FOXC2 regulate growth plate chondrocyte maturation
            towards hypertrophy in the embryonic mouse limb skeleton
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39012257
REFERENCE   6  (bases 1 to 7077)
  AUTHORS   Gilardi-Hebenstreit,P., Nieto,M.A., Frain,M., Mattei,M.G.,
            Chestier,A., Wilkinson,D.G. and Charnay,P.
  TITLE     An Eph-related receptor protein tyrosine kinase gene segmentally
            expressed in the developing mouse hindbrain
  JOURNAL   Oncogene 7 (12), 2499-2506 (1992)
   PUBMED   1281307
  REMARK    Erratum:[Oncogene. 1993 Apr;8(4):1103. PMID: 8455939]
REFERENCE   7  (bases 1 to 7077)
  AUTHORS   Saito,H., Kouhara,H., Kasayama,S., Kishimoto,T. and Sato,B.
  TITLE     Characterization of the promoter region of the murine fibroblast
            growth factor receptor 1 gene
  JOURNAL   Biochem Biophys Res Commun 183 (2), 688-693 (1992)
   PUBMED   1312839
REFERENCE   8  (bases 1 to 7077)
  AUTHORS   Ueno,H., Gunn,M., Dell,K., Tseng,A. Jr. and Williams,L.
  TITLE     A truncated form of fibroblast growth factor receptor 1 inhibits
            signal transduction by multiple types of fibroblast growth factor
            receptor
  JOURNAL   J Biol Chem 267 (3), 1470-1476 (1992)
   PUBMED   1309784
REFERENCE   9  (bases 1 to 7077)
  AUTHORS   Peters,K.G., Werner,S., Chen,G. and Williams,L.T.
  TITLE     Two FGF receptor genes are differentially expressed in epithelial
            and mesenchymal tissues during limb formation and organogenesis in
            the mouse
  JOURNAL   Development 114 (1), 233-243 (1992)
   PUBMED   1315677
REFERENCE   10 (bases 1 to 7077)
  AUTHORS   Werner,S., Duan,D.S., de Vries,C., Peters,K.G., Johnson,D.E. and
            Williams,L.T.
  TITLE     Differential splicing in the extracellular region of fibroblast
            growth factor receptor 1 generates receptor variants with different
            ligand-binding specificities
  JOURNAL   Mol Cell Biol 12 (1), 82-88 (1992)
   PUBMED   1309595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160526.13.
            
            On Aug 30, 2022 this sequence version replaced NM_010206.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: U22324.1, M28998.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-638               AC160526.13        71167-71804         c
            639-817             AC160526.13        58168-58346         c
            818-1084            AC160526.13        34822-35088         c
            1085-1174           AC160526.13        32776-32865         c
            1175-1347           AC160526.13        32353-32525         c
            1348-1471           AC160526.13        29753-29876         c
            1472-1662           AC160526.13        28268-28458         c
            1663-1807           AC160526.13        26112-26256         c
            1808-2010           AC160526.13        23683-23885         c
            2011-2156           AC160526.13        22263-22408         c
            2157-2278           AC160526.13        20836-20957         c
            2279-2389           AC160526.13        20345-20455         c
            2390-2580           AC160526.13        19696-19886         c
            2581-2703           AC160526.13        18136-18258         c
            2704-2774           AC160526.13        17807-17877         c
            2775-2912           AC160526.13        17336-17473         c
            2913-3018           AC160526.13        16945-17050         c
            3019-7077           AC160526.13        12793-16851         c
FEATURES             Location/Qualifiers
     source          1..7077
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 14.12 cM"
     gene            1..7077
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /note="fibroblast growth factor receptor 1"
                     /db_xref="GeneID:14182"
                     /db_xref="MGI:MGI:95522"
     exon            1..638
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            639..817
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     CDS             727..3195
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; basic fibroblast growth factor receptor 1;
                     proto-oncogene c-Fgr"
                     /codon_start=1
                     /product="fibroblast growth factor receptor 1 isoform 1
                     precursor"
                     /protein_id="NP_034336.2"
                     /db_xref="CCDS:CCDS52526.1"
                     /db_xref="GeneID:14182"
                     /db_xref="MGI:MGI:95522"
                     /translation="MWGWKCLLFWAVLVTATLCTARPAPTLPEQAQPWGVPVEVESLL
                     VHPGDLLQLRCRLRDDVQSINWLRDGVQLVESNRTRITGEEVEVRDSIPADSGLYACV
                     TSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRRPVAPYWTSPEK
                     MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMD
                     SVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFM
                     CKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFE
                     DAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMLG
                     SVIIYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLS
                     SSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV
                     TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK
                     GNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDL
                     AARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSD
                     VWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAV
                     PSQRPTFKQLVEDLDRIVALTSNQEYLDLSIPLDQYSPSFPDTRSSTCSSGEDSVFSH
                     EPLPEEPCLPRHPTQLANSGLKRR"
     exon            818..1084
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1174
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1347
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1471
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1662
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1807
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..2010
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2156
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2278
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2389
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2580
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2703
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2774
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2912
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3018
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            3019..7077
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4037..4042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /note="hexamer: AATAAA"
     polyA_site      4065
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /note="major polyA site"
     regulatory      4893..4898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /note="hexamer: AATGAA"
     polyA_site      4923
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
     polyA_site      4981
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
     polyA_site      4992
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
     regulatory      7048..7053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /note="hexamer: ATTAAA"
     polyA_site      7077
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
ORIGIN      
        1 gcacagcgct cggagcgctc ctgcgggtac tttggcgggg ctctccgctg cgggcggcgc
       61 ggaacgggag ccggaaccct ggtgcagccg ctgcgtgcag aggacccggg ctgcgcaggg
      121 aagcggggcc gagacgtccg gactggactg agactgtgct tagcgcattg cggcgacctc
      181 gcctttcccg gccgcgagcg cgcgccgcag ctggaaaagc agcggagacc gaggactttt
      241 ctcaggtccc aggggcgcac cacagccgtg ctgcagtcaa tgcacgccgg agccccagga
      301 ggggtgatgg aactcgggct gccagaagcc tgagacgccg ccaccgccgc cgctgcgtac
      361 tggagagcgg ggggcgcacg atctggggac cccgggcggc ggacccgagc cctccccccc
      421 gccccgcctc cggggcacca gcttcggctc cattgttccc gcccgggctg gaggcgcccg
      481 gctcggagtg ccgccgggag tcgtgcctcg gccgcggagc cctcgagacc ccatcaggat
      541 ctgaacggag cccggagacg agcggcggga gcgcaagaca cagacacccg ccgcgccacg
      601 gcgagctctc cagaggcggg accgcagcgc caagtgagag tcagcttgcg aaggcagacc
      661 acgctcacgg tggaatatcc atggaggtac ggagccttgt taccaacctc taaccgcaga
      721 actgggatgt ggggctggaa gtgcctcctc ttctgggctg tgctggtcac agccactctc
      781 tgcactgcca ggccagcccc aaccttgcct gaacaagctc agccctgggg agtccctgtg
      841 gaagtggagt ctctcctggt ccaccctggc gacctgctac agcttcgctg tcggcttcgc
      901 gatgatgtgc agagcatcaa ctggctgcgg gatggggtgc agctggtgga gagcaaccgt
      961 acccgcatca caggggagga ggtggaggtg cgggactcca tccccgctga ctctggcctc
     1021 tacgcttgcg tgaccagcag cccctctggc agcgatacca cctacttctc cgtcaatgtc
     1081 tcagatgcac tcccatcctc ggaagatgat gacgacgacg atgactcctc ctcggaggag
     1141 aaagagacgg acaacaccaa accaaaccgt aggcctgtag ctccctactg gacatcccca
     1201 gagaaaatgg agaagaaact gcatgcggtg cccgctgcca agacggtgaa gttcaagtgc
     1261 ccgtcgagtg ggacacccaa ccccactctg cgctggttga aaaatggcaa agagtttaag
     1321 cctgaccacc gaattggagg ctacaaggtt cgctatgcca cctggagcat cataatggat
     1381 tctgtggtgc cttctgacaa gggcaactac acctgcatcg tggagaatga gtatgggagc
     1441 atcaaccaca cctaccagct tgacgtcgtg gaacgatctc cgcaccgacc catccttcag
     1501 gcagggctgc ctgccaacaa gacagtggcc ctgggcagca atgtggagtt catgtgtaag
     1561 gtgtacagcg atccgcagcc tcacattcag tggctgaagc acatcgaggt gaacgggagt
     1621 aagatcgggc cagacaactt gccgtatgtc cagatcctga agactgctgg agttaatacc
     1681 accgacaagg aaatggaggt gcttcatcta cggaatgtct cctttgagga tgcgggggag
     1741 tatacgtgct tggcgggtaa ctctatcgga ctctcccatc actctgcatg gttgaccgtt
     1801 ctggaagccc tggaagagag accagctgtg atgacctcac cgctctacct ggagatcatt
     1861 atctactgca ccggggcctt cctgatctcc tgcatgttgg gctctgtcat catctataag
     1921 atgaagagcg gcaccaagaa gagcgacttc catagccaga tggctgtgca caagctggcc
     1981 aagagcatcc ctctgcgcag acaggtaaca gtgtcagctg actccagtgc atccatgaac
     2041 tctggggttc tcctggttcg gccctcacgg ctctcctcca gcgggacccc catgctggct
     2101 ggagtctccg aatatgagct ccctgaggat ccccgctggg agctgccacg agacagactg
     2161 gtcttaggca aaccacttgg cgagggctgc ttcgggcagg tggtgttggc tgaggccatc
     2221 gggctggata aggacaaacc caaccgtgtg accaaagtgg ccgtgaagat gttgaagtcc
     2281 gacgcaacgg agaaggacct gtcggatctg atctcggaga tggagatgat gaaaatgatt
     2341 gggaagcaca agaatatcat caaccttctg ggagcgtgca cacaggatgg tcctctttat
     2401 gtcattgtgg agtacgcctc caaaggcaat ctccgggagt atctacaggc ccggaggcct
     2461 cctgggctgg agtactgcta taaccccagc cacaaccccg aggaacagct gtcttccaaa
     2521 gatctggtat cctgtgccta tcaggtggct cggggcatgg agtatcttgc ctctaagaag
     2581 tgtatacacc gagacctggc tgctaggaac gtcctggtga ccgaggataa cgtaatgaag
     2641 atcgcagact ttggcttagc tcgagacatt catcatatcg actactacaa gaaaaccacc
     2701 aacggccggc tgcctgtgaa gtggatggcc cctgaggcgt tgtttgaccg gatctacaca
     2761 caccagagcg atgtgtggtc ttttggagtg ctcttgtggg agatcttcac tctgggtggc
     2821 tccccatacc ccggtgtgcc tgtggaggaa cttttcaagc tgctgaagga gggtcatcga
     2881 atggacaagc ccagtaactg taccaatgag ctgtacatga tgatgcggga ctgctggcat
     2941 gcagtgccct ctcagagacc tacgttcaag cagttggtgg aagacctgga ccgcattgtg
     3001 gccttgacct ccaaccagga gtatctggac ctgtccatac cgctggacca gtactcaccc
     3061 agctttcccg acacacggag ctccacctgc tcctcagggg aggactctgt cttctctcat
     3121 gagccgttac ctgaggagcc ctgtctgcct cgacacccca cccagcttgc caacagtgga
     3181 ctcaaacggc gctgactacc aaccctgtcc ccagttttct cccattccgt cgtcacccgt
     3241 gcccctcacc cacaatcccc ttgttggaca cactgccttt ctcctcctcc tttgccgctg
     3301 gcaagagcca gtgcctgact gaggccttcc tgtgttgtgg ccttccccct ccatcacccc
     3361 caagacccct cttctccctc ttcttagcct gctgtgtgag agaggagcca agaggcaggt
     3421 gcttgccgac ggccgcatcc tccttcccag gtgttggacc aagacccgcc ccgctgcctg
     3481 gcactgcttg gaggtgtgca gagcggaagc aagtggagca tccggggcat tcctgttgac
     3541 ccatcagccc cttctgttct ggcggcaggg gccttggggc tcctggaagc cgtgaggttt
     3601 ctgtttaggc cttaaccgaa ggcaacctct gctccagatg gatggtacca gtagcttctt
     3661 aattccaata ctaatttgct ttgctgacca aatacctgcc tggtaccaga agacagggag
     3721 gcagagactg ggagccgtga tgtgcccttg ggctgagccc tagacttggg gctctgtaca
     3781 tagctatgaa gaaaaacaca aagtgtataa atcttgagta tatatttaca tgtcttttta
     3841 aaaagggtcg ttactagaga tttacccatg ggggagacgc ccagggtagc atccgttgct
     3901 atatattaaa aacaaacgaa cagaaagaaa aaaaaaagga aaatgttttt taaaaggtca
     3961 tatatttttt tgctactttt gctgttttat ttttttaaat tatgttttaa acctattttc
     4021 agtttaggtt tccctcaata aaaaattgct gctgcttcat ttttatcctg ggcgtgtgaa
     4081 aagagagcag gtgtccagcg cagaggaggg agacaggggg taaagggcca tgagctggtc
     4141 ttccccctgc cccccatgac ctctgtctcc tggattgtgc cccagacctc ccagccaagc
     4201 cttctatctc ccgatgcatt gggaacagca ggagaagact gaggtcctga gggcagagag
     4261 ccaagctcgc acacttgatt gtttcctcgg aggagagagt gagaggatga ggttagccag
     4321 agggtagaac tggacagaaa cccaaaccct agaccctgta cattcagatg tcttgtctat
     4381 cttccccaac ctactcctca tattcctctc ctgtaaatat cctccccttc cctgttggtc
     4441 tctgttaccc agttgggtct gtccctgagc ttggcttcct atagtttttc cttcacaaac
     4501 tccacccatc cctcaggaaa cagaaaacga tctctttggt tggggtcaac ttggcaactc
     4561 aattctgcca cctgctggtt gctttggtac cttggtctct tattcaaacc cacaccactc
     4621 aagccttaga gggtttgttt ttgttttttg tttgtttgtt tggttggttg gttggtcttt
     4681 tttttctggg tctgctgaat acaaacctgt tcagtatgat ttcatctgta ggggttaggg
     4741 ctgcttcttt aaatgcagtt ttggcagctg tggtttgggt cattgtcata agagttctta
     4801 tcgttgtttc tctctgtaca catgtaactg tcaaaatatt atgaatggtt tttatgctga
     4861 aagaagacat catttggcaa agagggctag ggaatgaatt tagcacaaac tcattttctt
     4921 ggagaccgtg tatcatagtg gttttttttt tttttctttc tcttgttaaa actgaacatt
     4981 atttctgcct caggtctact tgactcactg ctgtgtggat ggaaggagaa cacagaaagg
     5041 gcttagtgtg actcaaggag aggagctagg aactggaagg aactgaagtc ccctctgtta
     5101 ctattcagat tgcccgcaga cggcccctgg gacaggggtg gctatcaaat agaaagtagt
     5161 gacattgaca tgaagggaaa tgaaatggct atttcactta gaggaccaga ttaggtctcg
     5221 tgggaggggg aacccagctt acagaatgaa gatgttactg tcagagcaca gcatctgtct
     5281 ggtttcctgg gggttaaaat atggcccagg catcaatcaa tactgcttcc ccatcttttc
     5341 taattgccat aggctaaagg ccatcagtcc cctggctctg ttaatgtaat gtatcgattt
     5401 caggtaagta agattgaaca tagatgaagt aagaaatcgg ccttaatggt aatgaactct
     5461 gtttatcaac tgccactggg tggagccagc aagctaaaat atcctcctac acacagacag
     5521 tgttaggtta tactgtcaga gccactgtcc tctgaagtaa cagacctacc tgcaagcggg
     5581 aacttttggc ctggatatag cattgtcaga ctctggacat gaccaatatg tcttgtacag
     5641 aattggacat ggcacaagtg cagggccata ctattaagta gcagcaacaa ctattacaat
     5701 tctgtgtaga atgtgtgctg tgtctaatgt cgctacaggc gcatgttaga gcttaaaact
     5761 gtacccaatg agcttgttag cagctgttag cagctggtag agcttggttc caccacatat
     5821 gcaggaaata gctgggaggg agaatggagg gctttgaagc aacatggcat gtagaaacca
     5881 agaagggagt agaccagcaa gaaccctgaa gttggctggt cctggtagtg aatgcctgta
     5941 atcccagact cagaaggcag agaccggtag atcttgagtt cagggacaac ttggtctaca
     6001 tcgtgagttc agggcctgct gaagatgcac agtgagactc ttgtctaaaa ggaaattaaa
     6061 cgaaccagaa cacactgaag ttatgaagga ctctggaact ggttccctct tgtttgacac
     6121 acagcagcat tcagaatctt tactgcctgc tgggtacgtg catgtcctgg tgcacagaag
     6181 caatgcattc aattgccgtg ctgtcggagg ttccagtggt gtgctgaaac tggctctcta
     6241 aaggaaagta tgtgtgtcag cctggggtta tggcctagta acccaaattt tgaaaacaaa
     6301 aggtgatggt ctttaatcct gaactcaggg ggcagaagcc agtggatctc ttaaattcaa
     6361 ggccagcctg gtctatatat tgagttctag gtcaaccaag attgcatggt gataccctgt
     6421 ctccaaaaaa gtaaaatggg ggatgggagt ggggtgggtc ggggcacagg tggagtcctc
     6481 aatggccaga ctccatgact taactacttc catttgctca ttgagaaggc cagaaggaat
     6541 ccacgtgcat cagggagatg agaggattaa gccagttaag tagctaatcc ctttcccata
     6601 ttacacatct atagtatgca ctaagtttaa aaacccacca cttccagacg gaagttgtat
     6661 tgtgagatac cttagattag agcaatggca gcttcccaga gtggtgtatg aacacagcct
     6721 acagaagtca gttgattagc acactgggtg ggactggtcc tccatgacta gggagcattt
     6781 tgaggaggta catgctctgg gctggggtgt agtccagttg cttgaatgat gattaaggag
     6841 ttcattggct atgtggtagt ggcacacacc tataatccca gcactcctga gttcaaggcc
     6901 tgggaagtgg gtggagatgt ctgtgtcttg tttgtttcga gatagggtct cactgtgtag
     6961 ctctggctgt cctggaactc actctgtaga ccagcctgga ctcccaactc acaaagagcc
     7021 accggcctct ccttccagag tgcttgaatt aaaggtacgt gccaccacgg tctggca
//
