LOCUS       NM_001079908            7071 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus fibroblast growth factor receptor 1 (Fgfr1),
            transcript variant 2, mRNA.
ACCESSION   NM_001079908
VERSION     NM_001079908.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7071)
  AUTHORS   De Vincenti,A.P., Bonafina,A., Ledda,F. and Paratcha,G.
  TITLE     Lrig1 regulates cell fate specification of glutamatergic neurons
            via FGF-driven Jak2/Stat3 signaling in cortical progenitors
  JOURNAL   Development 151 (17) (2024)
   PUBMED   39250533
REFERENCE   2  (bases 1 to 7071)
  AUTHORS   Esteve,N.A., Rogers,D.J., Stagray,J.A., Mayeux,H., Nora,G.,
            Huval,L. and Smith,K.M.
  TITLE     Tanycyte radial morphology and proliferation are influenced by
            fibroblast growth factor receptor 1 and high-fat diet
  JOURNAL   Eur J Neurosci 60 (5), 5000-5018 (2024)
   PUBMED   39087621
  REMARK    GeneRIF: Tanycyte radial morphology and proliferation are
            influenced by fibroblast growth factor receptor 1 and high-fat
            diet.
REFERENCE   3  (bases 1 to 7071)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7071)
  AUTHORS   de Jaime-Soguero,A., Hattemer,J., Bufe,A., Haas,A., van den
            Berg,J., van Batenburg,V., Das,B., di Marco,B., Androulaki,S.,
            Bohly,N., Landry,J.J.M., Schoell,B., Rosa,V.S., Villacorta,L.,
            Baskan,Y., Trapp,M., Benes,V., Chabes,A., Shahbazi,M., Jauch,A.,
            Engel,U., Patrizi,A., Sotillo,R., van Oudenaarden,A., Bageritz,J.,
            Alfonso,J., Bastians,H. and Acebron,S.P.
  TITLE     Developmental signals control chromosome segregation fidelity
            during pluripotency and neurogenesis by modulating replicative
            stress
  JOURNAL   Nat Commun 15 (1), 7404 (2024)
   PUBMED   39191776
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7071)
  AUTHORS   Almubarak,A., Zhang,Q., Zhang,C.H., Abdelwahab,N., Kume,T.,
            Lassar,A.B. and Berry,F.B.
  TITLE     FOXC1 and FOXC2 regulate growth plate chondrocyte maturation
            towards hypertrophy in the embryonic mouse limb skeleton
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39012257
REFERENCE   6  (bases 1 to 7071)
  AUTHORS   Gilardi-Hebenstreit,P., Nieto,M.A., Frain,M., Mattei,M.G.,
            Chestier,A., Wilkinson,D.G. and Charnay,P.
  TITLE     An Eph-related receptor protein tyrosine kinase gene segmentally
            expressed in the developing mouse hindbrain
  JOURNAL   Oncogene 7 (12), 2499-2506 (1992)
   PUBMED   1281307
  REMARK    Erratum:[Oncogene. 1993 Apr;8(4):1103. PMID: 8455939]
REFERENCE   7  (bases 1 to 7071)
  AUTHORS   Saito,H., Kouhara,H., Kasayama,S., Kishimoto,T. and Sato,B.
  TITLE     Characterization of the promoter region of the murine fibroblast
            growth factor receptor 1 gene
  JOURNAL   Biochem Biophys Res Commun 183 (2), 688-693 (1992)
   PUBMED   1312839
REFERENCE   8  (bases 1 to 7071)
  AUTHORS   Ueno,H., Gunn,M., Dell,K., Tseng,A. Jr. and Williams,L.
  TITLE     A truncated form of fibroblast growth factor receptor 1 inhibits
            signal transduction by multiple types of fibroblast growth factor
            receptor
  JOURNAL   J Biol Chem 267 (3), 1470-1476 (1992)
   PUBMED   1309784
REFERENCE   9  (bases 1 to 7071)
  AUTHORS   Peters,K.G., Werner,S., Chen,G. and Williams,L.T.
  TITLE     Two FGF receptor genes are differentially expressed in epithelial
            and mesenchymal tissues during limb formation and organogenesis in
            the mouse
  JOURNAL   Development 114 (1), 233-243 (1992)
   PUBMED   1315677
REFERENCE   10 (bases 1 to 7071)
  AUTHORS   Werner,S., Duan,D.S., de Vries,C., Peters,K.G., Johnson,D.E. and
            Williams,L.T.
  TITLE     Differential splicing in the extracellular region of fibroblast
            growth factor receptor 1 generates receptor variants with different
            ligand-binding specificities
  JOURNAL   Mol Cell Biol 12 (1), 82-88 (1992)
   PUBMED   1309595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160526.13.
            
            On Aug 29, 2022 this sequence version replaced NM_001079908.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049704.1, BC010200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-638               AC160526.13        71167-71804         c
            639-817             AC160526.13        58168-58346         c
            818-1084            AC160526.13        34822-35088         c
            1085-1168           AC160526.13        32782-32865         c
            1169-1341           AC160526.13        32353-32525         c
            1342-1465           AC160526.13        29753-29876         c
            1466-1656           AC160526.13        28268-28458         c
            1657-1801           AC160526.13        26112-26256         c
            1802-2004           AC160526.13        23683-23885         c
            2005-2150           AC160526.13        22263-22408         c
            2151-2272           AC160526.13        20836-20957         c
            2273-2383           AC160526.13        20345-20455         c
            2384-2574           AC160526.13        19696-19886         c
            2575-2697           AC160526.13        18136-18258         c
            2698-2768           AC160526.13        17807-17877         c
            2769-2906           AC160526.13        17336-17473         c
            2907-3012           AC160526.13        16945-17050         c
            3013-7071           AC160526.13        12793-16851         c
FEATURES             Location/Qualifiers
     source          1..7071
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 14.12 cM"
     gene            1..7071
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /note="fibroblast growth factor receptor 1"
                     /db_xref="GeneID:14182"
                     /db_xref="MGI:MGI:95522"
     exon            1..638
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            639..817
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     CDS             727..3189
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /EC_number="2.7.10.1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; basic fibroblast growth factor receptor 1;
                     proto-oncogene c-Fgr"
                     /codon_start=1
                     /product="fibroblast growth factor receptor 1 isoform 2
                     precursor"
                     /protein_id="NP_001073377.1"
                     /db_xref="CCDS:CCDS57614.1"
                     /db_xref="GeneID:14182"
                     /db_xref="MGI:MGI:95522"
                     /translation="MWGWKCLLFWAVLVTATLCTARPAPTLPEQAQPWGVPVEVESLL
                     VHPGDLLQLRCRLRDDVQSINWLRDGVQLVESNRTRITGEEVEVRDSIPADSGLYACV
                     TSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKME
                     KKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSV
                     VPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCK
                     VYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDA
                     GEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMLGSV
                     IIYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSS
                     GTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTK
                     VAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN
                     LREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAA
                     RNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVW
                     SFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPS
                     QRPTFKQLVEDLDRIVALTSNQEYLDLSIPLDQYSPSFPDTRSSTCSSGEDSVFSHEP
                     LPEEPCLPRHPTQLANSGLKRR"
     exon            818..1084
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1168
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1341
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1465
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1656
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1801
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..2004
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2150
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2272
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2383
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2574
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2697
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2768
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2906
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3012
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..7071
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4031..4036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /note="hexamer: AATAAA"
     polyA_site      4059
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /note="major polyA site"
     regulatory      4887..4892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /note="hexamer: AATGAA"
     polyA_site      4917
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
     polyA_site      4975
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
     polyA_site      4986
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
     regulatory      7042..7047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
                     /note="hexamer: ATTAAA"
     polyA_site      7071
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG;
                     Flt-2; Fr1; Hspy; MFR"
ORIGIN      
        1 gcacagcgct cggagcgctc ctgcgggtac tttggcgggg ctctccgctg cgggcggcgc
       61 ggaacgggag ccggaaccct ggtgcagccg ctgcgtgcag aggacccggg ctgcgcaggg
      121 aagcggggcc gagacgtccg gactggactg agactgtgct tagcgcattg cggcgacctc
      181 gcctttcccg gccgcgagcg cgcgccgcag ctggaaaagc agcggagacc gaggactttt
      241 ctcaggtccc aggggcgcac cacagccgtg ctgcagtcaa tgcacgccgg agccccagga
      301 ggggtgatgg aactcgggct gccagaagcc tgagacgccg ccaccgccgc cgctgcgtac
      361 tggagagcgg ggggcgcacg atctggggac cccgggcggc ggacccgagc cctccccccc
      421 gccccgcctc cggggcacca gcttcggctc cattgttccc gcccgggctg gaggcgcccg
      481 gctcggagtg ccgccgggag tcgtgcctcg gccgcggagc cctcgagacc ccatcaggat
      541 ctgaacggag cccggagacg agcggcggga gcgcaagaca cagacacccg ccgcgccacg
      601 gcgagctctc cagaggcggg accgcagcgc caagtgagag tcagcttgcg aaggcagacc
      661 acgctcacgg tggaatatcc atggaggtac ggagccttgt taccaacctc taaccgcaga
      721 actgggatgt ggggctggaa gtgcctcctc ttctgggctg tgctggtcac agccactctc
      781 tgcactgcca ggccagcccc aaccttgcct gaacaagctc agccctgggg agtccctgtg
      841 gaagtggagt ctctcctggt ccaccctggc gacctgctac agcttcgctg tcggcttcgc
      901 gatgatgtgc agagcatcaa ctggctgcgg gatggggtgc agctggtgga gagcaaccgt
      961 acccgcatca caggggagga ggtggaggtg cgggactcca tccccgctga ctctggcctc
     1021 tacgcttgcg tgaccagcag cccctctggc agcgatacca cctacttctc cgtcaatgtc
     1081 tcagatgcac tcccatcctc ggaagatgat gacgacgacg atgactcctc ctcggaggag
     1141 aaagagacgg acaacaccaa accaaaccct gtagctccct actggacatc cccagagaaa
     1201 atggagaaga aactgcatgc ggtgcccgct gccaagacgg tgaagttcaa gtgcccgtcg
     1261 agtgggacac ccaaccccac tctgcgctgg ttgaaaaatg gcaaagagtt taagcctgac
     1321 caccgaattg gaggctacaa ggttcgctat gccacctgga gcatcataat ggattctgtg
     1381 gtgccttctg acaagggcaa ctacacctgc atcgtggaga atgagtatgg gagcatcaac
     1441 cacacctacc agcttgacgt cgtggaacga tctccgcacc gacccatcct tcaggcaggg
     1501 ctgcctgcca acaagacagt ggccctgggc agcaatgtgg agttcatgtg taaggtgtac
     1561 agcgatccgc agcctcacat tcagtggctg aagcacatcg aggtgaacgg gagtaagatc
     1621 gggccagaca acttgccgta tgtccagatc ctgaagactg ctggagttaa taccaccgac
     1681 aaggaaatgg aggtgcttca tctacggaat gtctcctttg aggatgcggg ggagtatacg
     1741 tgcttggcgg gtaactctat cggactctcc catcactctg catggttgac cgttctggaa
     1801 gccctggaag agagaccagc tgtgatgacc tcaccgctct acctggagat cattatctac
     1861 tgcaccgggg ccttcctgat ctcctgcatg ttgggctctg tcatcatcta taagatgaag
     1921 agcggcacca agaagagcga cttccatagc cagatggctg tgcacaagct ggccaagagc
     1981 atccctctgc gcagacaggt aacagtgtca gctgactcca gtgcatccat gaactctggg
     2041 gttctcctgg ttcggccctc acggctctcc tccagcggga cccccatgct ggctggagtc
     2101 tccgaatatg agctccctga ggatccccgc tgggagctgc cacgagacag actggtctta
     2161 ggcaaaccac ttggcgaggg ctgcttcggg caggtggtgt tggctgaggc catcgggctg
     2221 gataaggaca aacccaaccg tgtgaccaaa gtggccgtga agatgttgaa gtccgacgca
     2281 acggagaagg acctgtcgga tctgatctcg gagatggaga tgatgaaaat gattgggaag
     2341 cacaagaata tcatcaacct tctgggagcg tgcacacagg atggtcctct ttatgtcatt
     2401 gtggagtacg cctccaaagg caatctccgg gagtatctac aggcccggag gcctcctggg
     2461 ctggagtact gctataaccc cagccacaac cccgaggaac agctgtcttc caaagatctg
     2521 gtatcctgtg cctatcaggt ggctcggggc atggagtatc ttgcctctaa gaagtgtata
     2581 caccgagacc tggctgctag gaacgtcctg gtgaccgagg ataacgtaat gaagatcgca
     2641 gactttggct tagctcgaga cattcatcat atcgactact acaagaaaac caccaacggc
     2701 cggctgcctg tgaagtggat ggcccctgag gcgttgtttg accggatcta cacacaccag
     2761 agcgatgtgt ggtcttttgg agtgctcttg tgggagatct tcactctggg tggctcccca
     2821 taccccggtg tgcctgtgga ggaacttttc aagctgctga aggagggtca tcgaatggac
     2881 aagcccagta actgtaccaa tgagctgtac atgatgatgc gggactgctg gcatgcagtg
     2941 ccctctcaga gacctacgtt caagcagttg gtggaagacc tggaccgcat tgtggccttg
     3001 acctccaacc aggagtatct ggacctgtcc ataccgctgg accagtactc acccagcttt
     3061 cccgacacac ggagctccac ctgctcctca ggggaggact ctgtcttctc tcatgagccg
     3121 ttacctgagg agccctgtct gcctcgacac cccacccagc ttgccaacag tggactcaaa
     3181 cggcgctgac taccaaccct gtccccagtt ttctcccatt ccgtcgtcac ccgtgcccct
     3241 cacccacaat ccccttgttg gacacactgc ctttctcctc ctcctttgcc gctggcaaga
     3301 gccagtgcct gactgaggcc ttcctgtgtt gtggccttcc ccctccatca cccccaagac
     3361 ccctcttctc cctcttctta gcctgctgtg tgagagagga gccaagaggc aggtgcttgc
     3421 cgacggccgc atcctccttc ccaggtgttg gaccaagacc cgccccgctg cctggcactg
     3481 cttggaggtg tgcagagcgg aagcaagtgg agcatccggg gcattcctgt tgacccatca
     3541 gccccttctg ttctggcggc aggggccttg gggctcctgg aagccgtgag gtttctgttt
     3601 aggccttaac cgaaggcaac ctctgctcca gatggatggt accagtagct tcttaattcc
     3661 aatactaatt tgctttgctg accaaatacc tgcctggtac cagaagacag ggaggcagag
     3721 actgggagcc gtgatgtgcc cttgggctga gccctagact tggggctctg tacatagcta
     3781 tgaagaaaaa cacaaagtgt ataaatcttg agtatatatt tacatgtctt tttaaaaagg
     3841 gtcgttacta gagatttacc catgggggag acgcccaggg tagcatccgt tgctatatat
     3901 taaaaacaaa cgaacagaaa gaaaaaaaaa aggaaaatgt tttttaaaag gtcatatatt
     3961 tttttgctac ttttgctgtt ttattttttt aaattatgtt ttaaacctat tttcagttta
     4021 ggtttccctc aataaaaaat tgctgctgct tcatttttat cctgggcgtg tgaaaagaga
     4081 gcaggtgtcc agcgcagagg agggagacag ggggtaaagg gccatgagct ggtcttcccc
     4141 ctgcccccca tgacctctgt ctcctggatt gtgccccaga cctcccagcc aagccttcta
     4201 tctcccgatg cattgggaac agcaggagaa gactgaggtc ctgagggcag agagccaagc
     4261 tcgcacactt gattgtttcc tcggaggaga gagtgagagg atgaggttag ccagagggta
     4321 gaactggaca gaaacccaaa ccctagaccc tgtacattca gatgtcttgt ctatcttccc
     4381 caacctactc ctcatattcc tctcctgtaa atatcctccc cttccctgtt ggtctctgtt
     4441 acccagttgg gtctgtccct gagcttggct tcctatagtt tttccttcac aaactccacc
     4501 catccctcag gaaacagaaa acgatctctt tggttggggt caacttggca actcaattct
     4561 gccacctgct ggttgctttg gtaccttggt ctcttattca aacccacacc actcaagcct
     4621 tagagggttt gtttttgttt tttgtttgtt tgtttggttg gttggttggt cttttttttc
     4681 tgggtctgct gaatacaaac ctgttcagta tgatttcatc tgtaggggtt agggctgctt
     4741 ctttaaatgc agttttggca gctgtggttt gggtcattgt cataagagtt cttatcgttg
     4801 tttctctctg tacacatgta actgtcaaaa tattatgaat ggtttttatg ctgaaagaag
     4861 acatcatttg gcaaagaggg ctagggaatg aatttagcac aaactcattt tcttggagac
     4921 cgtgtatcat agtggttttt tttttttttc tttctcttgt taaaactgaa cattatttct
     4981 gcctcaggtc tacttgactc actgctgtgt ggatggaagg agaacacaga aagggcttag
     5041 tgtgactcaa ggagaggagc taggaactgg aaggaactga agtcccctct gttactattc
     5101 agattgcccg cagacggccc ctgggacagg ggtggctatc aaatagaaag tagtgacatt
     5161 gacatgaagg gaaatgaaat ggctatttca cttagaggac cagattaggt ctcgtgggag
     5221 ggggaaccca gcttacagaa tgaagatgtt actgtcagag cacagcatct gtctggtttc
     5281 ctgggggtta aaatatggcc caggcatcaa tcaatactgc ttccccatct tttctaattg
     5341 ccataggcta aaggccatca gtcccctggc tctgttaatg taatgtatcg atttcaggta
     5401 agtaagattg aacatagatg aagtaagaaa tcggccttaa tggtaatgaa ctctgtttat
     5461 caactgccac tgggtggagc cagcaagcta aaatatcctc ctacacacag acagtgttag
     5521 gttatactgt cagagccact gtcctctgaa gtaacagacc tacctgcaag cgggaacttt
     5581 tggcctggat atagcattgt cagactctgg acatgaccaa tatgtcttgt acagaattgg
     5641 acatggcaca agtgcagggc catactatta agtagcagca acaactatta caattctgtg
     5701 tagaatgtgt gctgtgtcta atgtcgctac aggcgcatgt tagagcttaa aactgtaccc
     5761 aatgagcttg ttagcagctg ttagcagctg gtagagcttg gttccaccac atatgcagga
     5821 aatagctggg agggagaatg gagggctttg aagcaacatg gcatgtagaa accaagaagg
     5881 gagtagacca gcaagaaccc tgaagttggc tggtcctggt agtgaatgcc tgtaatccca
     5941 gactcagaag gcagagaccg gtagatcttg agttcaggga caacttggtc tacatcgtga
     6001 gttcagggcc tgctgaagat gcacagtgag actcttgtct aaaaggaaat taaacgaacc
     6061 agaacacact gaagttatga aggactctgg aactggttcc ctcttgtttg acacacagca
     6121 gcattcagaa tctttactgc ctgctgggta cgtgcatgtc ctggtgcaca gaagcaatgc
     6181 attcaattgc cgtgctgtcg gaggttccag tggtgtgctg aaactggctc tctaaaggaa
     6241 agtatgtgtg tcagcctggg gttatggcct agtaacccaa attttgaaaa caaaaggtga
     6301 tggtctttaa tcctgaactc agggggcaga agccagtgga tctcttaaat tcaaggccag
     6361 cctggtctat atattgagtt ctaggtcaac caagattgca tggtgatacc ctgtctccaa
     6421 aaaagtaaaa tgggggatgg gagtggggtg ggtcggggca caggtggagt cctcaatggc
     6481 cagactccat gacttaacta cttccatttg ctcattgaga aggccagaag gaatccacgt
     6541 gcatcaggga gatgagagga ttaagccagt taagtagcta atccctttcc catattacac
     6601 atctatagta tgcactaagt ttaaaaaccc accacttcca gacggaagtt gtattgtgag
     6661 ataccttaga ttagagcaat ggcagcttcc cagagtggtg tatgaacaca gcctacagaa
     6721 gtcagttgat tagcacactg ggtgggactg gtcctccatg actagggagc attttgagga
     6781 ggtacatgct ctgggctggg gtgtagtcca gttgcttgaa tgatgattaa ggagttcatt
     6841 ggctatgtgg tagtggcaca cacctataat cccagcactc ctgagttcaa ggcctgggaa
     6901 gtgggtggag atgtctgtgt cttgtttgtt tcgagatagg gtctcactgt gtagctctgg
     6961 ctgtcctgga actcactctg tagaccagcc tggactccca actcacaaag agccaccggc
     7021 ctctccttcc agagtgcttg aattaaaggt acgtgccacc acggtctggc a
//
