LOCUS       NM_008009               1198 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus fibroblast growth factor binding protein 1 (Fgfbp1),
            transcript variant 2, mRNA.
ACCESSION   NM_008009
VERSION     NM_008009.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1198)
  AUTHORS   Ke,X., van Soldt,B., Vlahos,L., Zhou,Y., Qian,J., George,J.,
            Capdevila,C., Glass,I., Yan,K., Califano,A. and Cardoso,W.V.
  TITLE     Morphogenesis and regeneration share a conserved core transition
            cell state program that controls lung epithelial cell fate
  JOURNAL   Dev Cell (2024) In press
   PUBMED   39667932
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1198)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1198)
  AUTHORS   Qi,M., Fan,S., Huang,M., Pan,J., Li,Y., Miao,Q., Lyu,W., Li,X.,
            Deng,L., Qiu,S., Liu,T., Deng,W., Chu,X., Jiang,C., He,W., Xia,L.,
            Yang,Y., Hong,J., Qi,Q., Yin,W., Liu,X., Shi,C., Chen,M., Ye,W. and
            Zhang,D.
  TITLE     Targeting FAPalpha-expressing hepatic stellate cells overcomes
            resistance to antiangiogenics in colorectal cancer liver metastasis
            models
  JOURNAL   J Clin Invest 132 (19), e157399 (2022)
   PUBMED   35951441
  REMARK    GeneRIF: Targeting FAPalpha-expressing hepatic stellate cells
            overcomes resistance to antiangiogenics in colorectal cancer liver
            metastasis models.
            Erratum:[J Clin Invest. 2023 Feb 01;133(3):e168771. doi:
            10.1172/JCI168771. PMID: 36719375]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1198)
  AUTHORS   Chen,X., Miao,M., Zhou,M., Chen,J., Li,D., Zhang,L., Sun,A.,
            Guan,M., Wang,Z., Liu,P., Zhang,S., Zha,X. and Fan,X.
  TITLE     Poly-L-arginine promotes asthma angiogenesis through induction of
            FGFBP1 in airway epithelial cells via activation of the
            mTORC1-STAT3 pathway
  JOURNAL   Cell Death Dis 12 (8), 761 (2021)
   PUBMED   34341336
  REMARK    GeneRIF: Poly-L-arginine promotes asthma angiogenesis through
            induction of FGFBP1 in airway epithelial cells via activation of
            the mTORC1-STAT3 pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1198)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1198)
  AUTHORS   Hurle,B., Lane,K., Kenney,J., Tarantino,L.M., Bucan,M.,
            Brownstein,B.H. and Ornitz,D.M.
  TITLE     Physical mapping of the mouse tilted locus identifies an
            association between human deafness loci DFNA6/14 and vestibular
            system development
  JOURNAL   Genomics 77 (3), 189-199 (2001)
   PUBMED   11597144
REFERENCE   7  (bases 1 to 1198)
  AUTHORS   Mongiat,M., Otto,J., Oldershaw,R., Ferrer,F., Sato,J.D. and
            Iozzo,R.V.
  TITLE     Fibroblast growth factor-binding protein is a novel partner for
            perlecan protein core
  JOURNAL   J Biol Chem 276 (13), 10263-10271 (2001)
   PUBMED   11148217
REFERENCE   8  (bases 1 to 1198)
  AUTHORS   Lametsch,R., Rasmussen,J.T., Johnsen,L.B., Purup,S., Sejrsen,K.,
            Petersen,T.E. and Heegaard,C.W.
  TITLE     Structural characterization of the fibroblast growth factor-binding
            protein purified from bovine prepartum mammary gland secretion
  JOURNAL   J Biol Chem 275 (26), 19469-19474 (2000)
   PUBMED   10867016
REFERENCE   9  (bases 1 to 1198)
  AUTHORS   Kurtz,A., Wang,H.L., Darwiche,N., Harris,V. and Wellstein,A.
  TITLE     Expression of a binding protein for FGF is associated with
            epithelial development and skin carcinogenesis
  JOURNAL   Oncogene 14 (22), 2671-2681 (1997)
   PUBMED   9178765
REFERENCE   10 (bases 1 to 1198)
  AUTHORS   Madarame,H. and Sakurai,H.
  TITLE     Spontaneous adenocarcinoma of the colon in a DDD mouse
  JOURNAL   Lab Anim Sci 43 (1), 108-110 (1993)
   PUBMED   8384674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164004.3, BC065774.1 and CB524251.1.
            
            On Oct 25, 2012 this sequence version replaced NM_008009.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065774.1, AK146625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC164004.3         180458-180494       c
            38-1196             BC065774.1         1-1159
            1197-1198           CB524251.1         507-508
FEATURES             Location/Qualifiers
     source          1..1198
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 23.95 cM"
     gene            1..1198
                     /gene="Fgfbp1"
                     /gene_synonym="FGF-BP; FGF-BP1; FGFBP-1"
                     /note="fibroblast growth factor binding protein 1"
                     /db_xref="GeneID:14181"
                     /db_xref="MGI:MGI:1096350"
     exon            1..87
                     /gene="Fgfbp1"
                     /gene_synonym="FGF-BP; FGF-BP1; FGFBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            88..1198
                     /gene="Fgfbp1"
                     /gene_synonym="FGF-BP; FGF-BP1; FGFBP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..863
                     /gene="Fgfbp1"
                     /gene_synonym="FGF-BP; FGF-BP1; FGFBP-1"
                     /note="FGF-binding protein 1"
                     /codon_start=1
                     /product="fibroblast growth factor-binding protein 1
                     precursor"
                     /protein_id="NP_032035.2"
                     /db_xref="CCDS:CCDS19268.1"
                     /db_xref="GeneID:14181"
                     /db_xref="MGI:MGI:1096350"
                     /translation="MRLHSLILLSFLLLATQAFSEKVRKRAKNAPHSTAEEGVEGSAP
                     SLGKAQNKQRSRTSKSLTHGKFVTKDQATCRWAVTEEEQGISLKVQCTQADQEFSCVF
                     AGDPTDCLKHDKDQIYWKQVARTLRKQKNICRNAKSVLKTRVCRKRFPESNLKLVNPN
                     ARGNTKPRKEKAEVSAREHNKVQEAVSTEPNRVKEDITLNPAATQTMAIRDPECLEDP
                     DVLNQRKTALEFCGESWSSICTFFLNMLQATSC"
     regulatory      1171..1176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgfbp1"
                     /gene_synonym="FGF-BP; FGF-BP1; FGFBP-1"
                     /note="hexamer: AATAAA"
     polyA_site      1196
                     /gene="Fgfbp1"
                     /gene_synonym="FGF-BP; FGF-BP1; FGFBP-1"
                     /note="major polyA site"
ORIGIN      
        1 ctgtataaat agtacaacct gcaccccagc gtgaggactg gaagcctgca ttccccagta
       61 cacctggatc tgcacactca cagaaaggtg tccacccagc tgacgtgatg agactccaca
      121 gcctcatcct gctctccttc cttctcctgg ctactcaggc gttctcagaa aaggtcagaa
      181 agagagccaa gaacgcacca cacagcacag cggaggaggg ggtagagggt tcagctccct
      241 cgttagggaa ggcccagaat aagcagagaa gcaggacatc taaatctctg acgcatggca
      301 agtttgtcac caaagaccaa gccacatgca gatgggctgt gactgaggag gagcagggca
      361 tcagcctgaa ggtccagtgc acacaagccg atcaggagtt ttcttgtgtt tttgctggtg
      421 acccaactga ctgccttaaa cacgacaaag accagatcta ctggaaacag gttgcccgca
      481 cgctgcgcaa acagaaaaat atctgcagga acgccaagag tgtcttgaag accagagtgt
      541 gcagaaagag atttccagag tctaacctca agctggtgaa ccccaacgca cgtggaaaca
      601 cgaagcccag gaaggagaaa gcagaggtct ccgcaaggga gcacaacaag gtccaagaag
      661 ctgtctccac ggagccaaac agggtcaaag aagacatcac actcaatcca gctgcgaccc
      721 agaccatggc cattagagat ccagagtgtc tagaggatcc agatgtgctc aaccagagga
      781 agaccgccct ggagttctgt ggggaatctt ggagctccat ttgcacattc ttcctcaaca
      841 tgttacaggc gacatcatgc taatgaagtc agagggagca gcctgagaca tgtggtatca
      901 gagccccact gtctgctgga aacttcccga gttccccaca agatacattt ctaatatggg
      961 aacaaaatga agtatttaaa cagattttgt aaattttgtt tttgtgtttt agaatttgct
     1021 tttttttttc cacatccttg gatatgcttt tcagggacgc tttacctcag cgtattcttc
     1081 catggaccac aaacctaggt gcatataagt agtggatcaa tgcatgtgat aatatgcaag
     1141 caaggaattg ttggctgtat ttaccaggat aataaagttc tgggcattct cagaaata
//
