LOCUS       NM_013518               4145 bp    mRNA    linear   ROD 06-MAY-2023
DEFINITION  Mus musculus fibroblast growth factor 9 (Fgf9), mRNA.
ACCESSION   NM_013518
VERSION     NM_013518.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4145)
  AUTHORS   Bunce C, Barske L, Zhang G and Capel B.
  TITLE     Biased precursor ingression underlies the center-to-pole pattern of
            male sex determination in mouse
  JOURNAL   Development 150 (5) (2023)
   PUBMED   36912416
REFERENCE   2  (bases 1 to 4145)
  AUTHORS   Ganji E, Leek C, Duncan W, Patra D, Ornitz DM and Killian ML.
  TITLE     Targeted deletion of Fgf9 in tendon disrupts mineralization of the
            developing enthesis
  JOURNAL   FASEB J 37 (3), e22777 (2023)
   PUBMED   36734881
  REMARK    GeneRIF: Targeted deletion of Fgf9 in tendon disrupts
            mineralization of the developing enthesis.
            Erratum:[FASEB J. 2023 Apr;37(4):e22856. PMID: 36929525]
REFERENCE   3  (bases 1 to 4145)
  AUTHORS   Pan YN, Jia C, Yu JP, Wu ZW, Xu GC and Huang YX.
  TITLE     Fibroblast growth factor 9 reduces TBHP-induced oxidative stress in
            chondrocytes and diminishes mouse osteoarthritis by activating
            ERK/Nrf2 signaling pathway
  JOURNAL   Int Immunopharmacol 114, 109606 (2023)
   PUBMED   36700776
  REMARK    GeneRIF: Fibroblast growth factor 9 reduces TBHP-induced oxidative
            stress in chondrocytes and diminishes mouse osteoarthritis by
            activating ERK/Nrf2 signaling pathway.
REFERENCE   4  (bases 1 to 4145)
  AUTHORS   Uchida A, Imaimatsu K, Suzuki H, Han X, Ushioda H, Uemura M,
            Imura-Kishi K, Hiramatsu R, Takase HM, Hirate Y, Ogura A,
            Kanai-Azuma M, Kudo A and Kanai Y.
  TITLE     SOX17-positive rete testis epithelium is required for Sertoli valve
            formation and normal spermiogenesis in the male mouse
  JOURNAL   Nat Commun 13 (1), 7860 (2022)
   PUBMED   36543770
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4145)
  AUTHORS   Sun Y, Ying X, Li R, Weng M, Shi J and Chen Z.
  TITLE     FGF9 Promotes Expression of HAS2 in Palatal Elevation via the
            Wnt/beta-Catenin/TCF7L2 Pathway
  JOURNAL   Biomolecules 12 (11), 1639 (2022)
   PUBMED   36358989
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4145)
  AUTHORS   Santos-Ocampo S, Colvin JS, Chellaiah A and Ornitz DM.
  TITLE     Expression and biological activity of mouse fibroblast growth
            factor-9
  JOURNAL   J Biol Chem 271 (3), 1726-1731 (1996)
   PUBMED   8576175
REFERENCE   7  (bases 1 to 4145)
  AUTHORS   Seo M and Noguchi K.
  TITLE     Retinoic acid induces gene expression of fibroblast growth factor-9
            during induction of neuronal differentiation of mouse embryonal
            carcinoma P19 cells
  JOURNAL   FEBS Lett 370 (3), 231-235 (1995)
   PUBMED   7656983
REFERENCE   8  (bases 1 to 4145)
  AUTHORS   Muenke M and Schell U.
  TITLE     Fibroblast-growth-factor receptor mutations in human skeletal
            disorders
  JOURNAL   Trends Genet 11 (8), 308-313 (1995)
   PUBMED   8585128
  REMARK    Review article
REFERENCE   9  (bases 1 to 4145)
  AUTHORS   Matsumoto-Yoshitomi S, Seko C, Kuroshima K, Naruo K, Shino A, Kondo
            T and Kurokawa T.
  TITLE     Stimulation of thrombopoiesis in mice by fibroblast growth factor 9
  JOURNAL   Growth Factors 12 (3), 179-190 (1995)
   PUBMED   8619924
REFERENCE   10 (bases 1 to 4145)
  AUTHORS   Miyamoto M, Naruo K, Seko C, Matsumoto S, Kondo T and Kurokawa T.
  TITLE     Molecular cloning of a novel cytokine cDNA encoding the ninth
            member of the fibroblast growth factor family, which has a unique
            secretion property
  JOURNAL   Mol Cell Biol 13 (7), 4251-4259 (1993)
   PUBMED   8321227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158782.1, AK041815.1, BX512213.1 and AI414273.1.
            
            [WARNING] On Jun 2, 2023 this sequence was replaced by NM_013518.5.
            
            On Oct 21, 2009 this sequence version replaced NM_013518.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.84531.1, AK158782.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1556              AK158782.1         2-1557
            1557-3756           AK041815.1         1011-3210
            3757-4138           BX512213.1         121-502
            4139-4145           AI414273.1         1-7                 c
FEATURES             Location/Qualifiers
     source          1..4145
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 30.51 cM"
     gene            1..4145
                     /gene="Fgf9"
                     /gene_synonym="Eks; Fgf4b"
                     /note="fibroblast growth factor 9"
                     /db_xref="GeneID:14180"
                     /db_xref="MGI:MGI:104723"
     exon            1..647
                     /gene="Fgf9"
                     /gene_synonym="Eks; Fgf4b"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..997
                     /gene="Fgf9"
                     /gene_synonym="Eks; Fgf4b"
                     /note="glia-activating factor; GAF; FGF-9; HBGF-9; elbow
                     knee synostosis; fibroblast growth factor 4b"
                     /codon_start=1
                     /product="fibroblast growth factor 9"
                     /protein_id="NP_038546.2"
                     /db_xref="CCDS:CCDS27164.1"
                     /db_xref="GeneID:14180"
                     /db_xref="MGI:MGI:104723"
                     /translation="MAPLGEVGSYFGVQDAVPFGNVPVLPVDSPVLLSDHLGQSEAGG
                     LPRGPAVTDLDHLKGILRRRQLYCRTGFHLEIFPNGTIQGTRKDHSRFGILEFISIAV
                     GLVSIRGVDSGLYLGMNEKGELYGSEKLTQECVFREQFEENWYNTYSSNLYKHVDTGR
                     RYYVALNKDGTPREGTRTKRHQKFTHFLPRPVDPDKVPELYKDILSQS"
     exon            648..751
                     /gene="Fgf9"
                     /gene_synonym="Eks; Fgf4b"
                     /inference="alignment:Splign:2.1.0"
     exon            752..4139
                     /gene="Fgf9"
                     /gene_synonym="Eks; Fgf4b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attctgatct ctaagcaaat ggagaaacta cggatttttt tcccttatta cggtcggatg
       61 ggatgaagac ctttctgcct gctgagagtc gaggctccat atgtagcgat gcatagctgt
      121 gttgatcaat gtcagtgtgt gagtataaag tggtggcttc ttagactatc agtggtttga
      181 ccttgaacct gtgccagaga aacagccgat tacttttatt tatgcatcgg atggattgaa
      241 gaaaagaacc ctttttccct ctctgtctgc aactgcggca agggagggga gttggatata
      301 cctcgcctag tgtctcctgg ttgataccat cattattgtt tattcttgtg cttaaaagcc
      361 gagtcctctg atggctccct taggtgaagt tgggagctat ttcggtgtgc aggacgcggt
      421 accgttcggg aacgtaccgg tgttgccggt ggacagtccg gtgttgctaa gtgaccacct
      481 gggtcagtcc gaagcagggg ggctgccccg gggccccgca gtcacggact tggatcattt
      541 aaaggggatt ctcaggcgga ggcagctgta ctgcaggact ggatttcatt tagagatctt
      601 ccccaacggt actatccagg gaaccaggaa agaccacagc cgcttcggca ttctggaatt
      661 tatcagtata gcagtgggcc tggtcagcat tcgcggtgtg gacagtggac tctacctcgg
      721 catgaacgag aagggggagc tgtatggatc agaaaaacta acacaggaat gtgtgttcag
      781 agaacagttt gaagagaact ggtacaacac ctactcttcc aacctctata aacatgtgga
      841 caccggaagg agatactatg ttgcattaaa taaggacggg actccaagag aagggaccag
      901 gactaaacgg caccagaaat ttacacattt tttacctaga ccagtggacc ctgacaaagt
      961 acctgaacta tataaggata ttctaagcca aagctgacaa agacagtgtc ttcacttgag
     1021 cccttaaaac ataaccacta taaatgcttt catgcggtgg gttcttattg attagcagtg
     1081 ccgtcacctc agctccactg ttgccaaact ttgtcgcatg catatgaatg atggaagctt
     1141 ggatgaggac ttgccaattt gctctgcact tactggctgg tcctcctgga gggctgccta
     1201 gggccacttg cttgatttat tacaaaagca ggggagagag gctgcgggag agggtgcgag
     1261 tgcatgagtg agtggagggg actgcagcgc gccacgagga caatggcctg atgcatgctg
     1321 ggaaatagac acgcttttac atttttgatc agttgaactt cattctatat cagcacagct
     1381 gccatacttc aactcatcag gatttttggc tggtggcctg ctcaagggaa cactgccttt
     1441 ccacaggcgt ggagagagca gtctcactta aaaagactat cagttcattc acactggtat
     1501 catagcccag tgaatttaaa gcaaagacct cttagtttaa aagaaaaaaa aaaaaagaaa
     1561 gaaaaaaaag aaaagaaaaa gaaaaaaaca aggaaaaaaa gaaaaaaaag aaaaaaggtt
     1621 aaatttattt atagaaattc caaaggcaac attttattta ttttatatat ttatttatta
     1681 tatagagttt atttttaatg aaatatgtac aggccagata ggcattttgg aagctttagg
     1741 ctctgtaggc attaaatggc aaagtctgct atgaacctgt ggtaacttca tgcaagtagg
     1801 tatacgagaa attctaatgg ccctaatgta ctaaaggcga caatctattt tgtgcccata
     1861 ttattgtaaa cttctgcaca tcgctcatga cactgaggag tcactcttca gactgcttgt
     1921 ttcatagctt atcccagagg attaaagata aactgggttt caacccttca tttcgtgtct
     1981 gtaattttcc tctctcgtaa ttcagtctct cagtgtaact gggcggttgg aacatatgag
     2041 ggttggtgta tgtcttactt gttttaatct attgcagagt gtaccaaagc taagcaatga
     2101 ctatgcgttt taaatttcag cccacttctg tgacaacagg gctaacatca aacatggcac
     2161 tgattaaaaa ttcccaaggg agaggaaaat ccatttacat agctcctcct cctcttcctc
     2221 cgcctcttcc tcctcttcct cttcgacttc ctcggcctcc tcttcttttc tttcttttct
     2281 tttcttttct tttcttttct tttcttttct tttcttttct tttcttttct tttcttttct
     2341 tttcttttct tttctttctt ttcttttctt ttctcttctc ttctcttctc ttcttttctt
     2401 ttcttttctt ttcttttctt ttctttcctt ttcttttctt ttctgaggca aaaattagat
     2461 gaccgggatc attcttgtaa acattttatt tgtgtcttgg ctatcaaata tgaaattcta
     2521 catggaccct agggctcact ataacatttt taatggagct ggcatttggt gtgaactgtc
     2581 ataatcacat ggggttagta acctccaagt taaactggca acatggaact aatgtcttca
     2641 tcagtaacga ccttggaggg gttactgtag ccattgcctg tgcttcatct ccgaatcgga
     2701 cttcagcagt tctcagagaa gtgggtacta aatagaacac tgtttacaaa accttttata
     2761 acattatatg ctgaaaagcc caagaataca tacttatttg atagccaaaa tcctcctgtt
     2821 gggtaaggga gactatttct ctctcactat ataccaaggt gaaaagagcc aagttcttga
     2881 agcaataaag aaatctataa cacattctca ctctctagct cgttgatgtg gggaaattga
     2941 aagtgacagc taaaaaaata tgtttgaatt tgtgcagcta attttaagat gcaatattct
     3001 ggcttcactt tgcttggatg cacattctcg atgggaagcg aaagcgtgtc actggcaagg
     3061 gatagctgtt gtggtctaga aatgcctgtc ttcctgtcct gagcaaatcc atgtagccat
     3121 cttatggtcc aagctggagc gggtgacgat cttccgtgct gatgagcatt agggaggaac
     3181 ttgtatttgg aactgagaga tgtcacagag agaggagcca gacgctctgt ggatcaggca
     3241 ataggataaa gatcaggatg cattctgcat gtgtgttctg tggatccccc acccgctttc
     3301 taaacaggag ccggcgtgaa ttttgagcag tgtttttgtt tgttatttaa cactttgctg
     3361 ctaaaatgta cacatactca gatttccatt tatccaaaag cacttatttt attttatttt
     3421 gctgcaaaag attcaacatt tggccatagg aaagaattag gttggtagga tgtcatagct
     3481 gtaatatctg aagaaattga ttttaggaga cagccaataa taatcataaa gtagcaggtg
     3541 ttccagaaaa tcagcccaga agaataaaaa agaactgtgc agaaactaaa aatttcatat
     3601 attcccagaa aatgctactt taatgtctct ttttggactt tgttttggta cttttttttt
     3661 ttttttttcc tttctgaaaa gcaaaatgtt gtctgctttt ggtaaccagt acaataaact
     3721 gtaatggtct gtaaataaat aaatattgat gtatgctatt tatgtaaata ggcattctgg
     3781 gagggaagat ggctcagggt ttctgtgtat caccctggga agtggatgga ttctttccag
     3841 ctctccggtt tgcatcaggt tcagttcctg ctttaagagg cacaaagcct gttggatggc
     3901 agccccatgc cactgtgggc tgggtgattc cagctcagaa gcagatgctc agatagccaa
     3961 accactctct cgttggtgcc aacactggca tcctggtcaa agtcttagcc agggtggact
     4021 gaaccacctt cccatctgtc atgcaaatgt ccccaagcag tgttgaagga catgccaggt
     4081 cagtgttgga acctgccctg ccaggtcctg ttttgtagat taaaaaaaaa atggcttcaa
     4141 aaaaa
//
