LOCUS       NM_001166363            1324 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus fibroblast growth factor 8 (Fgf8), transcript variant
            4, mRNA.
ACCESSION   NM_001166363
VERSION     NM_001166363.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1324)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1324)
  AUTHORS   Sun,Y., Ren,M., Zhang,Y., Li,S., Luo,Z., Sun,S., He,S., Wang,G.,
            Zhang,D., Mansour,S.L., Song,L. and Liu,Z.
  TITLE     Casz1 is required for both inner hair cell fate stabilization and
            outer hair cell survival
  JOURNAL   Science, eado4930 (2025) In press
   PUBMED   39883789
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 1324)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   4  (bases 1 to 1324)
  AUTHORS   Wang,Y., Wang,J., Xu,T., Yang,S., Wang,X., Zhu,L., Li,N., Liu,B.,
            Xiao,J. and Liu,C.
  TITLE     Ectopic Activation of Fgf8 in Dental Mesenchyme Causes Incisor
            Agenesis and Molar Microdontia
  JOURNAL   Int J Mol Sci 25 (13), 7045 (2024)
   PUBMED   39000154
  REMARK    GeneRIF: Ectopic Activation of Fgf8 in Dental Mesenchyme Causes
            Incisor Agenesis and Molar Microdontia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1324)
  AUTHORS   Soussi,G., Girdziusaite,A., Jhanwar,S., Palacio,V., Notaro,M.,
            Sheth,R., Zeller,R. and Zuniga,A.
  TITLE     TBX3 is essential for establishment of the posterior boundary of
            anterior genes and upregulation of posterior genes together with
            HAND2 during the onset of limb bud development
  JOURNAL   Development 151 (11) (2024)
   PUBMED   38828908
REFERENCE   6  (bases 1 to 1324)
  AUTHORS   Chan,D.C., Wynshaw-Boris,A. and Leder,P.
  TITLE     Formin isoforms are differentially expressed in the mouse embryo
            and are required for normal expression of fgf-4 and shh in the limb
            bud
  JOURNAL   Development 121 (10), 3151-3162 (1995)
   PUBMED   7588050
REFERENCE   7  (bases 1 to 1324)
  AUTHORS   Mahmood,R., Bresnick,J., Hornbruch,A., Mahony,C., Morton,N.,
            Colquhoun,K., Martin,P., Lumsden,A., Dickson,C. and Mason,I.
  TITLE     A role for FGF-8 in the initiation and maintenance of vertebrate
            limb bud outgrowth
  JOURNAL   Curr Biol 5 (7), 797-806 (1995)
   PUBMED   7583127
REFERENCE   8  (bases 1 to 1324)
  AUTHORS   Tanaka,A., Miyamoto,K., Matsuo,H., Matsumoto,K. and Yoshida,H.
  TITLE     Human androgen-induced growth factor in prostate and breast cancer
            cells: its molecular cloning and growth properties
  JOURNAL   FEBS Lett 363 (3), 226-230 (1995)
   PUBMED   7737407
REFERENCE   9  (bases 1 to 1324)
  AUTHORS   Mattei,M.G., deLapeyriere,O., Bresnick,J., Dickson,C., Birnbaum,D.
            and Mason,I.
  TITLE     Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth
            factor 8) genes map to chromosomes 2 and 19 respectively
  JOURNAL   Mamm Genome 6 (3), 196-197 (1995)
   PUBMED   7749227
REFERENCE   10 (bases 1 to 1324)
  AUTHORS   Tanaka,A., Miyamoto,K., Minamino,N., Takeda,M., Sato,B., Matsuo,H.
            and Matsumoto,K.
  TITLE     Cloning and characterization of an androgen-induced growth factor
            essential for the androgen-dependent growth of mouse mammary
            carcinoma cells
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 8928-8932 (1992)
   PUBMED   1409588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149086.4.
            
            On Mar 28, 2022 this sequence version replaced NM_001166363.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U18673.1, Z48746.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               AC149086.4         116785-117026       c
            243-279             AC149086.4         116648-116684       c
            280-427             AC149086.4         115631-115778       c
            428-534             AC149086.4         112250-112356       c
            535-1324            AC149086.4         110623-111412       c
FEATURES             Location/Qualifiers
     source          1..1324
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.75 cM"
     gene            1..1324
                     /gene="Fgf8"
                     /gene_synonym="Aigf; Fgf-8; Fgf6c; HBGF-8"
                     /note="fibroblast growth factor 8"
                     /db_xref="GeneID:14179"
                     /db_xref="MGI:MGI:99604"
     exon            1..242
                     /gene="Fgf8"
                     /gene_synonym="Aigf; Fgf-8; Fgf6c; HBGF-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..825
                     /gene="Fgf8"
                     /gene_synonym="Aigf; Fgf-8; Fgf6c; HBGF-8"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; androgen-induced growth factor; heparin-binding
                     growth factor 8; fibroblast growth factor 6c"
                     /codon_start=1
                     /product="fibroblast growth factor 8 isoform 4 precursor"
                     /protein_id="NP_001159835.1"
                     /db_xref="CCDS:CCDS50450.1"
                     /db_xref="GeneID:14179"
                     /db_xref="MGI:MGI:99604"
                     /translation="MGSPRSALSCLLLHLLVLCLQAQHVREQSLVTDQLSRRLIRTYQ
                     LYSRTSGKHVQVLANKRINAMAEDGDPFAKLIVETDTFGSRVRVRGAETGLYICMNKK
                     GKLIAKSNGKGKDCVFTEIVLENNYTALQNAKYEGWYMAFTRKGRPRKGSKTRQHQRE
                     VHFMKRLPRGHHTTEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR"
     exon            243..279
                     /gene="Fgf8"
                     /gene_synonym="Aigf; Fgf-8; Fgf6c; HBGF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            280..427
                     /gene="Fgf8"
                     /gene_synonym="Aigf; Fgf-8; Fgf6c; HBGF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            428..534
                     /gene="Fgf8"
                     /gene_synonym="Aigf; Fgf-8; Fgf6c; HBGF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            535..1324
                     /gene="Fgf8"
                     /gene_synonym="Aigf; Fgf-8; Fgf6c; HBGF-8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      987..992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf8"
                     /gene_synonym="Aigf; Fgf-8; Fgf6c; HBGF-8"
                     /note="hexamer: AACAAA"
     polyA_site      1017
                     /gene="Fgf8"
                     /gene_synonym="Aigf; Fgf-8; Fgf6c; HBGF-8"
                     /note="major polyA site"
     regulatory      1295..1300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf8"
                     /gene_synonym="Aigf; Fgf-8; Fgf6c; HBGF-8"
                     /note="hexamer: ATTAAA"
     polyA_site      1324
                     /gene="Fgf8"
                     /gene_synonym="Aigf; Fgf-8; Fgf6c; HBGF-8"
                     /note="major polyA site"
ORIGIN      
        1 gagcagccag cggccaccgg ctccagcagc ggctcagagg ggttcggcgc gcgcggcgag
       61 cacgacattc cacgagccgc gtcgggatag ccgctggcct cccgcacccc gacctccctc
      121 agcctccgca ccttcggctt gtccccccgc ggcctccagt gggacggcgt gaccccgctc
      181 gggctctcag tgctcccggg gccgcgcgcc atgggcagcc cccgctccgc gctgagctgc
      241 ctgctgttgc acttgctggt tctctgcctc caagcccagc atgtgaggga gcagagcctg
      301 gtgacggatc agctcagccg ccgcctcatc cggacctacc agctctacag ccgcaccagc
      361 gggaagcacg tgcaggtcct ggccaacaag cgcatcaacg ccatggcaga agacggagac
      421 cccttcgcga agctcattgt ggagaccgat acttttggaa gcagagtccg agttcgcggc
      481 gcagagacag gtctctacat ctgcatgaac aagaagggga agctaattgc caagagcaac
      541 ggcaaaggca aggactgcgt attcacagag atcgtgctgg agaacaacta cacggcgctg
      601 cagaacgcca agtacgaggg ctggtacatg gcctttaccc gcaagggccg gccccgcaag
      661 ggctccaaga cgcgccagca tcagcgcgag gtgcacttca tgaagcgcct gccgcggggc
      721 caccacacca ccgagcagag cctgcgcttc gagttcctca actacccgcc cttcacgcgc
      781 agcctgcgcg gcagccagag gacttgggcc ccggagcccc gataggcgct cgcccagctc
      841 ctccccaccc agccggccga ggaatccagc gggagctcgg cggcacagca aaggggaggg
      901 gctggggagc tgccttctag ttgtgcatat tgtttgctgt tgggtttttt tgttttttgt
      961 tttttgtttt tgttttttgt tttttaaaca aaagagaggc tctatttttg tattccactg
     1021 gctgtggtgt ctgtcttctt agctctcagg aaaagcccac tagtgaccta agactgggtt
     1081 cctctggggt tccctggggt ggagggctct ctggtctgtt ctcctgaaat cccaggattg
     1141 gcagggtacc tggccaggcc aaccagggcc actctgtacc cccggcaggg ggagagagag
     1201 agagagagag agagagagag agagagagat attaggccta ggtcagtcct ttaggggagt
     1261 gggtgtcagt gaaggtggct gtgtaccagt tactattaaa tgactgaatt taacttgcat
     1321 atta
//
