LOCUS       NM_008008               2672 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus fibroblast growth factor 7 (Fgf7), mRNA.
ACCESSION   NM_008008
VERSION     NM_008008.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2672)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2672)
  AUTHORS   Ikeda,S., Sato,K., Fujita,H., Ono-Minagi,H., Miyaishi,S., Nohno,T.
            and Ohuchi,H.
  TITLE     Harderian Gland Development and Degeneration in the Fgf10-Deficient
            Heterozygous Mouse
  JOURNAL   J Dev Biol 12 (2), 16 (2024)
   PUBMED   38921483
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2672)
  AUTHORS   Meng,H., Liao,Z., Ji,Y., Wang,D., Han,Y., Huang,C., Hu,X., Chen,J.,
            Zhang,H., Li,Z., Wang,C., Sun,H., Sun,J., Chen,L., Yin,J., Zhao,J.,
            Xu,T. and Liu,H.
  TITLE     FGF7 enhances the expression of ACE2 in human islet organoids
            aggravating SARS-CoV-2 infection
  JOURNAL   Signal Transduct Target Ther 9 (1), 104 (2024)
   PUBMED   38654010
  REMARK    GeneRIF: FGF7 enhances the expression of ACE2 in human islet
            organoids aggravating SARS-CoV-2 infection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2672)
  AUTHORS   Liu,X., Hu,X., Niu,C., Yang,Y., Huang,Z. and Xie,J.
  TITLE     Fibroblast growth factor 7 protects osteoblasts against oxidative
            damage through targeting mitochondria
  JOURNAL   FASEB J 38 (5), e23524 (2024)
   PUBMED   38466191
  REMARK    GeneRIF: Fibroblast growth factor 7 protects osteoblasts against
            oxidative damage through targeting mitochondria.
REFERENCE   5  (bases 1 to 2672)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 2672)
  AUTHORS   Danilenko,D.M., Ring,B.D., Yanagihara,D., Benson,W., Wiemann,B.,
            Starnes,C.O. and Pierce,G.F.
  TITLE     Keratinocyte growth factor is an important endogenous mediator of
            hair follicle growth, development, and differentiation.
            Normalization of the nu/nu follicular differentiation defect and
            amelioration of chemotherapy-induced alopecia
  JOURNAL   Am J Pathol 147 (1), 145-154 (1995)
   PUBMED   7604876
REFERENCE   7  (bases 1 to 2672)
  AUTHORS   Rubin,J.S., Bottaro,D.P., Chedid,M., Miki,T., Ron,D., Cheon,G.,
            Taylor,W.G., Fortney,E., Sakata,H., Finch,P.W. et al.
  TITLE     Keratinocyte growth factor
  JOURNAL   Cell Biol Int 19 (5), 399-411 (1995)
   PUBMED   7640656
  REMARK    Review article
REFERENCE   8  (bases 1 to 2672)
  AUTHORS   Miki,T., Fleming,T.P., Bottaro,D.P., Rubin,J.S., Ron,D. and
            Aaronson,S.A.
  TITLE     Expression cDNA cloning of the KGF receptor by creation of a
            transforming autocrine loop
  JOURNAL   Science 251 (4989), 72-75 (1991)
   PUBMED   1846048
REFERENCE   9  (bases 1 to 2672)
  AUTHORS   Finch,P.W., Rubin,J.S., Miki,T., Ron,D. and Aaronson,S.A.
  TITLE     Human KGF is FGF-related with properties of a paracrine effector of
            epithelial cell growth
  JOURNAL   Science 245 (4919), 752-755 (1989)
   PUBMED   2475908
REFERENCE   10 (bases 1 to 2672)
  AUTHORS   Rubin,J.S., Osada,H., Finch,P.W., Taylor,W.G., Rudikoff,S. and
            Aaronson,S.A.
  TITLE     Purification and characterization of a newly identified growth
            factor specific for epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 86 (3), 802-806 (1989)
   PUBMED   2915979
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK037172.1 and AL845292.4.
            
            On Apr 21, 2009 this sequence version replaced NM_008008.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037172.1, AK086639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1817              AK037172.1         3-1819
            1818-2672           AL845292.4         144526-145380
FEATURES             Location/Qualifiers
     source          1..2672
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.76 cM"
     gene            1..2672
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf"
                     /note="fibroblast growth factor 7"
                     /db_xref="GeneID:14178"
                     /db_xref="MGI:MGI:95521"
     exon            1..193
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf"
                     /inference="alignment:Splign:2.1.0"
     exon            194..749
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf"
                     /inference="alignment:Splign:2.1.0"
     exon            750..853
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf"
                     /inference="alignment:Splign:2.1.0"
     exon            854..2672
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1800..1805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf"
                     /note="hexamer: AATAAA"
     polyA_site      1820
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf"
                     /note="major polyA site"
     regulatory      1931..1936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf"
                     /note="hexamer: ATTAAA"
     polyA_site      1959
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf"
                     /note="major polyA site"
     regulatory      1993..1998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf"
                     /note="hexamer: TATAAA"
     regulatory      1997..2002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf"
                     /note="hexamer: AAGAAA"
     polyA_site      2012
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf"
     polyA_site      2019
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf"
ORIGIN      
        1 gcactcacac aagcgcacgc gctcacacac ggagaaaatc cttttgcctg ttgatttatg
       61 gaaacaatta tgattctgct gggggatttc tcagctgaga aatagtttgt agctacagta
      121 gagaggctca agttgcacga ggcagacagc agacacggaa ctcttgtgta cccagctgtt
      181 ccaaacagaa caaaagtcaa ggagcaaccg cactgcagca actggccttg tcacgacctg
      241 tttctataag gatataccta tcagctgtgt tcctgaagga ggaatcgtgt tattggtatc
      301 agaagctaaa agataaggtt aacagtttgg aaagagcgac gactttttct ctcatcaatc
      361 tccagttcac aaataggagg aggcccatga cctaggagta gcaatcaacg caagattcaa
      421 ttctcattat gttattcatg aacacccggg gcactacact ataatgcgca aatggatact
      481 gacacggatc ctgccaactc tgctctacag atcatgcttc cacctcgtct gtctagtggg
      541 cactatatct ctagcttgca atgacatgag tccggagcaa acggctacga gtgtgaactg
      601 ttccagcccc gagcgacaca ccagaagtta tgactacatg gaaggagggg atataagggt
      661 gagaagactg ttctgtcgca cccagtggta cctgaggatt gacaaacgag gcaaagtgaa
      721 agggacccag gagatgaaga acagctacaa catcatggaa atcaggaccg tggcagttgg
      781 aattgtggca atcaaagggg tggaaagtga atactatctt gccatgaaca aggaagggaa
      841 actctatgca aagaaagaat gcaatgagga ttgcaacttc aaagaactga ttctggaaaa
      901 ccattataac acctatgcat cagctaaatg gacacacagc ggaggggaaa tgttcgttgc
      961 cttaaatcaa aaggggattc ctgtcaaagg gaagaaaacg aagaaagaac aaaaaacagc
     1021 ccattttctt cctatggcaa taacctaagt gtacatggta tttgagaaac cagtttcatt
     1081 cagcagggag atttctttcc agtggacttt tcttctctct ctctctctct ctctctctct
     1141 ctctctctct ctctcagtaa ccaagaaagg ctggaaaact actgaaaact gatcaagctg
     1201 gacttgcgca tttttgttta ttttaaaaga ctgcattaaa gaaagatttg aagaatatac
     1261 acaaaaatca gatttagtaa aggttgtaaa aagttgtaaa agtggttgta caatcatgat
     1321 gttagtaacg tgatattttt cttaaattaa tttaccctta agagtatgtt agatttgact
     1381 atctgataat gaatatttaa tatcactatc tgcttataaa atggctgcta taataatatt
     1441 aataatgcag atgatgttat ataaggtatg tcagacctaa aggctgctgg gatgctttgt
     1501 cagatgatca agccccacac aaactacaga cgatgagcag tgtttgaaag ctttccagtg
     1561 agaactataa tccggaaaaa tgaatgtttt caacatttta ttatagaata gaatctacag
     1621 gtggttttac aaaatcacag gcttggaaca tgcctgtact gactaatatg aacaaaaatc
     1681 cactcaaatt gaaaaggtat tgctaacagg atgttttaaa aatctgtata taaaatagca
     1741 ataatgatga taatattgta tttcatctca ccacaaaata atattttata atcccttaaa
     1801 ataaatttca gaaatcttta catttttttc aagtaaatct atctgttgta taaatcacat
     1861 ttgggaacac aacttttagt aaatgctctt cccacaaata atcatgctta tttccctctg
     1921 tgattacagc attaaactct actttaagtt gtatttgaat tttattgttt tgttatttaa
     1981 gtttatgtta tttataaaga aaaaaacctt aagaagctgt atctgtttca tatgctttta
     2041 atttcaaggg agcaacaaac ccgactggct gcagtgcaga tgtcccctcc cctggtggct
     2101 gacaccatga ctagcacaca acacttggct agcaagtgct ggatggcaga caaaaacgac
     2161 agcctgtagc catgctcaca atagatgtct cacagagaac aatacaaata tgtgggagag
     2221 attttacaca acgctcgtgc caatgaattt ggatcatata cgtaaaaaag aagtatttag
     2281 tgaggatgta tttttgaaaa taggcatatt taaagttagc aatttgatgt ctttagaagt
     2341 ttttgccata caagatatgc caacattgaa atggcaagag tgaaactcca atagaggttg
     2401 tagtcagcct tgaggcctca ggttgggcca caaatgacag gcttaataag tagatgaata
     2461 cttactccat agttctgcaa ccagtagatg gatgctgaca taaatttatg aataagtact
     2521 tatgaaggga agggcaacat ttatttaaat tgttggtata ttaattaatg cggtatcaac
     2581 ttcatagtgc ttgtcattaa agtttcttta tattacatac aacacttttt ggtaatatgt
     2641 ttatatgtta aggtatatga taaagccttg tc
//
