LOCUS       NM_010204               1232 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus fibroblast growth factor 6 (Fgf6), mRNA.
ACCESSION   NM_010204 XM_001003439 XM_485825 XM_983076
VERSION     NM_010204.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1232)
  AUTHORS   Meuser,M., Deuper,L., Rudat,C., Aydogdu,N., Thiesler,H.,
            Zarnovican,P., Hildebrandt,H., Trowe,M.O. and Kispert,A.
  TITLE     FGFR2 signaling enhances the SHH-BMP4 signaling axis in early
            ureter development
  JOURNAL   Development 149 (1) (2022)
   PUBMED   35020897
REFERENCE   2  (bases 1 to 1232)
  AUTHORS   Zofkie,W., Southard,S.M., Braun,T. and Lepper,C.
  TITLE     Fibroblast growth factor 6 regulates sizing of the muscle stem cell
            pool
  JOURNAL   Stem Cell Reports 16 (12), 2913-2927 (2021)
   PUBMED   34739848
  REMARK    GeneRIF: Fibroblast growth factor 6 regulates sizing of the muscle
            stem cell pool.
REFERENCE   3  (bases 1 to 1232)
  AUTHORS   Xu,B., Liu,C., Zhang,H., Zhang,R., Tang,M., Huang,Y., Jin,L.,
            Xu,L., Hu,C. and Jia,W.
  TITLE     Skeletal muscle-targeted delivery of Fgf6 protects mice from
            diet-induced obesity and insulin resistance
  JOURNAL   JCI Insight 6 (19), e149969 (2021)
   PUBMED   34491915
  REMARK    GeneRIF: Skeletal muscle-targeted delivery of Fgf6 protects mice
            from diet-induced obesity and insulin resistance.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1232)
  AUTHORS   Lopez-Delgado,A.C., Delgado,I., Cadenas,V., Sanchez-Cabo,F. and
            Torres,M.
  TITLE     Axial skeleton anterior-posterior patterning is regulated through
            feedback regulation between Meis transcription factors and retinoic
            acid
  JOURNAL   Development 148 (1) (2021)
   PUBMED   33298461
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1232)
  AUTHORS   Shamsi,F., Xue,R., Huang,T.L., Lundh,M., Liu,Y., Leiria,L.O.,
            Lynes,M.D., Kempf,E., Wang,C.H., Sugimoto,S., Nigro,P.,
            Landgraf,K., Schulz,T., Li,Y., Emanuelli,B., Kothakota,S.,
            Williams,L.T., Jessen,N., Pedersen,S.B., Bottcher,Y., Bluher,M.,
            Korner,A., Goodyear,L.J., Mohammadi,M., Kahn,C.R. and Tseng,Y.H.
  TITLE     FGF6 and FGF9 regulate UCP1 expression independent of brown
            adipogenesis
  JOURNAL   Nat Commun 11 (1), 1421 (2020)
   PUBMED   32184391
  REMARK    GeneRIF: FGF6 and FGF9 are potent inducers of UCP1 expression in
            adipocytes and preadipocytes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1232)
  AUTHORS   Ollendorff,V., Rosnet,O., Marics,I., Birnbaum,D. and
            deLapeyriere,O.
  TITLE     Isolation and sequence of the murine Fgf6 cDNA
  JOURNAL   Biochimie 74 (11), 1035-1038 (1992)
   PUBMED   1477139
REFERENCE   7  (bases 1 to 1232)
  AUTHORS   Yi,T., Gilbert,D.J., Jenkins,N.A., Copeland,N.G. and Ihle,J.N.
  TITLE     Assignment of a novel protein tyrosine phosphatase gene (Hcph) to
            mouse chromosome 6
  JOURNAL   Genomics 14 (3), 793-795 (1992)
   PUBMED   1427910
REFERENCE   8  (bases 1 to 1232)
  AUTHORS   Foroni,L., Boehm,T., White,L., Forster,A., Sherrington,P.,
            Liao,X.B., Brannan,C.I., Jenkins,N.A., Copeland,N.G. and
            Rabbitts,T.H.
  TITLE     The rhombotin gene family encode related LIM-domain proteins whose
            differing expression suggests multiple roles in mouse development
  JOURNAL   J Mol Biol 226 (3), 747-761 (1992)
   PUBMED   1507224
REFERENCE   9  (bases 1 to 1232)
  AUTHORS   Ludwig,T., Ruther,U., Metzger,R., Copeland,N.G., Jenkins,N.A.,
            Lobel,P. and Hoflack,B.
  TITLE     Gene and pseudogene of the mouse cation-dependent mannose
            6-phosphate receptor. Genomic organization, expression, and
            chromosomal localization
  JOURNAL   J Biol Chem 267 (17), 12211-12219 (1992)
   PUBMED   1376319
REFERENCE   10 (bases 1 to 1232)
  AUTHORS   Mattei,M.G., Pebusque,M.J. and Birnbaum,D.
  TITLE     Chromosomal localizations of mouse Fgf2 and Fgf5 genes
  JOURNAL   Mamm Genome 2 (2), 135-137 (1992)
   PUBMED   1543906
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163683.4 and AK086530.1.
            
            On or before Aug 17, 2006 this sequence version replaced
            XM_001003439.1, XM_485825.4, XM_983076.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK086530.1, M92416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AC163683.4         88045-88201
            158-1232            AK086530.1         76-1150
FEATURES             Location/Qualifiers
     source          1..1232
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 61.92 cM"
     gene            1..1232
                     /gene="Fgf6"
                     /gene_synonym="Fgf-6; Fgf7b; HSTF-2"
                     /note="fibroblast growth factor 6"
                     /db_xref="GeneID:14177"
                     /db_xref="MGI:MGI:95520"
     exon            1..390
                     /gene="Fgf6"
                     /gene_synonym="Fgf-6; Fgf7b; HSTF-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..671
                     /gene="Fgf6"
                     /gene_synonym="Fgf-6; Fgf7b; HSTF-2"
                     /note="HST-2; HBGF-6; heparin-binding growth factor 6;
                     heparin secretory-transforming protein 2; fibroblast
                     growth factor 7b"
                     /codon_start=1
                     /product="fibroblast growth factor 6 precursor"
                     /protein_id="NP_034334.1"
                     /db_xref="CCDS:CCDS20561.1"
                     /db_xref="GeneID:14177"
                     /db_xref="MGI:MGI:95520"
                     /translation="MALGQRLFITMSRGAGRVQGTLQALVFLGVLVGMVVPSPAGARA
                     NGTLLDSRGWGTLLSRSRAGLAGEISGVNWESGYLVGIKRQRRLYCNVGIGFHLQVPP
                     DGRISGTHEENPYSLLEISTVERGVVSLFGVKSALFIAMNSKGRLYTTPSFHDECKFR
                     ETLLPNNYNAYESDLYRGTYIALSKYGRVKRGSKVSPIMTVTHFLPRI"
     exon            391..494
                     /gene="Fgf6"
                     /gene_synonym="Fgf-6; Fgf7b; HSTF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            495..1232
                     /gene="Fgf6"
                     /gene_synonym="Fgf-6; Fgf7b; HSTF-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttagggcca ttaattctga ccacgtgcct gagaggcaag gtggatggcc ctgggacaga
       61 ggctgttcat cactatgtcc cggggagcag gacgtgttca gggcacgctg caggctctcg
      121 tcttcttagg cgtcctagtg ggcatggtgg tgccctcacc tgccggcgcc cgcgccaacg
      181 gcacgctact ggactccaga ggctggggca ccctcttgtc caggtctcga gctgggctag
      241 ctggagagat ttcgggtgtg aattgggaaa gcggctattt ggtgggcatt aagcgacagc
      301 ggagactcta ctgcaacgtg ggcattggct tccacctcca ggtgcctcct gacggccgca
      361 tcagtggaac acacgaggag aacccctaca gcctgctgga gatctccacg gtagaacggg
      421 gtgtggtgag cctcttcggg gtgaagagtg ctctcttcat tgccatgaac agtaaaggaa
      481 gactgtacac aacgcccagc ttccacgacg aatgcaagtt ccgagaaacc ctccttccaa
      541 acaactacaa cgcctacgag tcagacctgt acagagggac ctacattgca ctgagcaaat
      601 atggacgggt aaagcggggc agcaaggtgt ccccaatcat gactgtcact cacttcctcc
      661 ccaggatata aggacccatg gatgaaggct cacggggtga cagctgcgtc ttttctgtca
      721 ggattttaca ctaagagaac gcttctgctc ctatcccgtg acttctgagt ttggcttatc
      781 tcggcctgaa gatctgagtg gatgccctgg gccactggac tgcatggtgt gtaagccacg
      841 tggctgaggg tctacagttc acatttcagg atggcagggg ctcctgtgct tcagcctcac
      901 ctgaggagag acaatacaga tgactcttgc agcgtgtggc cctgtgcata agaaaaagcc
      961 aaaatgggag tatgcatgtg tccgtgcata tccacacatc tattcgtaga ttctcagagc
     1021 aaaggcattt taggataccg agttcctttc tcccaacatc gtcaccgcag gaaactgcct
     1081 gtcagagcgt cacttgtcga gtcagcagga ttgagatgaa ccccattctg ccgttttctg
     1141 atcatctatc tatccagttg tctgtgtaac agtgagcagc tatcttttat gtgccaggag
     1201 gaaggtaggg gtataaaata taactgtaaa ct
//
