LOCUS       NM_010203               2439 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus fibroblast growth factor 5 (Fgf5), transcript variant
            1, mRNA.
ACCESSION   NM_010203
VERSION     NM_010203.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2439)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   2  (bases 1 to 2439)
  AUTHORS   Li,Y., Cui,S., Wu,B., Gao,J., Li,M., Zhang,F. and Xia,H.
  TITLE     FGF5 alleviated acute lung injury via AKT signal pathway in
            endothelial cells
  JOURNAL   Biochem Biophys Res Commun 634, 152-158 (2022)
   PUBMED   36244113
  REMARK    GeneRIF: FGF5 alleviated acute lung injury via AKT signal pathway
            in endothelial cells.
REFERENCE   3  (bases 1 to 2439)
  AUTHORS   Takahashi,R., Takahashi,G., Kameyama,Y., Sato,M., Ohtsuka,M. and
            Wada,K.
  TITLE     Gender-Difference in Hair Length as Revealed by Crispr-Based
            Production of Long-Haired Mice with Dysfunctional FGF5 Mutations
  JOURNAL   Int J Mol Sci 23 (19), 11855 (2022)
   PUBMED   36233155
  REMARK    GeneRIF: Gender-Difference in Hair Length as Revealed by
            Crispr-Based Production of Long-Haired Mice with Dysfunctional FGF5
            Mutations.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2439)
  AUTHORS   Itoh,N. and Ornitz,D.M.
  TITLE     Functional evolutionary history of the mouse Fgf gene family
  JOURNAL   Dev Dyn 237 (1), 18-27 (2008)
   PUBMED   18058912
  REMARK    Review article
REFERENCE   5  (bases 1 to 2439)
  AUTHORS   Ozawa,K., Suzuki,S., Asada,M., Tomooka,Y., Li,A.J., Yoneda,A.,
            Komi,A. and Imamura,T.
  TITLE     An alternatively spliced fibroblast growth factor (FGF)-5 mRNA is
            abundant in brain and translates into a partial agonist/antagonist
            for FGF-5 neurotrophic activity
  JOURNAL   J Biol Chem 273 (44), 29262-29271 (1998)
   PUBMED   9786939
REFERENCE   6  (bases 1 to 2439)
  AUTHORS   Mattei,M.G., Pebusque,M.J. and Birnbaum,D.
  TITLE     Chromosomal localizations of mouse Fgf2 and Fgf5 genes
  JOURNAL   Mamm Genome 2 (2), 135-137 (1992)
   PUBMED   1543906
REFERENCE   7  (bases 1 to 2439)
  AUTHORS   Haub,O. and Goldfarb,M.
  TITLE     Expression of the fibroblast growth factor-5 gene in the mouse
            embryo
  JOURNAL   Development 112 (2), 397-406 (1991)
   PUBMED   1794310
REFERENCE   8  (bases 1 to 2439)
  AUTHORS   Goldfarb,M., Bates,B., Drucker,B., Hardin,J. and Haub,O.
  TITLE     Expression and possible functions of the FGF-5 gene
  JOURNAL   Ann N Y Acad Sci 638, 38-52 (1991)
   PUBMED   1785812
  REMARK    Review article
REFERENCE   9  (bases 1 to 2439)
  AUTHORS   Haub,O., Drucker,B. and Goldfarb,M.
  TITLE     Expression of the murine fibroblast growth factor 5 gene in the
            adult central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 87 (20), 8022-8026 (1990)
   PUBMED   1700424
REFERENCE   10 (bases 1 to 2439)
  AUTHORS   Hebert,J.M., Basilico,C., Goldfarb,M., Haub,O. and Martin,G.R.
  TITLE     Isolation of cDNAs encoding four mouse FGF family members and
            characterization of their expression patterns during embryogenesis
  JOURNAL   Dev Biol 138 (2), 454-463 (1990)
   PUBMED   2318343
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125073.4.
            
            On Sep 29, 2022 this sequence version replaced NM_010203.5.
            
            Summary: This gene encodes a secreted protein that is a member of a
            family of heparin-binding growth factors. The encoded protein
            regulates cell proliferation, particularly the growth of hair
            follicles. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Mar 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071227.1, SRR7652917.953878.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-512               AC125073.4         112510-113021
            513-616             AC125073.4         120204-120307
            617-2439            AC125073.4         133472-135294
FEATURES             Location/Qualifiers
     source          1..2439
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 47.77 cM"
     gene            1..2439
                     /gene="Fgf5"
                     /gene_synonym="angora; Fgf-5; Fgf3a; go; HBGF-5"
                     /note="fibroblast growth factor 5"
                     /db_xref="GeneID:14176"
                     /db_xref="MGI:MGI:95519"
     exon            1..512
                     /gene="Fgf5"
                     /gene_synonym="angora; Fgf-5; Fgf3a; go; HBGF-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..958
                     /gene="Fgf5"
                     /gene_synonym="angora; Fgf-5; Fgf3a; go; HBGF-5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; heparin-binding growth factor 5; fibroblast
                     growth factor 3a"
                     /codon_start=1
                     /product="fibroblast growth factor 5 isoform 1 precursor"
                     /protein_id="NP_034333.1"
                     /db_xref="CCDS:CCDS19455.1"
                     /db_xref="GeneID:14176"
                     /db_xref="MGI:MGI:95519"
                     /translation="MSLSLLFLIFCSHLIHSAWAHGEKRLTPEGQPAPPRNPGDSSGS
                     RGRSSATFSSSSASSPVAASPGSQGSGSEHSSFQWSPSGRRTGSLYCRVGIGFHLQIY
                     PDGKVNGSHEASVLSILEIFAVSQGIVGIRGVFSNKFLAMSKKGKLHASAKFTDDCKF
                     RERFQENSYNTYASAIHRTEKTGREWYVALNKRGKAKRGCSPRVKPQHVSTHFLPRFK
                     QSEQPELSFTVTVPEKKKPPVKPKVPLSQPRRSPSPVKYRLKFRFG"
     exon            513..616
                     /gene="Fgf5"
                     /gene_synonym="angora; Fgf-5; Fgf3a; go; HBGF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            617..2439
                     /gene="Fgf5"
                     /gene_synonym="angora; Fgf-5; Fgf3a; go; HBGF-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2416..2421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf5"
                     /gene_synonym="angora; Fgf-5; Fgf3a; go; HBGF-5"
                     /note="hexamer: AATAAA"
     polyA_site      2439
                     /gene="Fgf5"
                     /gene_synonym="angora; Fgf-5; Fgf3a; go; HBGF-5"
                     /note="major polyA site"
ORIGIN      
        1 gctcgggtgg cctctctctc tccccctctc cctctccctt ccccgaggct atgtccaccc
       61 tgtgcggcga gggaggcagc gccagaggca cgcagccgcg cgggggctac ggagcccgga
      121 gccagccctg caagatgcac ttaggacccc cgcggccgga agaatgagcc tgtccttgct
      181 cttcctcatc ttctgcagcc acctgatcca cagcgcttgg gctcacgggg agaagcgtct
      241 cactcccgaa gggcaacccg cgcctcctag gaacccggga gactccagcg gcagccgggg
      301 cagaagtagc gcgacgtttt cttcgtcttc tgcctcctca ccagtcgcag cttctccggg
      361 cagccaagga agcggctcgg aacatagcag tttccagtgg agcccttcgg ggcgccggac
      421 cggcagcctg tactgcagag tgggcatcgg tttccatctg cagatctacc cggatggcaa
      481 agtcaatggc tcccacgaag ccagtgtgtt aagtattttg gaaatatttg ctgtgtctca
      541 ggggattgta ggaatacgag gagttttcag caacaaattt ttagcgatgt caaaaaaagg
      601 aaaactccat gcaagtgcca aatttacgga tgactgtaag ttcagggaga gattccaaga
      661 aaacagctat aatacctatg cgtccgcgat ccacagaact gaaaagacag gccgagagtg
      721 gtacgtggcc ctgaacaaga gagggaaagc caagagaggc tgcagcccac gggtcaaacc
      781 ccaacacgtc tccacccact tcctacccag gttcaagcag tccgagcaac cggaactttc
      841 cttcaccgtc actgttccag aaaagaaaaa gccaccggtg aaaccaaagg tgcccctgtc
      901 gcagcctcgc agaagtccca gcccagtgaa gtacagactg aagtttcgct ttggatgatg
      961 ctcgtccatc ctggccttgt gggaaacaac tctctataca ggcgtcatcg gagccctgaa
     1021 ggaaactcgg atacagcatc cctctgctgt gcctacacgt gtggaagtca ggtcattttg
     1081 tttcgctttg actggaacta aactgctttc taaaatttaa gtcgaaacag aagtgggatt
     1141 ctctgtagcg atccagggag ctcatctctt cagatcaccg aggatataaa ggcttcgtga
     1201 tttgaggatg gttagcattc tgcgttttca gaccagtttg atagcctgga actatgtact
     1261 tttctcattt ttacagatca accggaaaga acatacatga tacatgttta tttttgtttt
     1321 ccaaagaata ttttgatgca gataaaatat tttataaact tttgtttttt taaggtacct
     1381 cagcattgag catattttct tacttttatt attttaatta acgtgacaca agcagttggt
     1441 ttattgctgt tcatggatta taaacatttt aatagtttgt gtggtaggat ctggatctcc
     1501 tttgcgtttt tctctctact acagcatcgt ttactttatt ttagctatac ctcaagtcgt
     1561 ataaatttag ttctacattt taaaaaaaat ttttaaatgt gctttcgaag ccccaaaagg
     1621 ctcagcttgg aggtgtgcat tgtgtatgaa gttatggcat tatgtggaat ctggccatat
     1681 tagtggctgg gctcaatgat cagaaggagg aaaatatgag gacgttttga tggatttaaa
     1741 ggctttatgt aaagaaaagg acagaggcca ccgcacacta agtgtgcagc gtccacagag
     1801 atttaactct gtcttttgct tcttctcctt ttatctgccc cctgccctca ttcaagacca
     1861 gctgaaggaa taagttttat tctgtccacc aagcatacac taggaaactg gagtgcttaa
     1921 aaatacttct ataactccct gttatcctta ctgtatggac ccacagggag taactaatca
     1981 gggtgtgtgt gtgtgtgtgt gtgtgtgtgt ttgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     2041 gtgtgtgtgt agctgaagga gatgaatcac taaccaagtt ttcatgtcaa gtctcatggt
     2101 caaaaatact tctactattc agtcaaatac cctttgagct ttctacccta aaggtaatga
     2161 ctggaatgag tgcatctgct ctgctctaag aaaacctggt gcaccctaga agcttctgcc
     2221 cttgcgaccc aggagcttaa ttcgggaatg tgatgagctg aaaatgacac ttcattctca
     2281 acccaaattc caaaccctca acagaaacca cagacggttt agcttacaaa gagttacaaa
     2341 atgtattttc ttggataatc ctttttatgg agatctatga agtataagtg ttcaccttat
     2401 attcctaaat gctgcaataa agaggcgtag atgaccata
//
