LOCUS       NM_010202               3032 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus fibroblast growth factor 4 (Fgf4), mRNA.
ACCESSION   NM_010202
VERSION     NM_010202.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3032)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3032)
  AUTHORS   Nevorankova,P., Sulcova,M., Kavkova,M., Zimcik,D., Balkova,S.M.,
            Peleskova,K., Kristekova,D., Jakesova,V., Zikmund,T., Kaiser,J.,
            Hola,L.I., Kolar,M. and Buchtova,M.
  TITLE     Region-specific gene expression profiling of early mouse mandible
            uncovered SATB2 as a key molecule for teeth patterning
  JOURNAL   Sci Rep 14 (1), 18212 (2024)
   PUBMED   39107332
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3032)
  AUTHORS   Lin,J., Lin,H.W., Wang,Y.X., Fang,Y., Jiang,H.M., Li,T., Huang,J.,
            Zhang,H.D., Chen,D.Z. and Chen,Y.P.
  TITLE     FGF4 ameliorates the liver inflammation by reducing M1 macrophage
            polarization in experimental autoimmune hepatitis
  JOURNAL   J Transl Med 22 (1), 717 (2024)
   PUBMED   39095789
  REMARK    GeneRIF: FGF4 ameliorates the liver inflammation by reducing M1
            macrophage polarization in experimental autoimmune hepatitis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3032)
  AUTHORS   Adasooriya,D., Jeong,J.K., Kyeong,M., Kan,S., Kim,J., Cho,E.S. and
            Cho,S.W.
  TITLE     Notum regulates the cusp and root patterns in mouse molar
  JOURNAL   Sci Rep 14 (1), 13633 (2024)
   PUBMED   38871845
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3032)
  AUTHORS   Soussi,G., Girdziusaite,A., Jhanwar,S., Palacio,V., Notaro,M.,
            Sheth,R., Zeller,R. and Zuniga,A.
  TITLE     TBX3 is essential for establishment of the posterior boundary of
            anterior genes and upregulation of posterior genes together with
            HAND2 during the onset of limb bud development
  JOURNAL   Development 151 (11) (2024)
   PUBMED   38828908
REFERENCE   6  (bases 1 to 3032)
  AUTHORS   Vickers,P.J., O'Neill,G.P., Mancini,J.A., Charleson,S. and
            Abramovitz,M.
  TITLE     Cross-species comparison of 5-lipoxygenase-activating protein
  JOURNAL   Mol Pharmacol 42 (6), 1014-1019 (1992)
   PUBMED   1480129
REFERENCE   7  (bases 1 to 3032)
  AUTHORS   Lammie,G.A., Smith,R., Silver,J., Brookes,S., Dickson,C. and
            Peters,G.
  TITLE     Proviral insertions near cyclin D1 in mouse lymphomas: a parallel
            for BCL1 translocations in human B-cell neoplasms
  JOURNAL   Oncogene 7 (12), 2381-2387 (1992)
   PUBMED   1461646
REFERENCE   8  (bases 1 to 3032)
  AUTHORS   Ma,Y.G., Rosfjord,E., Huebert,C., Wilder,P., Tiesman,J., Kelly,D.
            and Rizzino,A.
  TITLE     Transcriptional regulation of the murine k-FGF gene in embryonic
            cell lines
  JOURNAL   Dev Biol 154 (1), 45-54 (1992)
   PUBMED   1426633
REFERENCE   9  (bases 1 to 3032)
  AUTHORS   Suzuki,H.R., Sakamoto,H., Yoshida,T., Sugimura,T., Terada,M. and
            Solursh,M.
  TITLE     Localization of HstI transcripts to the apical ectodermal ridge in
            the mouse embryo
  JOURNAL   Dev Biol 150 (1), 219-222 (1992)
   PUBMED   1531642
REFERENCE   10 (bases 1 to 3032)
  AUTHORS   Mattei,M.G., Pebusque,M.J. and Birnbaum,D.
  TITLE     Chromosomal localizations of mouse Fgf2 and Fgf5 genes
  JOURNAL   Mamm Genome 2 (2), 135-137 (1992)
   PUBMED   1543906
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK082814.1, AC161763.3 and BB398533.1.
            
            On Nov 29, 2016 this sequence version replaced NM_010202.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082814.1, BC104312.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-748               AK082814.1         2-749
            749-895             AC161763.3         151002-151148       c
            896-1448            AK082814.1         897-1449
            1449-1449           AC161763.3         150448-150448       c
            1450-2155           AK082814.1         1451-2156
            2156-3030           AK082814.1         2158-3032
            3031-3032           BB398533.1         226-227
FEATURES             Location/Qualifiers
     source          1..3032
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.88 cM"
     gene            1..3032
                     /gene="Fgf4"
                     /gene_synonym="Fgf-4; Fgf7a; Fgfk; HBGF-4; hst; hst-1;
                     Hst1; Hstf-1; kFGF; KS3"
                     /note="fibroblast growth factor 4"
                     /db_xref="GeneID:14175"
                     /db_xref="MGI:MGI:95518"
     exon            1..447
                     /gene="Fgf4"
                     /gene_synonym="Fgf-4; Fgf7a; Fgfk; HBGF-4; hst; hst-1;
                     Hst1; Hstf-1; kFGF; KS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..728
                     /gene="Fgf4"
                     /gene_synonym="Fgf-4; Fgf7a; Fgfk; HBGF-4; hst; hst-1;
                     Hst1; Hstf-1; kFGF; KS3"
                     /note="K-fibroblast growth factor; heparin-binding growth
                     factor 4; fibroblast growth factor 7a"
                     /codon_start=1
                     /product="fibroblast growth factor 4 precursor"
                     /protein_id="NP_034332.2"
                     /db_xref="CCDS:CCDS22052.1"
                     /db_xref="GeneID:14175"
                     /db_xref="MGI:MGI:95518"
                     /translation="MAKRGPTTGTLLPRVLLALVVALADRGTAAPNGTRHAELGHGWD
                     GLVARSLARLPVAAQPPQAAVRSGAGDYLLGLKRLRRLYCNVGIGFHLQVLPDGRIGG
                     VHADTRDSLLELSPVQRGVVSIFGVASRFFVAMSSRGKLFGVPFFTDECKFKEILLPN
                     NYNAYESYAYPGMFMALSKNGRTKKGNRVSPTMKVTHFLPRL"
     exon            448..551
                     /gene="Fgf4"
                     /gene_synonym="Fgf-4; Fgf7a; Fgfk; HBGF-4; hst; hst-1;
                     Hst1; Hstf-1; kFGF; KS3"
                     /inference="alignment:Splign:2.1.0"
     exon            552..3032
                     /gene="Fgf4"
                     /gene_synonym="Fgf-4; Fgf7a; Fgfk; HBGF-4; hst; hst-1;
                     Hst1; Hstf-1; kFGF; KS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3008..3013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf4"
                     /gene_synonym="Fgf-4; Fgf7a; Fgfk; HBGF-4; hst; hst-1;
                     Hst1; Hstf-1; kFGF; KS3"
                     /note="hexamer: ATTAAA"
     polyA_site      3032
                     /gene="Fgf4"
                     /gene_synonym="Fgf-4; Fgf7a; Fgfk; HBGF-4; hst; hst-1;
                     Hst1; Hstf-1; kFGF; KS3"
                     /note="major polyA site"
ORIGIN      
        1 gcgcggggac tatcccgcca ccgttgcgtc cctatttgct ctcgctactt aggtctgtgc
       61 gcagcactca ccgaactcac ggcccgcagc tcgaactcac gcacggcccg cgggccggga
      121 tggcgaaacg cgggccgacc acagggacgc tgctgcccag ggtcctgctg gccctggtgg
      181 tggccctggc ggaccgaggg accgccgcac ccaacggcac gcggcacgca gaattggggc
      241 acggctggga cggcttggtg gcccgctcgc tggcacgcct gccggtggcc gcgcagcccc
      301 cgcaggcggc ggtccgcagc ggcgcagggg actacctgct gggcctcaaa aggcttcggc
      361 ggctctactg caacgtgggc atcggattcc acctgcaggt gctgcccgac ggccgcatcg
      421 gtggtgtgca cgcagacacg agggacagtc ttctggagct ctctccggtg cagcgaggcg
      481 tggtgagcat cttcggagtg gccagccggt tcttcgtggc catgagcagc aggggcaagc
      541 tcttcggtgt gcctttcttt accgacgagt gtaaattcaa agaaatactt ctgcccaaca
      601 actacaacgc ctacgaatcc tacgcgtacc ccggtatgtt catggccctc agtaagaacg
      661 ggcggaccaa gaaggggaac cgagtgtcgc ctaccatgaa ggtaacccac ttccttccta
      721 gactgtgacc ctccggagcc ctgcctcagc ctcggaagca caccctaccc ctcaggagga
      781 gcactttctc tcgatggaga attgtttgca aaaaaactgg tctaagatat ttaaattatt
      841 taaatatgta tatatggacg cccaattatt tataatttta tgtattctca ttttcggggg
      901 gggggatatg accaaaagaa caaacaaatt gcagctcaga cctctttgga atagcggaac
      961 agacttcttt cttcactatc aaagatatgg gtgtgatgct gtttcatgtg tgcctctaaa
     1021 acttggtgac atcagtttcc aagggtgcct ggcctgtaac tggaaaggcc tgcctgggac
     1081 ctctgaggca gtgagaagga ccctgagcgt tcccgatcgg gagcattctg ccgtcgccgc
     1141 tccctctgct tcctttggta tgaaccctgt cggatcggtt tactccaggg acagaagtcc
     1201 tcccgcctct gtttttagat ctccaagact gatctttgaa ctctcttgca gtcaatcatc
     1261 ttcttggacc taccggatag gagaccctta gacaacttta taaactcctg tttgccattt
     1321 ttggactggc caacagggca cgttgcttgt agccactgga actttgcttt tctggagagg
     1381 aactaggaat ggacaagagg gtgtgtgcgc tcgccacaac tcaaaactct ggggatgaaa
     1441 ttctgttttg tgatagagga tgatttgttg ggatataaca atgtattttg caagaatcaa
     1501 actgagaaaa acaggcttcc ctgaatatgg gaagctttgt gctggaactc cataatttaa
     1561 gggtgagctg ccctttccca ccccaggcag cctttatgca ggcagactgc aggagtccga
     1621 attccggtgc tgccccaagg tgaaggaatt ctatccccat ctacctcaga gttcctgaga
     1681 ccctggtgac taagctggag gctctgctgg gtgcatctgc ctgcttctct tccacatgta
     1741 gtatctggac ccttgtcacg ttccagctat ctttacccaa tgatttactt ttagtaaggg
     1801 gtattcatgg tgaaaatatg cacgaccagc tgtcggagtg cactatatgg tcaccaagtc
     1861 aagtaaccct tatatttttc tttatatatt ttacgaatgt aacccctgtc actgagacca
     1921 aaatggaaga gcagggtcgg tggcatttaa aaaaaagggc tgaggtgagg gagaacaatt
     1981 aattttaatg aatgactttg gagtttatac aaaatgacct tagctcgctt cagggaatgc
     2041 ttctccccaa gatgttaaga ctctgctggg agacttctga gcaacctccc gaattaactt
     2101 tatgggaggc tacagacagc aagactggaa aatctcattg gcattttttt tttttgtctt
     2161 tcacattcct ttagaaaact ctttgtttgg atgctaatgg gatacttaaa atactattct
     2221 gtaccacagc ccaagatgga agaagccaca ccccaaagct gaggtgggag ctcctcccaa
     2281 acttcctttc tgtctggtgg ctcacaggac aataagattt tgtgtttttt aaatccaggc
     2341 cctaggctcc aagagtgttg gggagaagac agttgaaatg tcttttcttc ttgttatttt
     2401 ctaaaagacg gtctcatagc ccaggctgta cctgaacttg ctatgtcact aaagatgacc
     2461 ttgaatttct gatcctcttg ccccatttcc tagtgctaag gttacaggca ttgcccacca
     2521 cgcccactcc ttaggtgctg ggaattgaaa tcaagtgcct gccaggccac tccacagaga
     2581 taggcctccc tcttttttgt gggggaggaa atgtggggtc ttactctgta gccaaggctg
     2641 gcctactgct tgagcccaag tgttgagact acaggtagaa ggcacctgcc ctgttctgat
     2701 gggattctct gcagctatgt tgcttcaggc aggctgtggt cctacctgac acctattacc
     2761 tgtttcttca gccagctagc tccctttcct gcgcccaggg acaagactgt atctttggaa
     2821 ttttgttacc agaatgggtt tgatgtttct gctctgtatc tgccactgtt accgagtcgg
     2881 tctgtagtta ctacaggtgt cgacccagag atagtatgtg ctatgcacac tggatgctcc
     2941 atccaaagag aagcattcaa tcatgtatag acagccccat ggactgatgg gaatgattgg
     3001 gagagatatt aaaatgacaa acgtgtctgc aa
//
