LOCUS       NM_008007               1210 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus fibroblast growth factor 3 (Fgf3), mRNA.
ACCESSION   NM_008007
VERSION     NM_008007.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1210)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1210)
  AUTHORS   Luzzio,A., Edie,S., Palmer,K., Caddle,L.B., Urban,R., Goodwin,L.O.,
            Welsh,I.C., Reinholdt,L.G., Bergstrom,D.E., Cox,T.C., Donahue,L.R.
            and Murray,S.A.
  TITLE     The spontaneous mouse mutant low set ears (Lse) is caused by tandem
            duplication of Fgf3 and Fgf4
  JOURNAL   Mamm Genome 34 (3), 453-463 (2023)
   PUBMED   37341808
  REMARK    GeneRIF: The spontaneous mouse mutant low set ears (Lse) is caused
            by tandem duplication of Fgf3 and Fgf4.
REFERENCE   3  (bases 1 to 1210)
  AUTHORS   Jing,J., Feng,J., Yuan,Y., Guo,T., Lei,J., Pei,F., Ho,T.V. and
            Chai,Y.
  TITLE     Spatiotemporal single-cell regulatory atlas reveals neural crest
            lineage diversification and cellular function during tooth
            morphogenesis
  JOURNAL   Nat Commun 13 (1), 4803 (2022)
   PUBMED   35974052
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1210)
  AUTHORS   Lee,J.M., Qin,C., Chai,O.H., Lan,Y., Jiang,R. and Kwon,H.E.
  TITLE     MSX1 Drives Tooth Morphogenesis Through Controlling Wnt Signaling
            Activity
  JOURNAL   J Dent Res 101 (7), 832-839 (2022)
   PUBMED   35114852
REFERENCE   5  (bases 1 to 1210)
  AUTHORS   Meuser,M., Deuper,L., Rudat,C., Aydogdu,N., Thiesler,H.,
            Zarnovican,P., Hildebrandt,H., Trowe,M.O. and Kispert,A.
  TITLE     FGFR2 signaling enhances the SHH-BMP4 signaling axis in early
            ureter development
  JOURNAL   Development 149 (1) (2022)
   PUBMED   35020897
REFERENCE   6  (bases 1 to 1210)
  AUTHORS   Watson,M.L., Rao,J.K., Gilkeson,G.S., Ruiz,P., Eicher,E.M.,
            Pisetsky,D.S., Matsuzawa,A., Rochelle,J.M. and Seldin,M.F.
  TITLE     Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis
            gene to disease manifestations and renal disease-modifying loci
  JOURNAL   J Exp Med 176 (6), 1645-1656 (1992)
   PUBMED   1460423
REFERENCE   7  (bases 1 to 1210)
  AUTHORS   Stamp,G., Fantl,V., Poulsom,R., Jamieson,S., Smith,R., Peters,G.
            and Dickson,C.
  TITLE     Nonuniform expression of a mouse mammary tumor virus-driven
            int-2/Fgf-3 transgene in pregnancy-responsive breast tumors
  JOURNAL   Cell Growth Differ 3 (12), 929-938 (1992)
   PUBMED   1335281
REFERENCE   8  (bases 1 to 1210)
  AUTHORS   Ornitz,D.M., Cardiff,R.D., Kuo,A. and Leder,P.
  TITLE     Int-2, an autocrine and/or ultra-short-range effector in transgenic
            mammary tissue transplants
  JOURNAL   J Natl Cancer Inst 84 (11), 887-892 (1992)
   PUBMED   1317463
REFERENCE   9  (bases 1 to 1210)
  AUTHORS   Venesio,T., Taverna,D., Hynes,N.E., Deed,R., MacAllan,D.,
            Ciardiello,F., Valverius,E.M., Salomon,D.S., Callahan,R. and
            Merlo,G.
  TITLE     The int-2 gene product acts as a growth factor and substitutes for
            basic fibroblast growth factor in promoting the differentiation of
            a normal mouse mammary epithelial cell line
  JOURNAL   Cell Growth Differ 3 (1), 63-71 (1992)
   PUBMED   1376141
REFERENCE   10 (bases 1 to 1210)
  AUTHORS   Ramesh,V., Cheng,S.V., Kozak,C.A., Herron,B.J., Shih,V.E.,
            Taylor,B.A. and Gusella,J.F.
  TITLE     Mapping of ornithine aminotransferase gene sequences to mouse
            chromosomes 7, X, and 3
  JOURNAL   Mamm Genome 3 (1), 17-22 (1992)
   PUBMED   1349842
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU923457.1, BC117059.1 and BM942045.1.
            
            On Oct 20, 2007 this sequence version replaced NM_008007.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU923457.1, AK133901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BU923457.1         1-42
            43-920              BC117059.1         1-878
            921-1210            BM942045.1         1-290               c
FEATURES             Location/Qualifiers
     source          1..1210
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.85 cM"
     gene            1..1210
                     /gene="Fgf3"
                     /gene_synonym="Fgf-3; Fgf5c; Int-2; Int-P"
                     /note="fibroblast growth factor 3"
                     /db_xref="GeneID:14174"
                     /db_xref="MGI:MGI:95517"
     exon            1..316
                     /gene="Fgf3"
                     /gene_synonym="Fgf-3; Fgf5c; Int-2; Int-P"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..834
                     /gene="Fgf3"
                     /gene_synonym="Fgf-3; Fgf5c; Int-2; Int-P"
                     /note="INT-2 proto-oncogene protein; HBGF-3;
                     heparin-binding growth factor 3; proto-oncogene Int-2;
                     fibroblast growth factor 5c"
                     /codon_start=1
                     /product="fibroblast growth factor 3 precursor"
                     /protein_id="NP_032033.2"
                     /db_xref="CCDS:CCDS22051.1"
                     /db_xref="GeneID:14174"
                     /db_xref="MGI:MGI:95517"
                     /translation="MGLIWLLLLSLLEPSWPTTGPGTRLRRDAGGRGGVYEHLGGAPR
                     RRKLYCATKYHLQLHPSGRVNGSLENSAYSILEITAVEVGVVAIKGLFSGRYLAMNKR
                     GRLYASDHYNAECEFVERIHELGYNTYASRLYRTGSSGPGAQRQPGAQRPWYVSVNGK
                     GRPRRGFKTRRTQKSSLFLPRVLGHKDHEMVRLLQSSQPRAPGEGSQPRQRRQKKQSP
                     SDHGKMETLSTRATPSTQLHTGGLAVA"
     exon            317..420
                     /gene="Fgf3"
                     /gene_synonym="Fgf-3; Fgf5c; Int-2; Int-P"
                     /inference="alignment:Splign:2.1.0"
     exon            421..1194
                     /gene="Fgf3"
                     /gene_synonym="Fgf-3; Fgf5c; Int-2; Int-P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1162..1167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf3"
                     /gene_synonym="Fgf-3; Fgf5c; Int-2; Int-P"
                     /note="hexamer: ATTAAA"
     polyA_site      1192
                     /gene="Fgf3"
                     /gene_synonym="Fgf-3; Fgf5c; Int-2; Int-P"
                     /note="major polyA site"
ORIGIN      
        1 cgagccggcc tggcgcgcgg gcgtgtgctc ccagcgccgc gccttcgtga gacccgcgct
       61 ggcgcagcag ccgctgcggg cgggcgcgat gccgggatgg gcctgatctg gcttctgctg
      121 ctcagcttgc tggaacccag ctggccaact acggggcccg ggacgcgact acgacgcgat
      181 gcgggcggcc gtggtggcgt ttacgagcac ctcggcgggg cgccacggcg ccgcaagctc
      241 tactgcgcta ccaagtacca cctccagctg cacccaagcg gccgcgtgaa cggcagcctt
      301 gagaacagcg cctatagcat cctggagatt actgcggtgg aagtgggcgt ggtggccatc
      361 aaagggctct tttctgggcg gtacctggcc atgaacaaga gaggacggct gtatgcttcg
      421 gatcactaca acgcagagtg tgagtttgtg gaacggatcc atgagctggg ctacaataca
      481 tatgcttccc gcctgtaccg cacagggtcc agtgggccag gagctcaacg gcaacctggt
      541 gcccagagac cttggtacgt gtcggtgaat ggcaagggtc ggccacgcag gggcttcaag
      601 acccgccgca cacaaaagtc ctctctcttc ctgccccgag tgctgggcca caaggaccat
      661 gagatggtgc ggctgctgca gagtagccag ccacgagccc caggagaggg cagccagccc
      721 aggcagcgga ggcagaagaa gcagagccca agtgatcatg gcaagatgga gactttgtct
      781 accagggcca ctccaagcac ccagctgcat acaggtggac tggctgtggc ctgagtggcc
      841 acctggaaag ccctctgaga ccaactccag tgggcaccca agattcactt ggagccctgg
      901 cctccccacc cttgtctttg ggctggctgc ttgggggacc aagaacttgc atgcctttta
      961 cagctttcaa agagcaagtg ccagctgcta aggggcttga gtcagagact ctggaagact
     1021 cgaagttcaa gatgtatgtg gagttacatg agagggaatt cttattacag gggtcatcct
     1081 aatcccggat ggagcccagc caatggcagt cagtcctggc aacctgaggc agtggaccgt
     1141 ggagggggct gtgattcaca cattaaaggt gtctttctgt cttgctattt aacaaaaaaa
     1201 aaaaaaaaaa
//
