LOCUS       NM_022657               2696 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus fibroblast growth factor 23 (Fgf23), mRNA.
ACCESSION   NM_022657 XM_001003443 XM_983118
VERSION     NM_022657.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2696)
  AUTHORS   Yuan,Y.P., Shen,Z.Y., Teng,T., Xu,S.C., Kong,C.Y., Zeng,X.F., A
            Hofmann Bowman,M. and Yan,L.
  TITLE     S100a8/9 (S100 Calcium Binding Protein a8/9) Promotes Cardiac
            Hypertrophy Via Upregulation of FGF23 (Fibroblast Growth Factor 23)
            in Mice
  JOURNAL   J Am Heart Assoc 13 (10), e028006 (2024)
   PUBMED   38726894
  REMARK    GeneRIF: S100a8/9 (S100 Calcium Binding Protein a8/9) Promotes
            Cardiac Hypertrophy Via Upregulation of FGF23 (Fibroblast Growth
            Factor 23) in Mice.
REFERENCE   2  (bases 1 to 2696)
  AUTHORS   Jung,Y.S., Radhakrishnan,K., Hammad,S., Muller,S., Muller,J.,
            Noh,J.R., Kim,J., Lee,I.K., Cho,S.J., Kim,D.K., Kim,Y.H., Lee,C.H.,
            Dooley,S. and Choi,H.S.
  TITLE     ERRgamma-inducible FGF23 promotes alcoholic liver injury through
            enhancing CYP2E1 mediated hepatic oxidative stress
  JOURNAL   Redox Biol 71, 103107 (2024)
   PUBMED   38479224
REFERENCE   3  (bases 1 to 2696)
  AUTHORS   Ay,B., Cyr,S.M., Klovdahl,K., Zhou,W., Tognoni,C.M., Iwasaki,Y.,
            Rhee,E.P., Dedeoglu,A., Simic,P. and Bastepe,M.
  TITLE     Galpha11 deficiency increases fibroblast growth factor 23 levels in
            a mouse model of familial hypocalciuric hypercalcemia
  JOURNAL   JCI Insight 9 (9), e178993 (2024)
   PUBMED   38530370
  REMARK    GeneRIF: Galpha11 deficiency increases fibroblast growth factor 23
            levels in a mouse model of familial hypocalciuric hypercalcemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2696)
  AUTHORS   Cardarelli,S., Biglietto,M., Orsini,T., Fustaino,V., Monaco,L., de
            Oliveira do Rego,A.G., Liccardo,F., Masciarelli,S., Fazi,F.,
            Naro,F., De Angelis,L. and Pellegrini,M.
  TITLE     Modulation of cAMP/cGMP signaling as prevention of congenital heart
            defects in Pde2A deficient embryos: a matter of oxidative stress
  JOURNAL   Cell Death Dis 15 (2), 169 (2024)
   PUBMED   38395995
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2696)
  AUTHORS   Marsell,R. and Jonsson,K.B.
  TITLE     The phosphate regulating hormone fibroblast growth factor-23
  JOURNAL   Acta Physiol (Oxf) 200 (2), 97-106 (2010)
   PUBMED   20618171
  REMARK    Review article
REFERENCE   6  (bases 1 to 2696)
  AUTHORS   Yamashita,T., Konishi,M., Miyake,A., Inui,K. and Itoh,N.
  TITLE     Fibroblast growth factor (FGF)-23 inhibits renal phosphate
            reabsorption by activation of the mitogen-activated protein kinase
            pathway
  JOURNAL   J Biol Chem 277 (31), 28265-28270 (2002)
   PUBMED   12032146
REFERENCE   7  (bases 1 to 2696)
  AUTHORS   Hajihosseini,M.K. and Heath,J.K.
  TITLE     Expression patterns of fibroblast growth factors-18 and -20 in
            mouse embryos is suggestive of novel roles in calvarial and limb
            development
  JOURNAL   Mech Dev 113 (1), 79-83 (2002)
   PUBMED   11900978
REFERENCE   8  (bases 1 to 2696)
  AUTHORS   Ornitz,D.M. and Itoh,N.
  TITLE     Fibroblast growth factors
  JOURNAL   Genome Biol 2 (3), REVIEWS3005 (2001)
   PUBMED   11276432
  REMARK    Review article
REFERENCE   9  (bases 1 to 2696)
  CONSRTM   ADHR Consortium
  TITLE     Autosomal dominant hypophosphataemic rickets is associated with
            mutations in FGF23
  JOURNAL   Nat Genet 26 (3), 345-348 (2000)
   PUBMED   11062477
REFERENCE   10 (bases 1 to 2696)
  AUTHORS   Yamashita,T., Yoshioka,M. and Itoh,N.
  TITLE     Identification of a novel fibroblast growth factor, FGF-23,
            preferentially expressed in the ventrolateral thalamic nucleus of
            the brain
  JOURNAL   Biochem Biophys Res Commun 277 (2), 494-498 (2000)
   PUBMED   11032749
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC163683.4.
            
            On Oct 7, 2022 this sequence version replaced NM_022657.4.
            
            Summary: This gene encodes a member of the fibroblast growth factor
            family. The encoded protein regulates phosphate homeostasis and
            vitamin D metabolism. Mutation of the related gene in humans causes
            autosomal dominant hypophosphatemic rickets (ADHR). The secreted
            protein is further cleaved into N- and C-terminal chains, which
            results in loss of function. [provided by RefSeq, Mar 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155687.1, AF263536.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-335               AC163683.4         145409-145743
            336-439             AC163683.4         150643-150746
            440-2696            AC163683.4         152541-154797
FEATURES             Location/Qualifiers
     source          1..2696
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 61.92 cM"
     gene            1..2696
                     /gene="Fgf23"
                     /gene_synonym="Fgf8b"
                     /note="fibroblast growth factor 23"
                     /db_xref="GeneID:64654"
                     /db_xref="MGI:MGI:1891427"
     exon            1..335
                     /gene="Fgf23"
                     /gene_synonym="Fgf8b"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..880
                     /gene="Fgf23"
                     /gene_synonym="Fgf8b"
                     /note="FGF-23; fibroblast growth factor 8b"
                     /codon_start=1
                     /product="fibroblast growth factor 23 precursor"
                     /protein_id="NP_073148.1"
                     /db_xref="CCDS:CCDS20562.1"
                     /db_xref="GeneID:64654"
                     /db_xref="MGI:MGI:1891427"
                     /translation="MLGTCLRLLVGVLCTVCSLGTARAYPDTSPLLGSNWGSLTHLYT
                     ATARTSYHLQIHRDGHVDGTPHQTIYSALMITSEDAGSVVITGAMTRRFLCMDLHGNI
                     FGSLHFSPENCKFRQWTLENGYDVYLSQKHHYLVSLGRAKRIFQPGTNPPPFSQFLAR
                     RNEVPLLHFYTVRPRRHTRSAEDPPERDPLNVLKPRPRATPVPVSCSRELPSAEEGGP
                     AASDPLGVLRRGRGDARGGAGGADRCRPFPRFV"
     exon            336..439
                     /gene="Fgf23"
                     /gene_synonym="Fgf8b"
                     /inference="alignment:Splign:2.1.0"
     exon            440..2696
                     /gene="Fgf23"
                     /gene_synonym="Fgf8b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2675..2680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf23"
                     /gene_synonym="Fgf8b"
                     /note="hexamer: AATAAA"
     polyA_site      2696
                     /gene="Fgf23"
                     /gene_synonym="Fgf8b"
                     /note="major polyA site"
ORIGIN      
        1 ctagcccagg atccccacct cagttctcag cttcttccta ggaagaagag aaaggccagc
       61 aagggcccag cctgtctggg agtgtcagat ttcaaactca gcattagcca ctcagtgctg
      121 tgcaatgcta gggacctgcc ttagactcct ggtgggcgtg ctctgcactg tctgcagctt
      181 gggcactgct agagcctatc cggacacttc cccattgctt ggctccaact ggggaagcct
      241 gacccacctg tacacggcta cagccaggac cagctatcac ctacagatcc atagggatgg
      301 tcatgtagat ggcacccccc atcagaccat ctacagtgcc ctgatgatta catcagagga
      361 cgccggctct gtggtgataa caggagccat gactcgaagg ttcctttgta tggatctcca
      421 cggcaacatt tttggatcgc ttcacttcag cccagagaat tgcaagttcc gccagtggac
      481 gctggagaat ggctatgacg tctacttgtc gcagaagcat cactacctgg tgagcctggg
      541 ccgcgccaag cgcatcttcc agccgggcac caacccgccg cccttctccc agttcctggc
      601 tcgcaggaac gaggtcccgc tgctgcattt ctacactgtt cgcccacggc gccacacgcg
      661 cagcgccgag gacccaccgg agcgcgaccc actgaacgtg ctcaagccgc ggccccgcgc
      721 cacgcctgtg cctgtatcct gctctcgcga gctgccgagc gcagaggaag gtggccccgc
      781 agccagcgat cctctggggg tgctgcgcag aggccgtgga gatgctcgcg ggggcgcggg
      841 aggcgcggat aggtgtcgcc cctttcccag gttcgtctag gtccccaggc caggctgcgt
      901 ccgcctccat cctccagtcg gttcagccca cgtagaggaa ggactagggt acctcgagga
      961 tgtctgcttc tctcccttcc ctatgggcct gagagtcacc tgcgaggttc cagccaggca
     1021 ccgctattca gaattaagag ccaacggtgg gaggctggag aggtggcgca gacagttctc
     1081 agcacccaca aatacctgta attctagctc caggggaatc tgtactcaca cacacacaca
     1141 tccacacaca cacacacaca catacatgta attttaaatg ttaatctgat ttaaagaccc
     1201 caacaggtaa actagacacg aagctctttt tattttattt tactaacagg taaaccagac
     1261 acttggcctt tattagccgg gtctcttgcc tagcatttta atcgatcagt tagcacgagg
     1321 aaagagttca cgccttgaac acagggaaga ggccatctct gcagcttcta gttactattc
     1381 tgggattcac gggtgtttga gtttgagcac cttgacctta atgtcttcac taggcaagtc
     1441 gaagaaagac gcgcatttct tctctttggg aagagctttg gattggcggg aggctgacaa
     1501 ggacacctaa accgaacaca tttcagagtt cagcctccct gaggaatgat tcgccaatga
     1561 ttctgtgata ggaccagtca gtagcttttg aatttgccct ggctcagcaa agtctacctt
     1621 gctagggtgt tttgcaaaat gcaaacgctc gaactctctc taaagaggca tttttagtga
     1681 aagcctccgc tagcaggttg acttgtaata tattctaagc gaatgtgccc ggggtggggg
     1741 tggaggtggg gtgggggaga agggtccttg agacctcgga ttgttctagg ttagggtttc
     1801 tgtgaagagg aaagggaaaa aagaggtttt tttttttttg ttttgttttg tttttttgtt
     1861 tttttgtttt ttttaagttt gtttttgttt tcctaagtaa aatgggatcc aggattagct
     1921 aggtagagtc aggggaggac tcctgcagga gctaacccca aaatggcagc tactcttggg
     1981 aacttttagg gcattaaaca aagacatctt tcatttgtcc cagaaactcc agggctgtcc
     2041 tggggtgagc atagcctcac agtgaacagc aagaagtgtt aggcaggctt taaggttctc
     2101 cccgcttctg caccttagct ggtaatcgac ttcaacaaag ggcacctcct gtctacctct
     2161 atttaaatga gaatcagaag ggcacagtaa tggcccagtc cttcagacag ctttgagttt
     2221 tccactgtct tcctgtacac agccttagaa atggatccac tgctcttgct tgtcagatga
     2281 acagcaggca acaatagcag gcaactcggc cagttccacc cctgaagtac taacgctgtg
     2341 cacagcagta gatgccatga accccaaccc ttttccgcac tggctttcac ttcccattgg
     2401 ggtactagcc tgtacaccag ctaccagaag cctccccact gaggcaacca cgtgggaaac
     2461 cccagaaaga acttgagtag caaactggct gtaaactcac aagcccagaa ccaccgcggg
     2521 gctttctttt ttggcagagc caaggtcatc ttgtaattcc ttaggtccct tcacatgtgg
     2581 caatatttat ttatttattt gaaagatttt tgcctatcac tctatattta tagttattta
     2641 taaaatctaa ccccacttct gtccttgtgt tttaaataaa aataagactt ctctca
//
