LOCUS       NM_023304               1060 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus fibroblast growth factor 22 (Fgf22), transcript
            variant 1, mRNA.
ACCESSION   NM_023304
VERSION     NM_023304.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1060)
  AUTHORS   Cao,Y., Tang,L., Du,K., Paraiso,K., Sun,Q., Liu,Z., Ye,X., Fang,Y.,
            Yuan,F., Chen,H., Chen,Y., Wang,X., Yu,C., Blitz,I.L., Wang,P.H.,
            Huang,L., Cheng,H., Lu,X., Cho,K.W., Seldin,M., Fang,Z. and Yang,Q.
  TITLE     Anterograde regulation of mitochondrial genes and FGF21 signaling
            by hepatic LSD1
  JOURNAL   JCI Insight 6 (17), e147692 (2021)
   PUBMED   34314389
  REMARK    GeneRIF: Anterograde regulation of mitochondrial genes and FGF21
            signaling by hepatic LSD1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1060)
  AUTHORS   Luo,L., Ambrozkiewicz,M.C., Benseler,F., Chen,C., Dumontier,E.,
            Falkner,S., Furlanis,E., Gomez,A.M., Hoshina,N., Huang,W.H.,
            Hutchison,M.A., Itoh-Maruoka,Y., Lavery,L.A., Li,W., Maruo,T.,
            Motohashi,J., Pai,E.L., Pelkey,K.A., Pereira,A., Philips,T.,
            Sinclair,J.L., Stogsdill,J.A., Traunmuller,L., Wang,J., Wortel,J.,
            You,W., Abumaria,N., Beier,K.T., Brose,N., Burgess,H.A.,
            Cepko,C.L., Cloutier,J.F., Eroglu,C., Goebbels,S., Kaeser,P.S.,
            Kay,J.N., Lu,W., Luo,L., Mandai,K., McBain,C.J., Nave,K.A.,
            Prado,M.A.M., Prado,V.F., Rothstein,J., Rubenstein,J.L.R.,
            Saher,G., Sakimura,K., Sanes,J.R., Scheiffele,P., Takai,Y.,
            Umemori,H., Verhage,M., Yuzaki,M., Zoghbi,H.Y., Kawabe,H. and
            Craig,A.M.
  TITLE     Optimizing Nervous System-Specific Gene Targeting with Cre Driver
            Lines: Prevalence of Germline Recombination and Influencing Factors
  JOURNAL   Neuron 106 (1), 37-65 (2020)
   PUBMED   32027825
REFERENCE   3  (bases 1 to 1060)
  AUTHORS   Terauchi,A., Durlacher,E., Pitino,J. and Umemori,H.
  TITLE     Neuronal fibroblast growth factor 22 signaling during development,
            but not in adults, is involved in anhedonia
  JOURNAL   Neuroreport 31 (2), 125-130 (2020)
   PUBMED   31895747
  REMARK    GeneRIF: Neuronal fibroblast growth factor 22 signaling during
            development, but not in adults, is involved in anhedonia.
REFERENCE   4  (bases 1 to 1060)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1060)
  AUTHORS   Terauchi,A., Gavin,E., Wilson,J. and Umemori,H.
  TITLE     Selective Inactivation of Fibroblast Growth Factor 22 (FGF22) in
            CA3 Pyramidal Neurons Impairs Local Synaptogenesis and Affective
            Behavior Without Affecting Dentate Neurogenesis
  JOURNAL   Front Synaptic Neurosci 9, 17 (2017)
   PUBMED   29311892
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1060)
  AUTHORS   Beer,H.D., Bittner,M., Niklaus,G., Munding,C., Max,N., Goppelt,A.
            and Werner,S.
  TITLE     The fibroblast growth factor binding protein is a novel interaction
            partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity:
            implications for epithelial repair
  JOURNAL   Oncogene 24 (34), 5269-5277 (2005)
   PUBMED   15806171
REFERENCE   7  (bases 1 to 1060)
  AUTHORS   Umemori,H., Linhoff,M.W., Ornitz,D.M. and Sanes,J.R.
  TITLE     FGF22 and its close relatives are presynaptic organizing molecules
            in the mammalian brain
  JOURNAL   Cell 118 (2), 257-270 (2004)
   PUBMED   15260994
  REMARK    GeneRIF: FGF22 is expressed by cerebellar granule cells during the
            period when they receive synapses. Its receptor, FGFR2, is
            expressed by pontine neurons when they are making synapses on
            granule cells.
REFERENCE   8  (bases 1 to 1060)
  AUTHORS   Wright,T.J., Hatch,E.P., Karabagli,H., Karabagli,P.,
            Schoenwolf,G.C. and Mansour,S.L.
  TITLE     Expression of mouse fibroblast growth factor and fibroblast growth
            factor receptor genes during early inner ear development
  JOURNAL   Dev Dyn 228 (2), 267-272 (2003)
   PUBMED   14517998
REFERENCE   9  (bases 1 to 1060)
  AUTHORS   Beyer,T.A., Werner,S., Dickson,C. and Grose,R.
  TITLE     Fibroblast growth factor 22 and its potential role during skin
            development and repair
  JOURNAL   Exp Cell Res 287 (2), 228-236 (2003)
   PUBMED   12837279
  REMARK    GeneRIF: Fgf22 has a potential role in cutaneous development and
            repair.
REFERENCE   10 (bases 1 to 1060)
  AUTHORS   Nakatake,Y., Hoshikawa,M., Asaki,T., Kassai,Y. and Itoh,N.
  TITLE     Identification of a novel fibroblast growth factor, FGF-22,
            preferentially expressed in the inner root sheath of the hair
            follicle
  JOURNAL   Biochim Biophys Acta 1517 (3), 460-463 (2001)
   PUBMED   11342227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151828.3 and AK008922.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_023304.3.
            
            On Feb 14, 2019 this sequence version replaced NM_023304.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008922.1, BY708810.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC151828.3         163483-163500
            19-1060             AK008922.1         12-1053
FEATURES             Location/Qualifiers
     source          1..1060
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1060
                     /gene="Fgf22"
                     /gene_synonym="2210414E06Rik; FGF-22; Fgf5d"
                     /note="fibroblast growth factor 22"
                     /db_xref="GeneID:67112"
                     /db_xref="MGI:MGI:1914362"
     exon            1..197
                     /gene="Fgf22"
                     /gene_synonym="2210414E06Rik; FGF-22; Fgf5d"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..499
                     /gene="Fgf22"
                     /gene_synonym="2210414E06Rik; FGF-22; Fgf5d"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; fibroblast growth factor 5d"
                     /codon_start=1
                     /product="fibroblast growth factor 22 isoform 1 precursor"
                     /protein_id="NP_075793.1"
                     /db_xref="CCDS:CCDS23988.1"
                     /db_xref="GeneID:67112"
                     /db_xref="MGI:MGI:1914362"
                     /translation="MRSRLWLGLAWLLLARAPGAPGGYPHLEGDVRWRRLFSSTHFFL
                     RVDLGGRVQGTRWRHGQDSIVEIRSVRVGTVVIKAVYSGFYVAMNRRGRLYGSRVYSV
                     DCRFRERIEENGYNTYASRRWRHRGRPMFLALDSQGIPRQGRRTRRHQLSTHFLPVLV
                     SS"
     exon            198..301
                     /gene="Fgf22"
                     /gene_synonym="2210414E06Rik; FGF-22; Fgf5d"
                     /inference="alignment:Splign:2.1.0"
     exon            302..1060
                     /gene="Fgf22"
                     /gene_synonym="2210414E06Rik; FGF-22; Fgf5d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaggtcggg atgcgcagcc gcctctggct gggcctagcc tggctgctgt tggcgcgggc
       61 accgggcgct ccgggagggt acccgcatct ggagggcgac gtgcgctggc gccgcctctt
      121 ctcctccact cactttttcc tgcgtgtgga ccttggtggt cgggtgcagg ggacgcgttg
      181 gcggcacggc caggacagta tagtggagat ccgttctgtc cgtgtgggca ctgtggtgat
      241 caaagctgtg tactcaggct tctatgtggc catgaatcgc aggggccgcc tctatgggtc
      301 gcgggtctac tctgtggact gtaggttccg ggagcgcatc gaggagaacg gctacaacac
      361 atacgcctcg cgacgttgga ggcaccgcgg ccgacccatg ttcctggcac ttgacagcca
      421 aggcattccc aggcaaggca gacggacacg acggcaccaa ctgtccacac acttcctgcc
      481 agtcttggtc tcgtcttgaa gggcctgcca atggttcagg aggcatgggc ggcacacagg
      541 gcctggaaga tccggagctg aacaaccaag ggccaggcca gagaccctgg gccaacacga
      601 gtctttatgt cacaagccgg gcgcccgctg gctgccgggc atggagacat ggcagggtcc
      661 ctgcaagtga agccagcgct cagggggata cacagaactg gcagtttgca tccatctagt
      721 ttggagatga gaacactctg ggcacagcac ggagaggttt ggaggtggga acacacacca
      781 ggtggatgag gaaagcaggc agggaggacc ggggagggtg gacatgtcac ggagggcagg
      841 gcccgcgtca gtggggacag agacatgttc gcccatgtgg ccgaagcttg gggctggagt
      901 taagagcact tcttgctctt ccaaggggcc tgagtttagt tctcccacat caggctgctc
      961 ttaattatcc atatctccca ccccagagga tctgactccc ttttctgttc tctgcaggca
     1021 cttgcactcg tgtgcacata ccctgcacct atacacattt
//
