LOCUS       NM_020013                947 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus fibroblast growth factor 21 (Fgf21), mRNA.
ACCESSION   NM_020013
VERSION     NM_020013.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 947)
  AUTHORS   Khan,M.S.H., Kim,S.Q., Ross,R.C., Corpodean,F., Spann,R.A.,
            Albarado,D.A., Fernandez-Kim,S.O., Clarke,B., Berthoud,H.R.,
            Munzberg,H., McDougal,D.H., He,Y., Yu,S., Albaugh,V.L., Soto,P.L.
            and Morrison,C.D.
  TITLE     FGF21 acts in the brain to drive macronutrient-specific changes in
            behavioral motivation and brain reward signaling
  JOURNAL   Mol Metab 91, 102068 (2025)
   PUBMED   39571902
REFERENCE   2  (bases 1 to 947)
  AUTHORS   Xu,G., Qiu,F., Zhang,W., Li,S., Chen,J., Wang,G., Wang,Y., Pan,J.
            and Pan,X.
  TITLE     Fibroblast growth factor 21 alleviates acetaminophen induced acute
            liver injury by activating Sirt1 mediated autophagy
  JOURNAL   Cell Signal 123, 111379 (2024)
   PUBMED   39233207
  REMARK    GeneRIF: Fibroblast growth factor 21 alleviates acetaminophen
            induced acute liver injury by activating Sirt1 mediated autophagy.
REFERENCE   3  (bases 1 to 947)
  AUTHORS   Sun,J., Zhang,Y., Adams,J.A., Higgins,C.B., Kelly,S.C., Zhang,H.,
            Cho,K.Y., Johnson,U.G., Swarts,B.M., Wada,S.I., Patti,G.J.,
            Shriver,L.P., Finck,B.N., Herzog,E.D. and DeBosch,B.J.
  TITLE     Hepatocyte Period 1 dictates oxidative substrate selection
            independent of the core circadian clock
  JOURNAL   Cell Rep 43 (10), 114865 (2024)
   PUBMED   39412985
REFERENCE   4  (bases 1 to 947)
  AUTHORS   Sullivan,A.I., Jensen-Cody,S.O., Claflin,K.E., Vorhies,K.E.,
            Flippo,K.H. and Potthoff,M.J.
  TITLE     Characterization of FGF21 Sites of Production and Signaling in Mice
  JOURNAL   Endocrinology 165 (11) (2024)
   PUBMED   39253796
REFERENCE   5  (bases 1 to 947)
  AUTHORS   Zheng,H., Zhang,X., Li,C., Wang,D., Shen,Y., Lu,J., Zhao,L., Li,X.
            and Gao,H.
  TITLE     BCAA mediated microbiota-liver-heart crosstalk regulates diabetic
            cardiomyopathy via FGF21
  JOURNAL   Microbiome 12 (1), 157 (2024)
   PUBMED   39182099
  REMARK    GeneRIF: BCAA mediated microbiota-liver-heart crosstalk regulates
            diabetic cardiomyopathy via FGF21.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 947)
  AUTHORS   Kurose,H., Bito,T., Adachi,T., Shimizu,M., Noji,S. and Ohuchi,H.
  TITLE     Expression of Fibroblast growth factor 19 (Fgf19) during chicken
            embryogenesis and eye development, compared with Fgf15 expression
            in the mouse
  JOURNAL   Gene Expr Patterns 4 (6), 687-693 (2004)
   PUBMED   15465490
REFERENCE   7  (bases 1 to 947)
  AUTHORS   Wright,T.J., Hatch,E.P., Karabagli,H., Karabagli,P.,
            Schoenwolf,G.C. and Mansour,S.L.
  TITLE     Expression of mouse fibroblast growth factor and fibroblast growth
            factor receptor genes during early inner ear development
  JOURNAL   Dev Dyn 228 (2), 267-272 (2003)
   PUBMED   14517998
REFERENCE   8  (bases 1 to 947)
  AUTHORS   Hajihosseini,M.K. and Heath,J.K.
  TITLE     Expression patterns of fibroblast growth factors-18 and -20 in
            mouse embryos is suggestive of novel roles in calvarial and limb
            development
  JOURNAL   Mech Dev 113 (1), 79-83 (2002)
   PUBMED   11900978
REFERENCE   9  (bases 1 to 947)
  AUTHORS   Bachler,M. and Neubuser,A.
  TITLE     Expression of members of the Fgf family and their receptors during
            midfacial development
  JOURNAL   Mech Dev 100 (2), 313-316 (2001)
   PUBMED   11165488
REFERENCE   10 (bases 1 to 947)
  AUTHORS   Nishimura,T., Nakatake,Y., Konishi,M. and Itoh,N.
  TITLE     Identification of a novel FGF, FGF-21, preferentially expressed in
            the liver
  JOURNAL   Biochim Biophys Acta 1492 (1), 203-206 (2000)
   PUBMED   10858549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149057.7.
            
            On Apr 29, 2007 this sequence version replaced NM_020013.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007574.1, BC049592.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-422               AC149057.7         53292-53713
            423-526             AC149057.7         53813-53916
            527-947             AC149057.7         54472-54892
FEATURES             Location/Qualifiers
     source          1..947
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.38 cM"
     gene            1..947
                     /gene="Fgf21"
                     /gene_synonym="Fgf8c"
                     /note="fibroblast growth factor 21"
                     /db_xref="GeneID:56636"
                     /db_xref="MGI:MGI:1861377"
     exon            1..422
                     /gene="Fgf21"
                     /gene_synonym="Fgf8c"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..817
                     /gene="Fgf21"
                     /gene_synonym="Fgf8c"
                     /note="fibroblast growth factor 8c"
                     /codon_start=1
                     /product="fibroblast growth factor 21 precursor"
                     /protein_id="NP_064397.1"
                     /db_xref="CCDS:CCDS21253.1"
                     /db_xref="GeneID:56636"
                     /db_xref="MGI:MGI:1861377"
                     /translation="MEWMRSRVGTLGLWVRLLLAVFLLGVYQAYPIPDSSPLLQFGGQ
                     VRQRYLYTDDDQDTEAHLEIREDGTVVGAAHRSPESLLELKALKPGVIQILGVKASRF
                     LCQQPDGALYGSPHFDPEACSFRELLLEDGYNVYQSEAHGLPLRLPQKDSPNQDATSW
                     GPVRFLPMPGLLHEPQDQAGFLPPEPPDVGSSDPLSMVEPLQGRSPSYAS"
     exon            423..526
                     /gene="Fgf21"
                     /gene_synonym="Fgf8c"
                     /inference="alignment:Splign:2.1.0"
     exon            527..947
                     /gene="Fgf21"
                     /gene_synonym="Fgf8c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      918..923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf21"
                     /gene_synonym="Fgf8c"
                     /note="hexamer: AATAAA"
     polyA_site      939
                     /gene="Fgf21"
                     /gene_synonym="Fgf8c"
                     /note="major polyA site"
ORIGIN      
        1 agacagcctt agtgtcttct cagctgggga ttcaacacag gagaaacagc cattcacttt
       61 gcctgagccc cagtctgaac ctgacccatc cctgctgggc accggagtca gaacacaatt
      121 ccagctgcct tggctcctca gccgctcgct tgccaggggc tctcccgaac ggagcgcagc
      181 cctgatggaa tggatgagat ctagagttgg gaccctggga ctgtgggtcc gactgctgct
      241 ggctgtcttc ctgctggggg tctaccaagc ataccccatc cctgactcca gccccctcct
      301 ccagtttggg ggtcaagtcc ggcagaggta cctctacaca gatgacgacc aagacactga
      361 agcccacctg gagatcaggg aggatggaac agtggtaggc gcagcacacc gcagtccaga
      421 aagtctcctg gagctcaaag ccttgaagcc aggggtcatt caaatcctgg gtgtcaaagc
      481 ctctaggttt ctttgccaac agccagatgg agctctctat ggatcgcctc actttgatcc
      541 tgaggcctgc agcttcagag aactgctgct ggaggacggt tacaatgtgt accagtctga
      601 agcccatggc ctgcccctgc gtctgcctca gaaggactcc ccaaaccagg atgcaacatc
      661 ctggggacct gtgcgcttcc tgcccatgcc aggcctgctc cacgagcccc aagaccaagc
      721 aggattcctg cccccagagc ccccagatgt gggctcctct gaccccctga gcatggtaga
      781 gcctttacag ggccgaagcc ccagctatgc gtcctgactc ttcctgaatc tagggctgtt
      841 tctttttggg tttccactta tttattacgg gtatttatct tatttattta ttttagtttt
      901 tttttcttac ttggaataat aaagagtctg aaagaaaaat gtgtgtt
//
