LOCUS       NM_008006                695 bp    mRNA    linear   ROD 27-MAY-2024
DEFINITION  Mus musculus fibroblast growth factor 2 (Fgf2), mRNA.
ACCESSION   NM_008006 XM_903202
VERSION     NM_008006.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 695)
  AUTHORS   Ueno,K., Kurazumi,H., Suzuki,R., Yanagihara,M., Mizoguchi,T.,
            Harada,T., Morikage,N. and Hamano,K.
  TITLE     miR-709 exerts an angiogenic effect through a FGF2 upregulation
            induced by a GSK3B downregulation
  JOURNAL   Sci Rep 14 (1), 11372 (2024)
   PUBMED   38762650
  REMARK    GeneRIF: miR-709 exerts an angiogenic effect through a FGF2
            upregulation induced by a GSK3B downregulation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 695)
  AUTHORS   Hose,L., Langenhagen,A.K., Kefalakes,E., Schweitzer,T.,
            Kubinski,S., Barak,S., Pich,A. and Grothe,C.
  TITLE     A dual-omics approach on the effects of fibroblast growth factor-2
            (FGF-2) on ventral tegmental area dopaminergic neurons in response
            to alcohol consumption in mice
  JOURNAL   Eur J Neurosci 59 (7), 1519-1535 (2024)
   PUBMED   38185886
  REMARK    GeneRIF: A dual-omics approach on the effects of fibroblast growth
            factor-2 (FGF-2) on ventral tegmental area dopaminergic neurons in
            response to alcohol consumption in mice.
REFERENCE   3  (bases 1 to 695)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 695)
  AUTHORS   Chen,F., Zhan,J., Liu,M., Mamun,A.A., Huang,S., Tao,Y., Zhao,J.,
            Zhang,Y., Xu,Y., He,Z., Du,S., Lu,W., Li,X., Chen,Z. and Xiao,J.
  TITLE     FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury by
            KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses
  JOURNAL   Int J Biol Sci 19 (13), 4340-4359 (2023)
   PUBMED   37705747
  REMARK    GeneRIF: FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury
            by KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 695)
  AUTHORS   Wang,X., Fan,W., Li,N., Ma,Y., Yao,M., Wang,G., He,S., Li,W.,
            Tan,J., Lu,Q. and Hou,S.
  TITLE     YY1 lactylation in microglia promotes angiogenesis through
            transcription activation-mediated upregulation of FGF2
  JOURNAL   Genome Biol 24 (1), 87 (2023)
   PUBMED   37085894
  REMARK    GeneRIF: YY1 lactylation in microglia promotes angiogenesis through
            transcription activation-mediated upregulation of FGF2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 695)
  AUTHORS   Cam,Y., Neumann,M.R., Oliver,L., Raulais,D., Janet,T. and Ruch,J.V.
  TITLE     Immunolocalization of acidic and basic fibroblast growth factors
            during mouse odontogenesis
  JOURNAL   Int J Dev Biol 36 (3), 381-389 (1992)
   PUBMED   1280156
  REMARK    Erratum:[Int J Dev Biol 1992 Dec;36(4):following 599]
REFERENCE   7  (bases 1 to 695)
  AUTHORS   Chen,C.Y., Salles,G., Seldin,M.F., Kister,A.E., Reinherz,E.L. and
            Shipp,M.A.
  TITLE     Murine common acute lymphoblastic leukemia antigen (CD10 neutral
            endopeptidase 24.11). Molecular characterization, chromosomal
            localization, and modeling of the active site
  JOURNAL   J Immunol 148 (9), 2817-2825 (1992)
   PUBMED   1374101
REFERENCE   8  (bases 1 to 695)
  AUTHORS   Hannon,K., Smith,C.K. 2nd, Bales,K.R. and Santerre,R.F.
  TITLE     Temporal and quantitative analysis of myogenic regulatory and
            growth factor gene expression in the developing mouse embryo
  JOURNAL   Dev Biol 151 (1), 137-144 (1992)
   PUBMED   1374351
REFERENCE   9  (bases 1 to 695)
  AUTHORS   Yasuda,Y., Nishi,N., Takahashi,J.A., Konishi,H., Ohara,I.,
            Fujita,H., Ohta,M., Itoh,N., Hatanaka,M. and Tanimura,T.
  TITLE     Induction of avascular yolk sac due to reduction of basic
            fibroblast growth factor by retinoic acid in mice
  JOURNAL   Dev Biol 150 (2), 397-413 (1992)
   PUBMED   1372572
REFERENCE   10 (bases 1 to 695)
  AUTHORS   Venesio,T., Taverna,D., Hynes,N.E., Deed,R., MacAllan,D.,
            Ciardiello,F., Valverius,E.M., Salomon,D.S., Callahan,R. and
            Merlo,G.
  TITLE     The int-2 gene product acts as a growth factor and substitutes for
            basic fibroblast growth factor in promoting the differentiation of
            a normal mouse mammary epithelial cell line
  JOURNAL   Cell Growth Differ 3 (1), 63-71 (1992)
   PUBMED   1376141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ098597.1, BY730691.1, AF065904.1 and AL669927.9.
            
            On Nov 2, 2007 this sequence version replaced NM_008006.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY730691.1, BB660595.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               CJ098597.1         4-116
            114-220             BY730691.1         92-198
            221-662             AF065904.1         24-465
            663-685             BY730691.1         641-663
            686-687             AL669927.9         44019-44020
            688-695             BY730691.1         666-673
FEATURES             Location/Qualifiers
     source          1..695
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 18.41 cM"
     gene            1..695
                     /gene="Fgf2"
                     /gene_synonym="bFGF; Fgf-2; Fgf2a; Fgfb"
                     /note="fibroblast growth factor 2"
                     /db_xref="GeneID:14173"
                     /db_xref="MGI:MGI:95516"
     exon            1..372
                     /gene="Fgf2"
                     /gene_synonym="bFGF; Fgf-2; Fgf2a; Fgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            373..476
                     /gene="Fgf2"
                     /gene_synonym="bFGF; Fgf-2; Fgf2a; Fgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            477..695
                     /gene="Fgf2"
                     /gene_synonym="bFGF; Fgf-2; Fgf2a; Fgfb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccccgggc cgttgtacac tcaaggggct ctctcggctt caggaagagt ccggctgcac
       61 tgggctggga gcccggcggg acacggactg ggaggctggc agcccgcggg cgagccgcgc
      121 tggggggccg aggccggggt cggggccggg gagccccaag agctgccaca gcggggtccc
      181 ggggccgcgg aagggccatg gctgccagcg gcatcacctc gcttcccgca ctgccggagg
      241 acggcggcgc cgccttccca ccaggccact tcaaggaccc caagcggctc tactgcaaga
      301 acggcggctt cttcctgcgc atccatcccg acggccgcgt ggatggcgtc cgcgagaaga
      361 gcgacccaca cgtcaaacta caactccaag cagaagagag aggagttgtg tctatcaagg
      421 gagtgtgtgc caaccggtac cttgctatga aggaagatgg acggctgctg gcttctaagt
      481 gtgttacaga agagtgtttc ttctttgaac gactggaatc taataactac aatacttacc
      541 ggtcacggaa atactccagt tggtatgtgg cactgaaacg aactgggcag tataaactcg
      601 gatccaaaac gggacctgga cagaaggcca tactgtttct tccaatgtct gctaagagct
      661 gactcacttt tgacactgtc actgagacac tgtca
//
