LOCUS       NM_008005               1546 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus fibroblast growth factor 18 (Fgf18), transcript
            variant 1, mRNA.
ACCESSION   NM_008005
VERSION     NM_008005.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1546)
  AUTHORS   Bobzin,L., Nickle,A., Ko,S., Ince,M., Huang,A., Bhojwani,A.,
            Roberts,R. and Merrill,A.E.
  TITLE     FGFR2 directs inhibition of WNT signaling to regulate anterior
            fontanelle closure during skull development
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39775862
REFERENCE   2  (bases 1 to 1546)
  AUTHORS   Lv,Y., Wang,Q., Lin,C., Zheng,X., Zhang,Y. and Hu,X.
  TITLE     Overexpression of Fgf18 in cranial neural crest cells recapitulates
            Pierre Robin sequence in mice
  JOURNAL   Front Cell Dev Biol 12, 1376814 (2024)
   PUBMED   38694818
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1546)
  AUTHORS   Hu,Z., Dai,J., Xu,T., Chen,H., Shen,G., Zhou,J., Ma,H., Wang,Y. and
            Jin,L.
  TITLE     FGF18 alleviates sepsis-induced acute lung injury by inhibiting the
            NF-kappaB pathway
  JOURNAL   Respir Res 25 (1), 108 (2024)
   PUBMED   38419044
  REMARK    GeneRIF: FGF18 alleviates sepsis-induced acute lung injury by
            inhibiting the NF-kappaB pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1546)
  AUTHORS   Tsuchiya,Y., Seki,T., Kobayashi,K., Komazawa-Sakon,S., Shichino,S.,
            Nishina,T., Fukuhara,K., Ikejima,K., Nagai,H., Igarashi,Y.,
            Ueha,S., Oikawa,A., Tsurusaki,S., Yamazaki,S., Nishiyama,C.,
            Mikami,T., Yagita,H., Okumura,K., Kido,T., Miyajima,A.,
            Matsushima,K., Imasaka,M., Araki,K., Imamura,T., Ohmuraya,M.,
            Tanaka,M. and Nakano,H.
  TITLE     Fibroblast growth factor 18 stimulates the proliferation of hepatic
            stellate cells, thereby inducing liver fibrosis
  JOURNAL   Nat Commun 14 (1), 6304 (2023)
   PUBMED   37813881
  REMARK    GeneRIF: Fibroblast growth factor 18 stimulates the proliferation
            of hepatic stellate cells, thereby inducing liver fibrosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1546)
  AUTHORS   Tong,G., Chen,Y., Chen,X., Fan,J., Zhu,K., Hu,Z., Li,S., Zhu,J.,
            Feng,J., Wu,Z., Hu,Z., Zhou,B., Jin,L., Chen,H., Shen,J., Cong,W.
            and Li,X.
  TITLE     FGF18 alleviates hepatic ischemia-reperfusion injury via the
            USP16-mediated KEAP1/Nrf2 signaling pathway in male mice
  JOURNAL   Nat Commun 14 (1), 6107 (2023)
   PUBMED   37777507
  REMARK    GeneRIF: FGF18 alleviates hepatic ischemia-reperfusion injury via
            the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1546)
  AUTHORS   Zaret,K.S.
  TITLE     Liver specification and early morphogenesis
  JOURNAL   Mech Dev 92 (1), 83-88 (2000)
   PUBMED   10704889
  REMARK    Review article
REFERENCE   7  (bases 1 to 1546)
  AUTHORS   Lin,C.R., Kioussi,C., O'Connell,S., Briata,P., Szeto,D., Liu,F.,
            Izpisua-Belmonte,J.C. and Rosenfeld,M.G.
  TITLE     Pitx2 regulates lung asymmetry, cardiac positioning and pituitary
            and tooth morphogenesis
  JOURNAL   Nature 401 (6750), 279-282 (1999)
   PUBMED   10499586
REFERENCE   8  (bases 1 to 1546)
  AUTHORS   Hu,M.C., Qiu,W.R., Wang,Y.P., Hill,D., Ring,B.D., Scully,S.,
            Bolon,B., DeRose,M., Luethy,R., Simonet,W.S., Arakawa,T. and
            Danilenko,D.M.
  TITLE     FGF-18, a novel member of the fibroblast growth factor family,
            stimulates hepatic and intestinal proliferation
  JOURNAL   Mol Cell Biol 18 (10), 6063-6074 (1998)
   PUBMED   9742123
REFERENCE   9  (bases 1 to 1546)
  AUTHORS   Ohbayashi,N., Hoshikawa,M., Kimura,S., Yamasaki,M., Fukui,S. and
            Itoh,N.
  TITLE     Structure and expression of the mRNA encoding a novel fibroblast
            growth factor, FGF-18
  JOURNAL   J Biol Chem 273 (29), 18161-18164 (1998)
   PUBMED   9660775
REFERENCE   10 (bases 1 to 1546)
  AUTHORS   Maruoka,Y., Ohbayashi,N., Hoshikawa,M., Itoh,N., Hogan,B.L. and
            Furuta,Y.
  TITLE     Comparison of the expression of three highly related genes, Fgf8,
            Fgf17 and Fgf18, in the mouse embryo
  JOURNAL   Mech Dev 74 (1-2), 175-177 (1998)
   PUBMED   9651520
  REMARK    GeneRIF: The expression from early streak stage to midgestation of
            Fgf18 is measured. It is, closely related to Fgf8 (56.8% identical
            at the amino acid level). Fgf18 RNA is not expressed until later,
            in paraxial mesoderm.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772409.4, AF211187.1 and AL732390.10.
            
            On Apr 3, 2013 this sequence version replaced NM_008005.1.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF075291.1, AF211187.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AL772409.4         25294-25420         c
            128-1073            AF211187.1         1-946
            1074-1546           AL732390.10        188602-189074       c
FEATURES             Location/Qualifiers
     source          1..1546
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 19.21 cM"
     gene            1..1546
                     /gene="Fgf18"
                     /gene_synonym="D130055P09Rik; FGF-18; Fgf6a"
                     /note="fibroblast growth factor 18"
                     /db_xref="GeneID:14172"
                     /db_xref="MGI:MGI:1277980"
     exon            1..159
                     /gene="Fgf18"
                     /gene_synonym="D130055P09Rik; FGF-18; Fgf6a"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..751
                     /gene="Fgf18"
                     /gene_synonym="D130055P09Rik; FGF-18; Fgf6a"
                     /note="zFGF5; fibroblast growth factor 6a"
                     /codon_start=1
                     /product="fibroblast growth factor 18 precursor"
                     /protein_id="NP_032031.1"
                     /db_xref="CCDS:CCDS24531.1"
                     /db_xref="GeneID:14172"
                     /db_xref="MGI:MGI:1277980"
                     /translation="MYSAPSACTCLCLHFLLLCFQVQVLAAEENVDFRIHVENQTRAR
                     DDVSRKQLRLYQLYSRTSGKHIQVLGRRISARGEDGDKYAQLLVETDTFGSQVRIKGK
                     ETEFYLCMNRKGKLVGKPDGTSKECVFIEKVLENNYTALMSAKYSGWYVGFTKKGRPR
                     KGPKTRENQQDVHFMKRYPKGQAELQKPFKYTTVTKRSRRIRPTHPG"
     exon            160..196
                     /gene="Fgf18"
                     /gene_synonym="D130055P09Rik; FGF-18; Fgf6a"
                     /inference="alignment:Splign:2.1.0"
     exon            197..377
                     /gene="Fgf18"
                     /gene_synonym="D130055P09Rik; FGF-18; Fgf6a"
                     /inference="alignment:Splign:2.1.0"
     exon            378..484
                     /gene="Fgf18"
                     /gene_synonym="D130055P09Rik; FGF-18; Fgf6a"
                     /inference="alignment:Splign:2.1.0"
     exon            485..1546
                     /gene="Fgf18"
                     /gene_synonym="D130055P09Rik; FGF-18; Fgf6a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1395..1400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf18"
                     /gene_synonym="D130055P09Rik; FGF-18; Fgf6a"
                     /note="hexamer: ATTATA"
     polyA_site      1429
                     /gene="Fgf18"
                     /gene_synonym="D130055P09Rik; FGF-18; Fgf6a"
                     /note="major polyA site"
ORIGIN      
        1 cggcaaggag ggagcagcag cagcggcggc ggcggcggcg gcggcggcgg aggcgcccgg
       61 tcccggccgc gcggagcgga catgtgcagg ctgggctagg agccgccgcc tccccccccg
      121 ccccgcgatg tattcagcgc cctccgcctg cacttgcctg tgtttacact ttctactgct
      181 gtgcttccag gttcaggtgt tggcagccga ggagaatgtg gacttccgca tccacgtgga
      241 gaaccagacg cgggctcgag atgatgtgag tcggaagcag ctgcgcttgt accagctcta
      301 tagcaggacc agtgggaagc acattcaagt cctgggccgt aggatcagtg cccgtggcga
      361 ggacggggac aagtatgccc agctcctagt ggagacagat accttcggga gtcaagtccg
      421 gatcaagggc aaggagacag aattctacct gtgtatgaac cgaaaaggca agctcgtggg
      481 gaagcctgat ggtactagca aggagtgcgt gttcattgag aaggttctgg aaaacaacta
      541 cacggccctg atgtctgcca agtactctgg ttggtatgtg ggcttcacca agaaggggcg
      601 gcctcgcaag ggtcccaaga cccgcgagaa ccagcaagat gtacacttca tgaagcgtta
      661 ccccaaggga caggccgagc tgcagaagcc cttcaaatac accacagtca ccaagcgatc
      721 ccggcggatc cgccccactc accccggcta ggtccggcca cactcacccc cccagagaac
      781 tacatcagag gaatattttt acatgaaaaa taaggaagaa tctctatttt tgtacattgt
      841 gtttaaaaga agacaaaaac tgaacctaaa gtcttgggag gaggggcgat aggattccac
      901 tgttgacctg aaccccatga caaaggactc acacaagggg accgctgtca acccacaggt
      961 gcttgcctct ctctaggagg tgacaattca aaactcatcc ccagaggagg acttgaacga
     1021 ggaaactgcg agaaaccaaa gtcctttccc cccaaaggtt ctgaaagcaa acaaaacaaa
     1081 aacaaaaaaa caaaaaaaca acaaaaaaag gaaagtagtg ccccaccccc acccctctcc
     1141 ctgccctaga ctccaacaag aatcgctctc tggtttgcag tcatttattt attgtccact
     1201 gcaagctgtc ccgcgacacc gcgcagggaa ggcgcccttg agaattctcc gcgcctcgac
     1261 cttccgacga cagacgcctt gtccaatcat ggtggcctgc cttgcccgca gttctggagg
     1321 atgctgctgt ggaccttccg tgactcacgt gacctagtac accaatgata agggaatatt
     1381 ttaaaaccag ctatattata tatattatat atataagcta tttatttcac ctctctgtat
     1441 attgcagtct catgaaccaa gtattactgc ctcaacaatt aagaacaacc cacaaattat
     1501 ttaaaaaaac aaaacaaaac aaaaaacaac aacaacaaaa aaaaaa
//
