LOCUS       NM_008004               1738 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus fibroblast growth factor 17 (Fgf17), transcript
            variant 1, mRNA.
ACCESSION   NM_008004 XM_001000699
VERSION     NM_008004.6
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1738)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1738)
  AUTHORS   Yang,K.Y., Zhao,S., Feng,H., Shen,J., Chen,Y., Wang,S.T.,
            Wang,S.J., Zhang,Y.X., Wang,Y., Guo,C., Liu,H. and Tang,T.S.
  TITLE     Ca2+ homeostasis maintained by TMCO1 underlies corpus callosum
            development via ERK signaling
  JOURNAL   Cell Death Dis 13 (8), 674 (2022)
   PUBMED   35927240
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1738)
  AUTHORS   Zhao,T., McMahon,M., Reynolds,K., Saha,S.K., Stokes,A. and
            Zhou,C.J.
  TITLE     The role of Lrp6-mediated Wnt/beta-catenin signaling in the
            development and intervention of spinal neural tube defects in mice
  JOURNAL   Dis Model Mech 15 (6) (2022)
   PUBMED   35514236
REFERENCE   4  (bases 1 to 1738)
  AUTHORS   Iram,T., Kern,F., Kaur,A., Myneni,S., Morningstar,A.R., Shin,H.,
            Garcia,M.A., Yerra,L., Palovics,R., Yang,A.C., Hahn,O., Lu,N.,
            Shuken,S.R., Haney,M.S., Lehallier,B., Iyer,M., Luo,J.,
            Zetterberg,H., Keller,A., Zuchero,J.B. and Wyss-Coray,T.
  TITLE     Young CSF restores oligodendrogenesis and memory in aged mice via
            Fgf17
  JOURNAL   Nature 605 (7910), 509-515 (2022)
   PUBMED   35545674
  REMARK    GeneRIF: Young CSF restores oligodendrogenesis and memory in aged
            mice via Fgf17.
            Erratum:[Nature. 2023 Jan;613(7942):E1. PMID: 36513761]
REFERENCE   5  (bases 1 to 1738)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1738)
  AUTHORS   Goldman,D.C., Martin,G.R. and Tam,P.P.
  TITLE     Fate and function of the ventral ectodermal ridge during mouse tail
            development
  JOURNAL   Development 127 (10), 2113-2123 (2000)
   PUBMED   10769235
REFERENCE   7  (bases 1 to 1738)
  AUTHORS   Xu,J., Liu,Z. and Ornitz,D.M.
  TITLE     Temporal and spatial gradients of Fgf8 and Fgf17 regulate
            proliferation and differentiation of midline cerebellar structures
  JOURNAL   Development 127 (9), 1833-1843 (2000)
   PUBMED   10751172
REFERENCE   8  (bases 1 to 1738)
  AUTHORS   Xu,J., Lawshe,A., MacArthur,C.A. and Ornitz,D.M.
  TITLE     Genomic structure, mapping, activity and expression of fibroblast
            growth factor 17
  JOURNAL   Mech Dev 83 (1-2), 165-178 (1999)
   PUBMED   10381577
REFERENCE   9  (bases 1 to 1738)
  AUTHORS   Maruoka,Y., Ohbayashi,N., Hoshikawa,M., Itoh,N., Hogan,B.L. and
            Furuta,Y.
  TITLE     Comparison of the expression of three highly related genes, Fgf8,
            Fgf17 and Fgf18, in the mouse embryo
  JOURNAL   Mech Dev 74 (1-2), 175-177 (1998)
   PUBMED   9651520
  REMARK    GeneRIF: The expression from early streak stage to midgestation of
            Fgf17 is measured.  It is closely related to Fgf8 (63.7% identical
            at the amino acid level). Fgf17 is expressed during gastrulation
            but at lower levels than Fgf8.
REFERENCE   10 (bases 1 to 1738)
  AUTHORS   Hoshikawa,M., Ohbayashi,N., Yonamine,A., Konishi,M., Ozaki,K.,
            Fukui,S. and Itoh,N.
  TITLE     Structure and expression of a novel fibroblast growth factor,
            FGF-17, preferentially expressed in the embryonic brain
  JOURNAL   Biochem Biophys Res Commun 244 (1), 187-191 (1998)
   PUBMED   9514906
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154563.2.
            
            On Sep 13, 2022 this sequence version replaced NM_008004.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077555.1, AK082858.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849379 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-595               AC154563.2         80905-81499
            596-632             AC154563.2         81654-81690
            633-810             AC154563.2         84243-84420
            811-917             AC154563.2         84649-84755
            918-1738            AC154563.2         86199-87019
FEATURES             Location/Qualifiers
     source          1..1738
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.4 cM"
     gene            1..1738
                     /gene="Fgf17"
                     /gene_synonym="FGF-17; Fgf6b"
                     /note="fibroblast growth factor 17"
                     /db_xref="GeneID:14171"
                     /db_xref="MGI:MGI:1202401"
     exon            1..595
                     /gene="Fgf17"
                     /gene_synonym="FGF-17; Fgf6b"
                     /inference="alignment:Splign:2.1.0"
     exon            596..632
                     /gene="Fgf17"
                     /gene_synonym="FGF-17; Fgf6b"
                     /inference="alignment:Splign:2.1.0"
     exon            633..810
                     /gene="Fgf17"
                     /gene_synonym="FGF-17; Fgf6b"
                     /inference="alignment:Splign:2.1.0"
     exon            811..917
                     /gene="Fgf17"
                     /gene_synonym="FGF-17; Fgf6b"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1738
                     /gene="Fgf17"
                     /gene_synonym="FGF-17; Fgf6b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1718..1723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf17"
                     /gene_synonym="FGF-17; Fgf6b"
                     /note="hexamer: AATAAA"
     polyA_site      1738
                     /gene="Fgf17"
                     /gene_synonym="FGF-17; Fgf6b"
                     /note="major polyA site"
ORIGIN      
        1 gagccagaat tcgagacccc cagccccagc tcggtacctg cagctcattc ttaaggagat
       61 gaggttgccg catcaaacct gagggcggga gctgctgacc ctgaggaagg ggagggcaag
      121 gcgcctccct ccctgtgctt gccgctggcc ccgcacttca cggagaccgg caggttggtg
      181 cgggtcagga ataaatcaag agagatcgta ggggccagcc tcctgataga ggacgctctc
      241 gcagctccaa tcctttgcgc ccggggacct ctgcccgaag ccagtagccc aagagagcga
      301 gtacgccaat cggaccagct ccggcttcgc agccccactg gcccggaagg tggacacctc
      361 gcacctcagt ctctcaatta cgcctcccct tcattccccc ctcggctagc cttccccttc
      421 cctccatctc ctttcattcc tgaaaacctg tggctccgag aaaccttggc ttctctggga
      481 ctctacctca ggggcctggc cacatccgct cctgagtttg gggagcagag gggcaatcgc
      541 cccaagaagt ctctccagcg atgggagccg cccgcctgct gcctaacctt accctgtgct
      601 tgcagctatt gattctctgc tgtcaaacac agggggagaa tcacccgtct cctaatttta
      661 accagtacgt gagggaccag ggcgctatga ccgaccagct gagcaggcgg caaatccgtg
      721 aataccagct ctacagccgg accagtggca agcacgtgca ggtcaccgga cgtcgcatct
      781 ctgccaccgc agaggatggc aacaagttcg ccaagctcat cgtggagaca gatacattcg
      841 gcagcagagt ccgcatcaag ggggcagaga gcgagaagta catctgtatg aacaagaggg
      901 gcaagctgat tgggaagccg agcgggaaga gcaaagactg cgtgttcacc gagatcgtac
      961 tggagaacaa ctacacggcc ttccagaacg cccggcacga gggctggttc atggctttca
     1021 ctcggcaggg ccggccacgc caggcctccc ggagccgcca gaaccagcga gaggcccact
     1081 tcatcaagcg cctctaccaa ggccagctgc cttttcccaa ccacgctgaa aggcagaagc
     1141 agttcgaatt tgtgggctcc gcccccactc gcaggaccaa gcgcactcgg aggccccagt
     1201 cccaaacgta gtcagggagg ccagtagtgt gccaggctgg gtagatgccc ctcagcagcc
     1261 ttccctctct tctctaactc atccaaagat gggggctggg gaggaaggtg gggagccagt
     1321 ctccaaaagg accccgaggg catgaagttt ctgatcccca ctgggaagag acagtacttg
     1381 tgtatcccag ggtgggcacc attctatgga acaggtttga ggccagaggc agaccccggc
     1441 agaagaaata gggtctcctt gacctaaaat gcctgcttcc cagcgtctac ctgaaataag
     1501 cgggctgctc agcagattcc agagcttgca caactgtgct caaatcttgc tccctgaacc
     1561 tctctgaatc tgaaccaaat agccaaactc ttggccagac cgtagggact tacggttttg
     1621 ttttcaaaaa cagacagaga cagaaagaga aacaaaagcc agtcagccac tgttcttatt
     1681 tctcgcccca ggcctgcgtc cccaccccaa gccccagaat aaaaccattt tcctgcaa
//
