LOCUS       NM_030614               3040 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus fibroblast growth factor 16 (Fgf16), mRNA.
ACCESSION   NM_030614
VERSION     NM_030614.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3040)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   2  (bases 1 to 3040)
  AUTHORS   Jiang,F.Q., Liu,K., Chen,J.X., Cao,Y., Chen,W.Y., Zhao,W.L.,
            Song,G.H., Liang,C.Q., Zhou,Y.M., Huang,H.L., Huang,R.J., Zhao,H.,
            Park,K.S., Ju,Z., Cai,D. and Qi,X.F.
  TITLE     Mettl3-mediated m6A modification of Fgf16 restricts cardiomyocyte
            proliferation during heart regeneration
  JOURNAL   Elife 11, e77014 (2022)
   PUBMED   36399125
  REMARK    GeneRIF: Mettl3-mediated m[6]A modification of Fgf16 restricts
            cardiomyocyte proliferation during heart regeneration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3040)
  AUTHORS   Meuser,M., Deuper,L., Rudat,C., Aydogdu,N., Thiesler,H.,
            Zarnovican,P., Hildebrandt,H., Trowe,M.O. and Kispert,A.
  TITLE     FGFR2 signaling enhances the SHH-BMP4 signaling axis in early
            ureter development
  JOURNAL   Development 149 (1) (2022)
   PUBMED   35020897
REFERENCE   4  (bases 1 to 3040)
  AUTHORS   Zhang,X., Wang,Z., Xu,Q., Chen,Y., Liu,W., Zhong,T., Li,H.,
            Quan,C., Zhang,L. and Cui,C.P.
  TITLE     Splicing factor Srsf5 deletion disrupts alternative splicing and
            causes noncompaction of ventricular myocardium
  JOURNAL   iScience 24 (10), 103097 (2021)
   PUBMED   34622152
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3040)
  AUTHORS   Rulifson,I.C., Collins,P., Miao,L., Nojima,D., Lee,K.J., Hardy,M.,
            Gupte,J., Hensley,K., Samayoa,K., Cam,C., Rottman,J.B., Ollmann,M.,
            Richards,W.G. and Li,Y.
  TITLE     In Vitro and in Vivo Analyses Reveal Profound Effects of Fibroblast
            Growth Factor 16 as a Metabolic Regulator
  JOURNAL   J Biol Chem 292 (5), 1951-1969 (2017)
   PUBMED   28011645
  REMARK    GeneRIF: Overexpression of Fgf16 in vivo recapitulated several of
            our in vitro findings, specifically the significant induction of
            the Ucp1 gene and UCP1 protein expression in inguinal white adipose
            tissue (iWAT)
REFERENCE   6  (bases 1 to 3040)
  AUTHORS   Dichmann,D.S., Miller,C.P., Jensen,J., Scott Heller,R. and Serup,P.
  TITLE     Expression and misexpression of members of the FGF and TGFbeta
            families of growth factors in the developing mouse pancreas
  JOURNAL   Dev Dyn 226 (4), 663-674 (2003)
   PUBMED   12666204
REFERENCE   7  (bases 1 to 3040)
  AUTHORS   Sontag,D.P. and Cattini,P.A.
  TITLE     Cloning and bacterial expression of postnatal mouse heart FGF-16
  JOURNAL   Mol Cell Biochem 242 (1-2), 65-70 (2003)
   PUBMED   12619867
  REMARK    GeneRIF: cloning of the adult mouse FGF-16 cDNA
REFERENCE   8  (bases 1 to 3040)
  AUTHORS   Hajihosseini,M.K. and Heath,J.K.
  TITLE     Expression patterns of fibroblast growth factors-18 and -20 in
            mouse embryos is suggestive of novel roles in calvarial and limb
            development
  JOURNAL   Mech Dev 113 (1), 79-83 (2002)
   PUBMED   11900978
REFERENCE   9  (bases 1 to 3040)
  AUTHORS   Ornitz,D.M. and Itoh,N.
  TITLE     Fibroblast growth factors
  JOURNAL   Genome Biol 2 (3), REVIEWS3005 (2001)
   PUBMED   11276432
  REMARK    Review article
REFERENCE   10 (bases 1 to 3040)
  AUTHORS   Miyake,A., Konishi,M., Martin,F.H., Hernday,N.A., Ozaki,K.,
            Yamamoto,S., Mikami,T., Arakawa,T. and Itoh,N.
  TITLE     Structure and expression of a novel member, FGF-16, on the
            fibroblast growth factor family
  JOURNAL   Biochem Biophys Res Commun 243 (1), 148-152 (1998)
   PUBMED   9473496
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC132641.1, AL671893.7 and BB342405.2.
            
            On Feb 23, 2007 this sequence version replaced NM_030614.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132641.1, AB049219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-745               BC132641.1         1-745
            746-2903            AL671893.7         137152-139309
            2904-3040           BB342405.2         566-702
FEATURES             Location/Qualifiers
     source          1..3040
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 47.2 cM"
     gene            1..3040
                     /gene="Fgf16"
                     /gene_synonym="Fgf4c"
                     /note="fibroblast growth factor 16"
                     /db_xref="GeneID:80903"
                     /db_xref="MGI:MGI:1931627"
     exon            1..338
                     /gene="Fgf16"
                     /gene_synonym="Fgf4c"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..688
                     /gene="Fgf16"
                     /gene_synonym="Fgf4c"
                     /note="FGF-16; fibroblast growth factor 4c"
                     /codon_start=1
                     /product="fibroblast growth factor 16"
                     /protein_id="NP_085117.2"
                     /db_xref="CCDS:CCDS30336.1"
                     /db_xref="GeneID:80903"
                     /db_xref="MGI:MGI:1931627"
                     /translation="MAEVGGVFASLDWDLHGFSSSLGNVPLADSPGFLNERLGQIEGK
                     LQRGSPTDFAHLKGILRRRQLYCRTGFHLEIFPNGTVHGTRHDHSRFGILEFISLAVG
                     LISIRGVDSGLYLGMNERGELYGSKKLTRECVFREQFEENWYNTYASTLYKHSDSERQ
                     YYVALNKDGSPREGYRTKRHQKFTHFLPRPVDPSKLPSMSRDLFRYR"
     exon            339..442
                     /gene="Fgf16"
                     /gene_synonym="Fgf4c"
                     /inference="alignment:Splign:2.1.0"
     exon            443..3040
                     /gene="Fgf16"
                     /gene_synonym="Fgf4c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1422..1427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf16"
                     /gene_synonym="Fgf4c"
                     /note="hexamer: AATAAA"
     polyA_site      1447
                     /gene="Fgf16"
                     /gene_synonym="Fgf4c"
                     /note="major polyA site"
ORIGIN      
        1 ccgccaagac aggcagttcg cgccccgggg ccccggctcg gcccgcgccg ccgccggccc
       61 cgccatggcg gaggtcgggg gcgtctttgc ctccttggac tgggacctgc acggcttctc
      121 ctcctctctg gggaacgtgc ccttagctga ctccccgggt ttcctgaacg agcgcctggg
      181 ccagatcgag gggaagctgc agcgcggctc gcccacagac ttcgcccacc tgaaggggat
      241 cctgcggcgc cgccagctct actgccgcac cggcttccac cttgagatct tccccaacgg
      301 cacggtgcac ggcacccgcc acgaccacag ccgcttcgga attctggaat ttatcagctt
      361 ggctgtgggg ctgatcagca tcaggggagt ggactctggc ctgtacctag gaatgaatga
      421 gcgaggagag ctctatggat cgaagaaact cacacgtgaa tgtgttttcc gggaacagtt
      481 tgaagaaaac tggtacaaca cctatgcctc caccttgtac aaacactcgg actcggagag
      541 acagtattat gtggccctga ataaagacgg ctcaccccgg gagggataca ggactaaacg
      601 acaccagaaa ttcactcact ttttaccaag gccagtagat ccttctaagt tgccctccat
      661 gtccagagat ctcttccgct ataggtaatg gacctgtggt gccacctctg tgacccatgt
      721 actctgtgac catggttggc tctgcaaaca ctatactcat agcttttcaa tccttccttc
      781 ctatcaatta gataacagag aagcactcac tgttcaatgt gacccagctg tccccttgtt
      841 caaagtgtat atcaaggttg ggttattttg gggagggaca tgggggaggg gtggttctga
      901 gggaaatgtg tatatacttt ttgttttact catgttcttt cccgagatgt ggcattacaa
      961 agaacaaggg cccccattaa gggccaaggc tgtcttgcct cacaatctac ccagatacct
     1021 tgaaatgggg gtacaaatga aagaccaagg aatctgccac agatgctacc taaagagctc
     1081 tgggaaagtg ttatttggaa aatcctaggg gctccaaccc tgctgcaagc catccctacc
     1141 ctggctctgc agatctctca ttcgtcctga catgcagttt tcctgccacc ggaagtggga
     1201 gatatggggt aggttgtaag gaaatgatat taaaatgtaa gcgtggatac tgtgcataag
     1261 gacaaactat ttataaaatg tatatgctat ttattttata tatttattta tttcaaaata
     1321 attttatttt taatgagaga tgctatgact ggattttctt cagaaagaat aaggtcctac
     1381 tgaaacagga aaaaatgagt tattaaaggc ttttatttgg caataaaatt gtctttatat
     1441 tataaaacca gtgtctaatt ctattgcttt acacattcag tagaatgaag aggctggcca
     1501 gcttcttttt tttttcctcc aggttaataa aatccccaat gacaggctga tgcagcttga
     1561 gctgggtaac tccatcacct agtttggtag cattatccag gcaccttctt caagacctac
     1621 tgctcttttt tggtcccatg actcaaggga gctttaggaa gacctcaact cacagctcct
     1681 actgaagctc ccatttgtaa accttcagga ttgggcatag aggaaccttt cttggggaca
     1741 tgatgagggc ccacagctct aagaacagcg acctaatcag tggatcttta tttcagatat
     1801 gaaggtgaag caaattaaaa tagtagtcag caaggagagg agtttttgag ccaatcaagt
     1861 tccctgctgg aagacatcat cctactggct ctgaccatcc ccagcatctt ttaccagggc
     1921 ttctagagga ttctgggaaa ctgttagcac attcccttag agcagctctt gcccagcaga
     1981 atcacctgga aactgttgct caaggataga aatcagcaga aacttagttc tgggccaggc
     2041 actttgcatg gtaccgagct ttccagagtt tccctaagca tgccacatca tacatgtgat
     2101 ccctaagcat atagtgatag atttttgtta gtggtttttt ttttgttgtt tttttttgtt
     2161 tttttttttt tttgttttgt tttttgcagg caaatggctc ataagtgaat tggtgggcaa
     2221 gtgttagtcc agagaatgaa gaaggattag tttcatacct cagagctctt cctctccgag
     2281 atcagcccta aagtatcttg acttcaaatc catcgactct ggtatttcca gaagtagggg
     2341 tgcaagaggt tggaatcaaa gcaataaaag tcttggtgag cacaccaaca gtatgaaggc
     2401 ctaattggca aaggtttgga atctaggata gttcttcctc atcctgccca ttatgaaggc
     2461 atctgctact tttctaacta attgtacctg tgagtcagac agacaccagc tcacatgcaa
     2521 agcaaaccca gtggtatagg tgcagatcaa tggtgaagtg cttcttagca tgggacgagc
     2581 cctagattcc atccctccag caccacaaaa aagcaaaacc aaaagagcta ttaaagttca
     2641 cctcaattta agtacccaat aaagaagtca cacacatatg gggatactga cctgtggtga
     2701 gagctaaatt gagggctggg actatagctc aatggaagaa cactagcttt ccatggtcca
     2761 gtttgtagtg ctgcaagaaa taagtcagta aataaagaca aaaactaaca aacaaaatta
     2821 agttattaca tggcatgtag tcattggcta gcatgctgat tgggggaatc cctaaggtgg
     2881 acatttcagt gggctaggct tagtagggtg ttttccaaca gtgataatgt ctgctttgaa
     2941 gaaccaatag cattaaggaa agcaaaacat tgtttatgtt gagctatgga aaagagacac
     3001 tgtctataaa attctctaaa attaaaaacc tgctacatcc
//
