LOCUS       NM_008003               1809 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus fibroblast growth factor 15 (Fgf15), mRNA.
ACCESSION   NM_008003
VERSION     NM_008003.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1809)
  AUTHORS   Stebbins,K., Somaiya,R.D., Sabbagh,U., Khaksar,P., Liang,Y., Su,J.
            and Fox,M.A.
  TITLE     Retinal Input Is Required for the Maintenance of Neuronal Laminae
            in the Ventrolateral Geniculate Nucleus
  JOURNAL   eNeuro 11 (9) (2024)
   PUBMED   39160068
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1809)
  AUTHORS   Chow,M.D., Otersen,K., Wassef,A., Kong,B., Yamarthy,S., Rizzolo,D.,
            Yang,I., Buckley,B., Lu,A., Crook,N., Lee,M., Gao,J., Naganand,S.,
            Stofan,M.F., Armstrong,L., Schumacher,J., Taylor,R., Henry,Z.,
            Basaly,V., Yang,Z., Zhang,M., Huang,M., Kagan,L., Brunetti,L.,
            Sadek,R., Lee,Y.H. and Guo,G.L.
  TITLE     Effects of intestine-specific deletion of FGF15 on the development
            of fatty liver disease with vertical sleeve gastrectomy
  JOURNAL   Hepatol Commun 8 (6), e0444 (2024)
   PUBMED   38780301
  REMARK    GeneRIF: Effects of intestine-specific deletion of FGF15 on the
            development of fatty liver disease with vertical sleeve
            gastrectomy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1809)
  AUTHORS   Bozadjieva-Kramer,N., Shin,J.H., Li,Z., Rupp,A.C., Miller,N.,
            Kernodle,S., Lanthier,N., Henry,P., Seshadri,N., Myronovych,A.,
            MacDougald,O.A., O'Rourke,R.W., Kohli,R., Burant,C.F.,
            Rothberg,A.E. and Seeley,R.J.
  TITLE     Intestinal FGF15 regulates bile acid and cholesterol metabolism but
            not glucose and energy balance
  JOURNAL   JCI Insight 9 (7), e174164 (2024)
   PUBMED   38587078
  REMARK    GeneRIF: Intestinal FGF15 regulates bile acid and cholesterol
            metabolism but not glucose and energy balance.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1809)
  AUTHORS   Sun,M., Gao,Y., Li,Z., Yang,L., Liu,G., Xu,Z., Guo,R., You,Y. and
            Yang,Z.
  TITLE     ERK signaling expands mammalian cortical radial glial cells and
            extends the neurogenic period
  JOURNAL   Proc Natl Acad Sci U S A 121 (13), e2314802121 (2024)
   PUBMED   38498715
REFERENCE   5  (bases 1 to 1809)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 1809)
  AUTHORS   Zakin,L., Reversade,B., Virlon,B., Rusniok,C., Glaser,P.,
            Elalouf,J.M. and Brulet,P.
  TITLE     Gene expression profiles in normal and Otx2-/- early gastrulating
            mouse embryos
  JOURNAL   Proc Natl Acad Sci U S A 97 (26), 14388-14393 (2000)
   PUBMED   11114168
REFERENCE   7  (bases 1 to 1809)
  AUTHORS   Goldman,D.C., Martin,G.R. and Tam,P.P.
  TITLE     Fate and function of the ventral ectodermal ridge during mouse tail
            development
  JOURNAL   Development 127 (10), 2113-2123 (2000)
   PUBMED   10769235
REFERENCE   8  (bases 1 to 1809)
  AUTHORS   Xu,X., Li,C., Takahashi,K., Slavkin,H.C., Shum,L. and Deng,C.X.
  TITLE     Murine fibroblast growth factor receptor 1alpha isoforms mediate
            node regression and are essential for posterior mesoderm
            development
  JOURNAL   Dev Biol 208 (2), 293-306 (1999)
   PUBMED   10191046
REFERENCE   9  (bases 1 to 1809)
  AUTHORS   McWhirter,J.R., Goulding,M., Weiner,J.A., Chun,J. and Murre,C.
  TITLE     A novel fibroblast growth factor gene expressed in the developing
            nervous system is a downstream target of the chimeric homeodomain
            oncoprotein E2A-Pbx1
  JOURNAL   Development 124 (17), 3221-3232 (1997)
   PUBMED   9310317
REFERENCE   10 (bases 1 to 1809)
  AUTHORS   DeChiara,T.M. and Brosius,J.
  TITLE     Neural BC1 RNA: cDNA clones reveal nonrepetitive sequence content
  JOURNAL   Proc Natl Acad Sci U S A 84 (9), 2624-2628 (1987)
   PUBMED   2437583
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1987 Jul;84(14):4895]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161763.3.
            
            On Nov 17, 2006 this sequence version replaced NM_008003.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF007268.1, AK017829.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-400               AC161763.3         117179-117578       c
            401-504             AC161763.3         116891-116994       c
            505-1809            AC161763.3         113157-114461       c
FEATURES             Location/Qualifiers
     source          1..1809
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.92 cM"
     gene            1..1809
                     /gene="Fgf15"
                     /gene_synonym="FGF19; Fgf8a"
                     /note="fibroblast growth factor 15"
                     /db_xref="GeneID:14170"
                     /db_xref="MGI:MGI:1096383"
     exon            1..400
                     /gene="Fgf15"
                     /gene_synonym="FGF19; Fgf8a"
                     /inference="alignment:Splign:2.1.0"
     exon            401..504
                     /gene="Fgf15"
                     /gene_synonym="FGF19; Fgf8a"
                     /inference="alignment:Splign:2.1.0"
     exon            505..1809
                     /gene="Fgf15"
                     /gene_synonym="FGF19; Fgf8a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1782..1787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf15"
                     /gene_synonym="FGF19; Fgf8a"
                     /note="hexamer: ATTAAA"
     polyA_site      1809
                     /gene="Fgf15"
                     /gene_synonym="FGF19; Fgf8a"
                     /note="major polyA site"
ORIGIN      
        1 ctgtcggagc agtaactctg tgcgccccac gccacaagcg cccagttgct ttgtgggttg
       61 tgcctgccct gcgcctgcaa cttgagtccc cgccgcatcg cagtctccgc gccacctttg
      121 taacggcctt caggaccccg aggtgtcatg gcgagaaagt ggaacgggcg tgcggtggcc
      181 cgagccctgg tcctggccac tctgtggctg gctgtgtctg ggcgtcccct ggctcagcaa
      241 tcccagtctg tgtcagatga agatccactc tttctctacg gctggggcaa gattacccgc
      301 ctgcagtacc tgtactccgc tggtccctat gtctccaact gcttcctccg aatccggagc
      361 gacggctctg tggactgcga ggaggaccaa aacgaacgaa atttgttgga attccgcgcg
      421 gtcgctctga agacgattgc catcaaggac gtcagcagcg tgcggtacct ctgcatgagc
      481 gcggacggca agatatacgg gctgattcgc tactcggagg aagactgtac cttcagggag
      541 gaaatggact gtttaggcta caaccagtac agatccatga agcaccatct ccatatcatc
      601 ttcatccagg ccaagcccag agaacagctc caggaccaga aaccctcaaa ctttatcccc
      661 gtgtttcacc gctccttctt tgaaaccggg gaccagctga ggtctaaaat gttctccctg
      721 cccctggaga gtgacagcat ggatccgttc aggatggtgg aggatgtaga ccacctagtg
      781 aagagtccca gcttccagaa atgacaggat tccgacagga tggagaaaac cccaaggtcc
      841 cgtgaacttc ccccttagga agctgtacat attctaagtc tcacatggac cctgttgtgt
      901 tagtggctag acttgatcat gaacttaagt tgacaacctg cctggctgcc atcggagccc
      961 cactgacttt ggaggctgct gatatgtgcc taagttactc cagttctgtt tgaatacctc
     1021 cactaatagg gaacttactc ctgtgaaaca ttcttagttt tgagccaaat ctgtgacttg
     1081 gatggtttta gcgaggaagc cagaaggtat gaagtcaaat gataaaattc atgtatagaa
     1141 agtgggctct aaaatatata ttccctatat ggatctcatg ggatcttagc ttgcccccca
     1201 aatgtctcct ggccagaact aactggggtt acaaacttgg aacaaaggac agcctagaaa
     1261 actttgggag ccttgaagga tggtcttagg attacgaatt ccagctgact acgtagcttc
     1321 ccccttttcc acttataaat gtcagatgga agtgaccctt agctgagtgc atagccaagc
     1381 tgccacttag gccccaggag cttgtctctg tcccatgacc ccagatttcc aggacctgga
     1441 tcttctcctc tgacctttcc cagagttcac ctgggctctc caaccccaga gcaggtagct
     1501 tatgagccat ccagttgtgt ccccagctcc tggctctcag ttctggtcac caaacattgt
     1561 gaatcaacgt gtctgctgcc tgtgtcaacc tggacccctc atttacaaac aagattagga
     1621 agccccaaat tctccagtgg cagctgggga actgtggagt cctttccccg gcacttacgt
     1681 ggcagcatga tatttataag taatttattg tgtgtgtgtc ttctattttc ttactttatt
     1741 tatgccccag atcatattta tgtacatgac ttgttttcta cattaaaaag gagttggttt
     1801 gtatcaaaa
//
