LOCUS       NM_010200               2509 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus fibroblast growth factor 13 (Fgf13), transcript
            variant 1, mRNA.
ACCESSION   NM_010200 XM_904996 XM_919116 XM_919127 XM_919138 XM_919147
            XM_919159
VERSION     NM_010200.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2509)
  AUTHORS   Zhao,R., Yan,Y., Dong,Y., Wang,X., Li,X., Qiao,R., Zhang,H.,
            Cui,N., Han,Y., Wang,C., Han,J., Ma,Q., Liu,D., Yang,J., Gu,G. and
            Wang,C.
  TITLE     FGF13 deficiency ameliorates calcium signaling abnormality in heart
            failure by regulating microtubule stability
  JOURNAL   Biochem Pharmacol 225, 116329 (2024)
   PUBMED   38821375
  REMARK    GeneRIF: FGF13 deficiency ameliorates calcium signaling abnormality
            in heart failure by regulating microtubule stability.
REFERENCE   2  (bases 1 to 2509)
  AUTHORS   Dong,Z.S., Zhang,X.R., Xue,D.Z., Liu,J.H., Yi,F., Zhang,Y.Y.,
            Xian,F.Y., Qiao,R.Y., Liu,B.Y., Zhang,H.L. and Wang,C.
  TITLE     FGF13 enhances the function of TRPV1 by stabilizing microtubules
            and regulates acute and chronic itch
  JOURNAL   FASEB J 38 (10), e23661 (2024)
   PUBMED   38733310
  REMARK    GeneRIF: FGF13 enhances the function of TRPV1 by stabilizing
            microtubules and regulates acute and chronic itch.
REFERENCE   3  (bases 1 to 2509)
  AUTHORS   Marra,C., Hartke,T.V., Ringkamp,M. and Goldfarb,M.
  TITLE     Enhanced sodium channel inactivation by temperature and FHF2
            deficiency blocks heat nociception
  JOURNAL   Pain 164 (6), 1321-1331 (2023)
   PUBMED   36607284
  REMARK    GeneRIF: Enhanced sodium channel inactivation by temperature and
            FHF2 deficiency blocks heat nociception.
REFERENCE   4  (bases 1 to 2509)
  AUTHORS   Shen,K.F., Yue,J., Wu,Z.F., Wu,K.F., Zhu,G., Yang,X.L., Wang,Z.K.,
            Wang,J., Liu,S.Y., Yang,H. and Zhang,C.Q.
  TITLE     Fibroblast growth factor 13 is involved in the pathogenesis of
            temporal lobe epilepsy
  JOURNAL   Cereb Cortex 32 (23), 5259-5272 (2022)
   PUBMED   35195262
  REMARK    GeneRIF: Fibroblast growth factor 13 is involved in the
            pathogenesis of temporal lobe epilepsy.
REFERENCE   5  (bases 1 to 2509)
  AUTHORS   Meuser,M., Deuper,L., Rudat,C., Aydogdu,N., Thiesler,H.,
            Zarnovican,P., Hildebrandt,H., Trowe,M.O. and Kispert,A.
  TITLE     FGFR2 signaling enhances the SHH-BMP4 signaling axis in early
            ureter development
  JOURNAL   Development 149 (1) (2022)
   PUBMED   35020897
REFERENCE   6  (bases 1 to 2509)
  AUTHORS   Hajihosseini,M.K. and Heath,J.K.
  TITLE     Expression patterns of fibroblast growth factors-18 and -20 in
            mouse embryos is suggestive of novel roles in calvarial and limb
            development
  JOURNAL   Mech Dev 113 (1), 79-83 (2002)
   PUBMED   11900978
REFERENCE   7  (bases 1 to 2509)
  AUTHORS   Bachler,M. and Neubuser,A.
  TITLE     Expression of members of the Fgf family and their receptors during
            midfacial development
  JOURNAL   Mech Dev 100 (2), 313-316 (2001)
   PUBMED   11165488
REFERENCE   8  (bases 1 to 2509)
  AUTHORS   Munoz-Sanjuan,I., Smallwood,P.M. and Nathans,J.
  TITLE     Isoform diversity among fibroblast growth factor homologous factors
            is generated by alternative promoter usage and differential
            splicing
  JOURNAL   J Biol Chem 275 (4), 2589-2597 (2000)
   PUBMED   10644718
REFERENCE   9  (bases 1 to 2509)
  AUTHORS   Hartung,H., Feldman,B., Lovec,H., Coulier,F., Birnbaum,D. and
            Goldfarb,M.
  TITLE     Murine FGF-12 and FGF-13: expression in embryonic nervous system,
            connective tissue and heart
  JOURNAL   Mech Dev 64 (1-2), 31-39 (1997)
   PUBMED   9232594
REFERENCE   10 (bases 1 to 2509)
  AUTHORS   Smallwood,P.M., Munoz-Sanjuan,I., Tong,P., Macke,J.P., Hendry,S.H.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Fibroblast growth factor (FGF) homologous factors: new members of
            the FGF family implicated in nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9850-9857 (1996)
   PUBMED   8790420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC018238.1 and CD776909.1.
            
            On Mar 12, 2014 this sequence version replaced NM_010200.2.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018238.1, SRR1660821.143972.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2494              BC018238.1         1-2494
            2495-2509           CD776909.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..2509
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 33.31 cM"
     gene            1..2509
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /note="fibroblast growth factor 13"
                     /db_xref="GeneID:14168"
                     /db_xref="MGI:MGI:109178"
     exon            1..560
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..1111
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     fibroblast growth factor homologous factor 2; fibroblast
                     growth factor 1c"
                     /codon_start=1
                     /product="fibroblast growth factor 13 isoform 1"
                     /protein_id="NP_034330.2"
                     /db_xref="CCDS:CCDS30157.1"
                     /db_xref="GeneID:14168"
                     /db_xref="MGI:MGI:109178"
                     /translation="MAAAIASSLIRQKRQAREREKSNACKCVSSPSKGKTSCDKNKLN
                     VFSRVKLFGSKKRRRRRPEPQLKGIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLF
                     NLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSEHFTPECKFKESVFENYYVTYSSMIY
                     RQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDLTEFSRS
                     GSGTPTKSRSVSGVLNGGKSMSHNEST"
     exon            561..671
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..775
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..974
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     exon            975..2499
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2470..2475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /note="hexamer: AATAAA"
     polyA_site      2499
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /note="major polyA site"
ORIGIN      
        1 cgaaactccg acccgagccg cttggacttg caccgtgtcc tcggggctca ggggccgagc
       61 gcacgcagtc acaagcgcag ctctctgcct gcctcctgct agtctcgcct gccatcccgg
      121 cccggggctg tggcgtcggt tcggaccaag gctaccagaa cccgcgcggg agcccgagca
      181 ccttcggagg agctcagaag gcatgctgag ccccctccgc gactgaagcc ggagtgccca
      241 gaagccccgg ccaagcaagc gcaggctaag gagacccagg cggccaaggc gcgagcagcg
      301 cagcagcgga ggagcgagag gaggcgaagg cagaggggcc cccgaagaag tggtggtggt
      361 gggcgtcgtg gccatggcgg cggctatcgc cagctcgctc atccggcaaa agagacaagc
      421 ccgcgagcgc gagaaatcca atgcctgcaa gtgtgtcagc agccccagca aaggcaagac
      481 cagctgcgac aaaaacaagt taaacgtctt ttcccgggtc aaactctttg gctccaagaa
      541 gaggcgcaga aggagaccag agcctcagct taagggtata gttaccaaac tatacagccg
      601 acaaggctac cacttgcaac tgcaggcaga tggaaccatt gatggcacca aagacgagga
      661 cagcacttac actctgttta acctcatccc tgtgggtctt cgggtggtgg ctattcaagg
      721 agttcaaacc aagctgtatt tggcaatgaa cagcgaggga tacttgtaca cctcggaaca
      781 tttcacacct gagtgcaaat tcaaagaatc agtgtttgaa aattattacg tgacatactc
      841 atcaatgatc taccgtcagc agcaatccgg ccgagggtgg tatctaggtc tgaacaaaga
      901 aggagagatc atgaaaggca accatgtgaa gaagaacaag cctgcagcac attttctgcc
      961 caaaccactg aaagtggcca tgtacaagga gccatctctg cacgatctca cggagttctc
     1021 ccgatctgga agtgggaccc cgaccaagag cagaagcgtc tctggtgtac tgaatggagg
     1081 caaatccatg agccacaacg aatcaacgta gccagtgagg gcaaaacgag ggctctataa
     1141 cagaacctta ccttcaggtg ctgttgaatt cttctagcag tccttcatcc aaaagttcaa
     1201 acttatcagt gaggtttacc aaacacacag gcagacttcc ctattctctc tgccgttata
     1261 ccttgttatc acccatatta aagccccata atttattctg agcttgtgca aaagagtgcc
     1321 aagcattatc aatgaactaa acctggaaga aggactgcca aattttctca tgatctcacc
     1381 tgtactttgg ggataaataa aacagcaaaa atatttaaca gcacaaatgc tggtcaattt
     1441 gcttcccaat taagaaaaat taaaagacca cagctattct taacaaagca aaacaacaaa
     1501 acaaagttaa ctgcttaaat gttttgtagg ggcaaacaaa ttctgtgaac tgtgctgttt
     1561 tcttggcttc gtgttttcta tctctgcttg attcaaatgt actctttact ttcatatagt
     1621 gcaactttat gatttttgaa aattaatggt tctattgact ctgtcactta atccatatta
     1681 accaaaggca gggttgaatc tgaattggca tctgaggttc aaggtaaccg tgttcttatg
     1741 ggttttcctc tctcgcaccc tctcctttcc accctccctc tttctctctc tctctctctc
     1801 tttctctctc tctctctctc tttctctctc tctctctctc tctctctctc tctctctctc
     1861 tctctctctc tctctctcct tttttgttgt caattagaac tgtagcattc tggtcaagtt
     1921 cttgtgctgt actttgtgcg tagaaattga gttgtatcgt caatcccagt cagtaagata
     1981 agttgaaaca agattatcct caagtgtaga tttctcttaa ttccattcgt gtatcatgtt
     2041 aatctattgt ggcttcttgt gtaaagacag gaactgtgga acagtggcat tgtctttcgt
     2101 gttgttcaaa taagaagtgt ctcacctgta catgtacaag tcctcctgtc attggatttg
     2161 gcacgtgaac attgtgaaca aggcaatgtt aagaatggtt ccccctaaac aacatatatt
     2221 atacctgcta ctggaaaagt gtttaagact tagctaggtt tccatttaga tcttcatatc
     2281 tgttgcatgg aagaaagttg gaatcttggc atagagttgc atgatatgta agattttgtg
     2341 cattaataat tgttaaaacc tgtgttccaa aagtggacat agcatgtaca ggcagttttc
     2401 tgccctgtgc acaaaaagtt aaaaaaaaag ttgtttaata tttgttgttg tatacccaaa
     2461 tacgcaccga ataaactctt tatattcatt caaagaaaaa aaaaaaaaa
//
