LOCUS       NM_001411973            2412 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus fibroblast growth factor 13 (Fgf13), transcript
            variant 7, mRNA.
ACCESSION   NM_001411973 XM_006527796
VERSION     NM_001411973.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2412)
  AUTHORS   Zhao,R., Yan,Y., Dong,Y., Wang,X., Li,X., Qiao,R., Zhang,H.,
            Cui,N., Han,Y., Wang,C., Han,J., Ma,Q., Liu,D., Yang,J., Gu,G. and
            Wang,C.
  TITLE     FGF13 deficiency ameliorates calcium signaling abnormality in heart
            failure by regulating microtubule stability
  JOURNAL   Biochem Pharmacol 225, 116329 (2024)
   PUBMED   38821375
  REMARK    GeneRIF: FGF13 deficiency ameliorates calcium signaling abnormality
            in heart failure by regulating microtubule stability.
REFERENCE   2  (bases 1 to 2412)
  AUTHORS   Dong,Z.S., Zhang,X.R., Xue,D.Z., Liu,J.H., Yi,F., Zhang,Y.Y.,
            Xian,F.Y., Qiao,R.Y., Liu,B.Y., Zhang,H.L. and Wang,C.
  TITLE     FGF13 enhances the function of TRPV1 by stabilizing microtubules
            and regulates acute and chronic itch
  JOURNAL   FASEB J 38 (10), e23661 (2024)
   PUBMED   38733310
  REMARK    GeneRIF: FGF13 enhances the function of TRPV1 by stabilizing
            microtubules and regulates acute and chronic itch.
REFERENCE   3  (bases 1 to 2412)
  AUTHORS   Marra,C., Hartke,T.V., Ringkamp,M. and Goldfarb,M.
  TITLE     Enhanced sodium channel inactivation by temperature and FHF2
            deficiency blocks heat nociception
  JOURNAL   Pain 164 (6), 1321-1331 (2023)
   PUBMED   36607284
  REMARK    GeneRIF: Enhanced sodium channel inactivation by temperature and
            FHF2 deficiency blocks heat nociception.
REFERENCE   4  (bases 1 to 2412)
  AUTHORS   Shen,K.F., Yue,J., Wu,Z.F., Wu,K.F., Zhu,G., Yang,X.L., Wang,Z.K.,
            Wang,J., Liu,S.Y., Yang,H. and Zhang,C.Q.
  TITLE     Fibroblast growth factor 13 is involved in the pathogenesis of
            temporal lobe epilepsy
  JOURNAL   Cereb Cortex 32 (23), 5259-5272 (2022)
   PUBMED   35195262
  REMARK    GeneRIF: Fibroblast growth factor 13 is involved in the
            pathogenesis of temporal lobe epilepsy.
REFERENCE   5  (bases 1 to 2412)
  AUTHORS   Meuser,M., Deuper,L., Rudat,C., Aydogdu,N., Thiesler,H.,
            Zarnovican,P., Hildebrandt,H., Trowe,M.O. and Kispert,A.
  TITLE     FGFR2 signaling enhances the SHH-BMP4 signaling axis in early
            ureter development
  JOURNAL   Development 149 (1) (2022)
   PUBMED   35020897
REFERENCE   6  (bases 1 to 2412)
  AUTHORS   Hajihosseini,M.K. and Heath,J.K.
  TITLE     Expression patterns of fibroblast growth factors-18 and -20 in
            mouse embryos is suggestive of novel roles in calvarial and limb
            development
  JOURNAL   Mech Dev 113 (1), 79-83 (2002)
   PUBMED   11900978
REFERENCE   7  (bases 1 to 2412)
  AUTHORS   Bachler,M. and Neubuser,A.
  TITLE     Expression of members of the Fgf family and their receptors during
            midfacial development
  JOURNAL   Mech Dev 100 (2), 313-316 (2001)
   PUBMED   11165488
REFERENCE   8  (bases 1 to 2412)
  AUTHORS   Munoz-Sanjuan,I., Smallwood,P.M. and Nathans,J.
  TITLE     Isoform diversity among fibroblast growth factor homologous factors
            is generated by alternative promoter usage and differential
            splicing
  JOURNAL   J Biol Chem 275 (4), 2589-2597 (2000)
   PUBMED   10644718
REFERENCE   9  (bases 1 to 2412)
  AUTHORS   Hartung,H., Feldman,B., Lovec,H., Coulier,F., Birnbaum,D. and
            Goldfarb,M.
  TITLE     Murine FGF-12 and FGF-13: expression in embryonic nervous system,
            connective tissue and heart
  JOURNAL   Mech Dev 64 (1-2), 31-39 (1997)
   PUBMED   9232594
REFERENCE   10 (bases 1 to 2412)
  AUTHORS   Smallwood,P.M., Munoz-Sanjuan,I., Tong,P., Macke,J.P., Hendry,S.H.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Fibroblast growth factor (FGF) homologous factors: new members of
            the FGF family implicated in nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9850-9857 (1996)
   PUBMED   8790420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669891.12, AL672247.8 and AL713968.9.
            
            On Sep 13, 2022 this sequence version replaced XM_006527796.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3292158.1,
                                           SRR17784646.1138926.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AL669891.12        214568-214663       c
            97-305              AL669891.12        213944-214152       c
            306-473             AL672247.8         119843-120010       c
            474-584             AL713968.9         99124-99234         c
            585-688             AL713968.9         93178-93281         c
            689-887             AL713968.9         34685-34883         c
            888-2412            AL713968.9         29429-30953         c
FEATURES             Location/Qualifiers
     source          1..2412
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 33.31 cM"
     gene            1..2412
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /note="fibroblast growth factor 13"
                     /db_xref="GeneID:14168"
                     /db_xref="MGI:MGI:109178"
     exon            1..96
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     exon            97..305
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..1024
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /note="isoform 2 is encoded by transcript variant 7;
                     fibroblast growth factor homologous factor 2; fibroblast
                     growth factor 1c"
                     /codon_start=1
                     /product="fibroblast growth factor 13 isoform 2"
                     /protein_id="NP_001398902.1"
                     /db_xref="GeneID:14168"
                     /db_xref="MGI:MGI:109178"
                     /translation="MSGKVTKPKEEKDASKVLDDAPPGTQEYIMLRQDSIQSAELKKK
                     ESPFRAKCHEIFCCPLKQVHHKENTEPEEPQLKGIVTKLYSRQGYHLQLQADGTIDGT
                     KDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSEHFTPECKFKESVFEN
                     YYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPS
                     LHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST"
     exon            306..473
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     exon            474..584
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     exon            585..688
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     exon            689..887
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     exon            888..2412
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2383..2388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /note="hexamer: AATAAA"
     polyA_site      2412
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /note="major polyA site"
ORIGIN      
        1 gggcgagaag ctgcgcggct ctgcggtgta acaggctcac acgttgctca tcacatgttc
       61 aaacatttcc ctttcgggga ggctcgttat ttttaagcgg cgacagcagc ggcagcgggg
      121 gaaaaagcgg attccgcccg gagccacact gagagctcgc ggtcgcgact tgccgcccta
      181 agcgctctcg caagtccagc cagctcggcg aggacttcct tctcctggac gaatcttgtc
      241 aagcaagctg ggatctatga gtggaaaggt gaccaagccc aaagaggaga aagatgcttc
      301 taaggttctg gatgacgccc cccctggcac acaggaatac attatgttac gacaagattc
      361 catccaatct gcggaattaa agaaaaaaga gtcccccttt cgtgctaagt gtcacgaaat
      421 cttctgctgc ccgctgaagc aagtgcacca caaagaaaac acagaacccg aagagcctca
      481 gcttaagggt atagttacca aactatacag ccgacaaggc taccacttgc aactgcaggc
      541 agatggaacc attgatggca ccaaagacga ggacagcact tacactctgt ttaacctcat
      601 ccctgtgggt cttcgggtgg tggctattca aggagttcaa accaagctgt atttggcaat
      661 gaacagcgag ggatacttgt acacctcgga acatttcaca cctgagtgca aattcaaaga
      721 atcagtgttt gaaaattatt acgtgacata ctcatcaatg atctaccgtc agcagcaatc
      781 cggccgaggg tggtatctag gtctgaacaa agaaggagag atcatgaaag gcaaccatgt
      841 gaagaagaac aagcctgcag cacattttct gcccaaacca ctgaaagtgg ccatgtacaa
      901 ggagccatct ctgcacgatc tcacggagtt ctcccgatct ggaagtggga ccccgaccaa
      961 gagcagaagc gtctctggtg tactgaatgg aggcaaatcc atgagccaca acgaatcaac
     1021 gtagccagtg agggcaaaac gagggctcta taacagaacc ttaccttcag gtgctgttga
     1081 attcttctag cagtccttca tccaaaagtt caaacttatc agtgaggttt accaaacaca
     1141 caggcagact tccctattct ctctgccgtt ataccttgtt atcacccata ttaaagcccc
     1201 ataatttatt ctgagcttgt gcaaaagagt gccaagcatt atcaatgaac taaacctgga
     1261 agaaggactg ccaaattttc tcatgatctc acctgtactt tggggataaa taaaacagca
     1321 aaaatattta acagcacaaa tgctggtcaa tttgcttccc aattaagaaa aattaaaaga
     1381 ccacagctat tcttaacaaa gcaaaacaac aaaacaaagt taactgctta aatgttttgt
     1441 aggggcaaac aaattctgtg aactgtgctg ttttcttggc ttcgtgtttt ctatctctgc
     1501 ttgattcaaa tgtactcttt actttcatat agtgcaactt tatgattttt gaaaattaat
     1561 ggttctattg actctgtcac ttaatccata ttaaccaaag gcagggttga atctgaattg
     1621 gcatctgagg ttcaaggtaa ccgtgttctt atgggttttc ctctctcgca ccctctcctt
     1681 tccaccctcc ctctttctct ctctctctct ctctttctct ctctctctct ctctttctct
     1741 ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct ccttttttgt
     1801 tgtcaattag aactgtagca ttctggtcaa gttcttgtgc tgtactttgt gcgtagaaat
     1861 tgagttgtat cgtcaatccc agtcagtaag ataagttgaa acaagattat cctcaagtgt
     1921 agatttctct taattccatt cgtgtatcat gttaatctat tgtggcttct tgtgtaaaga
     1981 caggaactgt ggaacagtgg cattgtcttt cgtgttgttc aaataagaag tgtctcacct
     2041 gtacatgtac aagtcctcct gtcattggat ttggcacgtg aacattgtga acaaggcaat
     2101 gttaagaatg gttcccccta aacaacatat attatacctg ctactggaaa agtgtttaag
     2161 acttagctag gtttccattt agatcttcat atctgttgca tggaagaaag ttggaatctt
     2221 ggcatagagt tgcatgatat gtaagatttt gtgcattaat aattgttaaa acctgtgttc
     2281 caaaagtgga catagcatgt acaggcagtt ttctgccctg tgcacaaaaa gttaaaaaaa
     2341 aagttgttta atatttgttg ttgtataccc aaatacgcac cgaataaact ctttatattc
     2401 attcaaagaa aa
//
