LOCUS       NM_001411971            2440 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus fibroblast growth factor 13 (Fgf13), transcript
            variant 5, mRNA.
ACCESSION   NM_001411971 XM_006527795
VERSION     NM_001411971.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2440)
  AUTHORS   Zhao,R., Yan,Y., Dong,Y., Wang,X., Li,X., Qiao,R., Zhang,H.,
            Cui,N., Han,Y., Wang,C., Han,J., Ma,Q., Liu,D., Yang,J., Gu,G. and
            Wang,C.
  TITLE     FGF13 deficiency ameliorates calcium signaling abnormality in heart
            failure by regulating microtubule stability
  JOURNAL   Biochem Pharmacol 225, 116329 (2024)
   PUBMED   38821375
  REMARK    GeneRIF: FGF13 deficiency ameliorates calcium signaling abnormality
            in heart failure by regulating microtubule stability.
REFERENCE   2  (bases 1 to 2440)
  AUTHORS   Dong,Z.S., Zhang,X.R., Xue,D.Z., Liu,J.H., Yi,F., Zhang,Y.Y.,
            Xian,F.Y., Qiao,R.Y., Liu,B.Y., Zhang,H.L. and Wang,C.
  TITLE     FGF13 enhances the function of TRPV1 by stabilizing microtubules
            and regulates acute and chronic itch
  JOURNAL   FASEB J 38 (10), e23661 (2024)
   PUBMED   38733310
  REMARK    GeneRIF: FGF13 enhances the function of TRPV1 by stabilizing
            microtubules and regulates acute and chronic itch.
REFERENCE   3  (bases 1 to 2440)
  AUTHORS   Marra,C., Hartke,T.V., Ringkamp,M. and Goldfarb,M.
  TITLE     Enhanced sodium channel inactivation by temperature and FHF2
            deficiency blocks heat nociception
  JOURNAL   Pain 164 (6), 1321-1331 (2023)
   PUBMED   36607284
  REMARK    GeneRIF: Enhanced sodium channel inactivation by temperature and
            FHF2 deficiency blocks heat nociception.
REFERENCE   4  (bases 1 to 2440)
  AUTHORS   Shen,K.F., Yue,J., Wu,Z.F., Wu,K.F., Zhu,G., Yang,X.L., Wang,Z.K.,
            Wang,J., Liu,S.Y., Yang,H. and Zhang,C.Q.
  TITLE     Fibroblast growth factor 13 is involved in the pathogenesis of
            temporal lobe epilepsy
  JOURNAL   Cereb Cortex 32 (23), 5259-5272 (2022)
   PUBMED   35195262
  REMARK    GeneRIF: Fibroblast growth factor 13 is involved in the
            pathogenesis of temporal lobe epilepsy.
REFERENCE   5  (bases 1 to 2440)
  AUTHORS   Meuser,M., Deuper,L., Rudat,C., Aydogdu,N., Thiesler,H.,
            Zarnovican,P., Hildebrandt,H., Trowe,M.O. and Kispert,A.
  TITLE     FGFR2 signaling enhances the SHH-BMP4 signaling axis in early
            ureter development
  JOURNAL   Development 149 (1) (2022)
   PUBMED   35020897
REFERENCE   6  (bases 1 to 2440)
  AUTHORS   Hajihosseini,M.K. and Heath,J.K.
  TITLE     Expression patterns of fibroblast growth factors-18 and -20 in
            mouse embryos is suggestive of novel roles in calvarial and limb
            development
  JOURNAL   Mech Dev 113 (1), 79-83 (2002)
   PUBMED   11900978
REFERENCE   7  (bases 1 to 2440)
  AUTHORS   Bachler,M. and Neubuser,A.
  TITLE     Expression of members of the Fgf family and their receptors during
            midfacial development
  JOURNAL   Mech Dev 100 (2), 313-316 (2001)
   PUBMED   11165488
REFERENCE   8  (bases 1 to 2440)
  AUTHORS   Munoz-Sanjuan,I., Smallwood,P.M. and Nathans,J.
  TITLE     Isoform diversity among fibroblast growth factor homologous factors
            is generated by alternative promoter usage and differential
            splicing
  JOURNAL   J Biol Chem 275 (4), 2589-2597 (2000)
   PUBMED   10644718
REFERENCE   9  (bases 1 to 2440)
  AUTHORS   Hartung,H., Feldman,B., Lovec,H., Coulier,F., Birnbaum,D. and
            Goldfarb,M.
  TITLE     Murine FGF-12 and FGF-13: expression in embryonic nervous system,
            connective tissue and heart
  JOURNAL   Mech Dev 64 (1-2), 31-39 (1997)
   PUBMED   9232594
REFERENCE   10 (bases 1 to 2440)
  AUTHORS   Smallwood,P.M., Munoz-Sanjuan,I., Tong,P., Macke,J.P., Hendry,S.H.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Fibroblast growth factor (FGF) homologous factors: new members of
            the FGF family implicated in nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9850-9857 (1996)
   PUBMED   8790420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669891.12, AL672247.8 and AL713968.9.
            
            On Sep 13, 2022 this sequence version replaced XM_006527795.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.1260218.1,
                                           SRR7345562.718445.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AL669891.12        214300-214423       c
            125-333             AL669891.12        213944-214152       c
            334-501             AL672247.8         119843-120010       c
            502-612             AL713968.9         99124-99234         c
            613-716             AL713968.9         93178-93281         c
            717-915             AL713968.9         34685-34883         c
            916-2440            AL713968.9         29429-30953         c
FEATURES             Location/Qualifiers
     source          1..2440
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 33.31 cM"
     gene            1..2440
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /note="fibroblast growth factor 13"
                     /db_xref="GeneID:14168"
                     /db_xref="MGI:MGI:109178"
     exon            1..124
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     exon            125..333
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..1052
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /note="isoform 2 is encoded by transcript variant 5;
                     fibroblast growth factor homologous factor 2; fibroblast
                     growth factor 1c"
                     /codon_start=1
                     /product="fibroblast growth factor 13 isoform 2"
                     /protein_id="NP_001398900.1"
                     /db_xref="GeneID:14168"
                     /db_xref="MGI:MGI:109178"
                     /translation="MSGKVTKPKEEKDASKVLDDAPPGTQEYIMLRQDSIQSAELKKK
                     ESPFRAKCHEIFCCPLKQVHHKENTEPEEPQLKGIVTKLYSRQGYHLQLQADGTIDGT
                     KDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSEHFTPECKFKESVFEN
                     YYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPS
                     LHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST"
     exon            334..501
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     exon            502..612
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     exon            613..716
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     exon            717..915
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     exon            916..2440
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2411..2416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /note="hexamer: AATAAA"
     polyA_site      2440
                     /gene="Fgf13"
                     /gene_synonym="Fgf1c; Fhf2"
                     /note="major polyA site"
ORIGIN      
        1 gtggtcggcg cccgtggagc gagcgacccg cacagagccc cggcaggccg gcggcgaagc
       61 cgggaagtcc cggctgcgcc tcccgggtgc cccgagattc ctgagcgcgg ctctccgagg
      121 gcgggcggcg acagcagcgg cagcggggga aaaagcggat tccgcccgga gccacactga
      181 gagctcgcgg tcgcgacttg ccgccctaag cgctctcgca agtccagcca gctcggcgag
      241 gacttccttc tcctggacga atcttgtcaa gcaagctggg atctatgagt ggaaaggtga
      301 ccaagcccaa agaggagaaa gatgcttcta aggttctgga tgacgccccc cctggcacac
      361 aggaatacat tatgttacga caagattcca tccaatctgc ggaattaaag aaaaaagagt
      421 ccccctttcg tgctaagtgt cacgaaatct tctgctgccc gctgaagcaa gtgcaccaca
      481 aagaaaacac agaacccgaa gagcctcagc ttaagggtat agttaccaaa ctatacagcc
      541 gacaaggcta ccacttgcaa ctgcaggcag atggaaccat tgatggcacc aaagacgagg
      601 acagcactta cactctgttt aacctcatcc ctgtgggtct tcgggtggtg gctattcaag
      661 gagttcaaac caagctgtat ttggcaatga acagcgaggg atacttgtac acctcggaac
      721 atttcacacc tgagtgcaaa ttcaaagaat cagtgtttga aaattattac gtgacatact
      781 catcaatgat ctaccgtcag cagcaatccg gccgagggtg gtatctaggt ctgaacaaag
      841 aaggagagat catgaaaggc aaccatgtga agaagaacaa gcctgcagca cattttctgc
      901 ccaaaccact gaaagtggcc atgtacaagg agccatctct gcacgatctc acggagttct
      961 cccgatctgg aagtgggacc ccgaccaaga gcagaagcgt ctctggtgta ctgaatggag
     1021 gcaaatccat gagccacaac gaatcaacgt agccagtgag ggcaaaacga gggctctata
     1081 acagaacctt accttcaggt gctgttgaat tcttctagca gtccttcatc caaaagttca
     1141 aacttatcag tgaggtttac caaacacaca ggcagacttc cctattctct ctgccgttat
     1201 accttgttat cacccatatt aaagccccat aatttattct gagcttgtgc aaaagagtgc
     1261 caagcattat caatgaacta aacctggaag aaggactgcc aaattttctc atgatctcac
     1321 ctgtactttg gggataaata aaacagcaaa aatatttaac agcacaaatg ctggtcaatt
     1381 tgcttcccaa ttaagaaaaa ttaaaagacc acagctattc ttaacaaagc aaaacaacaa
     1441 aacaaagtta actgcttaaa tgttttgtag gggcaaacaa attctgtgaa ctgtgctgtt
     1501 ttcttggctt cgtgttttct atctctgctt gattcaaatg tactctttac tttcatatag
     1561 tgcaacttta tgatttttga aaattaatgg ttctattgac tctgtcactt aatccatatt
     1621 aaccaaaggc agggttgaat ctgaattggc atctgaggtt caaggtaacc gtgttcttat
     1681 gggttttcct ctctcgcacc ctctcctttc caccctccct ctttctctct ctctctctct
     1741 ctttctctct ctctctctct ctttctctct ctctctctct ctctctctct ctctctctct
     1801 ctctctctct ctctctctcc ttttttgttg tcaattagaa ctgtagcatt ctggtcaagt
     1861 tcttgtgctg tactttgtgc gtagaaattg agttgtatcg tcaatcccag tcagtaagat
     1921 aagttgaaac aagattatcc tcaagtgtag atttctctta attccattcg tgtatcatgt
     1981 taatctattg tggcttcttg tgtaaagaca ggaactgtgg aacagtggca ttgtctttcg
     2041 tgttgttcaa ataagaagtg tctcacctgt acatgtacaa gtcctcctgt cattggattt
     2101 ggcacgtgaa cattgtgaac aaggcaatgt taagaatggt tccccctaaa caacatatat
     2161 tatacctgct actggaaaag tgtttaagac ttagctaggt ttccatttag atcttcatat
     2221 ctgttgcatg gaagaaagtt ggaatcttgg catagagttg catgatatgt aagattttgt
     2281 gcattaataa ttgttaaaac ctgtgttcca aaagtggaca tagcatgtac aggcagtttt
     2341 ctgccctgtg cacaaaaagt taaaaaaaaa gttgtttaat atttgttgtt gtatacccaa
     2401 atacgcaccg aataaactct ttatattcat tcaaagaaaa
//
