LOCUS       NM_010199               5408 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus fibroblast growth factor 12 (Fgf12), transcript
            variant 2, mRNA.
ACCESSION   NM_010199
VERSION     NM_010199.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5408)
  AUTHORS   Huang,J., Sun,C., Zhu,Q., Wu,G., Cao,Y., Shi,J., He,S., Jiang,L.,
            Liao,J., Li,L., Zhong,C. and Lu,Y.
  TITLE     Phenotyping of FGF12AV52H mutation in mouse implies a complex FGF12
            network
  JOURNAL   Neurobiol Dis 200, 106637 (2024)
   PUBMED   39142611
  REMARK    GeneRIF: Phenotyping of FGF12A[V52H] mutation in mouse implies a
            complex FGF12 network.
REFERENCE   2  (bases 1 to 5408)
  AUTHORS   Wang,N., Xu,X., Guan,F., Lin,Y., Ye,Y., Zhou,J., Feng,J., Li,S.,
            Ye,J., Tang,Z., Gao,W., Sun,B., Shen,Y., Sun,L., Song,Y., Jin,L.,
            Li,X., Cong,W. and Zhu,Z.
  TITLE     FGF12 Positively Regulates Keratinocyte Proliferation by
            Stabilizing MDM2 and Inhibiting p53 Activity in Psoriasis
  JOURNAL   Adv Sci (Weinh) 11 (39), e2400107 (2024)
   PUBMED   39234815
  REMARK    GeneRIF: FGF12 Positively Regulates Keratinocyte Proliferation by
            Stabilizing MDM2 and Inhibiting p53 Activity in Psoriasis.
REFERENCE   3  (bases 1 to 5408)
  AUTHORS   Van Wauwe,J., Mahy,A., Craps,S., Ekhteraei-Tousi,S., Vrancaert,P.,
            Kemps,H., Dheedene,W., Donate Puertas,R., Trenson,S.,
            Roderick,H.L., Beerens,M. and Luttun,A.
  TITLE     PRDM16 determines specification of ventricular cardiomyocytes by
            suppressing alternative cell fates
  JOURNAL   Life Sci Alliance 7 (12), e202402719 (2024)
   PUBMED   39304345
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5408)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 5408)
  AUTHORS   Pulcrano,S., De Gregorio,R., De Sanctis,C., Volpicelli,F.,
            Piscitelli,R.M., Speranza,L., Perrone-Capano,C., di Porzio,U.,
            Caiazzo,M., Martini,A., Giacomet,C., Medina,D., Awatramani,R.,
            Viggiano,D., Federici,M., Mercuri,N.B., Guatteo,E. and
            Bellenchi,G.C.
  TITLE     miR-218 Promotes Dopaminergic Differentiation and Controls Neuron
            Excitability and Neurotransmitter Release through the Regulation of
            a Synaptic-Related Genes Network
  JOURNAL   J Neurosci 43 (48), 8104-8125 (2023)
   PUBMED   37816598
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5408)
  AUTHORS   Bachler,M. and Neubuser,A.
  TITLE     Expression of members of the Fgf family and their receptors during
            midfacial development
  JOURNAL   Mech Dev 100 (2), 313-316 (2001)
   PUBMED   11165488
REFERENCE   7  (bases 1 to 5408)
  AUTHORS   Munoz-Sanjuan,I., Smallwood,P.M. and Nathans,J.
  TITLE     Isoform diversity among fibroblast growth factor homologous factors
            is generated by alternative promoter usage and differential
            splicing
  JOURNAL   J Biol Chem 275 (4), 2589-2597 (2000)
   PUBMED   10644718
REFERENCE   8  (bases 1 to 5408)
  AUTHORS   Hartung,H., Feldman,B., Lovec,H., Coulier,F., Birnbaum,D. and
            Goldfarb,M.
  TITLE     Murine FGF-12 and FGF-13: expression in embryonic nervous system,
            connective tissue and heart
  JOURNAL   Mech Dev 64 (1-2), 31-39 (1997)
   PUBMED   9232594
REFERENCE   9  (bases 1 to 5408)
  AUTHORS   Hartung,H., Lovec,H., Verdier,A.S., Mattei,M.G., Coulier,F.,
            Goldfarb,M. and Birnbaum,D.
  TITLE     Assignment of Fgf12 to mouse chromosome bands 16B1-->B3 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 76 (3-4), 185-186 (1997)
   PUBMED   9186519
REFERENCE   10 (bases 1 to 5408)
  AUTHORS   Smallwood,P.M., Munoz-Sanjuan,I., Tong,P., Macke,J.P., Hendry,S.H.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Fibroblast growth factor (FGF) homologous factors: new members of
            the FGF family implicated in nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9850-9857 (1996)
   PUBMED   8790420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB611389.1, CX239635.1, AC154619.2, AK034335.1, BY477982.1,
            AK046130.1 and AK034150.1.
            
            On Dec 5, 2014 this sequence version replaced NM_010199.3.
            
            Transcript Variant: This variant (2) uses an alternate 5' exon
            structure, differs in the 5' UTR and initiates translation at an
            alternate start codon, compared to variant 1. It encodes isoform b
            which is shorter and has a distinct N-terminus, compared to isoform
            a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030485.1, SRR9219382.114688.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BB611389.1         3-58
            57-759              CX239635.1         1-703
            760-760             AC154619.2         11401-11401         c
            761-806             CX239635.1         704-749
            807-2620            AK034335.1         802-2615
            2621-2621           AC154619.2         9540-9540           c
            2622-3071           AK034335.1         2617-3066
            3072-3098           BY477982.1         484-510
            3099-3158           AC154619.2         9003-9062           c
            3159-3318           AK046130.1         1-160
            3319-3321           AC154619.2         8840-8842           c
            3322-3451           AK046130.1         164-293
            3452-5408           AK034150.1         166-2122
FEATURES             Location/Qualifiers
     source          1..5408
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 19.38 cM"
     gene            1..5408
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="fibroblast growth factor 12"
                     /db_xref="GeneID:14167"
                     /db_xref="MGI:MGI:109183"
     exon            1..98
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /inference="alignment:Splign:2.1.0"
     exon            99..241
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..774
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="isoform b is encoded by transcript variant 2;
                     myocyte-activating factor; fibroblast growth factor
                     homologous factor 1; fibroblast growth factor 1a"
                     /codon_start=1
                     /product="fibroblast growth factor 12 isoform b"
                     /protein_id="NP_034329.1"
                     /db_xref="CCDS:CCDS88909.1"
                     /db_xref="GeneID:14167"
                     /db_xref="MGI:MGI:109183"
                     /translation="MESKEPQLKGIVTRLFSQQGYFLQMHPDGTIDGTKDENSDYTLF
                     NLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSDVFTPECKFKESVFENYYVIYSSTLY
                     RQQESGRAWFLGLNKEGQIMKGNRVKKTKPSSHFVPKPIEVCMYREPSLHEIGEKQGR
                     SRKSSGTPTMNGGKVVNQDST"
     exon            242..352
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /inference="alignment:Splign:2.1.0"
     exon            353..456
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..655
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /inference="alignment:Splign:2.1.0"
     exon            656..5408
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1030..1035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="hexamer: AATAAA"
     polyA_site      1056
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="major polyA site"
     polyA_site      2867
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="major polyA site"
     regulatory      3073..3078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="hexamer: AATAAA"
     polyA_site      3097
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="major polyA site"
     regulatory      3520..3525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="hexamer: CATAAA"
     polyA_site      3542
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
     regulatory      4581..4586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="hexamer: AATAAA"
     polyA_site      4603
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
     regulatory      5207..5212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="hexamer: AATAAA"
     polyA_site      5232
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
ORIGIN      
        1 aaatctgctg tacatccaga gcaaagtggg atgatctgtc actacacctg cagcaccacg
       61 ctccgaggac agctccttct tgcagcttcc agactcagga agcctgaagg gaaagaagga
      121 agtacaggcg aaagcatcag attggctttc cagatttggg gatctgaagc gggcccacat
      181 cttcctgcca acttccattg aacttcccag cactctaaag ggaccgaaat ggagagcaaa
      241 gaaccccagc tgaaagggat tgtgacaagg ttattcagcc agcagggata tttcctgcag
      301 atgcatccag atggtaccat tgatgggacc aaggacgaaa acagcgacta caccctcttc
      361 aatctaattc ctgtaggact gcgtgtggtg gccatccaag gggttaaagc cagcctttat
      421 gtggccatga atggagaagg ctatctctac agctcagatg tttttacccc agaatgcaaa
      481 tttaaggagt ctgtgtttga aaactactat gtgatctatt cctcaaccct gtatcgccag
      541 caggaatcag gccgtgcatg gtttctagga ctcaataaag aaggtcaaat catgaagggg
      601 aacagagtga agaaaaccaa gccctcatct cattttgtac caaaacctat tgaagtgtgt
      661 atgtacagag aaccatcact acacgaaatt ggagaaaagc aaggacgctc aaggaaaagt
      721 tcgggaacac ccaccatgaa tggaggcaaa gtcgtgaatc aagattctac ataacctagc
      781 caagaactct tccgttcttc cctctcctcc ctgtcccttc ttctccctcc ctttccccat
      841 tttctccagt atatctaccc aacgagagag agaaaaaaat aaaacagcat cacaggactt
      901 agtagctgag attctgcact caaaatcttc ctttgtgtag gacaagaaat ttgaaccaaa
      961 gcttgcctgt tgcaatgtgg tagaaaattc acatgcataa caattattgc acataagagc
     1021 aaaggaaaaa ataaattgga ctccacaaac attaaattta actgtgttgt tattaacaga
     1081 gggctaattg taatgaagac aggctataat gcagacaaag cacagtcatt gaatggatgt
     1141 aaaaggtttg gaaagccact taaaatgttg ttgaattgta aatcctttta agttttagag
     1201 cattctgaaa tgtgcagatt tgtttcacgt ttgtattttc tttacacttc tgtccattat
     1261 atgcaattac atcctgtttc cagggtattc tttcaatcat aaaattgaat atgtcaaaat
     1321 tatattcttc taatatctgt tagacatata gccagggacc aacttgcatg aagaaaagtt
     1381 ttaaacttac tcttgatgtt agtaatattt ttttatttag aaaaggaaac tcttctgttg
     1441 aatttaatcc tattagctga tttaattacc ttgtaaacag tttcacattc tttgaggaga
     1501 acattatatt tttatctagg tattgatctc aaattttatt atttttttag gcattcagtg
     1561 aaaagggttt taatgtattc ctgaggagac ttagggaact cgctggcatc cggtgaagga
     1621 gcacaggctt cttgcatttt ccatgcagtc ttagtgtagg tatctttgag tgtgtatgtg
     1681 aatgtctagc tgtcatagaa agttgatttt tttttctaac catattttga agcaggagag
     1741 aaaaaagttg ggttttatag aaggaaataa gtctgaaata cagactcaaa gcaaaattta
     1801 attgcctttt tacattgcca cagttctgtg tgtaggttgc tttttaaact ctagaagaaa
     1861 ttagaaggat atgactgtga aaattctacc ttaccatcta tgaagcaagt ggcatgtttg
     1921 ttggatttat ccacatttat aagtctagtt tgcaataatt ctatgttcta gaaagcagaa
     1981 ggtaactagt taaacatgga tttttcaagg gacagagaga aaagatgtgg aattaacagc
     2041 tttggtttca atagacaggg ttttgtgggt gggtttgggt cgtgaaaaag aactccacat
     2101 gagagctaga acactattag aactctgaag tactagaaaa cattaacaaa gacatgaagc
     2161 tataccacag cattgaaatt actagactta cttcgccctg gatatcagga atggtgtaga
     2221 gaaatccaaa ttcaaagaga ccaaaccaga atgttaaaaa tgtttgcagc tttatggaat
     2281 atcataatga gaagacgtaa gcatgtaact tctcctatat ctctactgtc cagcatgtat
     2341 tattccaact atgactccct aaaatacata ctttgcagaa gatctaagcc ctcacttcaa
     2401 accttcccat gggatgctgt attctattaa ggtcaacata atgtctccct ctacacaaac
     2461 attattcttt ggtgtgactc ttgccctata aattgcccta taaattatct atttatgttc
     2521 tctggagggt ggcagaaaat ttactggggg aattttccca taaagcatag aagaatagag
     2581 gttatgcaca gagataagct tttggacaga ttttaaatca gaatatatgt aaagtaaaag
     2641 atacatttaa tgtgtatata tatgcatata tatacatata tatgtatata tatattatat
     2701 ggaatgttgc tttcttagga aaagtacacc catgtaaaga cacacattca gaagttgtac
     2761 tcattgtcac tgttgttcca acttgattat aagtacacct gtcacttcca ggaccaaaaa
     2821 tttcccaagc acaaagcctt attttctttt aaaaataaat aaataaataa agaggcttca
     2881 acaaaatgga tcataggctc ttttgaaggg aagtgcctgg agtttacggt gagatgttta
     2941 ctcaaccata gtgcactgag ggtccacagg aagtgccatt tctggaaacc acaattgccc
     3001 atctctctga ggatttcatg atagcaattt atcttcatta tttattaaaa tataatgctg
     3061 atattaatct ctaataaaaa tcccttctct attttcagtg gttgtccatt gttcatcatt
     3121 cagatacctt tgtcccaatc ctatcaatag ttaaaaagga gctttctaag cactcagtct
     3181 gtctctagtt tgccctccat atcatgataa ggaaatgtat atgcattttg gaaattaact
     3241 ttgcatcatt tgcacctgat ttcaagaacg aattgaaagc ctcacattcc tttttttttt
     3301 tttttttttt tttttttgta gacctgaaaa agaaaatgtt tagagcacaa tgtttatttg
     3361 ctcactttct ggttgctatt gaagtatatc aaaatcataa atagaaccaa tattcattgt
     3421 attgggttta aaatatatga aaaatacaaa tatataacca ttagatttca tttttaaaat
     3481 atgggtcagg ttcaatggtt ctttttcagc tttattccac ataaaatgtt tcttcactgt
     3541 gacactcttt gttctattgc ctggcttcaa ctcacctatc gcctgttctt tcattgtaat
     3601 gagggttctc tttttgttgt ttctaaaaca aggcaagggg ataatcccag gaaaggattc
     3661 tagtagagaa ccatcagagc ccttattagg ttttaaacaa atgggtttga taatattaac
     3721 caaacttcca tgagtctcac aaaatggctc tctggtcaat attctttact tgatatttta
     3781 gctaggtatt tgaggtctag aaacaaatgg tgctgaagtt ccatctgcta gcttagagac
     3841 cttgttcttc aggagactga aacacagtaa gccatcattt tcttgatcat attgatagtt
     3901 ttggttttga actacatata tgaagtttta agacatgttt ttagccattg cggattggca
     3961 cagggaatag acaataagac aatgtgactc cttatggacc tcaatccaat ctagaaattt
     4021 atacaaaata actcttctac ctaagaaaat ggcaatgctg ttgctgggta tatttttttt
     4081 tcagtttgtg attcatcatc gctacaggga agtgttgaga gtagtccaac aaaaggatgg
     4141 attgtatctt gtttgttgtg tattaaatgg tccttaagcc caacctggga ccccagattg
     4201 cttaatgaag aatatgatta cttcaacatt gatttatgtt ttaaaacata aacccagaat
     4261 tagaaaatct cttcttatac cctgtgactt agagtacaag gccttgcttt tgagaaggtt
     4321 ttccatgaac taggttgatt tcttctgcac aaggtgagaa acagtcaaac ttaaaaaatc
     4381 cctgctcatt ttaatgccat aaaagactga ggctattact ctgtcataga ctgtaaatag
     4441 cattttttaa agccagaatc acatttaaaa ctgtggattg ttctacaaat atatatgtgt
     4501 atatatacat atgcttctga aatgaggata tattatataa agtttttatt tgctctgtga
     4561 tctttcatta ggtagtcaaa aataaagaga tttgaatgca aaactttata tataaatgta
     4621 tatttctaat gatagtacta attgtaactt tataataaaa aaagaaacag gtgggagcaa
     4681 tactaaagca catgccagtg cagaaggttg gtgattttta atcctctctc atgcactgat
     4741 agctttaaat tctatagtat ttcttagaag gctataattc cctgtagaaa tctcaaggtg
     4801 atgctgaaag tctggctgag ggagagtcaa aggaagtaaa aggctgataa ggatattttg
     4861 aagtccatat ttaaaatcaa gattttagtc caaatagaat gaagattgct agtgttcagg
     4921 ggtgatatac tgaacttcat ccacaaataa aagcaggaca aagagaatac ttaacatcac
     4981 aacagcatta aaatagtgtg ataaacattg catcattagt tttactagtg gaaacaatga
     5041 gctgatgctt cttggtcttt gctccaagca caatttaatg acagtaacct tcattttact
     5101 caaagtcatt taaaagtata aaatatataa ccacaaatag aactgttact agctccattt
     5161 caagtgttat atataatctt agtaaagaat ggacactaaa atgtttaata aacatgttat
     5221 atgaagaaac aagcaaattc atatttgttt ttgcattaaa gcacagatta ttcaagtcat
     5281 tgggtttttg agatcagttt tgtaaaatgt ttatacacca ccacattcgt gaagtgaaaa
     5341 gaaattaaaa tcttgagata ttcatgcatg tagattactg gcactttaaa aaaaattaaa
     5401 cttctctg
//
