LOCUS       NM_001357064            5423 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus fibroblast growth factor 12 (Fgf12), transcript
            variant 5, mRNA.
ACCESSION   NM_001357064 XM_006521793
VERSION     NM_001357064.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5423)
  AUTHORS   Huang,J., Sun,C., Zhu,Q., Wu,G., Cao,Y., Shi,J., He,S., Jiang,L.,
            Liao,J., Li,L., Zhong,C. and Lu,Y.
  TITLE     Phenotyping of FGF12AV52H mutation in mouse implies a complex FGF12
            network
  JOURNAL   Neurobiol Dis 200, 106637 (2024)
   PUBMED   39142611
  REMARK    GeneRIF: Phenotyping of FGF12A[V52H] mutation in mouse implies a
            complex FGF12 network.
REFERENCE   2  (bases 1 to 5423)
  AUTHORS   Wang,N., Xu,X., Guan,F., Lin,Y., Ye,Y., Zhou,J., Feng,J., Li,S.,
            Ye,J., Tang,Z., Gao,W., Sun,B., Shen,Y., Sun,L., Song,Y., Jin,L.,
            Li,X., Cong,W. and Zhu,Z.
  TITLE     FGF12 Positively Regulates Keratinocyte Proliferation by
            Stabilizing MDM2 and Inhibiting p53 Activity in Psoriasis
  JOURNAL   Adv Sci (Weinh) 11 (39), e2400107 (2024)
   PUBMED   39234815
  REMARK    GeneRIF: FGF12 Positively Regulates Keratinocyte Proliferation by
            Stabilizing MDM2 and Inhibiting p53 Activity in Psoriasis.
REFERENCE   3  (bases 1 to 5423)
  AUTHORS   Van Wauwe,J., Mahy,A., Craps,S., Ekhteraei-Tousi,S., Vrancaert,P.,
            Kemps,H., Dheedene,W., Donate Puertas,R., Trenson,S.,
            Roderick,H.L., Beerens,M. and Luttun,A.
  TITLE     PRDM16 determines specification of ventricular cardiomyocytes by
            suppressing alternative cell fates
  JOURNAL   Life Sci Alliance 7 (12), e202402719 (2024)
   PUBMED   39304345
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5423)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 5423)
  AUTHORS   Pulcrano,S., De Gregorio,R., De Sanctis,C., Volpicelli,F.,
            Piscitelli,R.M., Speranza,L., Perrone-Capano,C., di Porzio,U.,
            Caiazzo,M., Martini,A., Giacomet,C., Medina,D., Awatramani,R.,
            Viggiano,D., Federici,M., Mercuri,N.B., Guatteo,E. and
            Bellenchi,G.C.
  TITLE     miR-218 Promotes Dopaminergic Differentiation and Controls Neuron
            Excitability and Neurotransmitter Release through the Regulation of
            a Synaptic-Related Genes Network
  JOURNAL   J Neurosci 43 (48), 8104-8125 (2023)
   PUBMED   37816598
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5423)
  AUTHORS   Bachler,M. and Neubuser,A.
  TITLE     Expression of members of the Fgf family and their receptors during
            midfacial development
  JOURNAL   Mech Dev 100 (2), 313-316 (2001)
   PUBMED   11165488
REFERENCE   7  (bases 1 to 5423)
  AUTHORS   Munoz-Sanjuan,I., Smallwood,P.M. and Nathans,J.
  TITLE     Isoform diversity among fibroblast growth factor homologous factors
            is generated by alternative promoter usage and differential
            splicing
  JOURNAL   J Biol Chem 275 (4), 2589-2597 (2000)
   PUBMED   10644718
REFERENCE   8  (bases 1 to 5423)
  AUTHORS   Hartung,H., Feldman,B., Lovec,H., Coulier,F., Birnbaum,D. and
            Goldfarb,M.
  TITLE     Murine FGF-12 and FGF-13: expression in embryonic nervous system,
            connective tissue and heart
  JOURNAL   Mech Dev 64 (1-2), 31-39 (1997)
   PUBMED   9232594
REFERENCE   9  (bases 1 to 5423)
  AUTHORS   Hartung,H., Lovec,H., Verdier,A.S., Mattei,M.G., Coulier,F.,
            Goldfarb,M. and Birnbaum,D.
  TITLE     Assignment of Fgf12 to mouse chromosome bands 16B1-->B3 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 76 (3-4), 185-186 (1997)
   PUBMED   9186519
REFERENCE   10 (bases 1 to 5423)
  AUTHORS   Smallwood,P.M., Munoz-Sanjuan,I., Tong,P., Macke,J.P., Hendry,S.H.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Fibroblast growth factor (FGF) homologous factors: new members of
            the FGF family implicated in nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9850-9857 (1996)
   PUBMED   8790420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154656.2, AC154663.2 and AC154619.2.
            
            On Oct 18, 2017 this sequence version replaced XM_006521793.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.49422.1,
                                           SRR1660811.13321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               AC154656.2         38037-38292         c
            257-367             AC154663.2         79979-80089
            368-471             AC154663.2         105351-105454
            472-670             AC154619.2         38404-38602         c
            671-5423            AC154619.2         6753-11505          c
FEATURES             Location/Qualifiers
     source          1..5423
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 19.38 cM"
     gene            1..5423
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="fibroblast growth factor 12"
                     /db_xref="GeneID:14167"
                     /db_xref="MGI:MGI:109183"
     exon            1..256
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /inference="alignment:Splign:2.1.0"
     exon            257..367
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..789
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="isoform e is encoded by transcript variant 5;
                     myocyte-activating factor; fibroblast growth factor
                     homologous factor 1; fibroblast growth factor 1a"
                     /codon_start=1
                     /product="fibroblast growth factor 12 isoform e"
                     /protein_id="NP_001343993.1"
                     /db_xref="GeneID:14167"
                     /db_xref="MGI:MGI:109183"
                     /translation="MHPDGTIDGTKDENSDYTLFNLIPVGLRVVAIQGVKASLYVAMN
                     GEGYLYSSDVFTPECKFKESVFENYYVIYSSTLYRQQESGRAWFLGLNKEGQIMKGNR
                     VKKTKPSSHFVPKPIEVCMYREPSLHEIGEKQGRSRKSSGTPTMNGGKVVNQDST"
     exon            368..471
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..670
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..5423
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1045..1050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="hexamer: AATAAA"
     polyA_site      1071
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="major polyA site"
     polyA_site      2882
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="major polyA site"
     regulatory      3088..3093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="hexamer: AATAAA"
     polyA_site      3112
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="major polyA site"
     regulatory      3535..3540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="hexamer: CATAAA"
     polyA_site      3557
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
     regulatory      4596..4601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="hexamer: AATAAA"
     polyA_site      4618
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
     regulatory      5222..5227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
                     /note="hexamer: AATAAA"
     polyA_site      5247
                     /gene="Fgf12"
                     /gene_synonym="B230343J05Rik; FGF-12; Fgf1a; FHF-1; Fhf1"
ORIGIN      
        1 gtgtgcgcga gtgcgcgtgt gtgtgagtgt gtgtagccct gaagtcaccc gcgctgtcgt
       61 cccgcaccca agctggagct agcgggtccg ggacgcgggg agcgggaggg accggctccc
      121 acacttcctc gcgcctcgct gctccttgtg acttgctagg gcagtctggg actcgcggtt
      181 gttcagggtc tcctcggaga agttgctggt gcaatcgcct gcagaggggg actttaaaca
      241 ggtggctggc agacagaacc ccagctgaaa gggattgtga caaggttatt cagccagcag
      301 ggatatttcc tgcagatgca tccagatggt accattgatg ggaccaagga cgaaaacagc
      361 gactacaccc tcttcaatct aattcctgta ggactgcgtg tggtggccat ccaaggggtt
      421 aaagccagcc tttatgtggc catgaatgga gaaggctatc tctacagctc agatgttttt
      481 accccagaat gcaaatttaa ggagtctgtg tttgaaaact actatgtgat ctattcctca
      541 accctgtatc gccagcagga atcaggccgt gcatggtttc taggactcaa taaagaaggt
      601 caaatcatga aggggaacag agtgaagaaa accaagccct catctcattt tgtaccaaaa
      661 cctattgaag tgtgtatgta cagagaacca tcactacacg aaattggaga aaagcaagga
      721 cgctcaagga aaagttcggg aacacccacc atgaatggag gcaaagtcgt gaatcaagat
      781 tctacataac ctagccaaga actcttccgt tcttccctct cctccctgtc ccttcttctc
      841 cctccctttc cccattttct ccagtatatc tacccaacga gagagagaaa aaaataaaac
      901 agcatcacag gacttagtag ctgagattct gcactcaaaa tcttcctttg tgtaggacaa
      961 gaaatttgaa ccaaagcttg cctgttgcaa tgtggtagaa aattcacatg cataacaatt
     1021 attgcacata agagcaaagg aaaaaataaa ttggactcca caaacattaa atttaactgt
     1081 gttgttatta acagagggct aattgtaatg aagacaggct ataatgcaga caaagcacag
     1141 tcattgaatg gatgtaaaag gtttggaaag ccacttaaaa tgttgttgaa ttgtaaatcc
     1201 ttttaagttt tagagcattc tgaaatgtgc agatttgttt cacgtttgta ttttctttac
     1261 acttctgtcc attatatgca attacatcct gtttccaggg tattctttca atcataaaat
     1321 tgaatatgtc aaaattatat tcttctaata tctgttagac atatagccag ggaccaactt
     1381 gcatgaagaa aagttttaaa cttactcttg atgttagtaa tattttttta tttagaaaag
     1441 gaaactcttc tgttgaattt aatcctatta gctgatttaa ttaccttgta aacagtttca
     1501 cattctttga ggagaacatt atatttttat ctaggtattg atctcaaatt ttattatttt
     1561 tttaggcatt cagtgaaaag ggttttaatg tattcctgag gagacttagg gaactcgctg
     1621 gcatccggtg aaggagcaca ggcttcttgc attttccatg cagtcttagt gtaggtatct
     1681 ttgagtgtgt atgtgaatgt ctagctgtca tagaaagttg attttttttt ctaaccatat
     1741 tttgaagcag gagagaaaaa agttgggttt tatagaagga aataagtctg aaatacagac
     1801 tcaaagcaaa atttaattgc ctttttacat tgccacagtt ctgtgtgtag gttgcttttt
     1861 aaactctaga agaaattaga aggatatgac tgtgaaaatt ctaccttacc atctatgaag
     1921 caagtggcat gtttgttgga tttatccaca tttataagtc tagtttgcaa taattctatg
     1981 ttctagaaag cagaaggtaa ctagttaaac atggattttt caagggacag agagaaaaga
     2041 tgtggaatta acagctttgg tttcaataga cagggttttg tgggtgggtt tgggtcgtga
     2101 aaaagaactc cacatgagag ctagaacact attagaactc tgaagtacta gaaaacatta
     2161 acaaagacat gaagctatac cacagcattg aaattactag acttacttcg ccctggatat
     2221 caggaatggt gtagagaaat ccaaattcaa agagaccaaa ccagaatgtt aaaaatgttt
     2281 gcagctttat ggaatatcat aatgagaaga cgtaagcatg taacttctcc tatatctcta
     2341 ctgtccagca tgtattattc caactatgac tccctaaaat acatactttg cagaagatct
     2401 aagccctcac ttcaaacctt cccatgggat gctgtattct attaaggtca acataatgtc
     2461 tccctctaca caaacattat tctttggtgt gactcttgcc ctataaattg ccctataaat
     2521 tatctattta tgttctctgg agggtggcag aaaatttact gggggaattt tcccataaag
     2581 catagaagaa tagaggttat gcacagagat aagcttttgg acagatttta aatcagaata
     2641 tatgtaaagt aaaagataca tttaatgtgt atatatatgc atatatatac atatatatgt
     2701 atatatatat tatatggaat gttgctttct taggaaaagt acacccatgt aaagacacac
     2761 attcagaagt tgtactcatt gtcactgttg ttccaacttg attataagta cacctgtcac
     2821 ttccaggacc aaaaatttcc caagcacaaa gccttatttt cttttaaaaa taaataaata
     2881 aataaagagg cttcaacaaa atggatcata ggctcttttg aagggaagtg cctggagttt
     2941 acggtgagat gtttactcaa ccatagtgca ctgagggtcc acaggaagtg ccatttctgg
     3001 aaaccacaat tgcccatctc tctgaggatt tcatgatagc aatttatctt cattatttat
     3061 taaaatataa tgctgatatt aatctctaat aaaaatccct tctctatttt cagtggttgt
     3121 ccattgttca tcattcagat acctttgtcc caatcctatc aatagttaaa aaggagcttt
     3181 ctaagcactc agtctgtctc tagtttgccc tccatatcat gataaggaaa tgtatatgca
     3241 ttttggaaat taactttgca tcatttgcac ctgatttcaa gaacgaattg aaagcctcac
     3301 attccttttt tttttttttt tttttttttt ttgtagacct gaaaaagaaa atgtttagag
     3361 cacaatgttt atttgctcac tttctggttg ctattgaagt atatcaaaat cataaataga
     3421 accaatattc attgtattgg gtttaaaata tatgaaaaat acaaatatat aaccattaga
     3481 tttcattttt aaaatatggg tcaggttcaa tggttctttt tcagctttat tccacataaa
     3541 atgtttcttc actgtgacac tctttgttct attgcctggc ttcaactcac ctatcgcctg
     3601 ttctttcatt gtaatgaggg ttctcttttt gttgtttcta aaacaaggca aggggataat
     3661 cccaggaaag gattctagta gagaaccatc agagccctta ttaggtttta aacaaatggg
     3721 tttgataata ttaaccaaac ttccatgagt ctcacaaaat ggctctctgg tcaatattct
     3781 ttacttgata ttttagctag gtatttgagg tctagaaaca aatggtgctg aagttccatc
     3841 tgctagctta gagaccttgt tcttcaggag actgaaacac agtaagccat cattttcttg
     3901 atcatattga tagttttggt tttgaactac atatatgaag ttttaagaca tgtttttagc
     3961 cattgcggat tggcacaggg aatagacaat aagacaatgt gactccttat ggacctcaat
     4021 ccaatctaga aatttataca aaataactct tctacctaag aaaatggcaa tgctgttgct
     4081 gggtatattt ttttttcagt ttgtgattca tcatcgctac agggaagtgt tgagagtagt
     4141 ccaacaaaag gatggattgt atcttgtttg ttgtgtatta aatggtcctt aagcccaacc
     4201 tgggacccca gattgcttaa tgaagaatat gattacttca acattgattt atgttttaaa
     4261 acataaaccc agaattagaa aatctcttct tataccctgt gacttagagt acaaggcctt
     4321 gcttttgaga aggttttcca tgaactaggt tgatttcttc tgcacaaggt gagaaacagt
     4381 caaacttaaa aaatccctgc tcattttaat gccataaaag actgaggcta ttactctgtc
     4441 atagactgta aatagcattt tttaaagcca gaatcacatt taaaactgtg gattgttcta
     4501 caaatatata tgtgtatata tacatatgct tctgaaatga ggatatatta tataaagttt
     4561 ttatttgctc tgtgatcttt cattaggtag tcaaaaataa agagatttga atgcaaaact
     4621 ttatatataa atgtatattt ctaatgatag tactaattgt aactttataa taaaaaaaga
     4681 aacaggtggg agcaatacta aagcacatgc cagtgcagaa ggttggtgat ttttaatcct
     4741 ctctcatgca ctgatagctt taaattctat agtatttctt agaaggctat aattccctgt
     4801 agaaatctca aggtgatgct gaaagtctgg ctgagggaga gtcaaaggaa gtaaaaggct
     4861 gataaggata ttttgaagtc catatttaaa atcaagattt tagtccaaat agaatgaaga
     4921 ttgctagtgt tcaggggtga tatactgaac ttcatccaca aataaaagca ggacaaagag
     4981 aatacttaac atcacaacag cattaaaata gtgtgataaa cattgcatca ttagttttac
     5041 tagtggaaac aatgagctga tgcttcttgg tctttgctcc aagcacaatt taatgacagt
     5101 aaccttcatt ttactcaaag tcatttaaaa gtataaaata tataaccaca aatagaactg
     5161 ttactagctc catttcaagt gttatatata atcttagtaa agaatggaca ctaaaatgtt
     5221 taataaacat gttatatgaa gaaacaagca aattcatatt tgtttttgca ttaaagcaca
     5281 gattattcaa gtcattgggt ttttgagatc agttttgtaa aatgtttata caccaccaca
     5341 ttcgtgaagt gaaaagaaat taaaatcttg agatattcat gcatgtagat tactggcact
     5401 ttaaaaaaaa ttaaacttct ctg
//
