LOCUS       NM_001362623            3467 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus fibroblast growth factor 11 (Fgf11), transcript
            variant 3, mRNA.
ACCESSION   NM_001362623 XM_011248724
VERSION     NM_001362623.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3467)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3467)
  AUTHORS   Cho,J.H., Kim,K., Cho,H.C., Lee,J. and Kim,E.K.
  TITLE     Silencing of hypothalamic FGF11 prevents diet-induced obesity
  JOURNAL   Mol Brain 15 (1), 75 (2022)
   PUBMED   36064426
  REMARK    GeneRIF: Silencing of hypothalamic FGF11 prevents diet-induced
            obesity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3467)
  AUTHORS   Meuser,M., Deuper,L., Rudat,C., Aydogdu,N., Thiesler,H.,
            Zarnovican,P., Hildebrandt,H., Trowe,M.O. and Kispert,A.
  TITLE     FGFR2 signaling enhances the SHH-BMP4 signaling axis in early
            ureter development
  JOURNAL   Development 149 (1) (2022)
   PUBMED   35020897
REFERENCE   4  (bases 1 to 3467)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3467)
  AUTHORS   Tejedor,G., Laplace-Builhe,B., Luz-Crawford,P., Assou,S.,
            Barthelaix,A., Mathieu,M., Kissa,K., Jorgensen,C., Collignon,J.,
            Chuchana,P. and Djouad,F.
  TITLE     Whole embryo culture, transcriptomics and RNA interference identify
            TBX1 and FGF11 as novel regulators of limb development in the mouse
  JOURNAL   Sci Rep 10 (1), 3597 (2020)
   PUBMED   32107392
  REMARK    GeneRIF: Whole embryo culture, transcriptomics and RNA interference
            identify TBX1 and FGF11 as novel regulators of limb development in
            the mouse.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3467)
  AUTHORS   Dichmann,D.S., Miller,C.P., Jensen,J., Scott Heller,R. and Serup,P.
  TITLE     Expression and misexpression of members of the FGF and TGFbeta
            families of growth factors in the developing mouse pancreas
  JOURNAL   Dev Dyn 226 (4), 663-674 (2003)
   PUBMED   12666204
REFERENCE   7  (bases 1 to 3467)
  AUTHORS   Hajihosseini,M.K. and Heath,J.K.
  TITLE     Expression patterns of fibroblast growth factors-18 and -20 in
            mouse embryos is suggestive of novel roles in calvarial and limb
            development
  JOURNAL   Mech Dev 113 (1), 79-83 (2002)
   PUBMED   11900978
REFERENCE   8  (bases 1 to 3467)
  AUTHORS   Bachler,M. and Neubuser,A.
  TITLE     Expression of members of the Fgf family and their receptors during
            midfacial development
  JOURNAL   Mech Dev 100 (2), 313-316 (2001)
   PUBMED   11165488
REFERENCE   9  (bases 1 to 3467)
  AUTHORS   Munoz-Sanjuan,I., Smallwood,P.M. and Nathans,J.
  TITLE     Isoform diversity among fibroblast growth factor homologous factors
            is generated by alternative promoter usage and differential
            splicing
  JOURNAL   J Biol Chem 275 (4), 2589-2597 (2000)
   PUBMED   10644718
REFERENCE   10 (bases 1 to 3467)
  AUTHORS   Smallwood,P.M., Munoz-Sanjuan,I., Tong,P., Macke,J.P., Hendry,S.H.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Fibroblast growth factor (FGF) homologous factors: new members of
            the FGF family implicated in nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9850-9857 (1996)
   PUBMED   8790420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603707.5.
            
            On Apr 21, 2018 this sequence version replaced XM_011248724.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.131933.1,
                                           SRR7345562.4306701.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-848               AL603707.5         180662-181509       c
            849-959             AL603707.5         178895-179005       c
            960-1063            AL603707.5         178581-178684       c
            1064-1262           AL603707.5         177793-177991       c
            1263-3467           AL603707.5         175297-177501       c
FEATURES             Location/Qualifiers
     source          1..3467
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.88 cM"
     gene            1..3467
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /note="fibroblast growth factor 11"
                     /db_xref="GeneID:14166"
                     /db_xref="MGI:MGI:109167"
     exon            1..848
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             656..1333
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /note="isoform 1 is encoded by transcript variant 3;
                     fibroblast growth factor homologous factor 3; fibroblast
                     growth factor 1d"
                     /codon_start=1
                     /product="fibroblast growth factor 11 isoform 1"
                     /protein_id="NP_001349552.1"
                     /db_xref="CCDS:CCDS24911.1"
                     /db_xref="GeneID:14166"
                     /db_xref="MGI:MGI:109167"
                     /translation="MAALASSLIRQKREVREPGGSRPVSAQRRVCPRGTKSLCQKQLL
                     ILLSKVRLCGGRPTRQDRGPEPQLKGIVTKLFCRQGFYLQANPDGSIQGTPEDTSSFT
                     HFNLIPVGLRVVTIQSAKLGHYMAMNAEGLLYSSPHFTAECRFKECVFENYYVLYASA
                     LYRQRRSGRAWYLGLDKEGRVMKGNRVKKTKAAAHFVPKLLEVAMYREPSLHSVPETS
                     PSSPPAH"
     exon            849..959
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1063
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1262
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..3467
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3443..3448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /note="hexamer: ATTAAA"
     polyA_site      3462
                     /gene="Fgf11"
                     /gene_synonym="Fgf-11; Fgf1d; Fhf-3; Fhf3"
                     /note="major polyA site"
ORIGIN      
        1 gggggtgaca atgagaaaaa gcattatcca gccagggggc ctgggaaccc cttttcactg
       61 aacctaaaca gcctgaattt tgagtcatat ttgctggcag aggggggatt tgaagaaagt
      121 gggagaccca ctccatttag agtatagaaa aggaaaaaag aaaacagagc tgggctcctc
      181 ttgacattga cagcagccta gggtgagcta atgtccacaa agcttaggac ccacaccctg
      241 tgtaagagta ggctgggcag gagcggcccc aaaatagggt agaaagaagc ctcggggtat
      301 tgagaacaca tcttagaaat ataggagggt cttgactgtg ggatagagga ggtatcttct
      361 atctggtaca gaggccagag aggagggaag gggaaagctt tcattagggg acagaattca
      421 tgggtgaggt cagctgagga gtgcataggc tgctggagcc gctggagcta gtcagggccc
      481 aagggtggga gccggtggtg ttggggaacg tactggggtc tggggtttct cttcagatcc
      541 tgtgggtggg gcggtgggtt gggtcctgag catgccctgg tgagagggct cctcttgggg
      601 agcccagggc gctccgggag cctgctggtt tgggggtgtc tcctcccggg gcgcgatggc
      661 ggcgttggcc agtagcctga tccgacagaa gcgggaggtc cgcgagcccg ggggcagccg
      721 gcccgtgtcg gcgcagcggc gcgtgtgtcc ccgcggtacc aagtcacttt gccagaaaca
      781 gctcctcatc ctgctgtcca aggtgcgact gtgcgggggg cgtcccacgc gacaggaccg
      841 cggcccagag cctcagctca aaggcatcgt caccaaactg ttctgccgcc agggtttcta
      901 cctccaggcg aatcccgatg ggagtatcca gggcacccca gaggacacca gctccttcac
      961 ccacttcaat ctgattcctg tgggactccg tgtggtcacc atccagagtg ccaagctggg
     1021 tcactacatg gccatgaacg ctgaggggct attgtacagc tcgccacatt tcacagcaga
     1081 gtgtcgcttt aaggagtgcg tctttgagaa ttactatgtc ctgtatgcct ctgctctcta
     1141 ccgtcagcgt cgttctggcc gggcctggta cctaggcctg gacaaggaag gccgggtcat
     1201 gaagggaaac cgagtcaaga agaccaaggc agctgcccac tttgtgccca agctcctgga
     1261 ggtggccatg taccgggagc cttctctcca cagtgttcct gagacctccc cttccagtcc
     1321 ccctgcccac tgagatatag tccctggact ggaggctccc tgctcttcca gtgagtcagc
     1381 caccgccaca tcctgtgtcc tagccctgcg ccgggccttg ccgctctcac ccctgttgcc
     1441 acacacatgc cctgagcagt caggtctcag caggtgctgc accctgtggg agcttcgggg
     1501 ctgtcaggga cctccggagt tgctgagctc ttagatcctg gggcccagga gaggtcccaa
     1561 gatgggggtg cctgagatga ccctgcctga tcacttctct tttttccaca ctaattccta
     1621 ccccttaaga gaacacccat tttttttcct aaaaggcacc ggggttccaa cactcaaggc
     1681 aggaaggtaa tactcttcac cctggctgag ccagtctctg aagccatgtc cttctttgca
     1741 tcgtctcgaa gccatagctt tctaggtcgg tccactggca ctcagaatgc atctccttct
     1801 ctctctgctc taccttctga cttggtctgg acaggttctg atagagctgg tcaccccagc
     1861 caggcagggc catccctatg ttctgtgttg gaacccaagt atgtatcctt tccacgtcta
     1921 tccttgtcct agatggacac ctcccacccc tggctttaaa aaagaggccc cctactgtag
     1981 caattggcct tggtctgaat tgggaccagt ctcaggtcac cactgattaa accttcttat
     2041 cccagagaca cccaattcta gaacgtggta ttctagacct ttctggagcc atacttcctc
     2101 ctgaatctca gttctaggac atagcccatg actctcagcc ctttcttccc ggatggagct
     2161 agggcctgta tagccatatt attgtactag agtaagttct agacctaccc ttccactttc
     2221 tctagcaatt aaaggatgag ctatgggtag aactcagcta tgattaatta aaaactgatt
     2281 ggctctgagc tgtgcttggt ggcacacacc tgtaattcag cacccgggag gctgaatcag
     2341 acagatcctg agttggaggc catcctgggc tacaatagca aaaccctgtc tcaaaagcca
     2401 atacacacac acacatacac acacacacac acacacacac acagagagag agagagagaa
     2461 agagagagag agagagagag agagagagaa ctaatcagta ctgaacggat caagaaccac
     2521 ttcttgcttt tcctaaataa ttttctaaaa atagtccctc cagaatacta accttacttt
     2581 tacatggttt ctagtttcag cattccaact agggttctgc cagggagaca agagtctggg
     2641 gaaagataca ggaattctgg aagaatatac ctggctccta gaagggaagc tgagagggag
     2701 aaaatgccat ggtatgattg aacctgtgtc tgaacactta gctacctcag caggaattcc
     2761 ttccagatcc cttttaaagc tgaggacttt cgttctgata tggtatgctg catctgtgag
     2821 gtaaaggaga ggaggagaat caggaaataa aaggctagcc tgggctacct agtgaggtca
     2881 gggccagcct aggctatgtg agaccctgtc tcaaacaaca ggaagctaag gtctacaatg
     2941 agaataactc tagaattaaa aaggacaaat agggacacag ccttgactcc ccctcacagc
     3001 agagagaccc ccaactcagc aataagttca acttctccga gccctctaca ggtcaggctt
     3061 aggaaacgag gagcctcttg ggctcccaga cctcatatgt atccccagag cttctaacta
     3121 aatagaattt actttacttt acagctttta aacctcaggt gggttctaag tacccaaaaa
     3181 ggacctgaaa aacggagaaa gccatgggga acctctagta aaataggagg tagattctga
     3241 gtctagcaga tgtaggtgga aacgtctatt gaggtcctaa gggaggggct agtgctcaaa
     3301 gacaggtcac ttttcctcag gcccttttac ttctggcttg ttgcaagaga tgcccccctc
     3361 cctcatacaa accccgctca ggctccgccc atctcctggc actgctctca ggggacgggg
     3421 tctccacttc atgctttctg taattaaaga tgatttatac aaccgga
//
