LOCUS       NM_008002               4150 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus fibroblast growth factor 10 (Fgf10), mRNA.
ACCESSION   NM_008002
VERSION     NM_008002.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4150)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4150)
  AUTHORS   Ikeda,S., Sato,K., Fujita,H., Ono-Minagi,H., Miyaishi,S., Nohno,T.
            and Ohuchi,H.
  TITLE     Harderian Gland Development and Degeneration in the Fgf10-Deficient
            Heterozygous Mouse
  JOURNAL   J Dev Biol 12 (2), 16 (2024)
   PUBMED   38921483
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4150)
  AUTHORS   Chen,K.Q., Kawakami,H., Anderson,A., Corcoran,D., Soni,A.,
            Nishinakamura,R. and Kawakami,Y.
  TITLE     Sall genes regulate hindlimb initiation in mouse embryos
  JOURNAL   Genetics 227 (1) (2024)
   PUBMED   38386912
REFERENCE   4  (bases 1 to 4150)
  AUTHORS   Lozovska,A., Korovesi,A.G., Dias,A., Lopes,A., Fowler,D.A.,
            Martins,G.G., Novoa,A. and Mallo,M.
  TITLE     Tgfbr1 controls developmental plasticity between the hindlimb and
            external genitalia by remodeling their regulatory landscape
  JOURNAL   Nat Commun 15 (1), 2509 (2024)
   PUBMED   38509075
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4150)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 4150)
  AUTHORS   Bellusci,S., Grindley,J., Emoto,H., Itoh,N. and Hogan,B.L.
  TITLE     Fibroblast growth factor 10 (FGF10) and branching morphogenesis in
            the embryonic mouse lung
  JOURNAL   Development 124 (23), 4867-4878 (1997)
   PUBMED   9428423
REFERENCE   7  (bases 1 to 4150)
  AUTHORS   Beer,H.D., Florence,C., Dammeier,J., McGuire,L., Werner,S. and
            Duan,D.R.
  TITLE     Mouse fibroblast growth factor 10: cDNA cloning, protein
            characterization, and regulation of mRNA expression
  JOURNAL   Oncogene 15 (18), 2211-2218 (1997)
   PUBMED   9393979
REFERENCE   8  (bases 1 to 4150)
  AUTHORS   Tagashira,S., Harada,H., Katsumata,T., Itoh,N. and Nakatsuka,M.
  TITLE     Cloning of mouse FGF10 and up-regulation of its gene expression
            during wound healing
  JOURNAL   Gene 197 (1-2), 399-404 (1997)
   PUBMED   9332392
REFERENCE   9  (bases 1 to 4150)
  AUTHORS   Holmberg,M., Leonardsson,G. and Ny,T.
  TITLE     The species-specific differences in the cAMP regulation of the
            tissue-type plasminogen activator gene between rat, mouse and human
            is caused by a one-nucleotide substitution in the cAMP-responsive
            element of the promoters
  JOURNAL   Eur J Biochem 231 (2), 466-474 (1995)
   PUBMED   7543410
REFERENCE   10 (bases 1 to 4150)
  AUTHORS   Vainio,S., Karavanova,I., Jowett,A. and Thesleff,I.
  TITLE     Identification of BMP-4 as a signal mediating secondary induction
            between epithelial and mesenchymal tissues during early tooth
            development
  JOURNAL   Cell 75 (1), 45-58 (1993)
   PUBMED   8104708
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155244.2 and AC163743.6.
            
            On Oct 3, 2022 this sequence version replaced NM_008002.4.
            
            Sequence Note: An in-frame AUG is located 51 codons upstream of the
            annotated translation start site but is not being annotated as a
            start site since extension of the N-terminus would disrupt a
            potential signal peptide in the shorter form. Also, the upstream
            AUG has an overlapping uORF with a strong Kozak signal and would
            not be used for translation initiation.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048229.1, AK141633.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1049              AC155244.2         137713-138761
            1050-1153           AC163743.6         84636-84739
            1154-4150           AC163743.6         92249-95245
FEATURES             Location/Qualifiers
     source          1..4150
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 67.14 cM"
     gene            1..4150
                     /gene="Fgf10"
                     /gene_synonym="AEY17; Fgf-10; Fgf5a; Gsfaey17"
                     /note="fibroblast growth factor 10"
                     /db_xref="GeneID:14165"
                     /db_xref="MGI:MGI:1099809"
     exon            1..1049
                     /gene="Fgf10"
                     /gene_synonym="AEY17; Fgf-10; Fgf5a; Gsfaey17"
                     /inference="alignment:Splign:2.1.0"
     CDS             722..1351
                     /gene="Fgf10"
                     /gene_synonym="AEY17; Fgf-10; Fgf5a; Gsfaey17"
                     /note="keratinocyte growth factor 2; fibroblast growth
                     factor 5a"
                     /codon_start=1
                     /product="fibroblast growth factor 10 precursor"
                     /protein_id="NP_032028.1"
                     /db_xref="CCDS:CCDS26795.1"
                     /db_xref="GeneID:14165"
                     /db_xref="MGI:MGI:1099809"
                     /translation="MWKWILTHCASAFPHLPGCCCCFLLLFLVSSFPVTCQALGQDMV
                     SQEATNCSSSSSSFSSPSSAGRHVRSYNHLQGDVRWRRLFSFTKYFLTIEKNGKVSGT
                     KNEDCPYSVLEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEEN
                     GYNTYASFNWQHNGRQMYVALNGKGAPRRGQKTRRKNTSAHFLPMTIQT"
     exon            1050..1153
                     /gene="Fgf10"
                     /gene_synonym="AEY17; Fgf-10; Fgf5a; Gsfaey17"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..4150
                     /gene="Fgf10"
                     /gene_synonym="AEY17; Fgf-10; Fgf5a; Gsfaey17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2889..2894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf10"
                     /gene_synonym="AEY17; Fgf-10; Fgf5a; Gsfaey17"
                     /note="hexamer: AATAAA"
     polyA_site      2907
                     /gene="Fgf10"
                     /gene_synonym="AEY17; Fgf-10; Fgf5a; Gsfaey17"
     regulatory      4127..4132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf10"
                     /gene_synonym="AEY17; Fgf-10; Fgf5a; Gsfaey17"
                     /note="hexamer: AATAAA"
     polyA_site      4150
                     /gene="Fgf10"
                     /gene_synonym="AEY17; Fgf-10; Fgf5a; Gsfaey17"
                     /note="major polyA site"
ORIGIN      
        1 gacatttaga ctccaggctt caacctgttt acaagcggct ttccaaggga cttggaggtg
       61 gagagaaggg cccaacaaaa cgccagccgc cagccgcccc ccaaacaaga agtggctttc
      121 ggaagacttc acatcaacag gcaccaccaa aaagagaaag gaaggagaag acaacagcgc
      181 ctgggcagct gcctccagtt ctgacaactc caaagagaca ctttttaagt ggccagcagg
      241 ctgggactct gcagagaagg accagaaggt gccaaccgca gaggggcgca gatgtcttcc
      301 tgcaccccca ccccacccac tttgggtttt gttcaccgtc ctgtcatctg tttttcagac
      361 ctcttttgca tctaacatgg tgaagaaagg agtgaagaag agaacaaagt aacccccggg
      421 gggagcgaag agctctggtg accgacacca ccagttccta ctgccgcggc cacccacgtc
      481 cactgttcac cctgagactg gagagacgca ggcagcggat ccgaggacgg agcgaggaca
      541 ggcagccggt ccttcctaga agttatggat gttggtgcac tcgcttctgg ccagatccgt
      601 acccagaggg agctatccag aagccaccac ctccagctgt ctctctgcct cgcagcaggt
      661 cttacccttc cagtatgttc cttctgatga gacaatttcc agtgccgaga gtttcagtac
      721 aatgtggaaa tggatactga cacattgtgc ctcagccttt ccccacctgc cgggctgctg
      781 ttgctgcttc ttgttgctct ttttggtgtc ttcgttccct gtcacctgcc aagctcttgg
      841 tcaggacatg gtgtcacagg aggccaccaa ctgctcttct tcctcctcgt ccttctcctc
      901 tccttccagt gcgggaaggc atgtgcggag ctacaatcac ctccaaggag atgtccgctg
      961 gagaaggctg ttctccttca ccaagtactt tctcacgatt gagaagaacg gcaaggtcag
     1021 cgggaccaag aatgaagact gtccgtacag tgtcctggag ataacatcag tggaaatcgg
     1081 agttgttgcc gtcaaagcca tcaacagcaa ctattactta gccatgaaca agaaggggaa
     1141 actctatggc tcaaaagagt ttaacaacga ctgtaagctg aaagagagaa tagaggaaaa
     1201 tggatacaac acctatgcat cttttaactg gcagcacaat ggcaggcaaa tgtatgtggc
     1261 attgaatgga aaaggagctc ccaggagagg acaaaaaaca agaaggaaaa acacctctgc
     1321 tcacttcctc cccatgacga tccaaacata gaagaaaaca ctgttggtgg atgcagtaca
     1381 accaatgact ctttggacag aaagagatgg tatcctcact gaagactgta gctcaaaagg
     1441 caaagacata gccctgaatt cagcttgttt aaaggaagga aggctttgga tgtttttgta
     1501 ctcactgctg acatacaaag ttcttttcac tagctctgtg tcattgtgtc atgccttata
     1561 atcaagatag aggcaagtca agtttggatg gaagttatcc tcaagtgaac aatgttgtgg
     1621 tgggggctgg gctttttttg tttgtttgtt tgtttcattt ttaagttttt gtttttgaac
     1681 ttctgagata gaacttaaag aacatggaac actctgttga atgatctttg ggaaagttat
     1741 ttatggaata tgaacacata tcaaagactt tcattgctca ttcaagcctg atgattcaat
     1801 gagcagtaag acacgcaagc atttactgga aagcacttgg gtcatatcat atgcacaacc
     1861 aaaggagctt tgggtgtggc accatggaag aattggatca gatttacaaa tataaacata
     1921 gtagtatgaa actgtcctaa tacaaatagt atggtatgct tgtgcattct gtctccatcc
     1981 ttttctattt ccttctaagt tatttattta ataggatgtt aaatatcttt tggggtttaa
     2041 agagtatctt caatgctgcc ctctggttta ccttttctct ctctctctct ctctctctct
     2101 ctctctctct ctctctctct ctctctctct ctctctctct ctctctctcc ctctctctcc
     2161 ctccctcccc cctctggcac catacgcaca ttcatgacaa agtgttttaa aaccttggca
     2221 aacacttcag aaataggaga tgagatcaag gaagcagtat gaatgcccca tgcgctctca
     2281 gttgacttaa tttgcacttc tgcaataaaa aacaccagca atgactatgg cagaattctg
     2341 ctatagatta tgtaacagat atctgtcatc atttgtcaac atatatcagt ccagagggac
     2401 ccttacctta aaatgtagaa ggccaaattc tctttcattg tcttatttca tcttcaagaa
     2461 tatactaaaa gaagaaaaaa tgaattgtta gactaacatt gttgggtttt ttttttccta
     2521 ctgatgatgg cttgccacag gtcacaatgg caaatgatgc aaaggttatc tgcacataca
     2581 tgagcccttt gtaaggccca cagaatcctt ctccctcaaa agaaccaaaa aaggaaattt
     2641 ggtatgaagt gcaactctcc ctggggctta acctgagcaa atatatccta gtatatgagt
     2701 aaccatatac tgacacctgt tcaagctgaa tggtctagtc tttacagaac cacataaacc
     2761 ttgttttctg taaatttaaa atgttctaga aggttccata atataaccac attgaaattc
     2821 attttcttag aaaaggtata gaaagcagta tgtaagtgtg ccatgcaccc tcgctctgta
     2881 gatcactaaa taaacacgta agccttattt gcagtgtctg tagtgatttt aagaatgtag
     2941 gaaacacttc taaaaaaatt ttaaaggata actctgagat gatattgatg ctgcagtctt
     3001 ctttcttgtt tggaaatgtc tgtttatttt cattgtttgg attcagtatt ttgataggaa
     3061 caaaaagact caccaaatgt gtctgtttac taaaatttaa cctctagaga ggctagtgat
     3121 ttgtgatcct cttctaactt atttgtgctg atgcttgacc agtacaaatc agctttttaa
     3181 aatattatta ttaaaggttg atcagtcatt ttaaaattgg cctttttttt cagaatgttc
     3241 ctacaggtca taatttatga tttctttgaa aagcttgcat ttcaagagaa aagcacagag
     3301 gcacaatgct ttggtttatg ggtataggtt gcattttgtg gtgttctttc aacttgtttt
     3361 ctgacaaatg ggatttttaa aatgtatact tcttgtggtt ggattctgta tgttagagtt
     3421 taattggtaa ctgagtctaa aggctctaat gtaatgaatc tctagaagaa ctaggtatct
     3481 ttttttactt ttattttaaa ataataatta tacctgacac atgaccatgg accacccaca
     3541 accaaaatta aatgtttggg gagacaaact atagtattca gtgacaaggg taacagcaaa
     3601 tagtgcagac gttggattct tatttcactt tgccatttag attactaaag agactatgtg
     3661 taaacagtca tcattatagt actcaagaca ttaaacagct tctagcaaaa tgtatcaaag
     3721 cttgcagagt ccaaaaatag aaaacatctt tccccctctc ccaccctaca tttccccctg
     3781 tatgcatcct aacagagata aatacaaaat gaattcggta aggagagagg agattcttct
     3841 tcacttcata tttgtttgat attaatagag aattctggtc ctttttacaa ctactgaaag
     3901 aaaagaagtt cagtcctaaa ttttgtgtgt taaaaaaaga aaagattttg tgagttctgc
     3961 ctccgtggga agtgtgggca ctgctccacc atgctgaagt gtgttagcca cgggtacaga
     4021 gcatatgact gttgacatca gactccttaa agatacagaa tcgcttccct cctcctaatc
     4081 ctcaaaaggc tgaacagtgt atattatgtt acatttaaat aaaggcaata aaaatgctgg
     4141 gaaaagagaa
//
