LOCUS       NM_010197               3909 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus fibroblast growth factor 1 (Fgf1), mRNA.
ACCESSION   NM_010197
VERSION     NM_010197.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3909)
  AUTHORS   Cao,R., Liu,Y., Wei,K., Jin,N., Liang,Y., Ao,R., Pan,W., Wang,X.,
            Wang,X., Zhang,L. and Xie,J.
  TITLE     Genes related to neural tube defects and glioblastoma
  JOURNAL   Sci Rep 15 (1), 3777 (2025)
   PUBMED   39885289
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3909)
  AUTHORS   Khetchoumian,K., Sochodolsky,K., Lafont,C., Gouhier,A., Bemmo,A.,
            Kherdjemil,Y., Kmita,M., Le Tissier,P., Mollard,P., Christian,H.
            and Drouin,J.
  TITLE     Paracrine FGF1 signaling directs pituitary architecture and size
  JOURNAL   Proc Natl Acad Sci U S A 121 (40), e2410269121 (2024)
   PUBMED   39320918
  REMARK    GeneRIF: Paracrine FGF1 signaling directs pituitary architecture
            and size.
REFERENCE   3  (bases 1 to 3909)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3909)
  AUTHORS   Miura,T., Kado,J., Ashisuke,K., Masuzawa,M. and Nakayama,F.
  TITLE     Sustained activation of the FGF1-MEK-ERK pathway inhibits
            proliferation, invasion and migration and enhances radiosensitivity
            in mouse angiosarcoma cells
  JOURNAL   J Radiat Res 65 (3), 303-314 (2024)
   PUBMED   38637316
  REMARK    GeneRIF: Sustained activation of the FGF1-MEK-ERK pathway inhibits
            proliferation, invasion and migration and enhances radiosensitivity
            in mouse angiosarcoma cells.
REFERENCE   5  (bases 1 to 3909)
  AUTHORS   Liu,B., Hua,D., Shen,L., Li,T., Tao,Z., Fu,C., Tang,Z., Yang,J.,
            Zhang,L., Nie,A., Jiang,Y., Wang,J., Li,Y., Gu,Y. and Ning,G.
  TITLE     NPC1 is required for postnatal islet beta cell differentiation by
            maintaining mitochondria turnover
  JOURNAL   Theranostics 14 (5), 2058-2074 (2024)
   PUBMED   38505613
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3909)
  AUTHORS   Miyatani,S., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Takeichi,M.
  TITLE     Genomic structure and chromosomal mapping of the mouse N-cadherin
            gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (18), 8443-8447 (1992)
   PUBMED   1528849
REFERENCE   7  (bases 1 to 3909)
  AUTHORS   Cam,Y., Neumann,M.R., Oliver,L., Raulais,D., Janet,T. and Ruch,J.V.
  TITLE     Immunolocalization of acidic and basic fibroblast growth factors
            during mouse odontogenesis
  JOURNAL   Int J Dev Biol 36 (3), 381-389 (1992)
   PUBMED   1280156
  REMARK    Erratum:[Int J Dev Biol 1992 Dec;36(4):following 599]
REFERENCE   8  (bases 1 to 3909)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   9  (bases 1 to 3909)
  AUTHORS   Johnson,K.R. and Davisson,M.T.
  TITLE     A multipoint genetic linkage map of mouse chromosome 18
  JOURNAL   Genomics 13 (4), 1143-1149 (1992)
   PUBMED   1354640
REFERENCE   10 (bases 1 to 3909)
  AUTHORS   Mattei,M.G., Pebusque,M.J. and Birnbaum,D.
  TITLE     Chromosomal localizations of mouse Fgf2 and Fgf5 genes
  JOURNAL   Mamm Genome 2 (2), 135-137 (1992)
   PUBMED   1543906
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK035330.1 and AC132098.4.
            
            On Jan 18, 2007 this sequence version replaced NM_010197.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035330.1, U67610.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1733              AK035330.1         2-1734
            1734-3909           AC132098.4         80971-83146
FEATURES             Location/Qualifiers
     source          1..3909
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 20.74 cM"
     gene            1..3909
                     /gene="Fgf1"
                     /gene_synonym="Dffrx; Fam; Fgf-1; Fgf2b; Fgfa"
                     /note="fibroblast growth factor 1"
                     /db_xref="GeneID:14164"
                     /db_xref="MGI:MGI:95515"
     exon            1..153
                     /gene="Fgf1"
                     /gene_synonym="Dffrx; Fam; Fgf-1; Fgf2b; Fgfa"
                     /inference="alignment:Splign:2.1.0"
     exon            154..356
                     /gene="Fgf1"
                     /gene_synonym="Dffrx; Fam; Fgf-1; Fgf2b; Fgfa"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..655
                     /gene="Fgf1"
                     /gene_synonym="Dffrx; Fam; Fgf-1; Fgf2b; Fgfa"
                     /note="heparin-binding growth factor 1; aFGF; HBGF-1;
                     acidic fibroblast growth factor; fibroblast growth factor
                     1 (acidic); fibroblast growth factor 2b"
                     /codon_start=1
                     /product="fibroblast growth factor 1"
                     /protein_id="NP_034327.1"
                     /db_xref="CCDS:CCDS29204.1"
                     /db_xref="GeneID:14164"
                     /db_xref="MGI:MGI:95515"
                     /translation="MAEGEITTFAALTERFNLPLGNYKKPKLLYCSNGGHFLRILPDG
                     TVDGTRDRSDQHIQLQLSAESAGEVYIKGTETGQYLAMDTEGLLYGSQTPNEECLFLE
                     RLEENHYNTYTSKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD"
     exon            357..460
                     /gene="Fgf1"
                     /gene_synonym="Dffrx; Fam; Fgf-1; Fgf2b; Fgfa"
                     /inference="alignment:Splign:2.1.0"
     exon            461..3909
                     /gene="Fgf1"
                     /gene_synonym="Dffrx; Fam; Fgf-1; Fgf2b; Fgfa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3889..3894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgf1"
                     /gene_synonym="Dffrx; Fam; Fgf-1; Fgf2b; Fgfa"
                     /note="hexamer: AATAAA"
     polyA_site      3909
                     /gene="Fgf1"
                     /gene_synonym="Dffrx; Fam; Fgf-1; Fgf2b; Fgfa"
                     /note="major polyA site"
ORIGIN      
        1 agagctgcag aaatcctgag gctcagagag ccggctggag aggcagcttc agtccaggca
       61 ccctgtgaca gcgcaaaggc tgcccagcgg acttcattcc cgtcttgtga taaagtggag
      121 tgaagagagc cccccagcct gccagttctt cagtgctgag cctaccaccg ctgcttgctg
      181 ccgagccatg gctgaagggg agatcacaac cttcgcagcc ctgaccgaga ggttcaacct
      241 gcctctagga aactacaaaa agcccaaact gctctactgc agcaacgggg gccacttctt
      301 gaggatcctt cctgatggca ccgtggatgg gacaagggac aggagcgacc agcacattca
      361 gctgcagctc agtgcggaaa gtgcgggcga agtgtatata aagggtacgg agaccggcca
      421 gtacttggcc atggacaccg aagggctttt atacggctcg cagacaccaa atgaggaatg
      481 tctgttcctg gaaaggctgg aagaaaacca ttataacact tacacctcca agaagcatgc
      541 ggagaagaac tggtttgtgg gcctcaagaa gaacgggagc tgtaagcgcg gtcctcggac
      601 tcactatggc cagaaagcca tcttgtttct gcccctcccg gtgtcttctg actagaggag
      661 tctgttctga gtgttctcta ttttggttga ccctaccatg ttcccttgac cattggctgc
      721 gctaaccctc aggccacaga gcctgaattt gtaagcagtg cttctaaaat agccagttca
      781 cttttctgct gagcccttcc ccaccacccc agcacaattt ggaacacagg gaccaaattg
      841 cttcaagagg acaactggct ggccagtcta ggtctgggtt tggatatccg gatgcctcag
      901 ggcacctgct acaagctgga cctggtgatg caaagttggg ggccatacga agcattcaaa
      961 ggggtctaag aagtgggttc ttagaaagat acccactgca tgctctttcc ccttctgagc
     1021 aatccctggt tttaagcacc ccaggcaatt agcatgacta cccttccccc taccagaacc
     1081 gcacaaatat cagtaaagca accggtagtg aggctgaagg aatttcatgg tagagagaac
     1141 cccccccccc cagcccccac atatggacaa gacttaaaac caaaagggag tgtggcgttt
     1201 ccgggacagc ctagaagcat gggatctcgg aacagagtaa gaaggcaaga gtcagccaca
     1261 gggagtcagg atgagcccac agcccagcag ttatcaccaa gttaccaagg aaacgtccac
     1321 agtcagggaa agagccccgg aaatggtttc ttagtaatgg caagcacaga gatctggggt
     1381 ctgaagagtg ggcgtaggag caaggagaca ggatgtcttc agccgtggat gttagcctct
     1441 aaaaaggaag atgttagacg ggaggaggag gagagaaaaa gtaatatcac gtcactgtgt
     1501 gcttggccac cacgaaactg gggttgtggg ggtcccagta cgatggcccc aaatagccca
     1561 tacattcaga tcatctgtat tcagattcat ttgtatgact gtgaaacctg atttggtggg
     1621 gctggtgtgg gggaggtctg tgtcttgaaa ggcccgcaag tcccatagat gctgctggct
     1681 tccccaccat gctttcaaga gcagccccag agaatgctgt tcaaatgaag gttgctcaga
     1741 cttcaccctc ttttacctcc agtgcccggg ttttcctgag tatccatcca ggcagtgtcc
     1801 atagttagtg aagcatggtt tcaaggcacc ttggcccagt gcctataaaa tgcccactca
     1861 gaaatcactg aaaccgtact tcaaaaaaaa atgttgaacc tcaccaaaag ctttctccca
     1921 agagaccatt tctgttacca ttaattcttc aaactggctt cctccttaaa gtaaacctgg
     1981 cccaagtgcc cagcaaatta gaaacactat tcatctctga cataggacac aaacgccatg
     2041 agaaggcctt tcatacgcca atttaatata ctgtgagact tatcttctcg ttgcttctta
     2101 tatagcttga aggcattaaa tagattcaca atcagccaca gaggataata acagcctaga
     2161 atgtaaaagc tacttagtta tctaacatgc tacattcatt catgaggcct ttcctctttg
     2221 tcttccactg tgctttaaga atgggtatct aggggctggt gagatgggac aggagttcag
     2281 ttcctagcat tcacagtgtg atgctcagac ccaattctaa ctccaactcc aggggtactg
     2341 catacacatg tacaaaccca cactttttca gaaatataaa ccaataatat ggttgtggat
     2401 taaaactgat gactgtgttc atttgtttga cagggatcta aagtcattat ttgctggaaa
     2461 aaaatcctta tagcaacact gtcatatctt agcacagaag tcagatgaca ctcttgagag
     2521 ttcagagtgc taatggggga actaaaccga gctatttcaa tacatgatta ataataatgt
     2581 tctttcagat gtggggatga acacctttaa tcccagcact caggaggcag aggcaggtag
     2641 atctatgtaa gactgaggct aacctggtct ccacagtgag ttcctgggca gccaggggta
     2701 tatagaaagg ccccgtatct tttttttttt taatcataat aatgttttgc ttttttacaa
     2761 aaagatgatt catggctttt taaagtctat aacttaaata tgtttctgtt ttgtttcagt
     2821 aaatcgtagg cacactggag ataatacagt atggtttccc atgtctttat ataaagattt
     2881 ggcccagaaa agtgtacaga gatgaaatct aggatattta gaatagtggg tagtttttta
     2941 tcaaatgaac ccaaacacaa gtataaccct gatcaagaca aattaaaaac cactgcacaa
     3001 ggatgaaatg aagtctgaga ccccagagac tcaaagcact gatgatggtc attgtagcct
     3061 taaccgtcaa cctagtcacc atccgggtat ttgctcaaca tatactgcag acccaatgtg
     3121 tgtcaggcac tggatatggc ccctggggac aatgtctgtc agctgtcctc tctctgggca
     3181 tatatttgtc aagagagatg ctatggattc atttccttca gtcacgtcaa aacatggact
     3241 tcatagtttc ctactgaatc aacagtatgt tctagaaacc ctcaacggtc agtcacacca
     3301 ccccaccccc aacaaagtga cagagacagg ctttgccaag taaacccagg gctttcaatg
     3361 ttagtcctct cagaggagtg gagtagtttc aaatcaggaa ggaaaaaaca aacaaaaaag
     3421 ctgtcggatc ttgcagaaag ggagcagaga gactgtccct gtgctggtgg gagcactgat
     3481 cataggaaca ttcggttgtg tacgaagtcc caagaccatc tgcttgtcac atgcctcctg
     3541 tatgcactca attccaagct gactgcaacc tggtgtctaa cactcactac gaactgtgag
     3601 gagcatatgg gcttttgaca attagtgaca cagtagatat ggagctgggt gtatcccctg
     3661 atggccagca gtgtgcccct acagaaatcc taactggtac atcagctgcc attgaagacg
     3721 aggcccctgc tttgtgttga aggcagtgga gcccgagtcc tcagctctgc agagaacacc
     3781 gcctaaaagc aatcacggtc gctggctgca aagcaggctc tgatggagac gacgcctgac
     3841 attcactctg cacccatact gtattacact ctgcacctta tcaatattaa taaatgttgt
     3901 attaatggc
//
