LOCUS       NM_053072               8061 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus FYVE, RhoGEF and PH domain containing 6 (Fgd6), mRNA.
ACCESSION   NM_053072
VERSION     NM_053072.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8061)
  AUTHORS   Vezzali,R., Weise,S.C., Hellbach,N., Machado,V., Heidrich,S. and
            Vogel,T.
  TITLE     The FOXG1/FOXO/SMAD network balances proliferation and
            differentiation of cortical progenitors and activates Kcnh3
            expression in mature neurons
  JOURNAL   Oncotarget 7 (25), 37436-37455 (2016)
   PUBMED   27224923
REFERENCE   2  (bases 1 to 8061)
  AUTHORS   Steenblock,C., Heckel,T., Czupalla,C., Espirito Santo,A.I.,
            Niehage,C., Sztacho,M. and Hoflack,B.
  TITLE     The Cdc42 guanine nucleotide exchange factor FGD6 coordinates cell
            polarity and endosomal membrane recycling in osteoclasts
  JOURNAL   J Biol Chem 289 (26), 18347-18359 (2014)
   PUBMED   24821726
  REMARK    GeneRIF: FGD6 coordinates cell polarity and endosomal membrane
            recycling in osteoclasts.
REFERENCE   3  (bases 1 to 8061)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   4  (bases 1 to 8061)
  AUTHORS   Rout,U.K., Krawetz,S.A. and Armant,D.R.
  TITLE     Ethanol-induced intracellular calcium mobilization rapidly alters
            gene expression in the mouse blastocyst
  JOURNAL   Cell Calcium 22 (6), 463-474 (1997)
   PUBMED   9502196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044341.1, AK173157.1 and BF464747.1.
            
            On Nov 20, 2007 this sequence version replaced NM_053072.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173157.1, BC139019.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AK044341.1         2-161
            161-8043            AK173157.1         1-7883
            8044-8061           BF464747.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..8061
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 48.76 cM"
     gene            1..8061
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /note="FYVE, RhoGEF and PH domain containing 6"
                     /db_xref="GeneID:13998"
                     /db_xref="MGI:MGI:1261419"
     exon            1..310
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            311..2642
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2790
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2858
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..2889
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3041
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3042..3198
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3199..3286
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3287..3337
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3396
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3397..3468
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3469..3537
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3621
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3622..3701
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3702..3804
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..3948
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3949..4051
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            4052..4179
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            4180..4308
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            4309..4457
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            4458..8044
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8023..8028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /note="hexamer: AATAAA"
     polyA_site      8044
                     /gene="Fgd6"
                     /gene_synonym="Etohd4; ZFYVE24"
                     /note="major polyA site"
ORIGIN      
        1 aagttgaggt ggggcgcgcg tccgcgaagc cgctgcgatc tcctctcgtg cgcgcgcctg
       61 gcgatcgtcc cggagcgcgg cggagcggcg ctcgtgcacg tccccctgtc gctggccgct
      121 agcgcccggg tccgccggag ggtcgcggga gccggcgtcc gtcctttgtg aggcgctcag
      181 gcggtgcggg acggaatgtg ggcgctgcgg ggacttttgt cttctgctca aactctgggg
      241 agtgtggact gaacgggagc catggactga gggcgtgagc cgcgcggggc agtcatgact
      301 tctgccgcgg agcttaagaa gccaccattg gctcccaagc caaagttagt ggggaccaat
      361 aataagccac ctccccctcc tattgcacct aaaccggaca ttggcagtgc tagtgttcca
      421 cggttaacga agaagaccaa accggcaatt gcgccaaaac caaaagtccc gacaaactca
      481 gttgttcaag acattaagca tccaccctca aagaaaccta ctttgaacct ggaggaaagg
      541 gagccagaat tacccgagag cactggcaag tctaattgca aggatgtcag ggatccacac
      601 agtgattata ttttaccaac gtgttcctgc agttctgggt gtattcacga gcctaggact
      661 cgagaaaccc agtgtgtaga gcagcttgtt ttagagcctc tgggaatgaa ggaaaattta
      721 gagaatagta aaaatggtga gtcctcaaaa agggggagta gctgggattc aagcagcgaa
      781 aagtgccggg gccagagtgg agttgtttta aaggcaagca tcttagaaga gaagctcaaa
      841 gaggtcctga cgcagcagcg atcaccttgt ggttccccgg ggaggcacag agctccaaaa
      901 aaaccagaaa tgaatggtga ccatagttgc accaggcaga tcagaattga atttgcagat
      961 gtgtcttctt ccctgaccgg ctttgaaaaa gttcccgctc atcacaactg ccacccacaa
     1021 cttcctaggg atgaatctca gactctcaag acttgtcaag atggcagtgc agagagccgt
     1081 ggtcacactg attcatgtga accggagaac aaaagagtgg cttcagatgg aattagtcag
     1141 aagacagagg tcaaaggtct cggtccttta gaaatccact tactaccgta tacctcaaag
     1201 tttccaactc ccaagcccag gaagacacac gcagctgctc gtcttcgccg ccagaagcat
     1261 gtagatactc ctggtgaaag cactgaagag ccagggaact caaacaatgg ctcttcttgc
     1321 ctcctggagg attattgttt gaaaaacaat aaagtcagtg ttcttcgtca gaatgctttg
     1381 tataaccagg gaccagtgga cgaggtgagg ccagcaaacc agagggcact gacaggggat
     1441 tccaacagtg gcggacagga ctcagtcggc tcacagaaag ctgtgcagca gcaaacgcct
     1501 tctttagata cagattctag tttgacttct gacagcagtg gttctggcgt gtcacctgct
     1561 gtggacaaag agactactta cacacagtgc agtactcagc ctttgagctt gcctaagcaa
     1621 gtcacatcag cctgcactga ccagccacca gctacctgta acccggaagt gtcagctcct
     1681 cccatacaaa aggaatcttc ctcctcgaga atcattccca aaaaacctca aagacacagc
     1741 ttgcctgcag caggggtgct taaaaaggct gcttcggagg agcttgtaga aaagagctct
     1801 tcaggtaagg agacaaatgt cgagaaaggt ctgcacagaa actaccttca ccatccgggg
     1861 cccccaaacc atggcgcgtc agcatcaccc tttgatatgc ccaacccgac ttcagagaag
     1921 ccagtgtgga agttacctca tcctattcta cctttttcag ggagcccaga ggccttgaaa
     1981 cgcgtcactt tatccttaaa taacgagcct tccgtttccc taaccaagcc aagagcaaaa
     2041 tccctgtctg ccgtggatgc ggaccggtgt aacaagcctt gcaaagaccc tccgaagaaa
     2101 acttctttta aaaagttgat caatgtgaaa ctgtccattg gcttcataaa gagcgacttt
     2161 cagaaaatta ggtcgaaaag ctgccaacac ggggatgtct ctgcaggaca tccgctcgct
     2221 agagagccaa aaggacttga aagtgattgg caaggtttgg ctacaggaga agagaagaga
     2281 agtaagccca cgaaggcaca ttctgcagaa aactgcagcc tggaatctca aaaggtgaag
     2341 tcctggggcc agagcagtgc agttaacggt cagagggcgg agtctttgga tgaccggatt
     2401 ctctccaggc acacgtcctg tacaggcgac ttcgggccag agtatgaaaa tgtccgccat
     2461 tatgaggaga tacccgagta tgagaatttg ccctttgtca tggctggaag gaacactccg
     2521 gacttgggat ggcagaactc cagcagtgtg gaggacactg atgcaagtct atatgaagta
     2581 gaagagccct acaatgctcc agatggccag ctgcaacttg atcctagaca tcagccttgc
     2641 agttctggaa catcccagga ggggaaggat gctctccatc ttggcctcag tgacctgcct
     2701 tctgatgagg aagtcatcaa tagttctgat gaagatgatg tcagctccga gtccagtaaa
     2761 ggcgagccag accccctgga ggataaacag gatgaagatg ctgggatgaa aagcaaagtt
     2821 catcatattg ccaaggagat catgagctcc gagaaagtgt ttgtggatgt gttaaagctt
     2881 ttgcatattg acttccgggg tgctgtagcc catgcatcca ggcagctcgg gaagcccgtg
     2941 attgaggacc ggatccttaa ccagatcctg tactacctgc ctcagctgta cgagctcaac
     3001 cgggatctcc tgaaggaact ggaagagcga atgctcacct ggacagaaca acaaagaatt
     3061 gctgatatct ttgtaaagaa ggggccatac ttaaaaatgt attccacata catcaaagaa
     3121 tttgataaga acgtagcttt gctggatgag cagtgcaaga aaaatccagg atttgctgca
     3181 gttgtcagag aattcgagat gagccctcga tgtgccaacc tggccctgaa gcactacctg
     3241 ctaaagccag ttcagaggat ccctcagtac aggctgctac tgacagatta cttaaagaac
     3301 cttctagaag actctgtaga tcacagagac acccaagatg ccctggctgt tgtcatagag
     3361 gtagctaacc atgccaatga caccatgaag caaggggaca actttcagaa gctcatgcag
     3421 attcagtaca gcttaagtgg acaccatgaa attgtgcaac ccgggcgggt ttttcttaaa
     3481 gaaggcaccc tgatgaagct gtctcggaaa gtcatgcagc cccggatgtt tttcctgttt
     3541 aacgatgctc ttctctacac cacacccatg cagtctggga tgtacaaact gaacaacatg
     3601 ctctcgctgg ctggaatgaa ggtcagaaaa cctacccagg aggcatatca gaacgagtta
     3661 aagattgaaa gtgtagagcg ttctttcatc ctctcagcta gttctgccgc agaaagagat
     3721 gactggctgg aggccatatc cagctccata gaagagtatg ccaagaaaag aatcacattc
     3781 tgccccagca ggagtcttga cgaggactca gaaaggaaag aagaagttag ccccctcggg
     3841 gcaaaggctc ccatctggat cccagacacc agagccacca tgtgtatgat ttgcacaagt
     3901 gaattcaccc tgacctggag aagacaccac tgcagggcct gtgggaagat tgtgtgccaa
     3961 gcttgctcat caaacaagta tggcttagat tacctgaaag ggcaactggc aagagtgtgc
     4021 gagcactgct tccaagagct acagaaatta gatcaccagc tgtcgcctag ggttgggtct
     4081 cccggaaatc acaagtctcc ttcaagtgcc ttgtcgtcag tcttacatag catcccgtca
     4141 gggaggaagc agaagaaaat ccccgctgct ctcaaagaag tgtcagcaaa cacagaagac
     4201 tccactatga gcggctacct ctacagatcc aagggcagta aaaagccatg gaaacactta
     4261 tggtttgtca tcaaaaacaa agtactctac acatatgctg caagcgagga cgtggcagct
     4321 ttggaaagtc agcctttatt aggcttcacc gtcactctag tcaaggatga gaactcagag
     4381 tctaaagtgt ttcagctgct gcacaaaggc atggtgtttt acgtatttaa ggcagacgat
     4441 gcccactcca cgcagaggtg gatagacgca tttcaggaag gcacagtatt gtagcagcac
     4501 tggctgcctt tcctctgggg ttccaacgag gtggaggtgc agcagaaagg attaaaaact
     4561 gctcaaaagc cgtgcaagaa tgaacactgc cgagacaaat ccgcccacag tcgttatgag
     4621 atagattgtt ttgttaggta tatatatagt tcctaaaaat gtttttcatg gatgttattt
     4681 attaaaatgt tgatgtttac tttctggtca taactgtttc tgagactcac actgaattct
     4741 aaagtactgt ttagcgcctg ggaacttact gtaatgctgt attctgtgta ccatggatga
     4801 tgtgccgtcc acactgctgt ctctgcctta cgtcatgaca ctctgactga tgggaaagct
     4861 ttgcacgtaa agcacacata ctaagtagca aatttccata cagtggttgg ttataaatta
     4921 caattttaaa actgctgatg aaaatgagta ttttcgagtc actaaactta ggtggaactg
     4981 tttatattgc agtagagatg cacattaccg gcttctacct cagcaactgt gaaatgaagt
     5041 cccagcagag tcagtactga taacgttgtc cacagccccc cagactccca caccccatag
     5101 gatcttgcca gttggcctcg aactaagtgt aggcaaagca tgagctgcag tcttcctgcc
     5161 tcaaactcta agcaacttga gtcccaggcc tgtaccacca tgtccagtct ttatttaaaa
     5221 ccgccagatc agtgtcaatg tgatttttct cttcattttc tgagacagaa gctcactttg
     5281 gaacccagac tggcctggaa cttgcgtaac ccatgccacc ctgtgaccca tggtttctca
     5341 actgctagga ttacatgtgt gtgccaccaa gctcagtaat taatgtctta aaaaacagaa
     5401 tatagcaggc aacatgttac ctaataccct ctattattct taagagtttt gaggccaagt
     5461 cagtgatggt atttctatct aaaaggatgt cacattttct gcaacatgta ttttacaagt
     5521 ggttcgaaac cactactctt ttttttttta aggaaatttt atgctacttt gattcattcc
     5581 ccttgacatt taaagtgtcg tcatcgacgt tgtcttcctc ctcttcctcc tcttcttctt
     5641 ccccctctct cttctctttt cctccccccc caacccccgc ccctctttgc cccttttgag
     5701 acagggtcct tccaagcagc ccaggctggc ctgaggctca ccgccccacc tcagctccta
     5761 catcctagga ctttagatga gtgctgccac tcggacctta ccagtcagtg ttcctcagta
     5821 gttaaggttc atgttcttaa ttctgacgtg cttactgttt aacatgcaaa cccacttgca
     5881 cgtaaagttg ttaattagca gcaggagatg aagttatgct taaagttgca tcagtgttta
     5941 aatattttgt tcactaagtt taaactgtca gctaagagac agggttatct ataaaatatc
     6001 ctattaaagg ctgcaggcat ttcccacttc gttatctgtg attcttagtg tgagatcagt
     6061 ggtagagaat tatattctgg atactatttt ttcatcctga acacattcgt gaggcctttt
     6121 ggatgccgtt tgctgcagat acagcagatc tagaggtagc aggtccagtt tttcttggat
     6181 gtctctggct atggcataat ttgaagccct gtgcaatttc ccagaaccct ataccctacc
     6241 ttccttgtca cggggaacaa atcagttctt ccaaacatat ttcagttgga tcacataacc
     6301 gttttccacg tgagcgtctg catagcgttt gttgacataa cctgtataga tcggttttcc
     6361 ccgacggccc ttgttttctg cagtaagaag cttgattcct tgagtattta ctgatttttt
     6421 tttctaaacg atgtcagaca cccccacttt gatttctaac acaatggaat ggcactgagg
     6481 aaaacaactg ggaagtatgt ttttgttagg cagatacata gtaggctgtg gagggatgga
     6541 ggagccttct attcgagaac ctaatgtcat cgccatatgg gggtatgcct taaacgtact
     6601 tccactgtgc tcactgtagt caaaaatgct ggaatttcca gaagtcaacc ctacctcact
     6661 gcacgccacg atccttaagg atagatacca tatttattct ctgcatttct cctggatctt
     6721 tgcagcttta gttgaataca ttgaagacag gcttcccaaa ggggttttgc cttaagtaag
     6781 aatctcactg ttttcccagg acagctcctg ctgacatctc cttagggtgt caccctgcct
     6841 gactcagtac aatacccagc tacccctgat gtcgtctcca aagcccccct gatccactct
     6901 ctcctcaccg cccttcaagc ccacatccag ggcaagacta gcacccagct ttcttcccgt
     6961 tcaagtctgt tttcttcagg acaccacctg gacctctggg atcgaactct gagtctctct
     7021 tgtccttacc atcttcattc ttccactgtt acaccccctt atgggtgcta cagctttccc
     7081 tctgagctgc agtaacactc acttgcctgc tatgcagtgc tatgtagaag gccctgggtt
     7141 caagccctta tctaggaaaa caaccgtgtt ttgttttgtt tttccttccc gattacaacc
     7201 cctctttctg tgtagtctat ttcaggcatt gcaaagcaat ctgcattact gtagaattct
     7261 gatttaatcc caatgcctgt gaacttcagt ggcattccca atggtttggc ctgcttcagc
     7321 ctttctcaca ccagtcagcc cagctctgcc ccttgttatg tgacacttcc cagtgatggg
     7381 atcctgttct tctgtccttc agactgtttg tgctcttttc cctggttcct gtagtcgtca
     7441 gctcataaac actctcacca ttcctactgc attctgttct tgaaaacact tcgccttgct
     7501 cactggagtt ggcccacatc caacaagaat gtcttacatg cagtggataa atgcttgctt
     7561 gtctagttag atgtctcctg tgggtccctg aaaaatatct tcggtacacg tgctctggag
     7621 cctatgccac ttttaatgtt attttctaaa tgaaaatcta tggtgttttc ccttctagga
     7681 aacgttagtt actactggga aaggattcta agaaaggaga caggtttatt taccacacag
     7741 tgaagacagc agtggttctg atgggagttt gcctgctaga aaaaagaagt taaaggtggt
     7801 aggagctttt aaaagactaa atatcaaaat atctttttca tggagcaatt tgctgcatgt
     7861 aaaaaccgat ttcagaaaag aaattaatca cttttaatgt ttttcacaaa ataccttttt
     7921 tttacataaa gtgataatgg tttgtatctt actgttcata agatcattta taaataaaaa
     7981 tagcattgta aataatgtta atatgtatta taattcatac aaaataaatg tactgtaata
     8041 tctaaaaaaa aaaaaaaaaa a
//
