LOCUS       NM_172731               6023 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus FYVE, RhoGEF and PH domain containing 5 (Fgd5), mRNA.
ACCESSION   NM_172731 XM_006506001 XM_488524
VERSION     NM_172731.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6023)
  AUTHORS   Zhang,T., Zhao,C., Li,Y., Wu,J., Wang,F., Yu,J., Wang,Z., Gao,Y.,
            Zhao,L., Liu,Y., Yan,Y., Li,X., Gao,H., Hu,Z., Cui,B. and Li,K.
  TITLE     FGD5 in basal cells induces CXCL14 secretion that initiates a
            feedback loop to promote murine mammary epithelial growth and
            differentiation
  JOURNAL   Dev Cell 59 (16), 2085-2100 (2024)
   PUBMED   38821057
  REMARK    GeneRIF: FGD5 in basal cells induces CXCL14 secretion that
            initiates a feedback loop to promote murine mammary epithelial
            growth and differentiation.
REFERENCE   2  (bases 1 to 6023)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6023)
  AUTHORS   Xu,Z., Lang,D., Wang,D., Hu,S. and Yang,L.
  TITLE     LncRNA FGD5-AS1 Promotes Abdominal Aortic Aneurysm Growth Through
            the Activation of MMP3 in Vascular Smooth Muscle Cells
  JOURNAL   Int Heart J 64 (3), 470-482 (2023)
   PUBMED   37197924
  REMARK    GeneRIF: LncRNA FGD5-AS1 Promotes Abdominal Aortic Aneurysm Growth
            Through the Activation of MMP3 in Vascular Smooth Muscle Cells.
REFERENCE   4  (bases 1 to 6023)
  AUTHORS   Konturek-Ciesla,A., Dhapola,P., Zhang,Q., Sawen,P., Wan,H.,
            Karlsson,G. and Bryder,D.
  TITLE     Temporal multimodal single-cell profiling of native hematopoiesis
            illuminates altered differentiation trajectories with age
  JOURNAL   Cell Rep 42 (4), 112304 (2023)
   PUBMED   36961818
REFERENCE   5  (bases 1 to 6023)
  AUTHORS   Kobayashi,M., Wei,H., Yamanashi,T., Azevedo Portilho,N.,
            Cornelius,S., Valiente,N., Nishida,C., Cheng,H., Latorre,A.,
            Zheng,W.J., Kang,J., Seita,J., Shih,D.J., Wu,J.Q. and Yoshimoto,M.
  TITLE     HSC-independent definitive hematopoiesis persists into adult life
  JOURNAL   Cell Rep 42 (3), 112239 (2023)
   PUBMED   36906851
REFERENCE   6  (bases 1 to 6023)
  AUTHORS   Sawen,P., Eldeeb,M., Erlandsson,E., Kristiansen,T.A., Laterza,C.,
            Kokaia,Z., Karlsson,G., Yuan,J., Soneji,S., Mandal,P.K., Rossi,D.J.
            and Bryder,D.
  TITLE     Murine HSCs contribute actively to native hematopoiesis but with
            reduced differentiation capacity upon aging
  JOURNAL   Elife 7, e41258 (2018)
   PUBMED   30561324
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6023)
  AUTHORS   Gazit,R., Mandal,P.K., Ebina,W., Ben-Zvi,A., Nombela-Arrieta,C.,
            Silberstein,L.E. and Rossi,D.J.
  TITLE     Fgd5 identifies hematopoietic stem cells in the murine bone marrow
  JOURNAL   J Exp Med 211 (7), 1315-1331 (2014)
   PUBMED   24958848
  REMARK    GeneRIF: Fgd5 identifies hematopoietic stem cells in the murine
            bone marrow.
REFERENCE   8  (bases 1 to 6023)
  AUTHORS   Cheng,C., Haasdijk,R., Tempel,D., van de Kamp,E.H., Herpers,R.,
            Bos,F., Den Dekker,W.K., Blonden,L.A., de Jong,R., Burgisser,P.E.,
            Chrifi,I., Biessen,E.A., Dimmeler,S., Schulte-Merker,S. and
            Duckers,H.J.
  TITLE     Endothelial cell-specific FGD5 involvement in vascular pruning
            defines neovessel fate in mice
  JOURNAL   Circulation 125 (25), 3142-3158 (2012)
   PUBMED   22661514
  REMARK    GeneRIF: A new endothelial specific gene named FYVE, RhoGEF, and PH
            domain-containing 5 (FGD5) plays a crucial role in vascular pruning
            in a murine model.
            Erratum:[Circulation. 2012 Sep 18;126(12):e194]
REFERENCE   9  (bases 1 to 6023)
  AUTHORS   Kurogane,Y., Miyata,M., Kubo,Y., Nagamatsu,Y., Kundu,R.K.,
            Uemura,A., Ishida,T., Quertermous,T., Hirata,K. and Rikitake,Y.
  TITLE     FGD5 mediates proangiogenic action of vascular endothelial growth
            factor in human vascular endothelial cells
  JOURNAL   Arterioscler Thromb Vasc Biol 32 (4), 988-996 (2012)
   PUBMED   22328776
REFERENCE   10 (bases 1 to 6023)
  AUTHORS   Narumiya,H., Hidaka,K., Shirai,M., Terami,H., Aburatani,H. and
            Morisaki,T.
  TITLE     Endocardiogenesis in embryoid bodies: novel markers identified by
            gene expression profiling
  JOURNAL   Biochem Biophys Res Commun 357 (4), 896-902 (2007)
   PUBMED   17462595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN446877.1, BB612302.1, CB246280.1, CX568970.1, BC060664.1,
            AK086031.1 and AW046885.1.
            
            On or before Jan 27, 2016 this sequence version replaced
            XM_006506001.2, NM_172731.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220153.1, SRR10223969.6874.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                CN446877.1         1-28
            29-379              BB612302.1         1-351
            380-814             CB246280.1         198-632
            815-924             CX568970.1         159-268
            925-5329            BC060664.1         1-4405
            5330-5980           AK086031.1         1453-2103
            5981-6023           AW046885.1         1-43                c
FEATURES             Location/Qualifiers
     source          1..6023
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 41.0 cM"
     gene            1..6023
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /note="FYVE, RhoGEF and PH domain containing 5"
                     /db_xref="GeneID:232237"
                     /db_xref="MGI:MGI:2443369"
     exon            1..78
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..4610
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /codon_start=1
                     /product="FYVE, RhoGEF and PH domain-containing protein 5"
                     /protein_id="NP_766319.3"
                     /db_xref="CCDS:CCDS20371.2"
                     /db_xref="GeneID:232237"
                     /db_xref="MGI:MGI:2443369"
                     /translation="MHRADSPKPPLAPKPKVATNPYAPAAKFPPSQRPDSFPSPNSMS
                     RGPKPPIAPKPRLTGPSEYLNNSLGKCSNGRLLCEDRGLYDGHHSTLNCLELEPDEQY
                     IMVPRAPQKEDTPVDGATEEPGFEGEVQEHGTEQTGTEGDLEAPDEEAPSRDSEEGMV
                     HALEDEDCDHDPETDGTPTSPDEGAPSRDSEEGEEDCDQGPGMEEHPMSEEEGEEEEV
                     KEHVYNSDNRAPWDGEEPFPNEVILTHVRSQSPEVPCWEPGPPETPGEAEEDCEDICN
                     NTEPGKPNQDTGQDTEDAGMGSPESEVSPDVQEQEAATDNPEVFEEDSADAAEGEDQI
                     EQEEPPNCDEEAYNRDAAAATMQVGEDLGEEGDHVQEDPAEESCQIIPFESDSVEEDF
                     SPTLTENPYEIFPTESTSFCNNTYSLDESANGHEPVCEICVEEVPGVGPPLNQHDSLP
                     DGSGEDSPVVPDVVVVPENEGPVDDALSSPYVMGVGLLSLGEGAQSDTQAASGTLSGY
                     STWEEGDSEGGQVPVDRKNIATRARPHSGKVAGHVPETVLEETGPETCSSGMGIRDTS
                     DEVRKIGILPEGKPPECVRALPAKPRAFTLYPRSFSVEGRESPLSMFREPEGAGLDSH
                     RVRRKEDNLSLPGAIGSSGSFSQRSHLPSSGTSTPSSVVDIPPPFDLACITKKPITKS
                     SPSLLIDGDTLEKASKKKKSSFKRFLELTFRKKTESKVHVDMNLSSSRSSSESSYHGP
                     ARVLELDRRSLSNSPQLKCRTGKLRASDSPAALIFYRDSKRKGVPFSRTVSRVESFED
                     RSRPPFLPLPLTKPRSISFPNADTSDYENIPAMNSDYENIQIPPRRPVRTGTFTKLFE
                     EQSRALSTANENDGYVDMSSFNAFESKQQSSEQEAESAYTEPYKVCPISAAPREDLTS
                     DEEQGSSEEEDSASRDPSLSHKGEGQSRALVIAQELLSSEKAYVQMLQHLSLDFHGAV
                     LRALENVEQEGREPLAQEELRQGLRELPAICDLHQGILESLEQRLGDCGEGQPQVADI
                     FLAQEQEFEHHAAHILQFDRYLGLLAESCLLSPRLATTVREFEQSSQGGGQSMKHRML
                     RVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQSALTLISKVTDRANESMEQGENLQKLV
                     HIEYSVRGQGDLLQPGREFLKEGTLMRVRGKSRHPRHLFLMNDTLLYTHPQKDGKYRL
                     KSSLPVANMKVSRPVMDKVPYALKIETPESCLTLSASSCAERDEWHYCLSRALPEDYK
                     TQALAAFHHSVEIRERLGISLGERLPTLVPVTHAMMCMNCGCDFSLTVRRHHCHACGK
                     IVCRNCSRNKYPLKCLKNRMAKVCDGCFRELKLRNGPVPGSMRERPVSMSFPLSSSRF
                     SSGSALSSVFQSISPSTFKKQKKVPSALSEVAASGEGSAISGYLSRCKSGKRRWKKLW
                     LVIKGKVLYTYLASEDKVAMESIPLLGFTIAPEKEEGSSEVGPVFHLYHKKTLFYSFK
                     AEDSNSAQRWMEAMEDASVL"
     exon            79..2743
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2873
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..2932
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            2933..2963
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3124
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3125..3284
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3372
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3373..3423
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3424..3482
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3483..3554
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3623
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..3707
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3708..3787
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3788..3887
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..4025
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            4026..4155
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            4156..4289
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            4290..4418
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            4419..4573
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            4574..6009
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5984..5989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /note="hexamer: AATAAA"
     polyA_site      6009
                     /gene="Fgd5"
                     /gene_synonym="C330025N11Rik; mFLJ00274; ZFYVE23"
                     /note="major polyA site"
ORIGIN      
        1 agtgggactc cgactgaccg acccgcacag cacgcagcga ccagcctcgg gctccgcggt
       61 ggaagatgca cagagcagat tcaccaaagc caccacttgc tcccaagcca aaggttgcta
      121 ccaaccctta tgcaccggca gccaagtttc ccccttcaca gaggcctgac agcttcccca
      181 gtcccaactc catgtccagg ggccccaagc cccctatcgc tcctaagccc agactgactg
      241 gccccagtga gtacctgaac aacagcctcg gcaaatgcag caatgggagg ctgctctgtg
      301 aggaccgggg cctgtacgac ggacaccact ccaccctgaa ttgcttggag ttggagcctg
      361 atgagcagta tatcatggtt cccagggctc cacagaaaga agatactccc gtggatgggg
      421 ctaccgagga gccggggttt gagggggaag tccaggagca tggtacagag cagacaggaa
      481 ctgaggggga cctggaagct ccagatgaag aggcaccaag tagagacagt gaggaaggca
      541 tggtccacgc tctggaagat gaagactgtg atcacgatcc agagacggat gggaccccaa
      601 catcgccaga tgaaggggca ccaagcagag acagtgagga aggtgaggag gactgtgatc
      661 agggcccagg tatggaggag catcccatga gtgaagagga gggagaagag gaggaggtga
      721 aggagcacgt gtacaacagt gataacaggg caccctggga tggagaggag cccttcccca
      781 atgaggtcat tctcacacat gtccgctctc agtcccctga agttccctgt tgggagccag
      841 gccctcctga gactcctgga gaggcagaag aggattgtga agacatctgt aacaacacag
      901 aacctgggaa acccaatcag gacactggtc aggacacaga ggatgccggc atgggatccc
      961 ctgagagtga ggtgtcccca gatgtccagg agcaagaggc agcaacggac aaccctgagg
     1021 tctttgagga ggactctgca gatgctgcag aaggtgagga tcagatagag caggaggaac
     1081 cacccaattg tgacgaggaa gcctataata gagatgccgc agcagccacc atgcaggtgg
     1141 gagaggacct cggagaggag ggagaccatg tgcaggagga ccctgctgag gaaagctgcc
     1201 agatcattcc ctttgagagc gacagtgtgg aggaggattt ctcacctaca ctcacagaga
     1261 atccctatga gattttccca accgagagca cttccttctg caataacacc tattcccttg
     1321 acgagtcagc caatgggcac gagccagtgt gcgagatctg tgtagaggag gttcctggtg
     1381 ttggccctcc acttaaccag catgattccc tgccagatgg atctggagag gactccccgg
     1441 tggtccctga tgtggtggtc gtgccagaga atgaggggcc cgtggatgat gcactcagca
     1501 gtccatacgt gatgggagtt ggcttgctga gccttggaga gggagcgcag tcagacaccc
     1561 aggctgcatc aggcactctg agtgggtaca gtacatggga ggaaggggac tctgagggag
     1621 ggcaggtccc agtggatagg aagaatattg ccacaagggc ccggcctcac tctgggaagg
     1681 tggctggtca tgttccagaa actgttctag aagaaacggg accagaaacc tgttcatcag
     1741 gcatgggcat cagagatacc agtgatgaag tgaggaagat aggtatattg ccagagggaa
     1801 agcctcccga gtgtgttcgg gccttgccgg ccaagcccag agcatttact ctctacccaa
     1861 ggtccttctc tgtagaaggc cgggagagtc ccctgtccat gttccgggag ccagagggag
     1921 ccgggctgga cagccaccgt gtaaggagga aagaggacaa cctctctctg ccgggcgcca
     1981 tcggctcctc cggtagcttc tcacagcgca gccacctgcc ttccagtggc acctccacac
     2041 catcctctgt ggttgacatc ccaccccctt ttgacttggc ctgcatcacg aagaaaccca
     2101 tcactaaaag ctcaccctca ctcctgatag acggagacac cctggaaaaa gcctctaaga
     2161 agaagaagtc ctccttcaaa cgcttcctgg agctgacgtt caggaagaag acagagagca
     2221 aggtgcacgt ggacatgaac ctgtcgtctt ccaggtcttc ctctgagtcc agctaccatg
     2281 gtccagccag ggtactggaa cttgaccgca gaagcctcag caactcgccc cagctcaagt
     2341 gtcgcactgg aaagctccgg gcctctgact ccccggccgc cctcatcttc tacagggaca
     2401 gcaagaggaa aggcgtcccc ttcagcagga cggtgtccag agtggagtcc ttcgaagacc
     2461 gctcccggcc gccctttctg cctctgcccc tcaccaagcc acggtccatc tcattcccca
     2521 atgccgacac ttcggactat gagaacattc cagccatgaa ctcagactat gagaatatcc
     2581 agatcccccc tcgcaggccg gtgaggactg gcactttcac aaagctgttc gaagaacaga
     2641 gccgagccct gtccaccgca aatgaaaatg acggctacgt ggacatgagc agcttcaatg
     2701 ccttcgagag caagcagcag agttcagagc aggaagctga gagcgcctac actgagccct
     2761 acaaggtctg tcccatctca gcggctccca gagaggacct cacatcagac gaagaacaag
     2821 gaagctccga ggaggaggac agtgcttcaa gagaccccag cctctcacac aagggtgaag
     2881 gacagtctag agcccttgtc atcgctcagg agctgctgtc ttcagagaaa gcatatgtgc
     2941 agatgttgca gcacttaagc ctggatttcc atggagccgt cctgagggcc ttggagaacg
     3001 tagagcaaga gggcagagag ccactggccc aggaggagct gcggcagggc ctgcgggagc
     3061 tcccagctat ctgtgacctt caccagggca tcctggagag cctggagcag aggctggggg
     3121 attgtgggga gggccagccg caggtggccg acatcttcct ggcccaggaa caggagttcg
     3181 agcatcatgc cgcacacatc ctgcaatttg acaggtacct ggggctgctc gctgagagct
     3241 gcctgctctc accccggcta gccaccacgg tccgggagtt tgagcagagt tcacaagggg
     3301 gtggccagag catgaagcat cgtatgctgc gtgtggtcca gcgcctcttc cagtaccaag
     3361 tgctgctcac tgattattta aataacctgt gcccggactc agcagagtac gacaacactc
     3421 agagtgctct gactctcatc tctaaagtga cagaccgtgc caacgaaagc atggaacagg
     3481 gggaaaacct gcagaagctg gtccacatcg agtacagtgt acgaggccaa ggggacctcc
     3541 tccagccagg aagggagttc ctgaaggaag ggacactgat gagggtgaga gggaaaagcc
     3601 gacacccccg ccacctgttc ctgatgaatg acacactcct gtacacacat ccccagaagg
     3661 atgggaagta ccggctgaag agctcgctgc cagtggccaa catgaaggtc agccgccctg
     3721 tgatggacaa agtgccctat gctctgaaga tcgaaactcc tgagtcttgt ctgacactgt
     3781 ctgcaagctc ctgcgcggag cgggacgagt ggcactactg tctgagcaga gcccttccgg
     3841 aggattacaa gactcaggcc ctggctgcct tccaccacag tgtggagatc cgggaaaggc
     3901 tggggatcag cctcggtgag aggctcccca ccctggtgcc tgtcactcat gccatgatgt
     3961 gcatgaactg cggctgtgac ttctccctca ccgtgaggcg ccaccactgc catgcctgcg
     4021 gcaagattgt gtgccggaac tgctctcgaa acaagtaccc attgaagtgc ctcaagaaca
     4081 ggatggccaa ggtctgtgat ggctgcttcc gggagctgaa gttgaggaat gggcctgtcc
     4141 caggctccat gagagagcgt ccagtcagca tgagcttccc actgtcctcg tcccgctttt
     4201 cctcgggcag cgccttgtcc tctgtcttcc agagtattag cccctcaact ttcaagaagc
     4261 agaaaaaagt cccttcggct ctgtccgagg tggccgcgtc aggagagggc tctgccatca
     4321 gcggctactt gagccgctgt aagagtggca agcggcgctg gaagaaactc tggctcgtca
     4381 tcaagggcaa agtactctac acctacttgg ccagcgagga caaagtggcc atggagagca
     4441 tacctctgct gggttttact attgccccag aaaaggagga gggcagcagc gaagtgggcc
     4501 ctgtttttca tctttatcac aagaaaaccc tgttttacag cttcaaagca gaggacagca
     4561 attctgctca gagatggatg gaggccatgg aagatgccag tgtgttatag cagtcaccag
     4621 gcccatggac taacaacaaa ctcctacatt aactcgagaa cccttccgga agtgactcct
     4681 gctttcagct catctggatg cacgtgtggg ttctgtgtgg agcttgacct caaggcgaaa
     4741 ccccaagagc tatttataga catcttcttt tctgcctcca tgtttcccaa ccccaatcac
     4801 agactgtaca cccttatcta aaagtgagtt aaaatttagt accttgaaga cgtggaaacc
     4861 aagtgaaaaa gacacttaga aatgtgggct ttttagtaga aactggcttt ttctggtttt
     4921 actcctggtg actaagacca ctttcaactt tccgcactct ccatatggtg cctcaggtga
     4981 tgtgggagcc agacaggaag tatcagctgt gtatctaagc actttactat cctgctgagc
     5041 tgcagcctcc agggctgtgt cttccaagga atggctgcaa acttcggtgc aaagtgactc
     5101 ctgcagcctt actgtggctt gccaccctaa ggagggaggg gctcagcacc acaccagggc
     5161 tgccctctaa agcatcacag atccctcaaa catggaagac ctgcatctgc gttaagtttc
     5221 tgtgtgcatt cctgtgtcca cactgtgcag gctgaccatc ctgttgatgg gagtctgtcc
     5281 tctttgtaac acgtgtcctt gggctgtacc agccacacca agcttacttt ttgagagagg
     5341 taaaggagaa agagagaagt tgggtcatca gaaagtggtc tgcacagaag gcttggccag
     5401 cccggaggca ctgagtggct ggaagacact ttgcacacct gaggccgaca gcatcacctc
     5461 cctctgggca cctgaggcag agccatcacc tgctggccag ttctttatgc cgaatggatt
     5521 ttacaaaatg caggaggagg aacaggattc ctcttcacta tccctacagt tgggaaaaaa
     5581 aaaaaaatgc ctccattttc tgaaatctct tcctgccttg tcccctacaa aaaagatttt
     5641 tgtaaaacaa acaaacaaac aaaccaccat ctcaaggact tatttacatt aattatgttc
     5701 agggatttct ttttctagtt tgaagttctt tttcaatgtt tttgcagtcg gtgtatagtt
     5761 agtaattcaa gtcggatgga agacaagtgt tactgttcac ttcacaatcc taggatcctt
     5821 cctagagtca ctcacatggg acccggacac cgagacccag gaacctttag agagtggagc
     5881 tggactcaag gacagtaatc ctcttccttt ggtttcattt ttctatgatt tcaattgcag
     5941 gagaccaact gtggactgaa aatattaaat ggaaaattcc agaaataaaa gtgcatgaat
     6001 ttccagtcaa aaaaaaaaaa aaa
//
