LOCUS       NM_013710               2631 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus FYVE, RhoGEF and PH domain containing 2 (Fgd2),
            transcript variant 2, mRNA.
ACCESSION   NM_013710
VERSION     NM_013710.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2631)
  AUTHORS   Huber,C., Martensson,A., Bokoch,G.M., Nemazee,D. and Gavin,A.L.
  TITLE     FGD2, a CDC42-specific exchange factor expressed by
            antigen-presenting cells, localizes to early endosomes and active
            membrane ruffles
  JOURNAL   J Biol Chem 283 (49), 34002-34012 (2008)
   PUBMED   18838382
REFERENCE   2  (bases 1 to 2631)
  AUTHORS   Wallace,L.T. and Erhart,M.A.
  TITLE     Recombination within mouse t haplotypes has replaced significant
            segments of t-specific DNA
  JOURNAL   Mamm Genome 19 (4), 263-271 (2008)
   PUBMED   18379846
REFERENCE   3  (bases 1 to 2631)
  AUTHORS   Bauer,H., Veron,N., Willert,J. and Herrmann,B.G.
  TITLE     The t-complex-encoded guanine nucleotide exchange factor Fgd2
            reveals that two opposing signaling pathways promote transmission
            ratio distortion in the mouse
  JOURNAL   Genes Dev 21 (2), 143-147 (2007)
   PUBMED   17234881
  REMARK    GeneRIF: The t allele of Fgd2 is overexpressed in testis compared
            with wild type, a loss-of-function allele of Fgd2 generated by gene
            targeting reduces the transmission ratio of the t haplotype t(h49),
            directly demonstrating the role of Fgd2 as Distorter.
REFERENCE   4  (bases 1 to 2631)
  AUTHORS   Samant,S.A., Ogunkua,O., Hui,L., Fossella,J. and Pilder,S.H.
  TITLE     The T complex distorter 2 candidate gene, Dnahc8, encodes at least
            two testis-specific axonemal dynein heavy chains that differ
            extensively at their amino and carboxyl termini
  JOURNAL   Dev Biol 250 (1), 24-43 (2002)
   PUBMED   12297094
REFERENCE   5  (bases 1 to 2631)
  AUTHORS   Erhart,M.A., Lekgothoane,S., Grenier,J. and Nadeau,J.H.
  TITLE     Pattern of segmental recombination in the distal inversion of mouse
            t haplotypes
  JOURNAL   Mamm Genome 13 (8), 438-444 (2002)
   PUBMED   12226709
REFERENCE   6  (bases 1 to 2631)
  AUTHORS   Samant,S.A., Fossella,J., Silver,L.M. and Pilder,S.H.
  TITLE     Mapping and cloning recombinant breakpoints demarcating the hybrid
            sterility 6-specific sperm tail assembly defect
  JOURNAL   Mamm Genome 10 (2), 88-94 (1999)
   PUBMED   9922385
REFERENCE   7  (bases 1 to 2631)
  AUTHORS   Sowden,J., Morrison,K., Schofield,J., Putt,W. and Edwards,Y.
  TITLE     A novel cDNA with homology to an RNA polymerase II elongation
            factor maps to human chromosome 5q31 (TCEB1L) and to mouse
            chromosome 11 (Tceb1l)
  JOURNAL   Genomics 29 (1), 145-151 (1995)
   PUBMED   8530064
REFERENCE   8  (bases 1 to 2631)
  AUTHORS   Himmelbauer,H., Artzt,K., Barlow,D., Fischer-Lindahl,K., Lyon,M.,
            Klein,J. and Silver,L.M.
  TITLE     Encyclopedia of the mouse genome III. October 1993. Mouse
            chromosome 17
  JOURNAL   Mamm Genome 4 Spec No, S230-S252 (1993)
   PUBMED   8268678
REFERENCE   9  (bases 1 to 2631)
  AUTHORS   Lyon,M.F.
  TITLE     Male sterility of the mouse t-complex is due to homozygosity of the
            distorter genes
  JOURNAL   Cell 44 (2), 357-363 (1986)
   PUBMED   3943128
REFERENCE   10 (bases 1 to 2631)
  AUTHORS   Lyon,M.F.
  TITLE     Transmission ratio distortion in mouse t-haplotypes is due to
            multiple distorter genes acting on a responder locus
  JOURNAL   Cell 37 (2), 621-628 (1984)
   PUBMED   6722884
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK042260.1 and AI451050.1.
            
            On Apr 18, 2009 this sequence version replaced NM_013710.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction at the 5' end of a coding exon compared to variant
            1. The resulting isoform (2) has the same N- and C-termini but is 1
            aa shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF017368.1, AK042260.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2337              AK042260.1         2-2338
            2338-2631           AI451050.1         1-294               c
FEATURES             Location/Qualifiers
     source          1..2631
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.26 cM"
     gene            1..2631
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /note="FYVE, RhoGEF and PH domain containing 2"
                     /db_xref="GeneID:26382"
                     /db_xref="MGI:MGI:1347084"
     exon            1..244
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..2147
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /note="isoform 2 is encoded by transcript variant 2; Fgd1
                     family, member 2; FYVE, RhoGEF and PH domain-containing
                     protein 2; faciogenital dysplasia homolog 2; Fgd2-like
                     protein; faciogenital dysplasia protein 2; t-complex
                     distorter 2"
                     /codon_start=1
                     /product="FYVE, RhoGEF and PH domain-containing protein 2
                     isoform 2"
                     /protein_id="NP_038738.2"
                     /db_xref="CCDS:CCDS37537.1"
                     /db_xref="GeneID:26382"
                     /db_xref="MGI:MGI:1347084"
                     /translation="MERACEKQDSVCNLVAVFENNRTPGEAPGSHSLEDQPHSPEHQL
                     SLSPEPWEAPPVKEALKSEFRPVSRTYLSSLKNKLSSGAWRRSCQPGVSPGPETQEPE
                     EKRVVRELLETEQAYVARLHLLDQVFFQELLREAGRSKAFPEDVVKLIFSNISSIYRF
                     HAQFFLPELQRRVDDWAATPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWMDKSQ
                     PFQEVVTRIQCSEASSSLTLQHHMLEPVQRIPRYELLLKEYVQKLPAQAPDLEDAQRA
                     LDMIFSAAQHSNAAIAEMERLQGLWDVYQRLGLEDDIVDPSNTLLREGPVLKISFRRS
                     DPMERYLVLFNNMLLYCVPRVLQVGAQFQVRTRIDVAGMKVRELTDAEFPHSFLVSGK
                     QRTLELQARSRDEMVSWMQACQAAIDQVEKRSETFKAAVQGPQGDTQEPKPQVEELGL
                     RAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCAKCSDYRAELKYDSNRPNR
                     VCLTCYTFLTGNVLPQGKEDKRRGILEKEASAAPEQSLVCSFLQLIGDKCSRSLPRSW
                     CVIPRDDPLVLYVYAAPQDTKAHTSIPLLGYQVISGPQGDPRVFQLQQSGQQYTFKAE
                     SVELQGRWVTAIKRAASGRTPEGPDEEDVSD"
     exon            245..476
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /inference="alignment:Splign:2.1.0"
     exon            477..557
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /inference="alignment:Splign:2.1.0"
     exon            558..706
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /inference="alignment:Splign:2.1.0"
     exon            707..863
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1002
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1061
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1208
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1301
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1381
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1412
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1505
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1637
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1784
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1931
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2622
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2386
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /note="major polyA site"
     regulatory      2598..2603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /note="hexamer: AATAAA"
     polyA_site      2622
                     /gene="Fgd2"
                     /gene_synonym="Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4"
                     /note="major polyA site"
ORIGIN      
        1 cacttcctct tttttcactc tgaagatagg aactgcccca aggcagtcag aagcgatggg
       61 cagattccag gctgtggtag acctgcttca cccgctggcc agggagtgct gagggcacca
      121 gcctattgcc tccctccctg cttctggggt aactgaggac caccttgcag gctagcagga
      181 tggagcgagc ctgtgagaag caggactcag tgtgcaacct ggtggctgtg tttgagaaca
      241 acaggactcc gggagaagca cctggatccc atagccttga ggaccagccc catagccctg
      301 aacaccagct gtccctgtcc ccagagcctt gggaggcacc ccctgtcaag gaggccttga
      361 agtctgaatt ccggccagtg agcaggacat atctgagttc cctcaagaac aagttatcga
      421 gtggggcttg gaggagatcc tgtcagcctg gggtcagccc ggggccagag acacaggaac
      481 ctgaggagaa gagggtcgtg cgagagcttc tggagacgga gcaggcctat gtggctcgcc
      541 tgcacctgct tgaccaggtg ttcttccagg agctgctgag ggaggcaggc cgcagcaagg
      601 ccttccctga ggacgtggtg aagctcattt tctccaacat ctcctccatc tatcgtttcc
      661 acgcccagtt cttccttccc gagctgcagc ggcgcgtgga tgactgggca gccacgcccc
      721 gcattgggga tgtgatccag aagctggccc cgtttctgaa aatgtacagc gagtacgtga
      781 agaactttga gcgggccgcg gaactgctgg ccacgtggat ggacaagtct cagcccttcc
      841 aggaggtggt cacccgcatc cagtgcagcg aggcctccag cagcctgacc ctgcagcacc
      901 acatgttgga gcctgtgcaa agaatcccgc ggtacgaact gctgctcaag gaatatgtgc
      961 agaagctgcc agcccaggcc ccagacctcg aagatgccca gagagcactg gacatgatct
     1021 tctcagctgc acagcactcc aatgcagcca ttgcagagat ggagcggctg cagggcctgt
     1081 gggatgtgta ccagcgcctg ggcttggagg atgacatcgt ggacccctcc aacaccctgc
     1141 tccgagaggg ccctgttctc aagatctctt tccgccgcag cgacccaatg gaacgctacc
     1201 tggttttgtt caacaacatg cttctgtatt gtgtaccccg agtcctccaa gtgggtgccc
     1261 agttccaggt gcggactcgc atcgatgtgg ccggcatgaa ggtgcgggag ctgaccgatg
     1321 ctgagttccc acactccttc ctggtgtccg gaaagcagcg cacactggag ctgcaggccc
     1381 ggtcccgaga tgaaatggtt tcctggatgc aggcctgcca ggcagccatt gaccaggttg
     1441 agaagcggag tgagaccttc aaggctgctg tccagggacc tcagggggac acgcaggagc
     1501 ccaagccaca ggtagaggag ctgggtctcc gagcgcctca gtgggtccgg gacaagatgg
     1561 tgaccatgtg catgcgctgc caggagccct tcaatgccct gactcgtcgg cgccaccact
     1621 gccgggcttg cggctatgta gtgtgtgcca agtgctctga ctaccgtgcg gagctgaaat
     1681 atgacagcaa caggcccaac cgagtctgcc tgacctgcta cacatttctc actggaaacg
     1741 tactccctca aggcaaggag gacaagaggc ggggcatctt ggagaaagag gcctcagcag
     1801 cacccgagca gagtctggtg tgcagcttcc tgcagctcat aggggacaag tgcagcagga
     1861 gccttccccg gagctggtgt gtgatccccc gggatgaccc ccttgtcctg tatgtctatg
     1921 cagcccccca ggacacaaag gctcacacct ccatccccct actgggctat caggtgattt
     1981 cagggcccca gggggaccct cgggttttcc agctgcaaca gtcaggccag cagtacacct
     2041 tcaaggccga gtctgtggag ctgcagggcc gctgggtgac agctatcaag cgtgcggcca
     2101 gtggccggac ccctgaggga cctgacgaag aagatgtgtc tgactgaacc acagccagct
     2161 gctcatcgag agtccatgac agccttccca ggcctacccc atggttctat cacttcaccc
     2221 caagctgggc tacccctgac ccacctgatg tctataccga gacaattcat cctgactctg
     2281 tatccagcag acacaggccc tttccttcag gaagatacca ccaagtgtcc cagctggctg
     2341 gagagggggc ggatatccct ggatcatgaa atcttcattg ctaaaacaat gttgtagctt
     2401 aatgggtggc atgcccatct aacatggatg aagccttggg ttcagtcctc agcgaaacat
     2461 aaactgggca tggtaataca tgcaacagtt gggtaggtag aggaagaagg accaaaaggc
     2521 cgaggtcgcc ctggctatag agtgagttac agtccagcct gggctacaca agaacctgag
     2581 agcacaaaaa aagtcaaaat aaaagatgac aagtaccaat aaaaaaaaaa a
//
