LOCUS       NM_008001               4166 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus FYVE, RhoGEF and PH domain containing 1 (Fgd1), mRNA.
ACCESSION   NM_008001
VERSION     NM_008001.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4166)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4166)
  AUTHORS   Zou,W., Greenblatt,M.B., Shim,J.H., Kant,S., Zhai,B., Lotinun,S.,
            Brady,N., Hu,D.Z., Gygi,S.P., Baron,R., Davis,R.J., Jones,D. and
            Glimcher,L.H.
  TITLE     MLK3 regulates bone development downstream of the faciogenital
            dysplasia protein FGD1 in mice
  JOURNAL   J Clin Invest 121 (11), 4383-4392 (2011)
   PUBMED   21965325
  REMARK    GeneRIF: activation of MLK3 specifically by FGD1/CDC42 is important
            for skeletal mineralization
REFERENCE   3  (bases 1 to 4166)
  AUTHORS   Egorov,M.V., Capestrano,M., Vorontsova,O.A., Di Pentima,A.,
            Egorova,A.V., Mariggio,S., Ayala,M.I., Tete,S., Gorski,J.L.,
            Luini,A., Buccione,R. and Polishchuk,R.S.
  TITLE     Faciogenital dysplasia protein (FGD1) regulates export of cargo
            proteins from the golgi complex via Cdc42 activation
  JOURNAL   Mol Biol Cell 20 (9), 2413-2427 (2009)
   PUBMED   19261807
  REMARK    GeneRIF: FGD1 is preferentially associated with the trans-Golgi
            network (TGN), suggesting its involvement in export of proteins
            from the Golgi.
REFERENCE   4  (bases 1 to 4166)
  AUTHORS   Hayakawa,M., Matsushima,M., Hagiwara,H., Oshima,T., Fujino,T.,
            Ando,K., Kikugawa,K., Tanaka,H., Miyazawa,K. and Kitagawa,M.
  TITLE     Novel insights into FGD3, a putative GEF for Cdc42, that undergoes
            SCF(FWD1/beta-TrCP)-mediated proteasomal degradation analogous to
            that of its homologue FGD1 but regulates cell morphology and
            motility differently from FGD1
  JOURNAL   Genes Cells 13 (4), 329-342 (2008)
   PUBMED   18363964
REFERENCE   5  (bases 1 to 4166)
  AUTHORS   Kostenko,E.V., Olabisi,O.O., Sahay,S., Rodriguez,P.L. and
            Whitehead,I.P.
  TITLE     Ccpg1, a novel scaffold protein that regulates the activity of the
            Rho guanine nucleotide exchange factor Dbs
  JOURNAL   Mol Cell Biol 26 (23), 8964-8975 (2006)
   PUBMED   17000758
REFERENCE   6  (bases 1 to 4166)
  AUTHORS   Whitehead,I.P., Abe,K., Gorski,J.L. and Der,C.J.
  TITLE     CDC42 and FGD1 cause distinct signaling and transforming activities
  JOURNAL   Mol Cell Biol 18 (8), 4689-4697 (1998)
   PUBMED   9671479
REFERENCE   7  (bases 1 to 4166)
  AUTHORS   Nagata,K., Driessens,M., Lamarche,N., Gorski,J.L. and Hall,A.
  TITLE     Activation of G1 progression, JNK mitogen-activated protein kinase,
            and actin filament assembly by the exchange factor FGD1
  JOURNAL   J Biol Chem 273 (25), 15453-15457 (1998)
   PUBMED   9624130
REFERENCE   8  (bases 1 to 4166)
  AUTHORS   Zheng,Y., Fischer,D.J., Santos,M.F., Tigyi,G., Pasteris,N.G.,
            Gorski,J.L. and Xu,Y.
  TITLE     The faciogenital dysplasia gene product FGD1 functions as a
            Cdc42Hs-specific guanine-nucleotide exchange factor
  JOURNAL   J Biol Chem 271 (52), 33169-33172 (1996)
   PUBMED   8969170
REFERENCE   9  (bases 1 to 4166)
  AUTHORS   Olson,M.F., Pasteris,N.G., Gorski,J.L. and Hall,A.
  TITLE     Faciogenital dysplasia protein (FGD1) and Vav, two related proteins
            required for normal embryonic development, are upstream regulators
            of Rho GTPases
  JOURNAL   Curr Biol 6 (12), 1628-1633 (1996)
   PUBMED   8994827
REFERENCE   10 (bases 1 to 4166)
  AUTHORS   Pasteris,N.G., de Gouyon,B., Cadle,A.B., Campbell,K., Herman,G.E.
            and Gorski,J.L.
  TITLE     Cloning and regional localization of the mouse faciogenital
            dysplasia (Fgd1) gene
  JOURNAL   Mamm Genome 6 (9), 658-661 (1995)
   PUBMED   8535076
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CA328503.1, CN702035.1,
            CN531569.1, AK148151.1, AV367660.2 and AI195396.1.
            
            On May 22, 2013 this sequence version replaced NM_008001.3.
            
            Summary: This gene encodes a member of family of Rho-specific
            guanine nucleotide exchange factors. Rho-specific guanine
            nucleotide exchange factors catalyze the exchange of GDP for GTP
            and activate small GTPases, which function as molecular switches in
            signaling. This protein specifically binds cell division cycle 42,
            a Rho (Ras homology) GTPase. Investigations in mouse suggest that
            this protein is important for skeletal mineralization and for
            regulating the actin cytoskeleton. In humans, mutations in this
            gene are associated with faciogenital dysplasia, also known as
            Aarskog-Scott syndrome. [provided by RefSeq, Mar 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148151.1, BC011462.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-510               CA328503.1         64-573
            511-1086            CN702035.1         1-576
            1087-1486           CN531569.1         200-599
            1487-3564           AK148151.1         1488-3565
            3565-4006           AV367660.2         155-596
            4007-4166           AI195396.1         36-195              c
FEATURES             Location/Qualifiers
     source          1..4166
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..4166
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /note="FYVE, RhoGEF and PH domain containing 1"
                     /db_xref="GeneID:14163"
                     /db_xref="MGI:MGI:104566"
     exon            1..812
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /inference="alignment:Splign:2.1.0"
     CDS             506..3388
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /note="rho/Rac GEF; faciogenital dysplasia 1 protein
                     homolog; zinc finger FYVE domain-containing protein 3;
                     rho/Rac guanine nucleotide exchange factor FGD1"
                     /codon_start=1
                     /product="FYVE, RhoGEF and PH domain-containing protein 1"
                     /protein_id="NP_032027.2"
                     /db_xref="CCDS:CCDS30467.1"
                     /db_xref="GeneID:14163"
                     /db_xref="MGI:MGI:104566"
                     /translation="MHGHRVPGGPGPSDPERSAANTPGAAPLACADSDPGALEPGLPV
                     SRGSGTALGGPLDPQFVGPSDASLGAPPSSRVLPCGPSPQHHRALRFSYHLEGSQPRP
                     GLHQGNRILVKSLSLDPGQSLEPHPEGPQRLRSDPGPPTEIPGPRPSPLKRAPGPKPQ
                     VPPKPSYLQMPRVLPPPEPIPPPPSRPLPADPRVAKGLVPRAEASTSSAAVSSLIEKF
                     EREPVIVASDRPAPGPCPVPPEPAMLPQPPPQPTGSQLPEGEASRCLFLLAPGPRDGE
                     KVPNRDSGIDSISSPSNSEETCFVSDDGPPIHSLCPGPPALASMPVALADPHRPGSQE
                     VDSDLEEEEEEEEEEKEREIPVPPMERQESVELTVQQKVFHIANELLQTEKAYVSRLH
                     LLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYP
                     RIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTL
                     QHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMER
                     MHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPR
                     LRLLGQKFSVRARIDVDGMELKESSNLNMPRTFLVSGKQRSLELQARTEEEKKDWVQA
                     INSTLLKHEQTLETFKLLNSTNRDDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQE
                     PFNSITKRRHHCKACGHVVCGKCSEFRARLIYDNNRSNRVCTDCYVALHGAPGSSPAC
                     SQHTPQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHKAWFVVPENEPLVLYIYG
                     APQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWYFSPETEELQRRWMAV
                     LGRAGRGDTFCPGPTLSEDKEMEETPVAASGATAEPPEASQTRDKT"
     exon            813..986
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1164
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1603
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1693
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1842
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1999
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2138
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2197
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2344
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2437
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2517
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2548
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2650
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2776
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2938
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3082
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..4166
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3974..3979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /note="hexamer: AATACA"
     polyA_site      4001
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /note="major polyA site"
     regulatory      4140..4145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /note="hexamer: ATTAAA"
     polyA_site      4165
                     /gene="Fgd1"
                     /gene_synonym="ZFYVE3"
                     /note="major polyA site"
ORIGIN      
        1 tccgccccca gcctccgctg cggcgggagg aagaaccctt cccgactagc ccagagaacc
       61 caggtcgatt ctcattccgg gagaaagaga cccccctcgg tgggatccgg ctggccgctc
      121 gcccccggct acggaagtga ctggtcatct attaggagag ctcgtgccta gcgcagcccc
      181 cgaccctcgc ctagccgcag ccgcatagac agcgctcccc agcgggcccc cggccccgcc
      241 gagcccactc cccgcttggg gccagggctg gcgatgcctg gcgcggcaac ggcggtggcc
      301 gcggctgctg ctgctgctgc cgccacggct gctggccgga gcccgggtcg ggggctcgag
      361 tctccgcagt ggggctgagc ccgcagcccc gccccccgag cctgaggccg ctgctccgcc
      421 gggcgccggg ccttctccgc ccgcgcctcc gccccaggaa ctggagccaa gcggggagcc
      481 cgggccccgc gcccaggccc ggaccatgca tggccaccga gtcccggggg gccctgggcc
      541 ttcggatccc gaacgctcag cggcaaatac ccccggtgcc gctccgctgg cctgtgccga
      601 ctcggaccct ggagccttgg aacccgggct gccggtgagc aggggctcag gcacggctct
      661 tggaggccct ttggatcctc agtttgttgg accctcggat gccagcctgg gagcgcctcc
      721 aagctcccgg gtcttaccct gcggccctag tcctcagcac caccgggccc tgcgcttctc
      781 ctaccacctg gagggctcgc agcctcggcc tggactgcac cagggaaacc ggatcctggt
      841 taaaagtttg tcccttgacc ctggccagag ccttgagcct catccagaag gtccccaacg
      901 gcttcgctca gatccaggcc ctcccactga aatccctggc ccacgtcctt caccactgaa
      961 gcgggcaccg ggcccaaagc cacaggttcc cccaaagccc agctacctgc agatgccccg
     1021 ggtgcttcct cctcctgagc ccattcctcc accaccatca cgccctctgc ctgcagaccc
     1081 tagagtggcc aagggactcg tccccagagc tgaggccagc actagttctg cagcagtatc
     1141 atcattgatt gagaagtttg aaagagagcc tgtgattgtt gcctcggata ggccagcccc
     1201 tggcccctgc ccagttcccc cagagccagc catgttgcca cagccacccc cgcagccaac
     1261 agggtcccag ctccctgagg gtgaagcttc tcgctgcctg ttcctgctgg ctcctgggcc
     1321 ccgggatggt gagaaggtgc ctaaccggga cagcggcatt gacagcatca gctcgccatc
     1381 caacagtgaa gagacctgct tcgtcagtga tgatgggccc cccatccaca gcctctgtcc
     1441 tgggcccccc gccctggcta gtatgccagt agctttggcc gacccccacc ggcctggctc
     1501 ccaggaggtt gacagtgacc tggaagagga agaggaagaa gaagaggagg aaaaggaaag
     1561 agaaattcca gtgcccccga tggagagaca ggagtctgtg gagctgactg tgcagcagaa
     1621 ggtgttccat attgccaatg agctcctgca aactgagaag gcctatgttt ccaggctcca
     1681 tctcctggat caggtattct gtgcccggct gctggaagaa gctcggaacc gcagttcctt
     1741 ccccgcagat gttgtccacg gcatcttctc taacatctgc tccatctatt gcttccacca
     1801 gcagttcctg ctgcctgagc tagagaagcg catggaggaa tgggaccgct acccacgcat
     1861 tggtgacatt cttcagaagt tggcaccctt cctcaagatg tatggcgagt atgtgaaaaa
     1921 cttcgaccgg gcggtagagc tggtcaacac atggacagag cggtctaccc agtttaaagt
     1981 catcatccat gaagtacaga aggaggaagc ctgtggcaac ctgaccttgc agcaccacat
     2041 gctggagccc gtgcagcgta tcccccgcta tgaacttctt ctcaaggact atctgttaaa
     2101 gctgcctcat ggctccccgg acagcaagga tgcccagaag tctttggagc tgatagccac
     2161 agcagcagaa cactctaatg ctgccatccg gaaaatggaa cgaatgcaca agctgctgaa
     2221 ggtgtatgag ctgctagggg gtgaggagga cattgtcagt cccaccaaag agctcataaa
     2281 ggaaggccat atccttaagc tgtcagcaaa gaatgggacc actcaagatc gatacctcat
     2341 attattcaac gaccgcctcc tttactgcgt gcccaggctg cggctccttg gtcagaagtt
     2401 tagcgtgcgg gcacgcattg atgtagatgg catggagcta aaggagagct ccaacctcaa
     2461 catgcctcgg accttcctgg tgtcaggaaa gcagcgctct ctcgaactgc aggccaggac
     2521 tgaggaggag aagaaagact gggtccaggc catcaattcc accctcctga agcatgaaca
     2581 gaccctggag actttcaaac tgttgaactc aacaaacagg gatgatgaag atactccccc
     2641 taactctcca aacgtggatc ttgggaagag ggcacctacg cctatccggg aaaaggaagt
     2701 caccatgtgc atgcgctgcc aggagccctt caattccatc accaaacgca ggcaccactg
     2761 caaggcctgt gggcatgtgg tttgtgggaa atgctctgag ttccgagccc gactcatcta
     2821 tgacaacaat cgttccaacc gtgtgtgcac tgattgctat gtggccttgc atggagcacc
     2881 tgggagcagt ccagcctgta gccagcatac accccagcgc aggaggtcca tcctagagaa
     2941 acaggcctcg gtcgctgctg agaacagcgt catctgcagc ttcctgcact acatggagaa
     3001 gggtgggaaa ggatggcaca aggcatggtt tgtggttcct gagaatgaac ccttggtgct
     3061 gtacatctat ggagcccctc aggatgtgaa agcccagcgc agcctgcccc tcattggctt
     3121 tgaggtgggg cctcctgagg caggagagcg gccagacagg aggcatgtct tcaagatcac
     3181 acaaagccac ctaagctggt acttcagccc agagacagaa gaactccagc ggcgctggat
     3241 ggctgttctc ggcagggcgg gccgtgggga cacattctgc ccagggccca cactgtctga
     3301 ggacaaggag atggaggaga caccagtggc agcctcagga gccactgctg aacctcctga
     3361 agcctcccag acccgagaca agacctagag ggtttggggg gaactgggag tttctgcccc
     3421 acactccagc tgcccatgtt caattggggg ctccagccca ctcccaatgc agtcaatact
     3481 tgaattccca tcaagggcac tttcaatccc gaatgctggg tcatgggttt tttaattcat
     3541 cttttcacaa aaggtgggct ttttaaaaaa aaaaaaaaaa ctattcctac attgatgtta
     3601 attttttaaa tccctgtccc cagggagggc gggagctaat tgctagactc acttgaatta
     3661 gtttcctccc agtaccccac ttccacccag ctccccacaa aagtaccaga ggcaggagac
     3721 ctggattcaa gtgccagctc tgctactgac cctgggaccc caacccaccc tttcctcctc
     3781 agccagtgtc ttcacatgta tgaccttaca tggggtggtg actagaccct tcttgccttt
     3841 cccatggctt atagcttcta cctagcccca aagcaatcca gtattttatc gtccagatcc
     3901 atggcagggc cactgggcag gacgggaatg ggggaggggg ggggaggaca atggatactg
     3961 ttttttaaag aaaaatacag tttatttcag gcatacagta actttcagag cactgctatg
     4021 gtccgtccgt ttgtccaaag tcccaggcta ctaagggaga tgggagggta cagaaactac
     4081 tctcttgcca aattttgaag ctcagcttgc agaaagctga ttccaaggtt aaatcatgga
     4141 ttaaacaaga aaatgttata tgttat
//
