LOCUS       NM_181849               1713 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus fibrinogen beta chain (Fgb), mRNA.
ACCESSION   NM_181849
VERSION     NM_181849.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1713)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1713)
  AUTHORS   Brutsch,S.M., Madzharova,E., Pantasis,S., Wustemann,T., Gurri,S.,
            Steenbock,H., Gazdhar,A., Kuhn,G., Angel,P., Bellusci,S.,
            Brinckmann,J., Auf dem Keller,U., Werner,S. and Bordoli,M.R.
  TITLE     Mesenchyme-derived vertebrate lonesome kinase controls lung
            organogenesis by altering the matrisome
  JOURNAL   Cell Mol Life Sci 80 (4), 89 (2023)
   PUBMED   36920550
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1713)
  AUTHORS   Liu,H., Xiang,L. and Mei,Y.
  TITLE     miR-877-5p Inhibits Epithelial Mesenchymal Transformation of Breast
            Cancer Cells by Targeting FGB
  JOURNAL   Dis Markers 2022, 4882375 (2022)
   PUBMED   36438895
  REMARK    GeneRIF: miR-877-5p Inhibits Epithelial Mesenchymal Transformation
            of Breast Cancer Cells by Targeting FGB.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1713)
  AUTHORS   Patel,M.M., Behar,A.R., Silasi,R., Regmi,G., Sansam,C.L.,
            Keshari,R.S., Lupu,F. and Lupu,C.
  TITLE     Role of ADTRP (Androgen-Dependent Tissue Factor Pathway Inhibitor
            Regulating Protein) in Vascular Development and Function
  JOURNAL   J Am Heart Assoc 7 (22), e010690 (2018)
   PUBMED   30571485
REFERENCE   5  (bases 1 to 1713)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1713)
  AUTHORS   Chan,J.C., Cornelissen,I., Collen,D., Ploplis,V.A. and
            Castellino,F.J.
  TITLE     Combined factor VII/protein C deficiency results in intrauterine
            coagulopathy in mice
  JOURNAL   J Clin Invest 105 (7), 897-903 (2000)
   PUBMED   10749569
REFERENCE   7  (bases 1 to 1713)
  AUTHORS   Jalbert,L.R., Rosen,E.D., Moons,L., Chan,J.C., Carmeliet,P.,
            Collen,D. and Castellino,F.J.
  TITLE     Inactivation of the gene for anticoagulant protein C causes lethal
            perinatal consumptive coagulopathy in mice
  JOURNAL   J Clin Invest 102 (8), 1481-1488 (1998)
   PUBMED   9788960
REFERENCE   8  (bases 1 to 1713)
  AUTHORS   Broze,G.J. Jr.
  TITLE     Tissue factor pathway inhibitor gene disruption
  JOURNAL   Blood Coagul Fibrinolysis 9 Suppl 1, S89-S92 (1998)
   PUBMED   9819035
  REMARK    Review article
REFERENCE   9  (bases 1 to 1713)
  AUTHORS   Rosen,E.D., Chan,J.C., Idusogie,E., Clotman,F., Vlasuk,G.,
            Luther,T., Jalbert,L.R., Albrecht,S., Zhong,L., Lissens,A.,
            Schoonjans,L., Moons,L., Collen,D., Castellino,F.J. and
            Carmeliet,P.
  TITLE     Mice lacking factor VII develop normally but suffer fatal perinatal
            bleeding
  JOURNAL   Nature 390 (6657), 290-294 (1997)
   PUBMED   9384381
REFERENCE   10 (bases 1 to 1713)
  AUTHORS   Mills,K.A., Mathews,K.D., Scherpbier-Heddema,T., Schelper,R.L.,
            Schmalzel,R., Bailey,H.L., Nadeau,J.H., Buetow,K.H. and Murray,J.C.
  TITLE     Genetic mapping near the myd locus on mouse chromosome 8
  JOURNAL   Mamm Genome 6 (4), 278-280 (1995)
   PUBMED   7613034
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC138394.7, AK168626.1 and
            AW110458.1.
            
            On Nov 17, 2015 this sequence version replaced NM_181849.2.
            
            Summary: This gene encodes the beta subunit of the coagulation
            factor fibrinogen, which is a component of the blood clot. The
            encoded preproprotein is proteolytically processed by thrombin to
            release an N-terminal fibrinopeptide during the conversion of
            fibrinogen to insoluble fibrin polymer. The encoded protein
            interacts with the amyloid beta peptide to form fibrin clots of
            abnormal structure, and may play an important role in Alzheimer's
            disease. This gene is located adjacent to the genes encoding
            fibrinogen alpha and gamma subunits on chromosome 3. [provided by
            RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168626.1, AK146960.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC138394.7         125035-125094       c
            61-1704             AK168626.1         2-1645
            1705-1713           AW110458.1         31-39               c
FEATURES             Location/Qualifiers
     source          1..1713
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 36.98 cM"
     gene            1..1713
                     /gene="Fgb"
                     /gene_synonym="2510049G14Rik"
                     /note="fibrinogen beta chain"
                     /db_xref="GeneID:110135"
                     /db_xref="MGI:MGI:99501"
     exon            1..183
                     /gene="Fgb"
                     /gene_synonym="2510049G14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1548
                     /gene="Fgb"
                     /gene_synonym="2510049G14Rik"
                     /note="fibrinogen, B beta polypeptide"
                     /codon_start=1
                     /product="fibrinogen beta chain preproprotein"
                     /protein_id="NP_862897.1"
                     /db_xref="CCDS:CCDS17432.1"
                     /db_xref="GeneID:110135"
                     /db_xref="MGI:MGI:99501"
                     /translation="MRHLWLLLLLCVFSVQTQAADDDYDEPTDSLDARGHRPVDRRKE
                     EPPSLRPAPPPISGGGYRARPAKATANQKKVERRPPDAGGCLHADTDMGVLCPTGCTL
                     QQTLLNQERPIKSSIAELNNNIQSVSDTSSVTFQYLTLLKDMWKKKQAQVKENENVIN
                     EYSSILEDQRLYIDETVNDNIPLNLRVLRSILEDLRSKIQKLESDISAQMEYCRTPCT
                     VSCNIPVVSGKECEEIIRKGGETSEMYLIQPDTSIKPYRVYCDMKTENGGWTVIQNRQ
                     DGSVDFGRKWDPYKKGFGNIATNEDAKKYCGLPGEYWLGNDKISQLTRMGPTELLIEM
                     EDWKGDKVKAHYGGFTVQNEASKYQVSVNKYKGTAGNALMDGASQLVGENRTMTIHNG
                     MFFSTYDRDNDGWVTTDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGLYSWDMSKHG
                     TDDGVVWMNWKGSWYSMRRMSMKIRPFFPQQ"
     exon            184..378
                     /gene="Fgb"
                     /gene_synonym="2510049G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            379..562
                     /gene="Fgb"
                     /gene_synonym="2510049G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            563..790
                     /gene="Fgb"
                     /gene_synonym="2510049G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            791..904
                     /gene="Fgb"
                     /gene_synonym="2510049G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1030
                     /gene="Fgb"
                     /gene_synonym="2510049G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1316
                     /gene="Fgb"
                     /gene_synonym="2510049G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1705
                     /gene="Fgb"
                     /gene_synonym="2510049G14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1626..1631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgb"
                     /gene_synonym="2510049G14Rik"
                     /note="hexamer: ATTATA"
     polyA_site      1648
                     /gene="Fgb"
                     /gene_synonym="2510049G14Rik"
     regulatory      1684..1689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgb"
                     /gene_synonym="2510049G14Rik"
                     /note="hexamer: GATAAA"
     polyA_site      1705
                     /gene="Fgb"
                     /gene_synonym="2510049G14Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtcatgccg gggagaggac ccactatata taggatcgac agtctcccag ctaagtctac
       61 aggcaaaggg caactgctcg gaatttcgga aactctgaaa ccatgaggca tctatggctg
      121 ctgctgctat tgtgtgtttt ctcagttcaa actcaagctg ccgatgatga ctacgatgaa
      181 ccgacggata gcttggatgc ccgtggtcat cgacctgttg acaggagaaa ggaagagcct
      241 cctagcctaa gacctgcccc tcctcctatc agtggagggg gctatcgagc ccgtccagcc
      301 aaggctactg ccaaccagaa gaaagtagaa cggagacccc ccgatgcagg aggctgtctt
      361 catgctgaca cagacatggg agtgttgtgt cctacgggat gtacattgca acaaacgttg
      421 ttaaaccagg aaaggccaat caagagtagt attgctgagt taaataacaa catacagtct
      481 gtttccgata cctcctcagt cacctttcag tacctgactc tgctaaagga catgtggaaa
      541 aagaagcaag ctcaagttaa agagaatgaa aatgtcataa atgagtactc ctccatcctg
      601 gaagatcaga gattatatat tgatgagact gtgaatgata atatccccct taatcttcgt
      661 gtgctccgct caatcctgga ggacctgaga agcaaaatac aaaaattaga gtctgacatc
      721 tcagctcaaa tggaatactg ccgcactcca tgcactgtca gctgcaacat tccagtggtg
      781 tctgggaaag agtgtgagga gatcattagg aagggaggtg agacatccga aatgtatctc
      841 atccagcctg acacctccat caagccgtac agagtatact gtgacatgaa aacagaaaac
      901 ggaggatgga cagtcataca gaaccgtcag gatggcagcg tcgactttgg caggaaatgg
      961 gacccataca aaaaaggatt cggaaatatt gccaccaatg aagacgcgaa gaagtactgt
     1021 ggcttgccag gtgaatattg gcttggcaat gataagatta gccagctcac caggatggga
     1081 cccacagaac ttctcattga aatggaggac tggaaaggag acaaggtgaa ggcacattat
     1141 ggaggcttca cggtacagaa cgaggccagc aaataccaag tctcagtgaa caaatacaaa
     1201 gggacggctg gcaacgccct catggacggg gcctctcaac tggtggggga gaacagaacc
     1261 atgaccatcc acaacggcat gttcttcagc acgtacgaca gggacaacga cggctgggta
     1321 actacggatc caagaaaaca gtgctccaaa gaagatggtg gtggctggtg gtataacaga
     1381 tgccatgcag ccaatccaaa tggcagatac tactggggtg gcctttacag ctgggacatg
     1441 tccaagcacg gcacagatga tggtgtggtg tggatgaact ggaagggatc gtggtactca
     1501 atgaggagga tgtctatgaa gatcaggccc ttcttcccac agcaatagtc ccccccaagc
     1561 acagactttc attcttctat gtctgacatt tttttacatt atgttattgg aattttcttt
     1621 gatacattat atccactaaa gctcaaaaca atggttgagt gtgtctcttt tggaacaata
     1681 taggataaag acattgaaaa cagcaaaaaa aaa
//
