LOCUS       NM_001111048            2649 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus fibrinogen alpha chain (Fga), transcript variant 1,
            mRNA.
ACCESSION   NM_001111048
VERSION     NM_001111048.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2649)
  AUTHORS   Ryu,J.K., Yan,Z., Montano,M., Sozmen,E.G., Dixit,K.,
            Suryawanshi,R.K., Matsui,Y., Helmy,E., Kaushal,P., Makanani,S.K.,
            Deerinck,T.J., Meyer-Franke,A., Rios Coronado,P.E., Trevino,T.N.,
            Shin,M.G., Tognatta,R., Liu,Y., Schuck,R., Le,L., Miyajima,H.,
            Mendiola,A.S., Arun,N., Guo,B., Taha,T.Y., Agrawal,A.,
            MacDonald,E., Aries,O., Yan,A., Weaver,O., Petersen,M.A., Meza
            Acevedo,R., Alzamora,M.D.P.S., Thomas,R., Traglia,M.,
            Kouznetsova,V.L., Tsigelny,I.F., Pico,A.R., Red-Horse,K.,
            Ellisman,M.H., Krogan,N.J., Bouhaddou,M., Ott,M., Greene,W.C. and
            Akassoglou,K.
  TITLE     Fibrin drives thromboinflammation and neuropathology in COVID-19
  JOURNAL   Nature 633 (8031), 905-913 (2024)
   PUBMED   39198643
REFERENCE   2  (bases 1 to 2649)
  AUTHORS   Mendiola,A.S., Yan,Z., Dixit,K., Johnson,J.R., Bouhaddou,M.,
            Meyer-Franke,A., Shin,M.G., Yong,Y., Agrawal,A., MacDonald,E.,
            Muthukumar,G., Pearce,C., Arun,N., Cabriga,B., Meza-Acevedo,R.,
            Alzamora,M.D.P.S., Zamvil,S.S., Pico,A.R., Ryu,J.K., Krogan,N.J.
            and Akassoglou,K.
  TITLE     Defining blood-induced microglia functions in neurodegeneration
            through multiomic profiling
  JOURNAL   Nat Immunol 24 (7), 1173-1187 (2023)
   PUBMED   37291385
REFERENCE   3  (bases 1 to 2649)
  AUTHORS   Liu,G., Xu,X., Geng,H., Li,J., Zou,S. and Li,X.
  TITLE     FGA inhibits metastases and induces autophagic cell death in
            gastric cancer via inhibiting ITGA5 to regulate the FAK/ERK pathway
  JOURNAL   Tissue Cell 76, 101767 (2022)
   PUBMED   35257941
  REMARK    GeneRIF: FGA inhibits metastases and induces autophagic cell death
            in gastric cancer via inhibiting ITGA5 to regulate the FAK/ERK
            pathway.
REFERENCE   4  (bases 1 to 2649)
  AUTHORS   Negron,O., Hur,W.S., Prasad,J., Paul,D.S., Rowe,S.E., Degen,J.L.,
            Abrahams,S.R., Antoniak,S., Conlon,B.P., Bergmeier,W., Hk,M. and
            Flick,M.J.
  TITLE     Fibrin(ogen) engagement of S. aureus promotes the host
            antimicrobial response and suppression of microbe dissemination
            following peritoneal infection
  JOURNAL   PLoS Pathog 18 (1), e1010227 (2022)
   PUBMED   35041705
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2649)
  AUTHORS   Hernandez,G.E., Ma,F., Martinez,G., Firozabadi,N.B., Salvador,J.,
            Juang,L.J., Leung,J., Zhao,P., Lopez,D.A., Ardehali,R.,
            Beaudin,A.E., Kastrup,C.J., Pellegrini,M., Flick,M.J. and
            Iruela-Arispe,M.L.
  TITLE     Aortic intimal resident macrophages are essential for maintenance
            of the non-thrombogenic intravascular state
  JOURNAL   Nat Cardiovasc Res 1 (1), 67-84 (2022)
   PUBMED   35599984
REFERENCE   6  (bases 1 to 2649)
  AUTHORS   Tsirka,S.E., Bugge,T.H., Degen,J.L. and Strickland,S.
  TITLE     Neuronal death in the central nervous system demonstrates a
            non-fibrin substrate for plasmin
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9779-9781 (1997)
   PUBMED   9275201
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1997 Dec 23;94(26):14976]
REFERENCE   7  (bases 1 to 2649)
  AUTHORS   Bugge,T.H., Kombrinck,K.W., Flick,M.J., Daugherty,C.C., Danton,M.J.
            and Degen,J.L.
  TITLE     Loss of fibrinogen rescues mice from the pleiotropic effects of
            plasminogen deficiency
  JOURNAL   Cell 87 (4), 709-719 (1996)
   PUBMED   8929539
REFERENCE   8  (bases 1 to 2649)
  AUTHORS   Suh,T.T., Holmback,K., Jensen,N.J., Daugherty,C.C., Small,K.,
            Simon,D.I., Potter,S. and Degen,J.L.
  TITLE     Resolution of spontaneous bleeding events but failure of pregnancy
            in fibrinogen-deficient mice
  JOURNAL   Genes Dev 9 (16), 2020-2033 (1995)
   PUBMED   7649481
REFERENCE   9  (bases 1 to 2649)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
REFERENCE   10 (bases 1 to 2649)
  AUTHORS   Murakawa,M., Okamura,T., Kamura,T., Shibuya,T., Harada,M. and
            Niho,Y.
  TITLE     Diversity of primary structures of the carboxy-terminal regions of
            mammalian fibrinogen A alpha-chains. Characterization of the
            partial nucleotide and deduced amino acid sequences in five
            mammalian species; rhesus monkey, pig, dog, mouse and Syrian
            hamster
  JOURNAL   Thromb Haemost 69 (4), 351-360 (1993)
   PUBMED   8497848
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY790061.1, AK146828.1,
            W78420.1, AC138394.7, BG081027.2 and AW113955.1.
            
            On Apr 8, 2015 this sequence version replaced NM_001111048.1.
            
            Summary: This gene encodes a subunit of the coagulation factor
            fibrinogen, which is a component of the blood clot. The encoded
            protein is proteolytically processed by thrombin during the
            conversion of fibrinogen to fibrin. Mice lacking the encoded
            protein display bleeding in the peritoneal cavity, skin and soft
            tissues around joints immediately after birth, and are predisposed
            to spontaneous fatal abdominal hemorrhage as they grow. Pregnant
            mice lacking the encoded protein succumb to uterine bleeding during
            gestation. Alternative splicing results in multiple transcript
            variants encoding different isoforms that may undergo similar
            proteolytic processing. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189673.110011.1,
                                           ERR2844020.183391.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BY790061.1         79-82
            5-1466              AK146828.1         2-1463
            1467-1703           AK146828.1         1465-1701
            1704-1807           W78420.1           250-353
            1808-1924           AC138394.7         108017-108133
            1925-2553           BG081027.2         1-629               c
            2554-2618           AW113955.1         19-83               c
            2619-2649           AC138394.7         108828-108858
FEATURES             Location/Qualifiers
     source          1..2649
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 36.96 cM"
     gene            1..2649
                     /gene="Fga"
                     /gene_synonym="Fib"
                     /note="fibrinogen alpha chain"
                     /db_xref="GeneID:14161"
                     /db_xref="MGI:MGI:1316726"
     exon            1..116
                     /gene="Fga"
                     /gene_synonym="Fib"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..2432
                     /gene="Fga"
                     /gene_synonym="Fib"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; fibrinogen, A alpha polypeptide"
                     /codon_start=1
                     /product="fibrinogen alpha chain isoform 1 preproprotein"
                     /protein_id="NP_001104518.1"
                     /db_xref="CCDS:CCDS50939.1"
                     /db_xref="GeneID:14161"
                     /db_xref="MGI:MGI:1316726"
                     /translation="MLSLRVTCLILSVASTVWTTDTEDKGEFLSEGGGVRGPRVVERH
                     QSQCKDSDWPFCSDDDWNHKCPSGCRMKGLIDEANQDFTNRINKLKNSLFDFQRNNKD
                     SNSLTRNIMEYLRGDFANANNFDNTYGQVSEDLRRRIEILRRKVIEKAQQIQALQSNV
                     RAQLIDMKRLEVDIDIKIRSCKGSCSRAVNREINLQDYEGHQKQLQQVIAKELLPTKD
                     RQYLPALKMSPVPDLVPGSFKSQLQEAPPEWKALTEMRQMRMELERPGKDGGSRGDSP
                     GDSRGDSRGDFATRGPGSKAENPTNPGPGGSGYWRPGNSGSGSDGNRNPGTTGSDGTG
                     DWGTGSPRPGSDSGNFRPANPNWGVFSEFGDSSSPATRKEYHTGKAVTSKGDKELLIG
                     KEKVTSSGTSTTHRSCSKTITKTVTGPDGRREVVKEVITSDDGSDCGDATELDISHSF
                     SGSLDELSERHPDLSGFFDNHFGLISPNFKEFGSKTHSDSDILTNIEDPSSHVPEFSS
                     SSKTSTVKKQVTKTYKMADEAGSEAHREGETRNTKRGRARARPTRDCDDVLQTQTSGA
                     QNGIFSIKPPGSSKVFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLND
                     KGEGEFWLGNDYLHLLTLRGSVLRVELEDWAGKEAYAEYHFRVGSEAEGYALQVSSYR
                     GTAGDALVQGSVEEGTEYTSHSNMQFSTFDRDADQWEENCAEVYGGGWWYNSCQAANL
                     NGIYYPGGTYDPRNNSPYEIENGVVWVPFRGADYSLRAVRMKIRPLVGQ"
     exon            117..245
                     /gene="Fga"
                     /gene_synonym="Fib"
                     /inference="alignment:Splign:2.1.0"
     exon            246..429
                     /gene="Fga"
                     /gene_synonym="Fib"
                     /inference="alignment:Splign:2.1.0"
     exon            430..575
                     /gene="Fga"
                     /gene_synonym="Fib"
                     /inference="alignment:Splign:2.1.0"
     exon            576..1722
                     /gene="Fga"
                     /gene_synonym="Fib"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..2649
                     /gene="Fga"
                     /gene_synonym="Fib"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcagtcct ccttcgcttc agctccagtt ctcctcatga gccatcccta aacgcagaca
       61 ccatgctgtc cctgagggtc acctgcctca tcttgagcgt ggccagcaca gtctggacta
      121 cagataccga agataaaggt gaattcctat cagaaggagg aggagtacgt ggcccaagag
      181 ttgtggagag acatcagagt caatgcaagg actcagactg gcccttctgc tctgatgatg
      241 actggaacca caaatgccct tcaggctgca ggatgaaagg gttgattgac gaagccaacc
      301 aggattttac aaacagaatc aacaagctca aaaactcact atttgacttt caaaggaaca
      361 acaaggattc taactcactg accaggaata tcatggagta tttgagaggg gacttcgcga
      421 atgccaacaa ctttgataac acttatgggc aagtgtcaga agacctgagg cgcagaattg
      481 agatcctgag gcgaaaagtc atagagaaag cgcaacagat tcaagctctg cagagcaatg
      541 tccgggctca gttgatagac atgaagcgcc tggaggtgga tattgatatc aagatccgct
      601 cttgcaaagg gtcctgcagc agggctgtaa accgtgagat aaatctacag gactatgaag
      661 gtcaccaaaa acagcttcaa caggtcatcg ctaaagaatt gcttcctaca aaagacaggc
      721 agtacttgcc agcactaaaa atgtctccag ttcccgactt ggttcccgga agttttaaga
      781 gccagcttca ggaggcccct ccagagtgga aggcattaac agaaatgcgg cagatgagaa
      841 tggagctgga gagacctggg aaggatgggg gttcgcgagg agattcacca ggagactcgc
      901 ggggagattc tagaggggac tttgcaacac gtggaccagg gtcaaaggca gaaaacccca
      961 cgaaccctgg acctggtgga tctgggtatt ggcgtcctgg gaactccggg tctggaagtg
     1021 atggaaatcg gaaccctggg accacggggt ctgatggcac tggagactgg ggtaccggaa
     1081 gccctagacc tggctcagac tctgggaact ttaggcctgc caaccctaac tggggtgtgt
     1141 tttcagagtt tggagacagt agcagcccag ccacaagaaa agagtatcac acaggtaaag
     1201 cggtcacttc taaaggagat aaagagctcc tgattggaaa ggagaaagtc acctcttctg
     1261 gcacaagcac cacacatcgt tcatgctcta aaaccattac caagactgtc acaggtcctg
     1321 atggtcgccg agaagtggtc aaagaagtga tcacctcgga tgatggctca gactgtggcg
     1381 atgccaccga gttagacata tcccacagtt ttagcggcag tctcgacgaa ctctctgaaa
     1441 ggcatcctga cctttctggg ttttttgaca accactttgg tttaatctca cctaacttca
     1501 aagaatttgg cagtaagacc cattctgatt ccgacatcct cacaaacatt gaggacccca
     1561 gctcccatgt acctgagttt tcttccagta gtaaaacctc aactgtcaaa aaacaagtaa
     1621 ccaagaccta taaaatggca gacgaggcag gaagcgaagc tcaccgggaa ggagaaactc
     1681 gcaacactaa gaggggccgt gccagagctc gcccaacgag agactgtgat gatgtcctcc
     1741 aaacacaaac ttcaggtgcc caaaatggca ttttcagtat caagccacct ggatccagta
     1801 aggttttttc tgtttattgc gatcaagaga ccagtttggg aggatggctt ttgatccagc
     1861 aaagaatgga tggatcgctg aattttaacc ggacctggca agactacaag agaggtttcg
     1921 gcagcctgaa tgacaaaggg gaaggagaat tctggctagg caatgactac ctccacttac
     1981 tcactctgag gggctcagtt ctcagggttg aattagagga ctgggctgga aaagaggctt
     2041 atgcggagta ccacttccgg gtaggctctg aggcagaggg ctacgcgctg caggtctcct
     2101 cctaccgggg cactgctgga gatgctctgg tgcagggctc tgtggaggag gggacagaat
     2161 acacctcaca cagcaacatg cagttcagta cctttgacag agatgccgac caatgggaag
     2221 agaactgtgc agaggtctat gggggaggct ggtggtacaa cagctgtcag gccgccaatc
     2281 tcaatggcat ttactacccc gggggcacct acgatcccag gaacaacagc ccctatgaga
     2341 tagagaacgg ggtggtctgg gttcccttca gaggagcaga ttattccctc agggccgttc
     2401 ggatgaaaat cagaccgctg gtgggacaat agctgaaggg ttagaaagtg ggggctctgt
     2461 tttctttgct cggttatccg agaagaaaga caaaacggaa gatgaaggtg tcacggatct
     2521 tgtgaacttt ttaaaacttt caaggtgcta ttccattgtt ctttgtactg tagctaaatg
     2581 taactgagat gagttactgc tttgaaaaaa taaagtttta cattttttcc accctttaaa
     2641 aaaaaaaaa
//
