LOCUS       NM_181748               1393 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Mus musculus free fatty acid receptor 4 (Ffar4), mRNA.
ACCESSION   NM_181748
VERSION     NM_181748.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1393)
  AUTHORS   Lee,J.E., Lee,J.H., Koh,J.M. and Im,D.S.
  TITLE     Free Fatty Acid 4 Receptor Activation Attenuates Collagen-Induced
            Arthritis by Rebalancing Th1/Th17 and Treg Cells
  JOURNAL   Int J Mol Sci 25 (11), 5866 (2024)
   PUBMED   38892051
  REMARK    GeneRIF: Free Fatty Acid 4 Receptor Activation Attenuates
            Collagen-Induced Arthritis by Rebalancing Th1/Th17 and Treg Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1393)
  AUTHORS   Son,S.E., Koh,J.M. and Im,D.S.
  TITLE     Free fatty acid receptor 4 (FFA4) activation attenuates obese
            asthma by suppressing adiposity and resolving metaflammation
  JOURNAL   Biomed Pharmacother 174, 116509 (2024)
   PUBMED   38574615
  REMARK    GeneRIF: Free fatty acid receptor 4 (FFA4) activation attenuates
            obese asthma by suppressing adiposity and resolving metaflammation.
REFERENCE   3  (bases 1 to 1393)
  AUTHORS   Hagihara,M., Ariyoshi,T., Eguchi,S., Oka,K., Takahashi,M., Kato,H.,
            Shibata,Y., Umemura,T., Mori,T., Miyazaki,N., Hirai,J., Asai,N.,
            Mori,N. and Mikamo,H.
  TITLE     Oral Clostridium butyricum on mice endometritis through uterine
            microbiome and metabolic alternations
  JOURNAL   Front Microbiol 15, 1351899 (2024)
   PUBMED   38450161
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1393)
  AUTHORS   Wang,W., Li,J., Cui,S., Li,J., Ye,X., Wang,Z., Zhang,T., Jiang,X.,
            Kong,Y., Chen,X., Chen,Y.Q. and Zhu,S.
  TITLE     Microglial Ffar4 deficiency promotes cognitive impairment in the
            context of metabolic syndrome
  JOURNAL   Sci Adv 10 (5), eadj7813 (2024)
   PUBMED   38306420
  REMARK    GeneRIF: Microglial Ffar4 deficiency promotes cognitive impairment
            in the context of metabolic syndrome.
REFERENCE   5  (bases 1 to 1393)
  AUTHORS   Nakajima,S., Demers,G., Machuca-Parra,A.I., Pour,Z.D.,
            Bairamian,D., Bouyakdan,K., Fisette,A., Kabahizi,A., Robb,J.,
            Rodaros,D., Laurent,C., Ferreira,G., Arbour,N., Alquier,T. and
            Fulton,S.
  TITLE     Central activation of the fatty acid sensor GPR120 suppresses
            microglia reactivity and alleviates sickness- and anxiety-like
            behaviors
  JOURNAL   J Neuroinflammation 20 (1), 302 (2023)
   PUBMED   38111048
  REMARK    GeneRIF: Central activation of the fatty acid sensor GPR120
            suppresses microglia reactivity and alleviates sickness- and
            anxiety-like behaviors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1393)
  AUTHORS   Gotoh,C., Hong,Y.H., Iga,T., Hishikawa,D., Suzuki,Y., Song,S.H.,
            Choi,K.C., Adachi,T., Hirasawa,A., Tsujimoto,G., Sasaki,S. and
            Roh,S.G.
  TITLE     The regulation of adipogenesis through GPR120
  JOURNAL   Biochem Biophys Res Commun 354 (2), 591-597 (2007)
   PUBMED   17250804
  REMARK    GeneRIF: Regulates adipogenic processes such as adipocyte
            development and differentiation.
REFERENCE   7  (bases 1 to 1393)
  AUTHORS   Katsuma,S., Hatae,N., Yano,T., Ruike,Y., Kimura,M., Hirasawa,A. and
            Tsujimoto,G.
  TITLE     Free fatty acids inhibit serum deprivation-induced apoptosis
            through GPR120 in a murine enteroendocrine cell line STC-1
  JOURNAL   J Biol Chem 280 (20), 19507-19515 (2005)
   PUBMED   15774482
REFERENCE   8  (bases 1 to 1393)
  AUTHORS   Hirasawa,A., Tsumaya,K., Awaji,T., Katsuma,S., Adachi,T.,
            Yamada,M., Sugimoto,Y., Miyazaki,S. and Tsujimoto,G.
  TITLE     Free fatty acids regulate gut incretin glucagon-like peptide-1
            secretion through GPR120
  JOURNAL   Nat Med 11 (1), 90-94 (2005)
   PUBMED   15619630
REFERENCE   9  (bases 1 to 1393)
  AUTHORS   Fredriksson,R., Hoglund,P.J., Gloriam,D.E., Lagerstrom,M.C. and
            Schioth,H.B.
  TITLE     Seven evolutionarily conserved human rhodopsin G protein-coupled
            receptors lacking close relatives
  JOURNAL   FEBS Lett 554 (3), 381-388 (2003)
   PUBMED   14623098
REFERENCE   10 (bases 1 to 1393)
  AUTHORS   Hohmann,J.G., Jureus,A., Teklemichael,D.N., Matsumoto,A.M.,
            Clifton,D.K. and Steiner,R.A.
  TITLE     Distribution and regulation of galanin receptor 1 messenger RNA in
            the forebrain of wild type and galanin-transgenic mice
  JOURNAL   Neuroscience 117 (1), 105-117 (2003)
   PUBMED   12605897
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101774.6.
            
            On Nov 17, 2006 this sequence version replaced NM_181748.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053698.1, AB115769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-615               AC101774.6         32141-32755         c
            616-744             AC101774.6         22324-22452         c
            745-1393            AC101774.6         15571-16219         c
FEATURES             Location/Qualifiers
     source          1..1393
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 32.73 cM"
     gene            1..1393
                     /gene="Ffar4"
                     /gene_synonym="Ffa4; Gpr120; Gpr129; GT01; KPG_013;
                     O3far1; Pgr4"
                     /note="free fatty acid receptor 4"
                     /db_xref="GeneID:107221"
                     /db_xref="MGI:MGI:2147577"
     exon            1..615
                     /gene="Ffar4"
                     /gene_synonym="Ffa4; Gpr120; Gpr129; GT01; KPG_013;
                     O3far1; Pgr4"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1134
                     /gene="Ffar4"
                     /gene_synonym="Ffa4; Gpr120; Gpr129; GT01; KPG_013;
                     O3far1; Pgr4"
                     /note="G-protein coupled receptor 120; G-protein-coupled
                     receptor GT01; omega-3 fatty acid receptor 1"
                     /codon_start=1
                     /product="free fatty acid receptor 4"
                     /protein_id="NP_861413.1"
                     /db_xref="CCDS:CCDS29783.1"
                     /db_xref="GeneID:107221"
                     /db_xref="MGI:MGI:2147577"
                     /translation="MSPECAQTTGPGPSHTLDQVNRTHFPFFSDVKGDHRLVLSVVET
                     TVLGLIFVVSLLGNVCALVLVARRRRRGATASLVLNLFCADLLFTSAIPLVLVVRWTE
                     AWLLGPVVCHLLFYVMTMSGSVTILTLAAVSLERMVCIVRLRRGLSGPGRRTQAALLA
                     FIWGYSALAALPLCILFRVVPQRLPGGDQEIPICTLDWPNRIGEISWDVFFVTLNFLV
                     PGLVIVISYSKILQITKASRKRLTLSLAYSESHQIRVSQQDYRLFRTLFLLMVSFFIM
                     WSPIIITILLILIQNFRQDLVIWPSLFFWVVAFTFANSALNPILYNMSLFRNEWRKIF
                     CCFFFPEKGAIFTDTSVRRNDLSVISS"
     exon            616..744
                     /gene="Ffar4"
                     /gene_synonym="Ffa4; Gpr120; Gpr129; GT01; KPG_013;
                     O3far1; Pgr4"
                     /inference="alignment:Splign:2.1.0"
     exon            745..1393
                     /gene="Ffar4"
                     /gene_synonym="Ffa4; Gpr120; Gpr129; GT01; KPG_013;
                     O3far1; Pgr4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1364..1369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ffar4"
                     /gene_synonym="Ffa4; Gpr120; Gpr129; GT01; KPG_013;
                     O3far1; Pgr4"
                     /note="hexamer: AATAAA"
     polyA_site      1393
                     /gene="Ffar4"
                     /gene_synonym="Ffa4; Gpr120; Gpr129; GT01; KPG_013;
                     O3far1; Pgr4"
                     /note="major polyA site"
ORIGIN      
        1 cgcagatgag cgctctctca gacagcggcg ggcggccggg cgcccggcat gtcccctgag
       61 tgtgcacaga cgacgggccc tggcccctcg cacaccctgg accaagtcaa tcgcacccac
      121 ttccctttct tctcggatgt caagggcgac caccggttgg tgttgagcgt cgtggagacc
      181 accgttctgg ggctcatctt tgtcgtctca ctgctgggca acgtgtgtgc tctagtgctg
      241 gtggcgcgcc gtcggcgccg tggggcgaca gccagcctgg tgctcaacct cttctgcgcg
      301 gatttgctct tcaccagcgc catccctcta gtgctcgtcg tgcgctggac tgaggcctgg
      361 ctgttggggc ccgtcgtctg ccacctgctc ttctacgtga tgacaatgag cggcagcgtc
      421 acgatcctca cactggccgc ggtcagcctg gagcgcatgg tgtgcatcgt gcgcctccgg
      481 cgcggcttga gcggcccggg gcggcggact caggcggcac tgctggcttt catatggggt
      541 tactcggcgc tcgccgcgct gcccctctgc atcttgttcc gcgtggtccc gcagcgcctt
      601 cccggcgggg accaggaaat tccgatttgc acattggatt ggcccaaccg cataggagaa
      661 atctcatggg atgtgttttt tgtgactttg aacttcctgg tgccgggact ggtcattgtg
      721 atcagttact ccaaaatttt acagatcacg aaagcatcgc ggaagaggct tacgctgagc
      781 ttggcatact ctgagagcca ccagatccga gtgtcccaac aagactaccg actcttccgc
      841 acgctcttcc tgctcatggt ttccttcttc atcatgtgga gtcccatcat catcaccatc
      901 ctcctcatct tgatccaaaa cttccggcag gacctggtca tctggccatc ccttttcttc
      961 tgggtggtgg ccttcacgtt tgccaactct gccctaaacc ccatactgta caacatgtcg
     1021 ctgttcagga acgaatggag gaagattttt tgctgcttct tttttccaga gaagggagcc
     1081 atttttacag atacgtctgt caggcgaaat gacttgtctg ttatttccag ctaactagcc
     1141 tctggtgcca ggtgaaccac ggtgtgcatg taaagggagt taacttcaag gaaagcccac
     1201 cagtgcgccc tgctttaaaa atacccgact tccaacagca ggcatctacg gagccagcaa
     1261 attaaggaat gatcgctcag tataaaaata tttttcctta aaagaacttt ctatgggttc
     1321 cttttgtgaa ctttttttag tgtgtttgta atatgatcta gttaataaat ttttatttat
     1381 aactgttcct aca
//
