LOCUS       NM_001033316            1625 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus free fatty acid receptor 3 (Ffar3), mRNA.
ACCESSION   NM_001033316 XM_145470 XM_909787
VERSION     NM_001033316.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1625)
  AUTHORS   Lee,A.R., Wilson,K.R., Clarke,M., Engel,S., Tscharke,D.C.,
            Gebhardt,T., Bedoui,S. and Bachem,A.
  TITLE     GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex
            virus type 1 infection
  JOURNAL   Front Immunol 15, 1332588 (2024)
   PUBMED   38524121
  REMARK    GeneRIF: GPR41 and GPR43 regulate CD8[+] T cell priming during
            herpes simplex virus type 1 infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1625)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1625)
  AUTHORS   Mishra,S.P., Jain,S., Wang,B., Wang,S., Miller,B.C., Lee,J.Y.,
            Borlongan,C.V., Jiang,L., Pollak,J., Taraphder,S., Layden,B.T.,
            Rane,S.G. and Yadav,H.
  TITLE     Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut
            impair brain function
  JOURNAL   JCI Insight 9 (3), e168443 (2024)
   PUBMED   38329121
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1625)
  AUTHORS   Ohue-Kitano,R., Masujima,Y., Nishikawa,S., Iwasa,M., Nishitani,Y.,
            Kawakami,H., Kuwahara,H. and Kimura,I.
  TITLE     3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to
            improved hepatic lipid metabolism via GPR41
  JOURNAL   Sci Rep 13 (1), 21246 (2023)
   PUBMED   38040866
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1625)
  AUTHORS   Ren,Z., Pan,X., Li,J., Dong,X., Tu,X., Pan,L.L. and Sun,J.
  TITLE     G protein coupled receptor 41 regulates fibroblast activation in
            pulmonary fibrosis via Galphai/o and downstream Smad2/3 and ERK1/2
            phosphorylation
  JOURNAL   Pharmacol Res 191, 106754 (2023)
   PUBMED   37019194
  REMARK    GeneRIF: G protein coupled receptor 41 regulates fibroblast
            activation in pulmonary fibrosis via Galphai/o and downstream
            Smad2/3 and ERK1/2 phosphorylation.
REFERENCE   6  (bases 1 to 1625)
  AUTHORS   Liu,C., Wu,J., Zhu,J., Kuei,C., Yu,J., Shelton,J., Sutton,S.W.,
            Li,X., Yun,S.J., Mirzadegan,T., Mazur,C., Kamme,F. and
            Lovenberg,T.W.
  TITLE     Lactate inhibits lipolysis in fat cells through activation of an
            orphan G-protein-coupled receptor, GPR81
  JOURNAL   J Biol Chem 284 (5), 2811-2822 (2009)
   PUBMED   19047060
REFERENCE   7  (bases 1 to 1625)
  AUTHORS   Swaminath,G.
  TITLE     Fatty acid binding receptors and their physiological role in type 2
            diabetes
  JOURNAL   Arch Pharm (Weinheim) 341 (12), 753-761 (2008)
   PUBMED   19009545
  REMARK    GeneRIF: In this review, the mechanism of receptor activation,
            pharmacology, and the physiological functions of the fatty acid
            binding receptors GPR40, GPR41, GPR43, and GPR119 are discussed.
            Review article
REFERENCE   8  (bases 1 to 1625)
  AUTHORS   Samuel,B.S., Shaito,A., Motoike,T., Rey,F.E., Backhed,F.,
            Manchester,J.K., Hammer,R.E., Williams,S.C., Crowley,J.,
            Yanagisawa,M. and Gordon,J.I.
  TITLE     Effects of the gut microbiota on host adiposity are modulated by
            the short-chain fatty-acid binding G protein-coupled receptor,
            Gpr41
  JOURNAL   Proc Natl Acad Sci U S A 105 (43), 16767-16772 (2008)
   PUBMED   18931303
  REMARK    GeneRIF: Gpr41 is a regulator of host energy balance through
            effects that are dependent upon the gut microbiota
REFERENCE   9  (bases 1 to 1625)
  AUTHORS   Hong,Y.H., Nishimura,Y., Hishikawa,D., Tsuzuki,H., Miyahara,H.,
            Gotoh,C., Choi,K.C., Feng,D.D., Chen,C., Lee,H.G., Katoh,K.,
            Roh,S.G. and Sasaki,S.
  TITLE     Acetate and propionate short chain fatty acids stimulate
            adipogenesis via GPCR43
  JOURNAL   Endocrinology 146 (12), 5092-5099 (2005)
   PUBMED   16123168
  REMARK    GeneRIF: Acetate and propionate short chain fatty acids may have
            important physiological roles in adipogenesis through GPCR43, but
            not through GPCR41.
REFERENCE   10 (bases 1 to 1625)
  AUTHORS   Xiong,Y., Miyamoto,N., Shibata,K., Valasek,M.A., Motoike,T.,
            Kedzierski,R.M. and Yanagisawa,M.
  TITLE     Short-chain fatty acids stimulate leptin production in adipocytes
            through the G protein-coupled receptor GPR41
  JOURNAL   Proc Natl Acad Sci U S A 101 (4), 1045-1050 (2004)
   PUBMED   14722361
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK148616.1.
            
            On Apr 6, 2007 this sequence version replaced NM_001033316.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148616.1, BY741744.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1625              AK148616.1         2-1626
FEATURES             Location/Qualifiers
     source          1..1625
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.25 cM"
     gene            1..1625
                     /gene="Ffar3"
                     /gene_synonym="Gm478; Gpr41"
                     /note="free fatty acid receptor 3"
                     /db_xref="GeneID:233080"
                     /db_xref="MGI:MGI:2685324"
     exon            1..50
                     /gene="Ffar3"
                     /gene_synonym="Gm478; Gpr41"
                     /inference="alignment:Splign:2.1.0"
     exon            51..1625
                     /gene="Ffar3"
                     /gene_synonym="Gm478; Gpr41"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1021
                     /gene="Ffar3"
                     /gene_synonym="Gm478; Gpr41"
                     /note="putative G protein-coupled receptor GPR41;
                     G-protein coupled receptor 41"
                     /codon_start=1
                     /product="free fatty acid receptor 3"
                     /protein_id="NP_001028488.1"
                     /db_xref="CCDS:CCDS21112.1"
                     /db_xref="GeneID:233080"
                     /db_xref="MGI:MGI:2685324"
                     /translation="MGTSFFLGNYWLFFSVYLLVFLVGLPLNVMALVVFVGKLRRRPV
                     AVDLLLLNLTISDLLLLLFLPFRMVEAACGMRWLLPFIFCPLSGFLFFTTIYLTSLFL
                     TAVSIERFLSVAYPLWYKTRPRLAQAGLVSVVCWFLASAHCSVVYITEYWGNATYSQG
                     TNGTCYLEFREDQLAILLPVRLEMAVVLFMVPLCITSYCYSRLVWILSRGASRRRRKR
                     IMGLLAATLLIFFVCFGPYNMSHVVGYVSRESPSWRSYVLLLSTLNSCIDPLVFYFSS
                     SKFQADFHQLLGRLLRTCVPWTQQVSLELKVKNGEEPSKECPS"
ORIGIN      
        1 aggagccagc cgggtgctgg gcagcagagt gccagttgtc caatactctg catctgtgac
       61 catggggaca agcttctttc ttggcaatta ctggcttttc ttttccgtct acctgttggt
      121 gttcctcgtg ggactccccc tcaacgtgat ggccctggtg gtcttcgtgg gcaagctgcg
      181 ccgacgccca gtggctgtgg acttactttt gctaaacctg accatttcgg acctgctcct
      241 gctcctcttc ctgccgtttc gcatggtgga ggcagcatgt ggcatgagat ggcttctgcc
      301 cttcatcttc tgcccccttt ctgggttcct tttcttcacc actatttacc tcacctccct
      361 cttcctgacg gcggtgagca tcgaacgttt tctgagcgtg gcctatccac tgtggtacaa
      421 aacccggccc cggctggccc aggctggtct ggtcagtgta gtctgttggt tcctggcatc
      481 ggctcactgt agtgtggttt acatcactga atactgggga aatgcaacct acagccaggg
      541 gaccaatgga acctgctacc tggaattccg ggaggaccag ctggccatcc tcctgcctgt
      601 acgactagag atggctgtgg tccttttcat ggtgcccctg tgtatcacga gttactgcta
      661 cagtcgcctg gtgtggatac tgagccgggg ggccagccgg cgccggcgca agaggataat
      721 ggggcttctt gcagccacac tgctcatctt cttcgtctgc ttcggcccct ataatatgtc
      781 ccatgtggtg ggctatgtca gccgtgagag tccgtcctgg cggagctacg tgctcctcct
      841 cagcaccctc aactcttgta tcgaccccct ggttttctac ttttcttcct ccaagttcca
      901 agccgacttt catcaactcc tggggaggct gctcagaact tgtgtgcctt ggactcagca
      961 agtcagcctg gaactgaagg taaagaatgg agaagagcca tccaaggagt gtccgagcta
     1021 gagaaaagag tggaccgcag gagggggtgg aaccattggc tcagtgctat ggctggcgga
     1081 gagctctcca ggggcaggca ggagtaggct ccagcgtgtc tgcaggtcat tccctagctc
     1141 agacggacta gagtgcactg tgacaggctg cagacattgc tgtcactcag attgccctga
     1201 gtgcactcac aaggactctc cttgccgccc tccttcctat cctctcataa accccgaatt
     1261 tcactctgaa aagttgtggg gattagagac ttctctagaa gaaagagcca agcctctgcc
     1321 ttggccatcc agcttcaagg cctccctggg tggaagagga agggattacc cagggctgga
     1381 actgagctgg gaacttgggg tgtgggtgtg taggggtgca gggtgtgtgt gtgtgtgtgt
     1441 gcaagccgct gactcctcct agctcctcag aatgggggag gtgggattcc agggattggg
     1501 gaacagcctg cccttgtgag cgttttccag acagttctca ctcttctgta aattcacatc
     1561 ttctgggatg cgtatgaaca atggtaggca attagaaaaa ttatccaaat aaattcggta
     1621 cctag
//
