LOCUS       NM_001168509            1969 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus free fatty acid receptor 2 (Ffar2), transcript variant
            2, mRNA.
ACCESSION   NM_001168509
VERSION     NM_001168509.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1969)
  AUTHORS   Jeong,H., Lee,B., Cho,S.Y., Lee,Y., Kim,J., Hur,S., Cho,K.,
            Kim,K.H., Kim,S.H. and Nam,K.T.
  TITLE     Microbiota-derived short-chain fatty acids determine stem cell
            characteristics of gastric chief cells
  JOURNAL   Dev Cell (2024) In press
   PUBMED   39642880
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1969)
  AUTHORS   Sa,A.K., Olimpio,F., Vasconcelos,J., Rosa,P., Faria Neto,H.C.,
            Rocha,C., Camacho,M.F., Barcick,U., Zelanis,A. and Aimbire,F.
  TITLE     Involvement of GPR43 Receptor in Effect of Lacticaseibacillus
            rhamnosus on Murine Steroid Resistant Chronic Obstructive Pulmonary
            Disease: Relevance to Pro-Inflammatory Mediators and Oxidative
            Stress in Human Macrophages
  JOURNAL   Nutrients 16 (10), 1509 (2024)
   PUBMED   38794746
  REMARK    GeneRIF: Involvement of GPR43 Receptor in Effect of
            Lacticaseibacillus rhamnosus on Murine Steroid Resistant Chronic
            Obstructive Pulmonary Disease: Relevance to Pro-Inflammatory
            Mediators and Oxidative Stress in Human Macrophages.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1969)
  AUTHORS   Caetano-Silva,M.E., Rund,L., Vailati-Riboni,M., Matt,S.,
            Soto-Diaz,K., Beever,J., Allen,J.M., Woods,J.A., Steelman,A.J. and
            Johnson,R.W.
  TITLE     The emergence of inflammatory microglia during gut inflammation is
            not affected by FFAR2 expression in intestinal epithelial cells or
            peripheral myeloid cells
  JOURNAL   Brain Behav Immun 118, 423-436 (2024)
   PUBMED   38467381
  REMARK    GeneRIF: The emergence of inflammatory microglia during gut
            inflammation is not affected by FFAR2 expression in intestinal
            epithelial cells or peripheral myeloid cells.
REFERENCE   4  (bases 1 to 1969)
  AUTHORS   Lee,A.R., Wilson,K.R., Clarke,M., Engel,S., Tscharke,D.C.,
            Gebhardt,T., Bedoui,S. and Bachem,A.
  TITLE     GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex
            virus type 1 infection
  JOURNAL   Front Immunol 15, 1332588 (2024)
   PUBMED   38524121
  REMARK    GeneRIF: GPR41 and GPR43 regulate CD8[+] T cell priming during
            herpes simplex virus type 1 infection.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1969)
  AUTHORS   Zhao,Z., Qin,J., Qian,Y., Huang,C., Liu,X., Wang,N., Li,L.,
            Chao,Y., Tan,B., Zhang,N., Qian,M., Li,D., Liu,M. and Du,B.
  TITLE     FFAR2 expressing myeloid-derived suppressor cells drive cancer
            immunoevasion
  JOURNAL   J Hematol Oncol 17 (1), 9 (2024)
   PUBMED   38402237
  REMARK    GeneRIF: FFAR2 expressing myeloid-derived suppressor cells drive
            cancer immunoevasion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1969)
  AUTHORS   Ge,H., Li,X., Weiszmann,J., Wang,P., Baribault,H., Chen,J.L.,
            Tian,H. and Li,Y.
  TITLE     Activation of G protein-coupled receptor 43 in adipocytes leads to
            inhibition of lipolysis and suppression of plasma free fatty acids
  JOURNAL   Endocrinology 149 (9), 4519-4526 (2008)
   PUBMED   18499755
  REMARK    GeneRIF: A potential role for GPR43 in regulating plasma lipid
            profiles and perhaps aspects of metabolic syndrome.
REFERENCE   7  (bases 1 to 1969)
  AUTHORS   Hong,Y.H., Nishimura,Y., Hishikawa,D., Tsuzuki,H., Miyahara,H.,
            Gotoh,C., Choi,K.C., Feng,D.D., Chen,C., Lee,H.G., Katoh,K.,
            Roh,S.G. and Sasaki,S.
  TITLE     Acetate and propionate short chain fatty acids stimulate
            adipogenesis via GPCR43
  JOURNAL   Endocrinology 146 (12), 5092-5099 (2005)
   PUBMED   16123168
  REMARK    GeneRIF: Acetate and propionate short chain fatty acids may have
            important physiological roles in adipogenesis through GPCR43, but
            not through GPCR41.
REFERENCE   8  (bases 1 to 1969)
  AUTHORS   Nilsson,N.E., Kotarsky,K., Owman,C. and Olde,B.
  TITLE     Identification of a free fatty acid receptor, FFA2R, expressed on
            leukocytes and activated by short-chain fatty acids
  JOURNAL   Biochem Biophys Res Commun 303 (4), 1047-1052 (2003)
   PUBMED   12684041
REFERENCE   9  (bases 1 to 1969)
  AUTHORS   Senga,T., Iwamoto,S., Yoshida,T., Yokota,T., Adachi,K., Azuma,E.,
            Hamaguchi,M. and Iwamoto,T.
  TITLE     LSSIG is a novel murine leukocyte-specific GPCR that is induced by
            the activation of STAT3
  JOURNAL   Blood 101 (3), 1185-1187 (2003)
   PUBMED   12393494
  REMARK    GeneRIF: induced by the activation of STAT3; might play pivotal
            role in differentiation and immune response of monocytes and
            granulocytes
REFERENCE   10 (bases 1 to 1969)
  AUTHORS   Andrade,S.P., Machado,R.D., Teixeira,A.S., Belo,A.V., Tarso,A.M.
            and Beraldo,W.T.
  TITLE     Sponge-induced angiogenesis in mice and the pharmacological
            reactivity of the neovasculature quantitated by a fluorimetric
            method
  JOURNAL   Microvasc Res 54 (3), 253-261 (1997)
   PUBMED   9441896
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI607149.1 and AK078861.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All five variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI607149.1, AF545043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               AI607149.1         1-318
            319-1363            AK078861.1         642-1686
            1364-1969           AK078861.1         1691-2296
FEATURES             Location/Qualifiers
     source          1..1969
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.25 cM"
     gene            1..1969
                     /gene="Ffar2"
                     /gene_synonym="GPCR43; Gpr43"
                     /note="free fatty acid receptor 2"
                     /db_xref="GeneID:233079"
                     /db_xref="MGI:MGI:2441731"
     exon            1..149
                     /gene="Ffar2"
                     /gene_synonym="GPCR43; Gpr43"
                     /inference="alignment:Splign:2.1.0"
     exon            150..211
                     /gene="Ffar2"
                     /gene_synonym="GPCR43; Gpr43"
                     /inference="alignment:Splign:2.1.0"
     exon            212..1969
                     /gene="Ffar2"
                     /gene_synonym="GPCR43; Gpr43"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1205
                     /gene="Ffar2"
                     /gene_synonym="GPCR43; Gpr43"
                     /note="G protein-coupled receptor 43; leukocyte-specific
                     STAT-induced GPCR"
                     /codon_start=1
                     /product="free fatty acid receptor 2"
                     /protein_id="NP_001161981.1"
                     /db_xref="CCDS:CCDS21111.1"
                     /db_xref="GeneID:233079"
                     /db_xref="MGI:MGI:2441731"
                     /translation="MTPDWHSSLILTAYILIFLTGLPANLLALRAFMGRVRQPQPAPV
                     HILLLNLTLADLLLLLLLPFRIVEAASNFRWYLPKIVCALTGFGFYSSIYCSTWLLAG
                     ISMERYLGVAFPVQYKLSRRPLYGVIAALVAWIMSFGHCTIVIIVQYLNSTEQVGTEN
                     QITCYENFTQEQLDVVLPVRLELCLVLFFVPMAVTIFCYWRFVWIMLTQPHVGAQRRR
                     RAVGLAVVTLLNFLVCFGPYNMSHLVGFYLRQSPSWRVEAVVFSSLNASLDPLLFYFS
                     SSVVRRAFGKGLLLIRNPASSMLGRGAKETVEGTKMDRGGSQAEGVQSSEFVTE"
ORIGIN      
        1 gaaacttggg gtggacacca ggagaccaca aagaagttag acaagggagg aatcacagga
       61 aacgggaagc ctcgttctga gaatgacatt gaccttctag acattgctct gaagaagcca
      121 atcagaagac agaaaaggag ctgacagggg ttccacagca ctggaccaga ggagaaccag
      181 gtagaagaaa cccctgaact tgcccaagga gaatgacccc agactggcac agttccttga
      241 tcctcacggc ctacatcctc atctttctta ctgggctccc tgccaacctg ctggccctgc
      301 gggccttcat gggccgggtt cgccagcctc agcctgcccc tgtgcacatc ctcctgctta
      361 atctgaccct ggcggacttg ctcctgttgc tgctgctgcc cttccggatc gtggaagcag
      421 catccaactt ccgctggtac ctaccaaaga tcgtgtgcgc gctgacaggc ttcggcttct
      481 acagcagcat ctactgcagc acgtggctgc tggcgggcat cagcatggaa cgctacctgg
      541 gagtggcctt cccggtgcag tacaagttat cccgccggcc actgtatgga gtgatcgctg
      601 ctctggtggc ctggatcatg tcctttggcc actgcaccat cgtcatcatc gttcagtacc
      661 tgaactcaac tgagcaggtg ggcactgaga accaaataac ctgctacgag aacttcaccc
      721 aagagcagct ggatgtggta ctgcccgtac gactggagct gtgcctggtc ctgtttttcg
      781 ttcccatggc agtcaccatc ttctgttatt ggcgcttcgt gtggatcatg ctcacgcagc
      841 cccacgttgg ggctcagagg cgacgccggg cagtgggcct ggctgttgtg acgcttctta
      901 atttcctggt gtgctttgga ccctacaaca tgtcccacct ggtggggttc tacctgaggc
      961 agagcccctc gtggcgggtg gaggctgtgg tgttcagttc cctcaatgcc agcctggatc
     1021 cattattgtt ctacttctcc tcctccgtgg tgcgcagagc ttttgggaaa ggtttgctac
     1081 tgatccgcaa tcctgcctcc tctatgctgg gcaggggagc caaagagaca gtggagggga
     1141 ccaagatgga caggggtgga agtcaagcag aaggggtaca gagttctgaa tttgtcaccg
     1201 agtagagagt cccccggatc ttcccgagca tttgggtcac ccagaagttg gtctggttag
     1261 cagagctcct gagacttggt aaaagataaa agattaagaa agaaagaaag aaagaaagaa
     1321 agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa agacacctcc acccatctgc
     1381 cactgccctc tcagctcagc agaaccactt gactgaattt tcctgcccag agaagcatag
     1441 ctccaggata caagaaggaa tggctacacc cttacactgt attttcacag tggggtcagg
     1501 ggctcagaag caaggtgact aataggggtg cagtaataaa agtaattttt ttcctcgagc
     1561 ttggaaatgc cacctagaga cagtgatctg gctggtgatg ctggaaagaa gccaatggaa
     1621 aagatggggg gagatggggg gaagaagagg aatgccggga aagctctaag ccacagcctt
     1681 gaggcagggg ctgagggcgg gcaacacaca gggctcccat ctctggtgat cttggccttt
     1741 ctatatccga ttgagctgtc ctttgtacat gtgctccgct gattttcata ttttggtctt
     1801 gtctccactg ttatgccggg atctgggtca catgcttatc ctctgtgtca ccagtcactg
     1861 ggtctaggag atgtcttggt acccgtctgt ctgacattga caatgacctg aaaggaagga
     1921 ttaaaaagaa aatctggttt ggcaggtaaa aataaagatt atgaaagtc
//
