LOCUS       NM_194057                903 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus free fatty acid receptor 1 (Ffar1), mRNA.
ACCESSION   NM_194057
VERSION     NM_194057.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 903)
  AUTHORS   Koganesawa,M., Dwyer,D.F., Alhallak,K., Nagai,J., Zaleski,K.,
            Samuchiwal,S., Hiroaki,H., Nishida,A., Hirsch,T.I., Brennan,P.J.,
            Puder,M. and Balestrieri,B.
  TITLE     Pla2g5 contributes to viral-like-induced lung inflammation through
            macrophage proliferation and LA/Ffar1 lung cell recruitment
  JOURNAL   Immunology 172 (1), 144-162 (2024)
   PUBMED   38361249
  REMARK    GeneRIF: Pla2g5 contributes to viral-like-induced lung inflammation
            through macrophage proliferation and LA/Ffar1 lung cell
            recruitment.
REFERENCE   2  (bases 1 to 903)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 903)
  AUTHORS   Dragano,N.R.V., Milbank,E., Haddad-Tovolli,R., Garrido-Gil,P.,
            Novoa,E., Fondevilla,M.F., Capelli,V., Zanesco,A.M., Solon,C.,
            Morari,J., Pires,L., Estevez-Salguero,A., Beiroa,D.,
            Gonzalez-Garcia,I., Barca-Mayo,O., Dieguez,C., Nogueiras,R.,
            Labandeira-Garcia,J.L., Rexen Ulven,E., Ulven,T., Claret,M.,
            Velloso,L.A. and Lopez,M.
  TITLE     Hypothalamic free fatty acid receptor-1 regulates whole-body energy
            balance
  JOURNAL   Mol Metab 79, 101840 (2024)
   PUBMED   38036170
REFERENCE   4  (bases 1 to 903)
  AUTHORS   Li,Y., Lu,Z., Kirkwood,C.L., Kirkwood,K.L., Wank,S.A., Li,A.J.,
            Lopes-Virella,M.F. and Huang,Y.
  TITLE     GPR40 deficiency worsens metabolic syndrome-associated
            periodontitis in mice
  JOURNAL   J Periodontal Res 58 (3), 575-587 (2023)
   PUBMED   36807310
  REMARK    GeneRIF: GPR40 deficiency worsens metabolic syndrome-associated
            periodontitis in mice.
REFERENCE   5  (bases 1 to 903)
  AUTHORS   Kurihara,T.
  TITLE     [Possible involvement of FFAR1 signaling in mouse emotional
            behaviors through the regulation of brain monoamine releases]
  JOURNAL   Nihon Yakurigaku Zasshi 158 (6), 454-459 (2023)
   PUBMED   37914322
  REMARK    GeneRIF: [Possible involvement of FFAR1 signaling in mouse
            emotional behaviors through the regulation of brain monoamine
            releases].
            Review article
REFERENCE   6  (bases 1 to 903)
  AUTHORS   Stewart,G., Hira,T., Higgins,A., Smith,C.P. and McLaughlin,J.T.
  TITLE     Mouse GPR40 heterologously expressed in Xenopus oocytes is
            activated by short-, medium-, and long-chain fatty acids
  JOURNAL   Am J Physiol Cell Physiol 290 (3), C785-C792 (2006)
   PUBMED   16267104
  REMARK    GeneRIF: GPR40 has the capacity to respond to fatty acids with
            chain lengths of four or greater.
REFERENCE   7  (bases 1 to 903)
  AUTHORS   Salehi,A., Flodgren,E., Nilsson,N.E., Jimenez-Feltstrom,J.,
            Miyazaki,J., Owman,C. and Olde,B.
  TITLE     Free fatty acid receptor 1 (FFA(1)R/GPR40) and its involvement in
            fatty-acid-stimulated insulin secretion
  JOURNAL   Cell Tissue Res 322 (2), 207-215 (2005)
   PUBMED   16044321
  REMARK    GeneRIF: The results demonstrate that GPR40 is indeed necessary, at
            least in part, for fatty-acid-stimulated insulin release.
REFERENCE   8  (bases 1 to 903)
  AUTHORS   Steneberg,P., Rubins,N., Bartoov-Shifman,R., Walker,M.D. and
            Edlund,H.
  TITLE     The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis,
            and impaired glucose homeostasis in mouse
  JOURNAL   Cell Metab 1 (4), 245-258 (2005)
   PUBMED   16054069
  REMARK    GeneRIF: GPR40 plays an important role in the chain of events
            linking obesity and type 2 diabetes.
REFERENCE   9  (bases 1 to 903)
  AUTHORS   Briscoe,C.P., Tadayyon,M., Andrews,J.L., Benson,W.G.,
            Chambers,J.K., Eilert,M.M., Ellis,C., Elshourbagy,N.A., Goetz,A.S.,
            Minnick,D.T., Murdock,P.R., Sauls,H.R. Jr., Shabon,U.,
            Spinage,L.D., Strum,J.C., Szekeres,P.G., Tan,K.B., Way,J.M.,
            Ignar,D.M., Wilson,S. and Muir,A.I.
  TITLE     The orphan G protein-coupled receptor GPR40 is activated by medium
            and long chain fatty acids
  JOURNAL   J Biol Chem 278 (13), 11303-11311 (2003)
   PUBMED   12496284
REFERENCE   10 (bases 1 to 903)
  AUTHORS   Itoh,Y., Kawamata,Y., Harada,M., Kobayashi,M., Fujii,R.,
            Fukusumi,S., Ogi,K., Hosoya,M., Tanaka,Y., Uejima,H., Tanaka,H.,
            Maruyama,M., Satoh,R., Okubo,S., Kizawa,H., Komatsu,H.,
            Matsumura,F., Noguchi,Y., Shinohara,T., Hinuma,S., Fujisawa,Y. and
            Fujino,M.
  TITLE     Free fatty acids regulate insulin secretion from pancreatic beta
            cells through GPR40
  JOURNAL   Nature 422 (6928), 173-176 (2003)
   PUBMED   12629551
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165340.3.
            
            On Sep 27, 2017 this sequence version replaced NM_194057.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB095745.1, BC138099.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-903               AC165340.3         183923-184825       c
FEATURES             Location/Qualifiers
     source          1..903
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.25 cM"
     gene            1..903
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="free fatty acid receptor 1"
                     /db_xref="GeneID:233081"
                     /db_xref="MGI:MGI:2684079"
     CDS             1..903
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="G protein-coupled receptor 40; G protein-coupled
                     receptor GPR40"
                     /codon_start=1
                     /product="free fatty acid receptor 1"
                     /protein_id="NP_918946.2"
                     /db_xref="CCDS:CCDS21113.1"
                     /db_xref="GeneID:233081"
                     /db_xref="MGI:MGI:2684079"
                     /translation="MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVY
                     TLHLGCSDLLLAITLPLKAVEALASGAWPLPLPFCPVFALAHFAPLYAGGGFLAALSA
                     GRYLGAAFPFGYQAIRRPRYSWGVCVAIWALVLCHLGLALGLETSGSWLDNSTSSLGI
                     NIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVRSGLSHKR
                     KLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLGGSWRKLGLITGAWSVVLNPLVT
                     GYLGTGPGRGTICVTRTQRGTIQK"
     exon            1..903
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggacctgc ccccacagct ctccttcgct ctctatgtat ctgcctttgc gctgggcttt
       61 ccattgaact tgttagccat ccgaggcgca gtgtcccacg ctaaactgcg actcactccc
      121 agcttggtct acactctcca tctgggctgc tctgatctcc tactggccat cactctgccc
      181 ctgaaggctg tggaggccct ggcttctgga gcctggcccc tgccgctccc cttctgccca
      241 gtctttgcct tggcccactt tgctcccctc tacgcaggcg gaggcttcct agctgctctc
      301 agcgctggcc gctacctggg ggctgccttc cccttcgggt accaagccat ccggaggccc
      361 cgctattcct ggggtgtgtg tgtggctata tgggcccttg tcctctgcca cctggggctg
      421 gcccttggct tggagacttc cggaagctgg ctggacaaca gtaccagttc cctgggcatc
      481 aacatacccg tgaatggctc cccggtctgc ctggaagcct gggatcccga ctctgcccgc
      541 cctgcccgtc tcagtttctc cattctgctc ttctttctgc ccttggtcat cactgccttc
      601 tgctatgtgg gctgcctccg ggccctggtg cgctcaggcc tgagccacaa acggaagctc
      661 agggcagctt gggtggccgg aggcgctctc ctcacactcc tgctctgcct ggggccctat
      721 aatgcctcca atgtggctag tttcataaac ccggacctag gaggctcctg gaggaagtta
      781 ggactcatca caggggcctg gagtgtggta ctcaacccac tggtcactgg ctacttggga
      841 acaggtcctg gacggggaac aatatgtgtg acgaggactc aaagaggaac aattcagaag
      901 tag
//
