LOCUS       NM_199448               1967 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus fasciculation and elongation protein zeta 2 (Fez2),
            transcript variant 2, mRNA.
ACCESSION   NM_199448 XM_128819
VERSION     NM_199448.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1967)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1967)
  AUTHORS   Lee,S., Walker,C.L., Karten,B., Kuny,S.L., Tennese,A.A.,
            O'Neill,M.A. and Wevrick,R.
  TITLE     Essential role for the Prader-Willi syndrome protein necdin in
            axonal outgrowth
  JOURNAL   Hum Mol Genet 14 (5), 627-637 (2005)
   PUBMED   15649943
REFERENCE   3  (bases 1 to 1967)
  AUTHORS   Fujita,T., Ikuta,J., Hamada,J., Okajima,T., Tatematsu,K.,
            Tanizawa,K. and Kuroda,S.
  TITLE     Identification of a tissue-non-specific homologue of axonal
            fasciculation and elongation protein zeta-1
  JOURNAL   Biochem Biophys Res Commun 313 (3), 738-744 (2004)
   PUBMED   14697253
  REMARK    GeneRIF: FEZ2 plays an important role in the morphological changes
            of various cells by associating with PKCzeta in a
            tissue-non-specific manner
REFERENCE   4  (bases 1 to 1967)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151270.3, AK150241.1 and AC103598.6.
            
            On Oct 25, 2013 this sequence version replaced NM_199448.2.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            central coding region compared to vatiant 1. The encoded isoform
            (2) is shorter than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096619.1, AY382580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC151270.3         60477-60511
            36-1417             AK150241.1         2-1383
            1418-1967           AC103598.6         12035-12584
FEATURES             Location/Qualifiers
     source          1..1967
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 48.57 cM"
     gene            1..1967
                     /gene="Fez2"
                     /gene_synonym="9030616F16; D17Ertd315e"
                     /note="fasciculation and elongation protein zeta 2"
                     /db_xref="GeneID:225020"
                     /db_xref="MGI:MGI:2675856"
     exon            1..320
                     /gene="Fez2"
                     /gene_synonym="9030616F16; D17Ertd315e"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1116
                     /gene="Fez2"
                     /gene_synonym="9030616F16; D17Ertd315e"
                     /note="isoform 2 is encoded by transcript variant 2; zygin
                     2; zygin II"
                     /codon_start=1
                     /product="fasciculation and elongation protein zeta-2
                     isoform 2"
                     /protein_id="NP_955519.1"
                     /db_xref="CCDS:CCDS28977.1"
                     /db_xref="GeneID:225020"
                     /db_xref="MGI:MGI:2675856"
                     /translation="MAADGDWQDFYEFQEPAGSVQEQENCNASPEAGAGAHAGGDSFP
                     ALASSLEEKLSLCFRPTSEAEPPRAAVRPITECSLLQGDEIWNALTDNYGNVMPVDWK
                     SSHTRTLHLLTLNLSEKGMNDGLLFDASDEEELREQLDMHSIIVSCVNEEPLFTADQV
                     IEEIEEMMQESPDPEDDETPTQSDRLSMLSQEIQTLKRSSMSSYEERVKRLSVSELNE
                     LLEEIEAAIKQYSEELVQQLALRDELEFEKEVENSFISALIEVQNKQKEHKETAKKKK
                     KLKSGSSQNGRSERSHMPGTYLTTVIPYEKKSGPPSVEDLQILTKILHAMKEDSEKVP
                     SLLTDYILKVLCPT"
     exon            321..429
                     /gene="Fez2"
                     /gene_synonym="9030616F16; D17Ertd315e"
                     /inference="alignment:Splign:2.1.0"
     exon            430..546
                     /gene="Fez2"
                     /gene_synonym="9030616F16; D17Ertd315e"
                     /inference="alignment:Splign:2.1.0"
     exon            547..688
                     /gene="Fez2"
                     /gene_synonym="9030616F16; D17Ertd315e"
                     /inference="alignment:Splign:2.1.0"
     exon            689..957
                     /gene="Fez2"
                     /gene_synonym="9030616F16; D17Ertd315e"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1033
                     /gene="Fez2"
                     /gene_synonym="9030616F16; D17Ertd315e"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1099
                     /gene="Fez2"
                     /gene_synonym="9030616F16; D17Ertd315e"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1967
                     /gene="Fez2"
                     /gene_synonym="9030616F16; D17Ertd315e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1943..1948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fez2"
                     /gene_synonym="9030616F16; D17Ertd315e"
                     /note="hexamer: AATAAA"
     polyA_site      1960
                     /gene="Fez2"
                     /gene_synonym="9030616F16; D17Ertd315e"
                     /note="major polyA site"
ORIGIN      
        1 gttggggcgt ggcctggaag cgacagggcg tggctgtctg accggggcgg ggcgccggca
       61 gcgggcgcga tggcggctga cggggactgg caggatttct atgagttcca ggagccggcc
      121 gggagtgtcc aggaacagga gaactgtaac gcgagcccgg aggctggcgc gggggcacac
      181 gcgggcggcg acagcttccc ggcgctggct tccagcctgg aggagaagct gagcctgtgc
      241 ttccgcccca cgtcggaggc cgagccccca cgggcggccg tgcggcccat cacggagtgc
      301 agcctcctgc aaggggacga gatttggaat gccctgacag ataactatgg gaatgtcatg
      361 cctgtagact ggaagtcgtc ccatacaagg accttgcatt tgcttactct gaacctctcg
      421 gagaaaggga tgaacgacgg cttgctcttt gacgcctcgg atgaggagga gctgagggag
      481 cagttggaca tgcattcgat cattgtctcc tgtgtcaacg aagagcctct cttcactgca
      541 gaccaggtga ttgaagaaat tgaagaaatg atgcaggagt caccagaccc agaagacgac
      601 gagaccccca cacagtcaga ccggctctct atgctctccc aggagattca gactctcaag
      661 aggtctagca tgagcagcta tgaagagcga gtgaaaaggc tgtcggtgtc tgagctaaac
      721 gaactgctgg aagagatcga ggcagccatt aagcagtact ctgaggagct ggtgcagcag
      781 ctggccctgc gagatgaact cgagttcgag aaggaagtgg aaaacagctt catttccgct
      841 ctgattgagg tgcagaacaa gcagaaagaa cacaaagaga cagccaagaa gaagaagaag
      901 ctcaaaagtg gcagctctca gaacgggagg agtgagagaa gtcacatgcc gggcacatat
      961 ctgacgacag tcatccctta cgagaagaag agtggcccgc cgtccgtgga agatcttcag
     1021 atactaacca aaatcctgca tgccatgaag gaggacagtg agaaagttcc aagcttgtta
     1081 accgactata tactgaaagt tctgtgtccg acatagagca gcgttatggt gggagccgct
     1141 tcctgttctg tgaaccccag gcaggcttga cttcctatgg tgttattctg gaacatgctg
     1201 ccacgagtcc cggcttttgg agtcccagca cacttgaact tggatttgcc attcagtatt
     1261 aatagatcat gatttcacta atccatcaca ttatagcacc atgagagcta cagtactctt
     1321 gaattctaga gataggtttt ggtaaatgtg aacttgtttc taggttaaca gtcaaggaga
     1381 gggacatgaa tcgtgcatgt tgttgttttt gacagtgtgg ctgtcagttt tgaattcctc
     1441 catctgaact gcactgaaga actagactaa agcaccgggc ggtccagctg tagctgttct
     1501 tcagtgaggg tgaggatcag tgtattagag catcttcgga gtgttaccta ccagtgttgt
     1561 ccagaagaag cagagactca gcgcggctgt tgtgaggtct gcctcacacc acccacctgc
     1621 actgctctcg cctaactgtg gacgccgggc actgttggaa acgaagtttt gtaatttctg
     1681 cctgattcac ccttattggc atgtgagcca ttgggatgcc attgagaatc atgatgaact
     1741 ttgggtgtgt ctgtcctgtg aggaagcgtg tctggaaagg ggttcatgcc tctaaggggc
     1801 ttacggagat gctgaggtac tgcctcgcct catgggtgtg tcaggtttct acacctgtgt
     1861 gcttttctag aaaaagctgc taatggctgc aacactaatc atgaacacgt ttttgccagt
     1921 ttcaatcaag tcagaggcat ttaataaaat tatctacaca cttcgga
//
