LOCUS       NM_001357610            2051 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus fasciculation and elongation protein zeta 1 (Fez1),
            transcript variant 1, mRNA.
ACCESSION   NM_001357610 XM_006510229
VERSION     NM_001357610.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2051)
  AUTHORS   Gobe,C., Elzaiat,M., Meunier,N., Andre,M., Sellem,E., Congar,P.,
            Jouneau,L., Allais-Bonnet,A., Naciri,I., Passet,B., Pailhoux,E. and
            Pannetier,M.
  TITLE     Dual role of DMXL2 in olfactory information transmission and the
            first wave of spermatogenesis
  JOURNAL   PLoS Genet 15 (2), e1007909 (2019)
   PUBMED   30735494
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2051)
  AUTHORS   Bryant,D.T., Landles,C., Papadopoulou,A.S., Benjamin,A.C.,
            Duckworth,J.K., Rosahl,T., Benn,C.L. and Bates,G.P.
  TITLE     Disruption to schizophrenia-associated gene Fez1 in the hippocampus
            of HDAC11 knockout mice
  JOURNAL   Sci Rep 7 (1), 11900 (2017)
   PUBMED   28928414
  REMARK    GeneRIF: Loss of HDAC11 had no obvious impact on brain morphology
            and neural stem/precursor cells isolated from Hdac11 (KO/KO) mice
            had comparable proliferation and differentiation characteristics.
            However, in differentiating neural cells this study observed
            decreased expression of schizophrenia-associated gene Fez1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2051)
  AUTHORS   Butkevich,E., Hartig,W., Nikolov,M., Erck,C., Grosche,J.,
            Urlaub,H., Schmidt,C.F., Klopfenstein,D.R. and Chua,J.J.
  TITLE     Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases
            regulates its function in presynaptic protein trafficking
  JOURNAL   Sci Rep 6, 26965 (2016)
   PUBMED   27247180
  REMARK    GeneRIF: Phosphorylation of FEZ1 by MARK regulates its function in
            presynaptic protein trafficking.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2051)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 2051)
  AUTHORS   Watanabe,Y., Khodosevich,K. and Monyer,H.
  TITLE     Dendrite development regulated by the schizophrenia-associated gene
            FEZ1 involves the ubiquitin proteasome system
  JOURNAL   Cell Rep 7 (2), 552-564 (2014)
   PUBMED   24726361
  REMARK    GeneRIF: Dendrite growth depends on degradation of FEZ1 regulated
            by Cdc20/APC.
REFERENCE   6  (bases 1 to 2051)
  AUTHORS   Sakae,N., Yamasaki,N., Kitaichi,K., Fukuda,T., Yamada,M.,
            Yoshikawa,H., Hiranita,T., Tatsumi,Y., Kira,J., Yamamoto,T.,
            Miyakawa,T. and Nakayama,K.I.
  TITLE     Mice lacking the schizophrenia-associated protein FEZ1 manifest
            hyperactivity and enhanced responsiveness to psychostimulants
  JOURNAL   Hum Mol Genet 17 (20), 3191-3203 (2008)
   PUBMED   18647754
  REMARK    GeneRIF: investigated the role of FEZ1 in brain development and the
            pathogenesis of schizophrenia by generating mice that lack Fez1
REFERENCE   7  (bases 1 to 2051)
  AUTHORS   Lee,S., Walker,C.L., Karten,B., Kuny,S.L., Tennese,A.A.,
            O'Neill,M.A. and Wevrick,R.
  TITLE     Essential role for the Prader-Willi syndrome protein necdin in
            axonal outgrowth
  JOURNAL   Hum Mol Genet 14 (5), 627-637 (2005)
   PUBMED   15649943
REFERENCE   8  (bases 1 to 2051)
  AUTHORS   Inoue,K., Terashima,T., Nishikawa,T. and Takumi,T.
  TITLE     Fez1 is layer-specifically expressed in the adult mouse neocortex
  JOURNAL   Eur J Neurosci 20 (11), 2909-2916 (2004)
   PUBMED   15579145
  REMARK    GeneRIF: Fez1 is mainly expressed in cortical layers V and VI, not
            in gamma-aminobutyric acid neurons but in pyramidal neurons, the
            projection neurons of the cerebral cortex. Immunohistochemistry
            also shows that Fez1 is expressed in deep layers of the neocortex.
REFERENCE   9  (bases 1 to 2051)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   10 (bases 1 to 2051)
  AUTHORS   Fujita,T., Ikuta,J., Hamada,J., Okajima,T., Tatematsu,K.,
            Tanizawa,K. and Kuroda,S.
  TITLE     Identification of a tissue-non-specific homologue of axonal
            fasciculation and elongation protein zeta-1
  JOURNAL   Biochem Biophys Res Commun 313 (3), 738-744 (2004)
   PUBMED   14697253
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT955982.10 and CT009699.13.
            
            On Nov 4, 2017 this sequence version replaced XM_006510229.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All six transcripts encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4072978.1,
                                           SRR1660817.198153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-485               CT955982.10        94425-94909
            486-841             CT009699.13        15439-15794
            842-941             CT009699.13        22124-22223
            942-1028            CT009699.13        32589-32675
            1029-1197           CT009699.13        35274-35442
            1198-1469           CT009699.13        39473-39744
            1470-1550           CT009699.13        40625-40705
            1551-1626           CT009699.13        42258-42333
            1627-1692           CT009699.13        48074-48139
            1693-2051           CT009699.13        50343-50701
FEATURES             Location/Qualifiers
     source          1..2051
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 20.69 cM"
     gene            1..2051
                     /gene="Fez1"
                     /gene_synonym="UNC-76; UNC76"
                     /note="fasciculation and elongation protein zeta 1"
                     /db_xref="GeneID:235180"
                     /db_xref="MGI:MGI:2670976"
     exon            1..485
                     /gene="Fez1"
                     /gene_synonym="UNC-76; UNC76"
                     /inference="alignment:Splign:2.1.0"
     exon            486..841
                     /gene="Fez1"
                     /gene_synonym="UNC-76; UNC76"
                     /inference="alignment:Splign:2.1.0"
     CDS             531..1709
                     /gene="Fez1"
                     /gene_synonym="UNC-76; UNC76"
                     /note="zygin I; zygin-1"
                     /codon_start=1
                     /product="fasciculation and elongation protein zeta-1"
                     /protein_id="NP_001344539.1"
                     /db_xref="CCDS:CCDS40581.1"
                     /db_xref="GeneID:235180"
                     /db_xref="MGI:MGI:2670976"
                     /translation="MEAPLVSLDEEFEDIRPSCTEEPEEKPQCLYGTSPHHLEDPSLS
                     ELENFSSEIISFKSMEDLVNEFDEKLNVCFRNYNAKTESLAPVKNQLQIQEEEETLRD
                     EEVWDALTDNYIPSLSEDWRDPNIEALNGNSSDIEIHEKEEEEFNEKSENDSGINEEP
                     LLTADQVIEEIEEMMQNSPDPEEEEEVLEEEDGGEISSQADSVLLQEMQALTQTFNNN
                     WSYEGLRHMSGSELTELLDRVEGAIRDFSEELVHQLARRDELEFEKEVKNSFITVLIE
                     VQNKQREQRELMKKRRKEKGLSLQSNRIEKGSQMPLKRFSMEGISNILQSGIRQTFGS
                     SGADRQYLNTVIPYEKKSSPPSVEDLQMLTNILFAMKEDNEKVPTLLTDYILKVLCPT
                     "
     exon            842..941
                     /gene="Fez1"
                     /gene_synonym="UNC-76; UNC76"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1028
                     /gene="Fez1"
                     /gene_synonym="UNC-76; UNC76"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1197
                     /gene="Fez1"
                     /gene_synonym="UNC-76; UNC76"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1469
                     /gene="Fez1"
                     /gene_synonym="UNC-76; UNC76"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1550
                     /gene="Fez1"
                     /gene_synonym="UNC-76; UNC76"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1626
                     /gene="Fez1"
                     /gene_synonym="UNC-76; UNC76"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1692
                     /gene="Fez1"
                     /gene_synonym="UNC-76; UNC76"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..2051
                     /gene="Fez1"
                     /gene_synonym="UNC-76; UNC76"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2029..2034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fez1"
                     /gene_synonym="UNC-76; UNC76"
                     /note="hexamer: AATAAA"
     polyA_site      2049
                     /gene="Fez1"
                     /gene_synonym="UNC-76; UNC76"
                     /note="major polyA site"
ORIGIN      
        1 aaaggaagaa ggcagtggga agtgttgtag tcctgagaaa gaggggaggg ggatgcagct
       61 ttctatcgtg ctgaggaaag aaaaaagagg agaaaatggc cagctggtcc tttagctctc
      121 tctctgattg gcactgacaa gaagctctgc tcgaattcag tcctcaaatc ttcatccagt
      181 tcaggaggtt ggtggagaag agcgataagc caacctgggc atggagacct aaatctactg
      241 atggttcttt ggttctaaag tgagatttgg ttgcaccaga aagggagcag agtctagcag
      301 acagaatgag ggatctcaga gcactgagac aaaggctgag tttagatgca aataccagtc
      361 agagctgtgg aaggctgtga gtctttgcag tacttgtatc ctatctggac acatgctttt
      421 tgtaagttct gttttccttt tgtaatgctg cagatagaac ccacccaagg cctcatgctt
      481 gctagggaaa cagatcttga cagttgctgt cattgtactt cggtgccagg atggaggccc
      541 cactggtgag tctggatgaa gagtttgaag atatcaggcc cagttgcact gaggagccag
      601 aggaaaagcc acagtgtctg tatggcacat ctcctcatca cctggaggac ccttccctct
      661 ctgagcttga gaatttttct tccgaaataa tcagcttcaa gtccatggag gacctcgtga
      721 atgaatttga tgagaagctc aatgtctgct ttcggaacta caacgccaag acggagagcc
      781 tggctccagt gaagaaccag ctgcagatcc aggaggagga ggagactctt cgggatgagg
      841 aggtttggga tgctctgaca gacaattaca tcccttcact ctcagaagac tggagggacc
      901 caaacattga agctctgaat ggcaacagct ctgacattga gattcatgag aaggaagaag
      961 aagagttcaa tgagaagagt gaaaatgact ctggcatcaa tgaggagcct ctcctcacag
     1021 ctgaccaggt gattgaggaa attgaagaaa tgatgcagaa ctctccagat cctgaagagg
     1081 aagaggaggt gctagaagag gaggatggag gagaaatctc atcccaggca gattcagtcc
     1141 tgctacaaga gatgcaggcc ttgacacaga ccttcaacaa caactggtcc tatgaagggc
     1201 tgagacacat gtctgggtct gagctgacag agctgctgga ccgggtagag ggtgccatcc
     1261 gtgacttctc agaggagctg gtccaccagc tggcccgcag agatgagctg gagtttgaga
     1321 aggaagtgaa gaactccttc atcacggtgc tcattgaggt tcagaacaag cagagggagc
     1381 agcgggaact gatgaagaag aggcggaaag agaaggggtt aagcctgcag agcaaccgga
     1441 tagagaaggg aagtcagatg cctctcaagc gcttcagcat ggaaggcatc tccaacatcc
     1501 tgcagagcgg catccgccag acctttggct cctcaggagc tgacagacag tatctgaaca
     1561 cagtcatccc ttatgagaag aaatcctctc ctccctctgt ggaagacctg cagatgctga
     1621 caaacattct cttcgccatg aaggaggata acgagaaggt gcctactttg ctaacggact
     1681 acattttaaa agtgctttgt ccaacctaac ctcatctttg gagcagcctc actacaggag
     1741 gtcactgagc aagaaagtca ttccatcgct gggattgcat gacaccacgt aacctccggc
     1801 gtgtatttaa acgtgtatag cttaacctgg attaaacaag agcaactgcg cgcgggatcc
     1861 tttgctgttg gcttctagtg ctagtaatca ttggatgcat gatcgggcgc agggccagag
     1921 attctgctcc ctctccacct gtgttgggga aggcaggtgc cctcaccact cattatgtag
     1981 tctggctcca gccctcaacc cagcttatac tcttaagact aattttgaaa taaaccttca
     2041 tttaattaat a
//
