LOCUS       NM_153111               1479 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus FEV transcription factor, ETS family member (Fev),
            mRNA.
ACCESSION   NM_153111
VERSION     NM_153111.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1479)
  AUTHORS   Patzek,S., Liu,Z., de la,O. S, Chang,S., Byrnes,L.E., Zhang,X.,
            Ornitz,D.M. and Sneddon,J.B.
  TITLE     Loss of Fgf9 in mice leads to pancreatic hypoplasia and asplenia
  JOURNAL   iScience 26 (4), 106500 (2023)
   PUBMED   37096042
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1479)
  AUTHORS   Bohuslavova,R., Fabriciova,V., Lebron-Mora,L., Malfatti,J.,
            Smolik,O., Valihrach,L., Benesova,S., Zucha,D., Berkova,Z.,
            Saudek,F., Evans,S.M. and Pavlinkova,G.
  TITLE     ISL1 controls pancreatic alpha cell fate and beta cell maturation
  JOURNAL   Cell Biosci 13 (1), 53 (2023)
   PUBMED   36899442
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1479)
  AUTHORS   Kameneva,P., Melnikova,V.I., Kastriti,M.E., Kurtova,A., Kryukov,E.,
            Murtazina,A., Faure,L., Poverennaya,I., Artemov,A.V.,
            Kalinina,T.S., Kudryashov,N.V., Bader,M., Skoda,J., Chlapek,P.,
            Curylova,L., Sourada,L., Neradil,J., Tesarova,M., Pasqualetti,M.,
            Gaspar,P., Yakushov,V.D., Sheftel,B.I., Zikmund,T., Kaiser,J.,
            Fried,K., Alenina,N., Voronezhskaya,E.E. and Adameyko,I.
  TITLE     Serotonin limits generation of chromaffin cells during adrenal
            organ development
  JOURNAL   Nat Commun 13 (1), 2901 (2022)
   PUBMED   35614045
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1479)
  AUTHORS   Kitt,M.M., Tabuchi,N., Spencer,W.C., Robinson,H.L., Zhang,X.L.,
            Eastman,B.A., Lobur,K.J., Silver,J., Mei,L. and Deneris,E.S.
  TITLE     An adult-stage transcriptional program for survival of serotonergic
            connectivity
  JOURNAL   Cell Rep 39 (3), 110711 (2022)
   PUBMED   35443166
REFERENCE   5  (bases 1 to 1479)
  AUTHORS   Muzerelle,A., Soiza-Reilly,M., Hainer,C., Ruet,P.L., Lesch,K.P.,
            Bader,M., Alenina,N., Scotto-Lomassese,S. and Gaspar,P.
  TITLE     Dorsal raphe serotonin neurotransmission is required for the
            expression of nursing behavior and for pup survival
  JOURNAL   Sci Rep 11 (1), 6004 (2021)
   PUBMED   33727585
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1479)
  AUTHORS   Ding,Y.Q., Marklund,U., Yuan,W., Yin,J., Wegman,L., Ericson,J.,
            Deneris,E., Johnson,R.L. and Chen,Z.F.
  TITLE     Lmx1b is essential for the development of serotonergic neurons
  JOURNAL   Nat Neurosci 6 (9), 933-938 (2003)
   PUBMED   12897786
REFERENCE   7  (bases 1 to 1479)
  AUTHORS   Brodski,C., Weisenhorn,D.M., Signore,M., Sillaber,I.,
            Oesterheld,M., Broccoli,V., Acampora,D., Simeone,A. and Wurst,W.
  TITLE     Location and size of dopaminergic and serotonergic cell populations
            are controlled by the position of the midbrain-hindbrain organizer
  JOURNAL   J Neurosci 23 (10), 4199-4207 (2003)
   PUBMED   12764108
REFERENCE   8  (bases 1 to 1479)
  AUTHORS   Pattyn,A., Vallstedt,A., Dias,J.M., Samad,O.A., Krumlauf,R.,
            Rijli,F.M., Brunet,J.F. and Ericson,J.
  TITLE     Coordinated temporal and spatial control of motor neuron and
            serotonergic neuron generation from a common pool of CNS
            progenitors
  JOURNAL   Genes Dev 17 (6), 729-737 (2003)
   PUBMED   12651891
REFERENCE   9  (bases 1 to 1479)
  AUTHORS   Hendricks,T.J., Fyodorov,D.V., Wegman,L.J., Lelutiu,N.B.,
            Pehek,E.A., Yamamoto,B., Silver,J., Weeber,E.J., Sweatt,J.D. and
            Deneris,E.S.
  TITLE     Pet-1 ETS gene plays a critical role in 5-HT neuron development and
            is required for normal anxiety-like and aggressive behavior
  JOURNAL   Neuron 37 (2), 233-247 (2003)
   PUBMED   12546819
  REMARK    GeneRIF: Pet-1 is a critical determinant of 5-HT neuron identity
            and Pet-1-dependent program is involved in serotonergic modulation
            of behavior
REFERENCE   10 (bases 1 to 1479)
  AUTHORS   Pfaar,H., von Holst,A., Vogt Weisenhorn,D.M., Brodski,C.,
            Guimera,J. and Wurst,W.
  TITLE     mPet-1, a mouse ETS-domain transcription factor, is expressed in
            central serotonergic neurons
  JOURNAL   Dev Genes Evol 212 (1), 43-46 (2002)
   PUBMED   11875656
  REMARK    GeneRIF: expressed in central serotonergic
            (5-hydroxytryptaminergic) neurons located in the mes-/metencephalic
            raphe nuclei from E11 on until adulthood
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139023.15 and BC138435.1.
            
            On May 21, 2009 this sequence version replaced NM_153111.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY049085.1, BC138435.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               AC139023.15        76538-76707         c
            171-982             BC138435.1         86-897
            983-1479            AC139023.15        72808-73304         c
FEATURES             Location/Qualifiers
     source          1..1479
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..1479
                     /gene="Fev"
                     /gene_synonym="mPet-1; Pet-1; Pet1; Pex1"
                     /note="FEV transcription factor, ETS family member"
                     /db_xref="GeneID:260298"
                     /db_xref="MGI:MGI:2449712"
     exon            1..250
                     /gene="Fev"
                     /gene_synonym="mPet-1; Pet-1; Pet1; Pex1"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..912
                     /gene="Fev"
                     /gene_synonym="mPet-1; Pet-1; Pet1; Pex1"
                     /note="FEV (fifth Ewing variant); PC12 ETS
                     domain-containing transcription factor 1; PC12 ETS factor
                     1; ETS-domain transcription factor Pet-1; pheochromocytoma
                     12 ETS (E26 transformation-specific); plasmacytoma
                     expressed transcript 1; FEV (ETS oncogene family)"
                     /codon_start=1
                     /product="protein FEV"
                     /protein_id="NP_694751.1"
                     /db_xref="CCDS:CCDS15058.1"
                     /db_xref="GeneID:260298"
                     /db_xref="MGI:MGI:2449712"
                     /translation="MRQSGTSQPLLINMYLPDPVGDGLFKEGKSPSWGPLSPAVQKGS
                     GQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLS
                     RALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAHAAAAAAAAAAAAQDGAL
                     YKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPNATAAAAATAALYPTPGLQP
                     PPGPFGAVAAASHLGGHYH"
     exon            251..325
                     /gene="Fev"
                     /gene_synonym="mPet-1; Pet-1; Pet1; Pex1"
                     /inference="alignment:Splign:2.1.0"
     exon            326..1479
                     /gene="Fev"
                     /gene_synonym="mPet-1; Pet-1; Pet1; Pex1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1461..1466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fev"
                     /gene_synonym="mPet-1; Pet-1; Pet1; Pex1"
                     /note="hexamer: ATTAAA"
     polyA_site      1479
                     /gene="Fev"
                     /gene_synonym="mPet-1; Pet-1; Pet1; Pex1"
                     /note="major polyA site"
ORIGIN      
        1 agcatcgctc caggaccccc tccctccccg ccacaccctg gctgcccgct cctgccaggc
       61 cttgccggac ccggcggcgt ctactcttcc ctgtcaccca cagtcgccac gggcggggat
      121 cggcacccca agcgcaaagc tgacgtgccc cccccccgtg ccatcccccc atctcccacc
      181 gcccagtccc cggcagcgat gagacagagc ggcacctccc agcccctgct gatcaacatg
      241 tacctgccag atcccgtcgg agatggtctt tttaaggaag ggaagagccc gagctggggg
      301 ccgctgagcc ccgcggtaca gaaaggcagc gggcagatcc agttgtggca gtttctcctg
      361 gagctgctgg cagatcgcgc gaacgccggt tgcatcgcgt gggagggcgg ccacggcgag
      421 ttcaagctca ccgacccgga cgaggtggcg cggcgctggg gcgagcgcaa gagcaagcct
      481 aacatgaact acgacaagct aagtcgcgcg ctgcgctact actacgacaa aaacatcatg
      541 agcaaggtgc acggcaagcg ctacgcctac cgctttgact tccagggcct ggcgcaggct
      601 tgccagccac cacccgcgca cgcccacgcc gctgcggccg ccgccgccgc cgctgcggcc
      661 gcccaggacg gcgccctcta caagctcccg gccggcctgg ccccgctgcc cttcccgggc
      721 ctatccaaac tcaacttgat ggcagcttcg gcgggcgttg cgcccgctgg tttctcctac
      781 tggcctggcc cgaacgccac cgccgctgcc gccgccaccg ccgcgctcta ccccaccccg
      841 ggcttgcagc cccctcccgg gcccttcggc gcagtggcgg cagcttcgca cttggggggt
      901 cattatcact agacggggac ggccgggtac agcggggcct ctctcacatg gcccagtgac
      961 caatcccatc ctcatcctcg gaggagcccc gaagctttcc ccgacgttcc tttaacacag
     1021 atttcattgc agcagccgcg cccagcccag ggaagaaagg atgggaaacc cccgaggtct
     1081 tccttgaaca tcaggcttcc aggccccgtt atcttcgccc caggaagggt gcatgggctc
     1141 ccactttaat ttttctcttc caagtctcca gattctggaa ctcccgtgtc tttttctttt
     1201 ctcacttgca cccctgcacc tcgttatgac ccctattttt ctgggatttt cttggtcctc
     1261 attttctgac tctctcccac aacccactcc aaaaggtagt acctcaaggc ttctcgcact
     1321 cccctatttc ctcgggatat gagaagcctc gataaacatc tctgccgttc cccatcccta
     1381 tatcaacact ctggcttccc tttctcccat atcacactct ggcccaagga ccccagcctg
     1441 tatatatccc tttcagcccc attaaagctc ccaagcgcc
//
