LOCUS       NM_021564               1600 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus fetuin beta (Fetub), transcript variant 1, mRNA.
ACCESSION   NM_021564
VERSION     NM_021564.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1600)
  AUTHORS   Zhang,W., Wang,X., Tian,S., Wang,J. and Zhou,A.
  TITLE     Fetuin-B Interacts With Insulin Receptor-beta and Promotes Insulin
            Resistance in Retina Cells
  JOURNAL   Invest Ophthalmol Vis Sci 65 (12), 16 (2024)
   PUBMED   39382879
  REMARK    GeneRIF: Fetuin-B Interacts With Insulin Receptor-beta and Promotes
            Insulin Resistance in Retina Cells.
REFERENCE   2  (bases 1 to 1600)
  AUTHORS   Zhang,W., Yao,J., Chen,C., Wang,J. and Zhou,A.
  TITLE     Fetuin-B Overexpression Promotes Inflammation in Diabetic
            Retinopathy Through Activating Microglia and the NF-kappaB
            Signaling Pathway
  JOURNAL   Curr Eye Res 49 (2), 168-179 (2024)
   PUBMED   37883127
  REMARK    GeneRIF: Fetuin-B Overexpression Promotes Inflammation in Diabetic
            Retinopathy Through Activating Microglia and the NF-kappaB
            Signaling Pathway.
REFERENCE   3  (bases 1 to 1600)
  AUTHORS   Schmitz,C., Sadr,S.Z., Korschgen,H., Kuske,M., Schoen,J.,
            Stocker,W., Jahnen-Dechent,W. and Floehr,J.
  TITLE     The E-modulus of the oocyte is a non-destructive measure of zona
            pellucida hardening
  JOURNAL   Reproduction 162 (4), 259-266 (2021)
   PUBMED   34320465
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1600)
  AUTHORS   Xing,W., Tan,Y., Li,K., Tian,P., Tian,F. and Zhang,H.
  TITLE     Upregulated hepatokine fetuin B aggravates myocardial
            ischemia/reperfusion injury through inhibiting insulin signaling in
            diabetic mice
  JOURNAL   J Mol Cell Cardiol 151, 163-172 (2021)
   PUBMED   32147518
  REMARK    GeneRIF: Upregulated hepatokine fetuin B aggravates myocardial
            ischemia/reperfusion injury through inhibiting insulin signaling in
            diabetic mice.
REFERENCE   5  (bases 1 to 1600)
  AUTHORS   Rabadi,M.M., Abdulmahdi,W., Nesi,L., Jules,E., Marghani,Y.,
            Sheinin,E., Tilzer,J., Gupta,S., Chen,S., Cassimatis,N.D.,
            Lipphardt,M., Kozlowski,P.B. and Ratliff,B.B.
  TITLE     Maternal malnourishment induced upregulation of fetuin-B blunts
            nephrogenesis in the low birth weight neonate
  JOURNAL   Dev Biol 443 (1), 78-91 (2018)
   PUBMED   30189195
REFERENCE   6  (bases 1 to 1600)
  AUTHORS   Bernhard,O.K., Kapp,E.A. and Simpson,R.J.
  TITLE     Enhanced analysis of the mouse plasma proteome using
            cysteine-containing tryptic glycopeptides
  JOURNAL   J Proteome Res 6 (3), 987-995 (2007)
   PUBMED   17330941
REFERENCE   7  (bases 1 to 1600)
  AUTHORS   Hsu,S.J., Nagase,H. and Balmain,A.
  TITLE     Identification of Fetuin-B as a member of a cystatin-like gene
            family on mouse chromosome 16 with tumor suppressor activity
  JOURNAL   Genome 47 (5), 931-946 (2004)
   PUBMED   15499407
  REMARK    GeneRIF: Overexpression of Fetuin-B in skin squamous carcinoma
            cells led to suppression of tumor growth in nude mice.
REFERENCE   8  (bases 1 to 1600)
  AUTHORS   Denecke,B., Graber,S., Schafer,C., Heiss,A., Woltje,M. and
            Jahnen-Dechent,W.
  TITLE     Tissue distribution and activity testing suggest a similar but not
            identical function of fetuin-B and fetuin-A
  JOURNAL   Biochem J 376 (Pt 1), 135-145 (2003)
   PUBMED   12943536
REFERENCE   9  (bases 1 to 1600)
  AUTHORS   Yoshida,Y., Tokunaga,F., Chiba,T., Iwai,K., Tanaka,K. and Tai,T.
  TITLE     Fbs2 is a new member of the E3 ubiquitin ligase family that
            recognizes sugar chains
  JOURNAL   J Biol Chem 278 (44), 43877-43884 (2003)
   PUBMED   12939278
REFERENCE   10 (bases 1 to 1600)
  AUTHORS   Olivier,E., Soury,E., Ruminy,P., Husson,A., Parmentier,F.,
            Daveau,M. and Salier,J.P.
  TITLE     Fetuin-B, a second member of the fetuin family in mammals
  JOURNAL   Biochem J 350 Pt 2 (Pt 2), 589-597 (2000)
   PUBMED   10947975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY011532.1, AJ242927.1 and AI255764.1.
            
            On Apr 7, 2007 this sequence version replaced NM_021564.1.
            
            Transcript Variant: This transcript (1) represents the longest
            transcript. Variants 1 and 3 encode the same protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY138459.1, AJ242927.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               BY011532.1         1-153
            154-1559            AJ242927.1         75-1480
            1560-1600           AI255764.1         1-41                c
FEATURES             Location/Qualifiers
     source          1..1600
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 13.76 cM"
     gene            1..1600
                     /gene="Fetub"
                     /gene_synonym="2310011O17Rik; D17980; Gugu"
                     /note="fetuin beta"
                     /db_xref="GeneID:59083"
                     /db_xref="MGI:MGI:1890221"
     exon            1..274
                     /gene="Fetub"
                     /gene_synonym="2310011O17Rik; D17980; Gugu"
                     /inference="alignment:Splign:2.1.0"
     exon            275..509
                     /gene="Fetub"
                     /gene_synonym="2310011O17Rik; D17980; Gugu"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1442
                     /gene="Fetub"
                     /gene_synonym="2310011O17Rik; D17980; Gugu"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; fetuin-B; IRL685; fetuin-like protein IRL685"
                     /codon_start=1
                     /product="fetuin-B isoform 1 precursor"
                     /protein_id="NP_067539.1"
                     /db_xref="CCDS:CCDS37300.1"
                     /db_xref="GeneID:59083"
                     /db_xref="MGI:MGI:1890221"
                     /translation="MGLLRLLVLCTLAACCMARSPPAPPLPQRPLSPLHPLGCNDSEV
                     LAVAGFALQNINRDQKDGYMLSLNRVHDVREHYQEDMGSLFYLTLDVLETDCHVLSRK
                     AQKDCKPRMFYESVYGQCKAMFHINKPRRVLYLPAYNCTLRPVSKRKTHTTCPDCPSP
                     IDLSNPSALEAATESLAKFNSKSPSKKYELVKVTKAMNQWVSGPAYYVEYLIKEAPCT
                     KSQASCSLQHSDSEPVGICQGSTVQSSLRHVPLIQPVEKSVTVTCEFFESQAQVPGDE
                     NPAVTQGPQKLPQKNTAPTSSPSVTAPRGSIQHLPELDDEKPEESKGGSPEEAFPVQL
                     DLTTNPQGDTLDVSFLYLEPGDKKLVVLPFPGKEQRSAECPGPEKENNPLVLPP"
     exon            510..620
                     /gene="Fetub"
                     /gene_synonym="2310011O17Rik; D17980; Gugu"
                     /inference="alignment:Splign:2.1.0"
     exon            621..708
                     /gene="Fetub"
                     /gene_synonym="2310011O17Rik; D17980; Gugu"
                     /inference="alignment:Splign:2.1.0"
     exon            709..872
                     /gene="Fetub"
                     /gene_synonym="2310011O17Rik; D17980; Gugu"
                     /inference="alignment:Splign:2.1.0"
     exon            873..971
                     /gene="Fetub"
                     /gene_synonym="2310011O17Rik; D17980; Gugu"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1082
                     /gene="Fetub"
                     /gene_synonym="2310011O17Rik; D17980; Gugu"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1575
                     /gene="Fetub"
                     /gene_synonym="2310011O17Rik; D17980; Gugu"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1540..1545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fetub"
                     /gene_synonym="2310011O17Rik; D17980; Gugu"
                     /note="hexamer: AATAAA"
     polyA_site      1575
                     /gene="Fetub"
                     /gene_synonym="2310011O17Rik; D17980; Gugu"
                     /note="major polyA site"
ORIGIN      
        1 ttaatctctg taaaggcgcc acctctccac aggtttcata agcgttcgtt ttctgagctt
       61 tgggaacgtg ttcaaagcac accagacttg caaagctctt gattccggac agcttacctt
      121 gattcctgac attgtgcagt ggctcagcca gaacctgtga gtcacaggta gctgctgtgt
      181 tacacaacat ctaacaacgt ctagccttct gcgatttctg gtgcagggtc atgattagtg
      241 catttgacag atttggcaga gtggcttaca gtggaatggg cctgctccga cttctggtgc
      301 tctgcaccct ggctgcatgc tgcatggccc gctctccccc agccccaccc ctgccacaac
      361 gccccctctc acctctgcat cctctgggct gtaacgactc tgaagtgctg gcagttgcag
      421 gatttgccct gcagaacatc aacagagacc aaaaggatgg ctatatgttg agccttaaca
      481 gagtgcatga tgttcgggag cactaccagg aagacatggg atctctgttc tacctcacat
      541 tggatgtctt agagactgac tgccacgtgc tcagcaggaa ggcacagaag gactgcaaac
      601 cgaggatgtt ctatgagtcg gtttatggcc agtgcaaagc aatgtttcac attaacaagc
      661 caagaagagt tctctactta cctgcttata actgtacact tcgcccagtt tccaaaagaa
      721 agactcatac aacgtgccct gactgcccta gccccattga cttgtcaaac cccagtgctc
      781 tggaagctgc cacggagtcg cttgcaaagt tcaacagtaa gagcccctca aaaaagtatg
      841 aactcgtcaa agtcaccaag gctatgaacc agtgggtgtc tggccctgct tactatgtgg
      901 aatatttgat caaagaggca ccatgtacca aatcccaggc cagctgttcg ctccagcact
      961 ctgactctga gcccgttggt atttgccaag gttctacggt ccaaagttct ctgaggcacg
     1021 ttcctctgat ccaacccgta gaaaagtctg tcactgtgac ttgtgagttc ttcgaatctc
     1081 aggctcaggt ccctggagat gagaaccctg ctgttaccca gggccctcag aaactccctc
     1141 agaaaaacac ggcccctacc agctccccct ccgtaactgc accaagagga tccatccagc
     1201 acctccccga actggatgat gagaagcccg aggagtccaa gggagggagc cctgaggaag
     1261 cctttcctgt gcagctggat ctaaccacca atccccaggg ggacacacta gatgtctcct
     1321 tcctgtacct ggagcctggg gacaagaagc tggtggtgct gcctttccct ggaaaggaac
     1381 agcgctccgc cgagtgccca gggcccgaga aggagaacaa ccctctggtt ctcccaccct
     1441 gagactccct agcagggttt catagggcta tggtccccag cactaaatgg gaggtggtgg
     1501 ggattgggaa ggacacagac aatgaaatgt agacaggcta ataaagtgtg tccttttgat
     1561 gcttcttggc ttcaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
