LOCUS       NM_010194               2780 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus feline sarcoma oncogene (Fes), mRNA.
ACCESSION   NM_010194 XM_981464
VERSION     NM_010194.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2780)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2780)
  AUTHORS   Laight,B.J., Jawa,N.A., Tyryshkin,K., Maslove,D.M., Boyd,J.G. and
            Greer,P.A.
  TITLE     Establishing the role of the FES tyrosine kinase in the
            pathogenesis, pathophysiology, and severity of sepsis and its
            outcomes
  JOURNAL   Front Immunol 14, 1145826 (2023)
   PUBMED   37122758
  REMARK    GeneRIF: Establishing the role of the FES tyrosine kinase in the
            pathogenesis, pathophysiology, and severity of sepsis and its
            outcomes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2780)
  AUTHORS   Karamanavi,E., McVey,D.G., van der Laan,S.W., Stanczyk,P.J.,
            Morris,G.E., Wang,Y., Yang,W., Chan,K., Poston,R.N., Luo,J.,
            Zhou,X., Gong,P., Jones,P.D., Cao,J., Kostogrys,R.B., Webb,T.R.,
            Pasterkamp,G., Yu,H., Xiao,Q., Greer,P.A., Stringer,E.J.,
            Samani,N.J. and Ye,S.
  TITLE     The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits
            Atherosclerosis
  JOURNAL   Circ Res 131 (12), 1004-1017 (2022)
   PUBMED   36321446
  REMARK    GeneRIF: The FES Gene at the 15q26 Coronary-Artery-Disease Locus
            Inhibits Atherosclerosis.
REFERENCE   4  (bases 1 to 2780)
  AUTHORS   Olvedy,M., Tisserand,J.C., Luciani,F., Boeckx,B., Wouters,J.,
            Lopez,S., Rambow,F., Aibar,S., Thienpont,B., Barra,J., Kohler,C.,
            Radaelli,E., Tartare-Deckert,S., Aerts,S., Dubreuil,P., van den
            Oord,J.J., Lambrechts,D., De Sepulveda,P. and Marine,J.C.
  TITLE     Comparative oncogenomics identifies tyrosine kinase FES as a tumor
            suppressor in melanoma
  JOURNAL   J Clin Invest 127 (6), 2310-2325 (2017)
   PUBMED   28463229
  REMARK    GeneRIF: FES is a driver of melanoma progression in a mouse model.
REFERENCE   5  (bases 1 to 2780)
  AUTHORS   Zhang,C., Ibrahim,P.N., Zhang,J., Burton,E.A., Habets,G., Zhang,Y.,
            Powell,B., West,B.L., Matusow,B., Tsang,G., Shellooe,R., Carias,H.,
            Nguyen,H., Marimuthu,A., Zhang,K.Y., Oh,A., Bremer,R., Hurt,C.R.,
            Artis,D.R., Wu,G., Nespi,M., Spevak,W., Lin,P., Nolop,K., Hirth,P.,
            Tesch,G.H. and Bollag,G.
  TITLE     Design and pharmacology of a highly specific dual FMS and KIT
            kinase inhibitor
  JOURNAL   Proc Natl Acad Sci U S A 110 (14), 5689-5694 (2013)
   PUBMED   23493555
REFERENCE   6  (bases 1 to 2780)
  AUTHORS   Leff,S.E., Brannan,C.I., Reed,M.L., Ozcelik,T., Francke,U.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Maternal imprinting of the mouse Snrpn gene and conserved linkage
            homology with the human Prader-Willi syndrome region
  JOURNAL   Nat Genet 2 (4), 259-264 (1992)
   PUBMED   1303276
REFERENCE   7  (bases 1 to 2780)
  AUTHORS   Foroni,L., Boehm,T., White,L., Forster,A., Sherrington,P.,
            Liao,X.B., Brannan,C.I., Jenkins,N.A., Copeland,N.G. and
            Rabbitts,T.H.
  TITLE     The rhombotin gene family encode related LIM-domain proteins whose
            differing expression suggests multiple roles in mouse development
  JOURNAL   J Mol Biol 226 (3), 747-761 (1992)
   PUBMED   1507224
REFERENCE   8  (bases 1 to 2780)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Chretien,M., Seidah,N.G. and
            Jenkins,N.A.
  TITLE     Regional localization of three convertases, PC1 (Nec-1), PC2
            (Nec-2), and furin (Fur), on mouse chromosomes
  JOURNAL   Genomics 13 (4), 1356-1358 (1992)
   PUBMED   1354647
REFERENCE   9  (bases 1 to 2780)
  AUTHORS   Colombo,M.P., Martinotti,A., Howard,T.A., Schneider,C.,
            D'Eustachio,P. and Seldin,M.F.
  TITLE     Localization of growth arrest-specific genes on mouse chromosomes
            1, 7, 8, 11, 13, and 16
  JOURNAL   Mamm Genome 2 (2), 130-134 (1992)
   PUBMED   1347472
REFERENCE   10 (bases 1 to 2780)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     A molecular genetic linkage map of mouse chromosome 7
  JOURNAL   Genomics 8 (3), 525-535 (1990)
   PUBMED   1981054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC136740.10, AK143639.1 and BC038130.1.
            
            On Aug 5, 2006 this sequence version replaced NM_010194.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170418.1, AK143639.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AC136740.10        162927-162977       c
            52-2754             AK143639.1         2-2704
            2755-2780           BC038130.1         747-772
FEATURES             Location/Qualifiers
     source          1..2780
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.65 cM"
     gene            1..2780
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /note="feline sarcoma oncogene"
                     /db_xref="GeneID:14159"
                     /db_xref="MGI:MGI:95514"
     exon            1..110
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            111..332
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..2588
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /EC_number="2.7.10.2"
                     /note="proto-oncogene tyrosine-protein kinase Fes/Fps;
                     tyrosine kinase Fps/Fes; proto-oncogene c-Fes"
                     /codon_start=1
                     /product="tyrosine-protein kinase Fes/Fps"
                     /protein_id="NP_034324.2"
                     /db_xref="CCDS:CCDS39999.1"
                     /db_xref="GeneID:14159"
                     /db_xref="MGI:MGI:95514"
                     /translation="MGFSSELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREY
                     AGLLHHMSLQDSGGQSWSSGPDSPVSQSWAEITSQTENLSRVLRQHAEDLNSGPLSKL
                     SVLIRERQHLRKTYNEQWQQLQQELTKTHSQDIEKLKTQYRTLVRDSTQARRKYQEAS
                     KDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHHHHHRFMLPGLLQSLQDLHEE
                     MAGILKDILQEYLEISSLVQDDVASIHRELAAAAARIQPEFEYLGFLRQYGSTPDVPP
                     CVTFDESLLEDGEQLEPGELQLNELTLESVQHTLTSVTDELAVATKEVLSRQEMVSQL
                     QRELQSEEQNTHPRERVQLLSKRQMLQEAIQGLQIALCSQDKLQAQQELLQSKMEQLG
                     TGEPPAVPLLQDDRHSTSSTEQEREGGRTPTLEILKSHFSGIFRPKFSIPPPLQLVPE
                     VQKPLYEQLWYHGAIPRAEVAELLTHSGDFLVRESQGKQEYVLSVMWDGQPRHFIIQS
                     SDNLYRLEGDGFPSIPLLITHLLSSQQPLTKKSGVVLFRAVPKDKWVLKHEDLVLGEQ
                     IGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIG
                     VCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHR
                     DLAARNCLVTEKNVLKISDFGMSREEADGIYAASAGLRQVPVKWTAPEALNYGRYSSE
                     SDVWSFGILLWETFSLGASPYPNLTNQQTREFVEKGHRLPCPELCPDAVFRLMEQCWA
                     YEPGQRPSFSIICQELHSIRKRHR"
     exon            333..506
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            507..603
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            604..787
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            788..925
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1045
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1168
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1355
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1439
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1649
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1772
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1826
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1945
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2040
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2164
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2322
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2445
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2762
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2738..2743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /note="hexamer: AATAAA"
     polyA_site      2762
                     /gene="Fes"
                     /gene_synonym="c-fes; FPS"
                     /note="major polyA site"
ORIGIN      
        1 agggcaactg aaaccacgga ggaggaagca ggaatcagga actggcccgg cagattctgg
       61 gccttagtcg gtccaccgcc acctacccca ggagcagctg cccgagaaag gacaccatta
      121 tgggcttctc ttcagagctg tgcagccccc agggccacgg ggcagtgcag cagatgcagg
      181 aagctgagct gcgcttattg gagggcatga ggaagtggat ggcccagagg gtcaagagtg
      241 accgggaata tgcaggattg cttcaccaca tgtccttgca ggacagcgga ggccagagct
      301 ggagcagcgg ccccgacagc cctgtcagcc agtcctgggc agagataaca agccagaccg
      361 agaacttgag ccgggtgctg cggcagcatg cagaagatct gaactcgggg cccttgagca
      421 aactgagcgt gctgatccgg gagcggcagc acctgagaaa gacgtacaac gagcagtggc
      481 agcagctgca gcaggagctc accaagaccc acagccagga cattgagaag ctgaagactc
      541 agtaccggac cctggtacga gatagcaccc aggccaggcg caagtaccag gaagccagca
      601 aagacaagga tcgagacaag gccaaagaca agtatgtccg gagcctgtgg aagctctttg
      661 cccaccacaa ccgctacgtc ctgggtgtga gggccgcaca gctgcaccac caccaccacc
      721 accggttcat gctgcctggc ctgctgcagt cactgcagga tttgcacgag gagatggcgg
      781 gcattctgaa ggacatcctg caggaatacc tggagattag cagtctggtg caggacgatg
      841 tggcatccat tcaccgtgag ctggctgcag ctgctgctcg gatccagcct gagtttgagt
      901 acctaggctt cctgcgacaa tatggatcca cccctgatgt gccaccttgt gtcacttttg
      961 atgagtcgct tcttgaagac ggggaacagc tggagccagg ggagctgcag ctgaacgagt
     1021 tgaccttgga gagcgtgcaa cacacgctga cttctgtgac agatgaactg gctgtggcca
     1081 ccaaagaggt gctgagccgg caggagatgg tcagtcagct gcagcgtgag ctccaaagtg
     1141 aggaacagaa cacccacccc cgggaacggg tgcagcttct gagcaagagg cagatgctgc
     1201 aagaggcaat acaagggttg cagatagcac tgtgcagcca ggacaagctt caggcccagc
     1261 aggaacttct gcagagcaag atggagcagc tcggcacggg cgagccccca gccgtgccgc
     1321 tccttcagga tgaccgccat tccacctcct ccacggagca ggagcgagag gggggaagga
     1381 cacccacact ggagatcctt aaaagccact tctccggaat cttccgcccc aagttctcta
     1441 tccctccacc actgcagctc gtgccggagg tgcagaagcc tctctatgag cagctgtggt
     1501 accacggggc tatccctcgg gcagaggtag ctgagctgct aacacactcc ggggacttcc
     1561 tggttcggga gagccagggc aagcaggagt atgtactgtc tgtgatgtgg gatggccagc
     1621 cccgacattt catcatccag tcctcagata acctgtaccg gctggaaggg gatggcttcc
     1681 ccagcatacc tctgctcatc actcacctgc tgtcctccca gcaacccctt acaaagaaga
     1741 gtggtgttgt cctgttcagg gcggtgccca aggacaagtg ggttctgaag cacgaggacc
     1801 tggtgctggg agagcagatc ggaaggggga acttcggaga ggtgtttagt ggccgccttc
     1861 gtgcagacaa taccccggtg gctgtgaagt cttgccgaga gacactccca cctgacctca
     1921 aggccaagtt tctgcaagaa gcaaggatcc tgaaacagta caaccacccc aacattgtgc
     1981 gtctcatcgg ggtctgcaca cagaaacagc cgatctacat cgtcatggag ctcgttcaag
     2041 ggggcgactt tctcaccttc ctgcggacag agggagcccg cctgcgggtg aagactctgc
     2101 tgcagatggt aggggacgca gctgctggca tggaatactt ggaaagcaag tgttgtatcc
     2161 acagggacct ggctgctcgg aactgcctgg tgacagagaa gaatgtcctg aagatcagcg
     2221 actttgggat gtcccgcgaa gaagctgatg ggatctatgc cgcctcagcg ggcctcagac
     2281 aagtccctgt taagtggact gcccctgagg cccttaacta cggacgctac tcctcagaga
     2341 gtgatgtgtg gagctttggc attttgctgt gggagacctt cagcctgggg gcctcaccct
     2401 atcccaacct caccaatcag cagacacggg agtttgtaga aaaggggcat cgtctgcctt
     2461 gcccagagct gtgccctgat gcggtcttca ggctcatgga gcagtgctgg gcctatgagc
     2521 ctgggcagag acctagtttc agcatcatct gccaggagct ccacagtatc cgcaagcggc
     2581 atcggtgaga cccggaggcg agcgtgtacc tcctcagcag ttcccactca ctgctggaca
     2641 gctccaagac cagggttcca accaccagca acagggcttc cggcagggtg cggctctcca
     2701 tccttcttcc tgcccaaatt cctctcttag gcagaaaaat aaaacaagtt gtgttcatcg
     2761 ggaaaaaaaa aaaaaaaaaa
//
