LOCUS       NM_153795               2587 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus fermitin family member 3 (Fermt3), transcript variant
            1, mRNA.
ACCESSION   NM_153795
VERSION     NM_153795.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2587)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2587)
  AUTHORS   Li,N., Ren,P., Wang,J., Zhu,X., Qiao,X., Zeng,Z., Ye,T., Wang,S.,
            Meng,Z., Gan,H., Liu,S., Sun,Y., Zhu,X., Dou,G. and Gu,R.
  TITLE     Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers
            Associated with Sepsis
  JOURNAL   Int J Mol Sci 25 (2), 749 (2024)
   PUBMED   38255822
  REMARK    GeneRIF: Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers
            Associated with Sepsis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2587)
  AUTHORS   Kamioka,Y., Ueda,Y., Kondo,N., Tokuhiro,K., Ikeda,Y., Bergmeier,W.
            and Kinashi,T.
  TITLE     Distinct bidirectional regulation of LFA1 and alpha4beta7 by Rap1
            and integrin adaptors in T cells under shear flow
  JOURNAL   Cell Rep 42 (6), 112580 (2023)
   PUBMED   37267105
REFERENCE   4  (bases 1 to 2587)
  AUTHORS   Szpak,D., Turpin,C., Goreke,U., Bialkowska,K., Bledzka,K.M.,
            Verbovetskiy,D., Mohandas,N., Gurkan,U.A., Qin,J., Plow,E.F. and
            Pluskota,E.
  TITLE     Kindlin-3 deficiency leads to impaired erythropoiesis and
            erythrocyte cytoskeleton
  JOURNAL   Blood Adv 7 (9), 1739-1753 (2023)
   PUBMED   36649586
REFERENCE   5  (bases 1 to 2587)
  AUTHORS   Fischer,A., Wannemacher,J., Christ,S., Koopmans,T., Kadri,S.,
            Zhao,J., Gouda,M., Ye,H., Muck-Hausl,M., Krenn,P.W., Machens,H.G.,
            Fassler,R., Neumann,P.A., Hauck,S.M. and Rinkevich,Y.
  TITLE     Neutrophils direct preexisting matrix to initiate repair in damaged
            tissues
  JOURNAL   Nat Immunol 23 (4), 518-531 (2022)
   PUBMED   35354953
REFERENCE   6  (bases 1 to 2587)
  AUTHORS   Malinin,N.L., Zhang,L., Choi,J., Ciocea,A., Razorenova,O., Ma,Y.Q.,
            Podrez,E.A., Tosi,M., Lennon,D.P., Caplan,A.I., Shurin,S.B.,
            Plow,E.F. and Byzova,T.V.
  TITLE     A point mutation in KINDLIN3 ablates activation of three integrin
            subfamilies in humans
  JOURNAL   Nat Med 15 (3), 313-318 (2009)
   PUBMED   19234460
  REMARK    GeneRIF: identify a genetic disease that severely compromises the
            health of the affected individuals and establish an essential role
            of KINDLIN-3 in integrin activation in humans
REFERENCE   7  (bases 1 to 2587)
  AUTHORS   Kruger,M., Moser,M., Ussar,S., Thievessen,I., Luber,C.A.,
            Forner,F., Schmidt,S., Zanivan,S., Fassler,R. and Mann,M.
  TITLE     SILAC mouse for quantitative proteomics uncovers kindlin-3 as an
            essential factor for red blood cell function
  JOURNAL   Cell 134 (2), 353-364 (2008)
   PUBMED   18662549
  REMARK    GeneRIF: Stable isotope labeling by amino acids in cell culture
            confirmed their absence and disclosed a structural defect of the
            red blood cell membrane skeleton in Kindlin-3-deficient
            erythrocytes.
REFERENCE   8  (bases 1 to 2587)
  AUTHORS   Moser,M., Nieswandt,B., Ussar,S., Pozgajova,M. and Fassler,R.
  TITLE     Kindlin-3 is essential for integrin activation and platelet
            aggregation
  JOURNAL   Nat Med 14 (3), 325-330 (2008)
   PUBMED   18278053
  REMARK    GeneRIF: Kindlin-3 was identified as a novel and essential element
            for platelet integrin activation in hemostasis and thrombosis.
REFERENCE   9  (bases 1 to 2587)
  AUTHORS   Ussar,S., Wang,H.V., Linder,S., Fassler,R. and Moser,M.
  TITLE     The Kindlins: subcellular localization and expression during murine
            development
  JOURNAL   Exp Cell Res 312 (16), 3142-3151 (2006)
   PUBMED   16876785
  REMARK    GeneRIF: The genomic organization, gene expression and subcellular
            localization of murine Kindlins-1 to -3, is described.
REFERENCE   10 (bases 1 to 2587)
  AUTHORS   Spinelli,S.L., Malik,H.S., Consaul,S.A. and Phizicky,E.M.
  TITLE     A functional homolog of a yeast tRNA splicing enzyme is conserved
            in higher eukaryotes and in Escherichia coli
  JOURNAL   Proc Natl Acad Sci U S A 95 (24), 14136-14141 (1998)
   PUBMED   9826666
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142912.1 and AC163098.4.
            
            On Dec 9, 2009 this sequence version replaced NM_153795.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142912.1, AK169682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-719               AK142912.1         2-720
            720-720             AC163098.4         41984-41984
            721-2025            AK142912.1         722-2026
            2026-2587           AK142912.1         2028-2589
FEATURES             Location/Qualifiers
     source          1..2587
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.13 cM"
     gene            1..2587
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /note="fermitin family member 3"
                     /db_xref="GeneID:108101"
                     /db_xref="MGI:MGI:2147790"
     exon            1..192
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /inference="alignment:Splign:2.1.0"
     exon            193..366
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..2204
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /note="unc-112-related protein 2"
                     /codon_start=1
                     /product="fermitin family homolog 3"
                     /protein_id="NP_722490.1"
                     /db_xref="CCDS:CCDS29518.1"
                     /db_xref="GeneID:108101"
                     /db_xref="MGI:MGI:2147790"
                     /translation="MAGMKTASGDYIDSSWELRVFVGEEDPEAQSVTLRVTGESHIGG
                     VLLKIVEEINRKQDWSDHAIWWEQKRQWLLQTHWTLDKYGILADARLFFGPQHRPVIL
                     RLPNRRVLRLRASFSKPLFQTVAAICRLLSIRHPEELSLLRAPEKKEKKKKEKEPEEE
                     VHDLTKVVLAGGVAPTLFRGMPAHFSDSAQTEACYHMLSRPQPAPDPLLLQRLPRPSS
                     LPDKTQLHSRWLDSSRCLMQQGIKAGDVLWLRFKYYSFFDLDPKTDPVRLTQLYEQAR
                     WDLLTEEIDCTEEEMMVFAALQYHINKLTLSGDVGELASGDLGLDDLDAALNNLEVKL
                     KGSAPSDMLDSLTTIPELKDHLRIFRPRKLTLKGYRQYWVVFKDTTLSYYKSQDEAPG
                     DPTQQLNLKGCEVVPDVNVSGQKFCIKLLVPSPEGMSEIYLRCQDEQQYAQWMAACRL
                     ASKGRTMADSSYASEVQAILAFLSLQRAGGSNGGSGNKPQGPEAPAEGLNPYGLVAPR
                     FQRKFKAKQLTPRILEAHQNVAQLSLTEAQLRFIQAWQSLPDFGISYVMVRFKGSRKD
                     EILGIANNRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSA
                     SCRIVHEYIGGYIFLSTRERARGEELDEDLFLQLTGGHEAF"
     exon            367..600
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /inference="alignment:Splign:2.1.0"
     exon            601..720
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /inference="alignment:Splign:2.1.0"
     exon            721..889
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /inference="alignment:Splign:2.1.0"
     exon            890..992
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1100
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1235
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1285
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1410
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1517
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1757
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1882
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2024
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2587
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2549..2554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /note="hexamer: AATAAA"
     polyA_site      2569
                     /gene="Fermt3"
                     /gene_synonym="Kindlin3"
                     /note="major polyA site"
ORIGIN      
        1 gtggagccct ctgcgtgctg gcagtgtgct tcctgtaccc agcaacagcc cgccctgggg
       61 agggactagt acaactttca tgataaggcc actacaggct gacctctgaa ggaagcaact
      121 gagcaggacc aggccagacc agggtaacag gtgtcccact gccacctgca gctgcagccc
      181 gttgcaggct agaaacagcc gcagccatgg cgggtatgaa gacagcctcc ggggactata
      241 tcgactcttc ctgggagctg agggtgtttg tgggcgagga ggaccctgag gcccagtctg
      301 tcacactccg agtcacgggg gagtcgcaca ttggtggggt acttctgaag atcgtggagg
      361 aaatcaatcg caagcaggac tggtctgacc atgccatttg gtgggagcag aagagacagt
      421 ggctgctgca gacacactgg acgctggaca agtacgggat tctggccgat gcccgcctct
      481 tctttgggcc acagcaccga cctgtcatcc tgcgactgcc caacagacgt gtgctgcggc
      541 ttcgggccag tttctccaag cccctcttcc aaacggtggc tgccatctgc cgcctcctca
      601 gtatcaggca cccagaggag ctgtctctgc tgcgtgctcc agagaagaag gagaagaaga
      661 agaaggagaa ggagcctgaa gaggaggtgc atgacctgac aaaggttgtc ttagctggcg
      721 gtgtggcacc cactttattc agaggcatgc cagcacactt ctcggacagc gcccagactg
      781 aggcttgtta ccacatgctg agccggccac agccggcacc tgaccctctc ctgctccagc
      841 gcctgccaag gcccagctcc ctgcctgaca agacccagct ccacagcagg tggctggatt
      901 catctcggtg cctcatgcag caaggtatca aggccgggga tgtgctttgg ctgcgattta
      961 agtactacag cttttttgac ctggatccca agacagaccc tgtgcggctg acccagctgt
     1021 atgagcaggc ccgctgggac ttactgacag aggagatcga ctgcactgaa gaagagatga
     1081 tggtgtttgc tgccctgcag taccacatca acaaactgac cctgagcggg gatgtgggtg
     1141 agctggcctc tggggacctg ggactggatg acctggatgc agccctgaac aacctggagg
     1201 tgaagctgaa ggggtcagca ccctcagaca tgctggatag tctcactacc atcccagaac
     1261 tcaaggacca tctccggatc ttccggcccc ggaagctgac cctgaagggc taccgccagt
     1321 actgggtggt atttaaggac accacactgt cctactataa gagccaagat gaagcaccgg
     1381 gggaccctac ccagcagctc aacctcaagg gctgtgaggt ggtccctgat gtcaatgtct
     1441 ctggccagaa gttctgcatc aaactcctgg taccctcacc agagggcatg agtgagatct
     1501 acctgaggtg ccaggatgaa cagcagtacg cacagtggat ggctgcctgc cgactggcct
     1561 ccaagggccg caccatggcg gacagcagct atgccagcga ggtgcaggcc attctggcct
     1621 tcctcagcct gcagcgggca ggtggtagca atggaggctc agggaacaaa cctcaaggtc
     1681 ctgaagcccc tgctgagggc cttaacccct atggcctcgt ggctcctcgg ttccagcgaa
     1741 agttcaaggc caagcagctc accccaagga tcctggaagc tcaccaaaac gtggcccaac
     1801 tctcactgac cgaggcccag ctgcgcttta tccaggcctg gcaatccttg cccgactttg
     1861 gcatctccta tgtgatggtc aggttcaagg gcagcaggaa agatgagatc ctaggcattg
     1921 ccaacaaccg actcatccgg attgatctgg ccgtgggtga cgtggtcaag acctggcgct
     1981 tcagcaacat gcggcaatgg aacgtcaact gggacatacg gcaggtggcc attgagttcg
     2041 atgaacacat caatgtggcc ttcagctgtg tgtctgctag ctgccgcatc gtgcacgagt
     2101 acatcggggg ttacatcttc ctgtccaccc gagagcgggc ccgaggggaa gagctggatg
     2161 aggatctgtt cctgcagctt acaggaggcc atgaggcctt ctgagggcag cccctgctcc
     2221 actcaccacc tccagggacc ccccaaaggc cacacccacc tgaacacact gctccatcac
     2281 tcccgggatg tacactgctg ggcaacttca cttgttgtca ccaggcaggc cagggccctc
     2341 gctggggtag gtgctaccac cagccagcct agggatgatg ggccctgagc cacacagagc
     2401 ccctcctctc accctgttgg cagaagctca cacccccgac ctctatgtag tccctaagca
     2461 cacgacgaat gccagacacg gatgaggaac cacaaatcct ggtttgaagc tggactttct
     2521 ttctgtgtct gtttcaggtt ttttaataaa taaatatttt attgttggat ctttcttctt
     2581 cctcctc
//
