LOCUS       NM_001360525            3276 bp    mRNA    linear   ROD 30-OCT-2023
DEFINITION  Mus musculus fermitin family member 2 (Fermt2), transcript variant
            1, mRNA.
ACCESSION   NM_001360525 XM_006518827
VERSION     NM_001360525.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3276)
  AUTHORS   Wang Z, Zhang L, Li B, Song J, Yu M, Zhang J, Chen C, Zhan J and
            Zhang H.
  TITLE     Kindlin-2 in myoepithelium controls luminal progenitor commitment
            to alveoli in mouse mammary gland
  JOURNAL   Cell Death Dis 14 (10), 675 (2023)
   PUBMED   37833248
  REMARK    GeneRIF: Kindlin-2 in myoepithelium controls luminal progenitor
            commitment to alveoli in mouse mammary gland.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3276)
  AUTHORS   Liu C, Jiang K, Ding Y, Yang A, Cai R, Bai P, Xiong M, Fu C, Quan
            M, Xiong Z, Deng Y, Tian R, Wu C and Sun Y.
  TITLE     Kindlin-2 enhances c-Myc translation through association with DDX3X
            to promote pancreatic ductal adenocarcinoma progression
  JOURNAL   Theranostics 13 (13), 4333-4355 (2023)
   PUBMED   37649609
  REMARK    GeneRIF: Kindlin-2 enhances c-Myc translation through association
            with DDX3X to promote pancreatic ductal adenocarcinoma progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3276)
  AUTHORS   Yao Q, Gong W, Wu X, Gan D, Tao C, Lin S, Qu M, Ouyang Z, Chen M,
            Hu X and Xiao G.
  TITLE     Comparison of Kindlin-2 deficiency-stimulated osteoarthritis-like
            lesions induced by Prg4CreERT2 versus AggrecanCreERT2 transgene in
            mice
  JOURNAL   J Orthop Translat 41, 12-19 (2023)
   PUBMED   37292436
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3276)
  AUTHORS   Gao H, Zhong Y, Zhou L, Lin S, Hou X, Ding Z, Li Y, Yao Q, Cao H,
            Zou X, Chen D, Bai X and Xiao G.
  TITLE     Kindlin-2 inhibits TNF/NF-kappaB-Caspase 8 pathway in hepatocytes
            to maintain liver development and function
  JOURNAL   Elife 12, e81792 (2023)
   PUBMED   36622102
  REMARK    GeneRIF: Kindlin-2 inhibits TNF/NF-kappaB-Caspase 8 pathway in
            hepatocytes to maintain liver development and function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3276)
  AUTHORS   Wu X, Lai Y, Chen S, Zhou C, Tao C, Fu X, Li J, Tong W, Tian H,
            Shao Z, Liu C, Chen D, Bai X, Cao H and Xiao G.
  TITLE     Kindlin-2 preserves integrity of the articular cartilage to protect
            against osteoarthritis
  JOURNAL   Nat Aging 2 (4), 332-347 (2022)
   PUBMED   37117739
  REMARK    GeneRIF: Kindlin-2 preserves integrity of the articular cartilage
            to protect against osteoarthritis.
REFERENCE   6  (bases 1 to 3276)
  AUTHORS   Easterday MC, Dougherty JD, Jackson RL, Ou J, Nakano I, Paucar AA,
            Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind
            DH and Kornblum HI.
  TITLE     Neural progenitor genes. Germinal zone expression and analysis of
            genetic overlap in stem cell populations
  JOURNAL   Dev Biol 264 (2), 309-322 (2003)
   PUBMED   14651920
REFERENCE   7  (bases 1 to 3276)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3276)
  AUTHORS   Mu X, Zhao S, Pershad R, Hsieh TF, Scarpa A, Wang SW, White RA,
            Beremand PD, Thomas TL, Gan L and Klein WH.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   9  (bases 1 to 3276)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 3276)
  AUTHORS   Geschwind DH, Ou J, Easterday MC, Dougherty JD, Jackson RL, Chen Z,
            Antoine H, Terskikh A, Weissman IL, Nelson SF and Kornblum HI.
  TITLE     A genetic analysis of neural progenitor differentiation
  JOURNAL   Neuron 29 (2), 325-339 (2001)
   PUBMED   11239426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            LXEJ02000532.1, BY241982.1, AK166552.1, CX242997.1, CX201801.1,
            BB669826.1 and CT025535.14.
            
            [WARNING] On Nov 24, 2023 this sequence was replaced by
            NM_001360525.2.
            
            On Feb 6, 2018 this sequence version replaced XM_006518827.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.156357.1,
                                           SRR1660819.119488.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 LXEJ02000532.1     585132-585133
            3-62                BY241982.1         2-61
            63-668              AK166552.1         2-607
            669-701             CX242997.1         567-599
            702-2323            AK166552.1         608-2229
            2324-2631           AK166552.1         2231-2538
            2632-3111           CX201801.1         118-597
            3112-3275           BB669826.1         264-427
            3276-3276           CT025535.14        124564-124564       c
FEATURES             Location/Qualifiers
     source          1..3276
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 22.97 cM"
     gene            1..3276
                     /gene="Fermt2"
                     /gene_synonym="Kindlin-2; Mig2; Plekhc1"
                     /note="fermitin family member 2"
                     /db_xref="GeneID:218952"
                     /db_xref="MGI:MGI:2385001"
     exon            1..132
                     /gene="Fermt2"
                     /gene_synonym="Kindlin-2; Mig2; Plekhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            133..299
                     /gene="Fermt2"
                     /gene_synonym="Kindlin-2; Mig2; Plekhc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2218
                     /gene="Fermt2"
                     /gene_synonym="Kindlin-2; Mig2; Plekhc1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitogen inducible 2; fermitin family homolog 2; pleckstrin
                     homology domain containing, family C (with FERM domain)
                     member 1; pleckstrin homology domain-containing family C
                     member 1"
                     /codon_start=1
                     /product="fermitin family homolog 2 isoform 1"
                     /protein_id="NP_001347454.1"
                     /db_xref="GeneID:218952"
                     /db_xref="MGI:MGI:2385001"
                     /translation="MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGV
                     MLKLVEKLDVKKDWSDHALWWEKKRTWLLKTHWTLDKCGIQADAKLQFTPQHKLLRLQ
                     LPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSE
                     DEALELEGPLIMPGSGTDVLYIGPLKGSIYSSPGLYSKTMTPTYDAHDGSPLSPTSAW
                     FGDSALSEGNPGILAVSQPVTSPEILAKMFKPQALLDKAKTNQGWLDSSRSLMEQDVK
                     ENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWALLLEEIECTEEEMMMFAALQYH
                     INKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGGKTSTILGDITSIPELADYIKV
                     FKPKKLTLKGYKQYWCTFKDTSISCYKSREESSGTPAHQLNLRGCEVTPDVNISGQKF
                     NIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTMADSSYNLEVQNILSFLK
                     MQHLNPDPQLIPDQITTDVNPECLVSPRYLKKYKSKQITARILEAHQNVAQMSLIEAK
                     MRFIQAWQSLPEFGITHFIARFQGGKREELIGIAYNRLIRMDASTGDAIKTWRFSNMK
                     QWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEM
                     FYKLTSGWV"
     exon            300..533
                     /gene="Fermt2"
                     /gene_synonym="Kindlin-2; Mig2; Plekhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            534..668
                     /gene="Fermt2"
                     /gene_synonym="Kindlin-2; Mig2; Plekhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..701
                     /gene="Fermt2"
                     /gene_synonym="Kindlin-2; Mig2; Plekhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            702..927
                     /gene="Fermt2"
                     /gene_synonym="Kindlin-2; Mig2; Plekhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1030
                     /gene="Fermt2"
                     /gene_synonym="Kindlin-2; Mig2; Plekhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1138
                     /gene="Fermt2"
                     /gene_synonym="Kindlin-2; Mig2; Plekhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1273
                     /gene="Fermt2"
                     /gene_synonym="Kindlin-2; Mig2; Plekhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1323
                     /gene="Fermt2"
                     /gene_synonym="Kindlin-2; Mig2; Plekhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1448
                     /gene="Fermt2"
                     /gene_synonym="Kindlin-2; Mig2; Plekhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1555
                     /gene="Fermt2"
                     /gene_synonym="Kindlin-2; Mig2; Plekhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1777
                     /gene="Fermt2"
                     /gene_synonym="Kindlin-2; Mig2; Plekhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1902
                     /gene="Fermt2"
                     /gene_synonym="Kindlin-2; Mig2; Plekhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2044
                     /gene="Fermt2"
                     /gene_synonym="Kindlin-2; Mig2; Plekhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..3276
                     /gene="Fermt2"
                     /gene_synonym="Kindlin-2; Mig2; Plekhc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagggggtgg ggcgggggcc gcggcgccgg gactccatta gcagcggcgc gaggcttcgc
       61 tttcctccag agcagcgacg cgggtgccgc cagcctcgcc tgttgccgcg ggagcccggc
      121 gggaggagcg cggaagggag ccatggctct ggacgggata aggatgccag atggctgcta
      181 cgcggacggg acgtgggaac tgagcgtcca tgtcacggac ctgaaccgtg atgtcactct
      241 gagagtgacc ggggaggtgc acatcggagg ggtgatgctg aagttggtgg aaaaactcga
      301 tgtcaaaaaa gattggtcgg accatgctct ctggtgggaa aagaagagga cttggctgct
      361 taagacacac tggaccttgg ataagtgtgg catccaggca gatgccaagc tccagttcac
      421 cccgcagcac aaactgctcc gcctgcagct tcccaacatg aagtatgtga aggtgaaagt
      481 gaacttctct gaccgagtct tcaaggctgt gtctgacatc tgcaagactt tcaatataag
      541 acaccctgaa gaactttctc tcttaaaaaa acccagagat cccacaaaga aaaaaaagaa
      601 aaagctagat gaccagtctg aagacgaagc gcttgagctg gaaggacctc ttatcatgcc
      661 tggatcaggc accgatgttc tttacattgg ccctctgaaa ggaagcatat attcaagccc
      721 gggactttat agtaaaacaa tgacccctac ttacgacgct catgatggaa gccctttgtc
      781 accaacttct gcctggtttg gtgacagtgc cctgtcagaa ggcaatcctg ggatacttgc
      841 tgtcagtcag ccagtaacat caccagaaat actggcaaaa atgttcaagc ctcaagctct
      901 tcttgataaa gcaaaaacca accaagggtg gctagattcc tcaagatctc tcatggagca
      961 agatgtgaag gagaacgagg ccttgctgct ccgattcaag tactacagct tttttgattt
     1021 gaatccaaag tatgatgcca tcagaatcaa tcagctttac gagcaggcca agtgggctct
     1081 tctcctagaa gagatcgaat gcacggaaga agagatgatg atgttcgcag ccttgcagta
     1141 tcatatcaat aagctgtcaa tcatgacatc agaaaatcat ttaaacaaca gtgacaaaga
     1201 agttgatgaa gttgacgctg ccctttctga cctggagatc actttggaag gcgggaaaac
     1261 atcaacaatt ctgggtgaca ttacttcaat cccagaactt gctgactata ttaaagtttt
     1321 caagccgaag aagctgactt taaaggggta caagcagtac tggtgcactt tcaaagacac
     1381 gtccatctcc tgctacaaga gccgagaaga gtccagtggt acacctgctc atcagctgaa
     1441 cctcagagga tgtgaagtta ctccggatgt aaacatttca ggccagaaat ttaacataaa
     1501 actcctaatt ccggtagcag agggcatgaa tgagatctgg cttcgctgtg ataacgagaa
     1561 gcagtacgcg cactggatgg cagcttgcag gttagcctcc aaaggcaaga ccatggcaga
     1621 cagttcttac aacctggaag ttcagaacat tctttccttc ctgaaaatgc agcatctgaa
     1681 cccagacccc cagctgatcc ctgaccagat cacaaccgac gtcaaccccg agtgtctggt
     1741 gtccccgcgg tacctgaaga agtataagag caaacagata acagcacgga tcttggaggc
     1801 ccatcaaaat gtagcccaga tgagcctgat tgaagccaag atgagattca ttcaagcctg
     1861 gcagtctctg cctgagttcg gcatcacaca cttcattgcg aggtttcaag gcggcaagag
     1921 agaagaactt attggaattg catacaacag gttgattcgg atggacgcca gcacaggtga
     1981 cgccatcaaa acctggcggt tcagcaacat gaagcagtgg aatgtcaact gggagatcaa
     2041 gatggtcact gtagagtttg cagatgaggt ccggttgtcc ttcatctgta ccgaagtaga
     2101 ctgcaaggtg gtccacgaat tcattggtgg ttacatattt ctctcaactc gtgcgaaaga
     2161 ccaaaatgaa agtttagatg aggagatgtt ctacaaactc accagtggtt gggtgtgaat
     2221 aggaaaactt gtaataaaac tccacagcca taacaatatt taactttaaa gctattgttt
     2281 cttatatgct gcttaataaa gtaagcttga actttattat tttatcatga tacctttttg
     2341 ccttaccaga ccagtacata tgtgcactaa caagcacgat tgttaatctg ctgcctacct
     2401 tgatatgccg tatgtggact gtggaattcc caacagtcct tagggccacg gaaagctgtc
     2461 actgactgac agtaaccaaa ctaagaaaca agccatctac caagccaccc agggcataca
     2521 tataacctat atgaagtcta tttatcatgt gtaatgcatg tgtttgtgtt taattgatgc
     2581 cttcttttaa agtaccctgc tcctggtacc cagttaatcc cctctcccag tataaagtcg
     2641 gtctacagtg gatgcttggt atttgttgat gctgttgacc ttgaaggaaa cactgctaac
     2701 ctgttgttat tgggtgggtt ttgtctttga gtaagcatgc tgtacattgt tttgtgttta
     2761 gttttacacc aaactgtatt acagtactct tagtattcac cagcatactc actatctgcc
     2821 taagatatgc agcctttgtg ttacaatatg aagtaaagat ctatgaagta ttcattttgt
     2881 gtaactaatg tacaaacaca aattttataa aattgtacag ttttttttaa aaaaaactat
     2941 tcacaactag gaaatggctt aaatgtagca tccttacatt aattaagtgc ttttaaaata
     3001 tataattaat ttgcagtttc agtatctgct aaattacgaa tgacttcatg atgctcgtga
     3061 cttgccgtga tgcccttaac tacagcctgg accggctgtg ttctagtctg ttgcgctatt
     3121 acatctgcgt tggtgctagt tagacaattc ctagctcacg agcccagaag ggcgccaggg
     3181 aggggtggac ttaccagtat tgtccaataa tccatgaatt aaagactgta taaatgcatt
     3241 ttattttaaa taaaagtaaa accttttatt taatgt
//
