LOCUS       NM_198029               5255 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus fermitin family member 1 (Fermt1), mRNA.
ACCESSION   NM_198029 XM_001000475 XM_001000492 XM_001000536 XM_141372
            XM_894922 XM_902117 XM_902119 XM_902122 XM_918304 XM_925626
            XM_925627 XM_925628 XM_925629
VERSION     NM_198029.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5255)
  AUTHORS   Webb,E.R., Dodd,G.L., Noskova,M., Bullock,E., Muir,M., Frame,M.C.,
            Serrels,A. and Brunton,V.G.
  TITLE     Kindlin-1 regulates IL-6 secretion and modulates the immune
            environment in breast cancer models
  JOURNAL   Elife 12, e85739 (2023)
   PUBMED   36883731
  REMARK    GeneRIF: Kindlin-1 regulates IL-6 secretion and modulates the
            immune environment in breast cancer models.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5255)
  AUTHORS   Gao,J., Bao,Y., Ge,S., Sun,P., Sun,J., Liu,J., Chen,F., Han,L.,
            Cao,Z., Qin,J., White,G.C., Xu,Z. and Ma,Y.Q.
  TITLE     Sharpin suppresses beta1-integrin activation by complexing with the
            beta1 tail and kindlin-1
  JOURNAL   Cell Commun Signal 17 (1), 101 (2019)
   PUBMED   31429758
  REMARK    GeneRIF: The sharpin may complex with both kindlin-1 and the
            integrin beta1 CT to restrict the talin head domain binding, thus
            inhibiting beta1-integrin activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5255)
  AUTHORS   Rostampour,N., Appelt,C.M., Abid,A. and Boughner,J.C.
  TITLE     Expression of new genes in vertebrate tooth development and p63
            signaling
  JOURNAL   Dev Dyn 248 (8), 744-755 (2019)
   PUBMED   30875130
REFERENCE   4  (bases 1 to 5255)
  AUTHORS   Zhang,Z., Mu,Y., Zhang,J., Zhou,Y., Cattaneo,P., Veevers,J.,
            Peter,A.K., Manso,A.M., Knowlton,K.U., Zhou,X., Evans,S.M.,
            Ross,R.S. and Chen,J.
  TITLE     Kindlin-2 Is Essential for Preserving Integrity of the Developing
            Heart and Preventing Ventricular Rupture
  JOURNAL   Circulation 139 (12), 1554-1556 (2019)
   PUBMED   30883226
REFERENCE   5  (bases 1 to 5255)
  AUTHORS   Sarvi,S., Patel,H., Li,J., Dodd,G.L., Creedon,H., Muir,M., Ward,J.,
            Dawson,J.C., Lee,M., Culley,J., Salter,D.M., Sims,A.H., Byron,A.
            and Brunton,V.G.
  TITLE     Kindlin-1 Promotes Pulmonary Breast Cancer Metastasis
  JOURNAL   Cancer Res 78 (6), 1484-1496 (2018)
   PUBMED   29330144
  REMARK    GeneRIF: Kindin-1 is a critical mediator of early lung metastasis
            of breast cancer.
REFERENCE   6  (bases 1 to 5255)
  AUTHORS   Bottcher,R.T., Stremmel,C., Meves,A., Meyer,H., Widmaier,M.,
            Tseng,H.Y. and Fassler,R.
  TITLE     Sorting nexin 17 prevents lysosomal degradation of beta1 integrins
            by binding to the beta1-integrin tail
  JOURNAL   Nat Cell Biol 14 (6), 584-592 (2012)
   PUBMED   22561348
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5255)
  AUTHORS   Harburger,D.S., Bouaouina,M. and Calderwood,D.A.
  TITLE     Kindlin-1 and -2 directly bind the C-terminal region of beta
            integrin cytoplasmic tails and exert integrin-specific activation
            effects
  JOURNAL   J Biol Chem 284 (17), 11485-11497 (2009)
   PUBMED   19240021
  REMARK    GeneRIF: Kindlin-1 and -2 directly bind the C-terminal region of
            beta integrin cytoplasmic tails and exert integrin-specific
            activation effects
REFERENCE   8  (bases 1 to 5255)
  AUTHORS   Ussar,S., Moser,M., Widmaier,M., Rognoni,E., Harrer,C.,
            Genzel-Boroviczeny,O. and Fassler,R.
  TITLE     Loss of Kindlin-1 causes skin atrophy and lethal neonatal
            intestinal epithelial dysfunction
  JOURNAL   PLoS Genet 4 (12), e1000289 (2008)
   PUBMED   19057668
  REMARK    GeneRIF: Kindlin-1 in mice gives rise to skin atrophy and an
            intestinal epithelial dysfunction with similarities to human
            ulcerative colitis.
REFERENCE   9  (bases 1 to 5255)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   10 (bases 1 to 5255)
  AUTHORS   Ussar,S., Wang,H.V., Linder,S., Fassler,R. and Moser,M.
  TITLE     The Kindlins: subcellular localization and expression during murine
            development
  JOURNAL   Exp Cell Res 312 (16), 3142-3151 (2006)
   PUBMED   16876785
  REMARK    GeneRIF: The genomic organization, gene expression and subcellular
            localization of murine Kindlins-1 to -3, is described.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831763.6, AK030947.1 and AK050804.1.
            
            On or before Feb 7, 2007 this sequence version replaced
            XM_925626.2, XM_918304.2, XM_925629.2, XM_925628.2, XM_925627.2,
            XM_902117.2, XM_894922.2, XM_902122.2, XM_141372.7, XM_902119.2,
            XM_001000536.1, XM_001000492.1, XM_001000475.1, NM_198029.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK050804.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-714               AL831763.6         73198-73911         c
            715-852             AK030947.1         308-445
            853-2878            AK050804.1         1-2026
            2879-5255           AL831763.6         32054-34430         c
FEATURES             Location/Qualifiers
     source          1..5255
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 64.8 cM"
     gene            1..5255
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
                     /note="fermitin family member 1"
                     /db_xref="GeneID:241639"
                     /db_xref="MGI:MGI:2443583"
     exon            1..714
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..883
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             733..2766
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
                     /note="unc-112-related protein 1"
                     /codon_start=1
                     /product="fermitin family homolog 1"
                     /protein_id="NP_932146.2"
                     /db_xref="CCDS:CCDS38248.1"
                     /db_xref="GeneID:241639"
                     /db_xref="MGI:MGI:2443583"
                     /translation="MLSSGDLTSASWELVVRVDHANGEQQTEITLRVSGDLHIGGVML
                     KLVEQMNIAQDWSDYALWWEQKRCWLLKTHWTLDKCGVQADANLLFTPQHKMLRLRLP
                     NAKTVRLRVSFSAVVFKAVADICKVLNIRRPEELSLLKPSSDYCKKKKKKEKNSKEPV
                     IEDILNLESSSTSSGSPVSPGLYSKTMTPTYDPINGTPALSTMTWFGDSPLTEQNCSV
                     LAFSQPPPSPDVLADMFQPRSLVDKAKMNAGWLDSSRSLMEQSIQEDEQLQLRFKYYT
                     FFDLNPKYDAVRINQLYEQARWAVLLEEIDCTEEEMLIFAALQYHISKLSQCAEIQDF
                     ATKSEVDEVEAALSSLEVTLEGGKADNTLEDITDIPKLADYLKLFRPKKLMLKACKQY
                     WFVFKDTSIAYFKNKELEQGEPIEKLNLRGCEIVPDVNVSGRKFGIKLLIPVADGMNE
                     VYLRCDHEDQYARWMAACILASKGKTMADSSYQPEVISILSFLKMKNRNSSPLVASSL
                     ENMDMNPECLVSPCCAKKHKSKQLAARILEAHHNVAQMPLVEAKLQFIQAWQSLPEFG
                     LTYYLVRFKGSKKDDILGVAYNRLIRIDAVTGIPVTTWRFANMKQWNVNWEIRQVAIE
                     FDQNVSIAFTCLSADCKIVHEYIGGYIFLSTRSKDQNETLDEDLFHKLTGGQD"
     exon            884..1117
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1264
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1478
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1581
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1689
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1821
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1871
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1996
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2103
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2325
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2450
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2592
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..5255
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5001..5006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
     polyA_site      5045
                     /gene="Fermt1"
                     /gene_synonym="5830467P10Rik; Kindlin-1"
ORIGIN      
        1 actctaggag tggtccagcc tttggcttgg agctcagtct gatcagaggg ggcttcctcc
       61 tgccagacct cacctttttt ggaggactga catcaccctt ttactcagag gtgaatcgcc
      121 tctgtgcatg ccacctgtct ggtcaggctt gctccagaac tctgcataga tagacagttg
      181 cagacaggaa gggattctcc ctggccccgg gtatcagtga cgaatttacc taagaggcag
      241 agaaaaaggc tgggccttgg gtcctgggcc agtaccaggg cttcagggta cccagaacgt
      301 tggcggcgtc caggaaaggc catacaaaag tggaggcggg aggggaggag tgtgttccag
      361 gctgcttggc tcctgtctgg agcagccctg cggctccctt caacccttat tgtatctgca
      421 gccttctcct actcggagcg agagcaagac ctagcaggct gggctggacg tgcccccacc
      481 tgcccgccgc gctagcctgc gccgccaagc tgtggccccg ggactcggac cgtgcttggg
      541 tgctgggagg aggactccag cagctctact ggctgtcgcg aggtccccgc aacatcactg
      601 gacccgctgt accttggtgc ggtcccgcga gacccctgct cgcccaaggc ggcctctggg
      661 gacgcagctg tccacgtgcg agctgcagac tggacgcggc aggctccata gcagacatct
      721 gcctgggcca caatgttgtc atctggtgac ttgacatctg catcctggga gcttgtggtc
      781 cgagttgacc atgcaaatgg agagcagcag acagagatca cgctgagggt gtctggggac
      841 ctacatatcg ggggagtgat gctcaagctc gtggaacaga tgaacatagc ccaagactgg
      901 tcagactatg ctctgtggtg ggaacagaag cgctgctggc ttctgaaaac acactggacc
      961 ctggacaagt gtggggtcca ggctgacgcc aaccttctct tcacccctca gcataagatg
     1021 cttcgccttc gcctgcccaa tgccaagacc gtgcgcctgc gcgtcagctt ttcggctgtg
     1081 gtgtttaagg ctgtcgctga tatctgcaaa gtgctgaata tcagaagacc agaagaactt
     1141 tcattgttaa agccttctag tgactactgt aaaaagaaaa aaaagaaaga aaaaaatagt
     1201 aaagagccag tgattgaaga catcctgaac ctggaaagtt cttcaacaag ttcaggttcc
     1261 ccagtaagcc ccggcttgta cagtaagacc atgacaccca catacgaccc catcaatggg
     1321 acaccagcct tatccactat gacctggttt ggtgatagcc ctttgacaga gcaaaactgc
     1381 agtgttctgg ccttcagcca acctcctcca tcaccagatg tccttgccga catgttccag
     1441 cctcgatctt tggttgacaa agccaagatg aatgcaggct ggctggattc ctcacgatcc
     1501 cttatggagc aaagcattca ggaggatgag cagctgcagt tgagatttaa atactacacc
     1561 ttctttgact tgaatcctaa atatgacgct gtcagaataa accaactcta cgagcaagcc
     1621 aggtgggcgg ttctcttgga ggaaatcgac tgcacagaag aagaaatgtt gatctttgca
     1681 gccctgcagt atcacatcag caagctgtcc cagtgtgctg aaatacagga ctttgcaacc
     1741 aagtctgagg ttgacgaggt agaagcagca ttgtctagtt tggaagtgac cctggaaggc
     1801 gggaaggccg acaacacttt ggaggacata actgacatcc ctaaactcgc agattatctc
     1861 aaattattta ggcccaagaa gctgatgtta aaagcttgca agcaatactg gtttgtcttt
     1921 aaagacacat ctatagccta ctttaaaaat aaggagcttg aacaaggaga gccaatagag
     1981 aagctaaacc ttagaggctg cgaaattgtg ccagatgtga atgtatcggg gagaaaattt
     2041 ggaatcaagt tactaatccc cgttgctgat ggtatgaatg aagtgtactt gagatgtgac
     2101 catgaggatc aatatgcccg atggatggct gcctgcatct tggcatcgaa gggtaaaact
     2161 atggcagaca gctcctatca gccagaggtc atcagcatcc tttcgtttct caagatgaaa
     2221 aaccggaact catcacctct ggtggcttcc agtcttgaaa acatggatat gaacccggaa
     2281 tgtttagtat cgccctgctg tgcaaaaaag cacaagtcta aacagctggc ggcccggatc
     2341 ctggaagctc accataacgt agcccagatg cctctggtcg aagccaaact gcagttcatc
     2401 caggcctggc aatccttacc tgagttcggc ctcacctact accttgtcag atttaaagga
     2461 agcaaaaaag atgacatcct gggagttgca tacaacaggt tgattagaat cgatgcggtc
     2521 actgggatac cagttacaac gtggagattc gccaatatga agcagtggaa tgtcaactgg
     2581 gaaatccggc aggtggcaat cgagtttgac caaaacgtct ccatcgcatt cacctgccta
     2641 agtgcagatt gcaagattgt ccatgagtac attggtggct acatcttctt gtccacccga
     2701 tccaaggacc aaaacgaaac gctcgatgag gacctcttcc acaaactgac tggcggtcag
     2761 gactgaagtg aagcaggccc acttggccta catggactag gacttccttc ctgaatgggt
     2821 agggtctgtg gctttccctg tgtgtagctg cagagcaaca caatgtatgc ttaccatcag
     2881 atgcccaggt cctgcctcat ctgagcgcac tgaacacatc cctctcctta ctgtgcctca
     2941 ggctgccagc agtagactgg gctcctgctt cttttcctat aaagtgggtg gaggggagag
     3001 agggctggta ccctatggat gctctaaggc ccatcatggc tccccagcaa catggctttg
     3061 caggcacatg taagtgctag ccggcagctg acctgcttgt atgcctcacg gtaagtcagc
     3121 agtgagcaga gaggggtaat agggatgcat agcaagtaca aatctcgctc cacacactct
     3181 ggtccttcct ttacaaaact gagcgtagct tacatcttgc caaagtggca gagggagtct
     3241 taacaccttt tttctttgga ggtcaaagag atgagtggga aggagcaggt tacaggggtc
     3301 ttcggcatca tcggtttact gtgactgtca catctgttaa ggtgaccact caccatctgg
     3361 tctaaccgtt gttcctcaca gtatggctga catgagaagc tccactccta gagaatccca
     3421 cagacacact gaagcccttc ttaaagacac aggtgctgaa gggataagtg ggagcccagt
     3481 ctcagccaag atccaagact cagtcgattt ggtcctgggc tgggtctcaa gaaaacaggc
     3541 ctggttctct gttaaccaaa agcaacttcc acagagctgg aaagatatag gtcagcagtt
     3601 aagagggctt gctgctctta cggaggacct cagctgagtt ccaagtacct agctttaagg
     3661 gatctgatgt cttcttctga actctgtgag tacctgcaca cacacacaca cacacacaca
     3721 cacacacaca cacacacaca cacacacaca aaccctggca ggattccaag tccattcagg
     3781 tctccgttcc agccaaccaa gccaagtaag agaaggcagg caaatctgtt tcagagtcca
     3841 ccatgttgaa gttctatttt taaagtcatg tccggtctgg gttataaaaa agtgttctta
     3901 ccactcagct gcattctgga tgtggagtct gcctctatga tccttgccat ttttccctaa
     3961 acaccttcag ctttgtaaat cacaagacaa taacagactc ttgggagctg ttttttgcag
     4021 tatcatccct gtcctgctat aagcataagc ccttggcagc tgcctgaatg tcatgttctg
     4081 gtttttcagt aggagggaat gagtgggttt tgagtaagtg gactgcagcc tcagagctaa
     4141 agggaggtgt tttctattgt cgatacacag ccttctcctt ccacacgaac tcagactgca
     4201 cagatagagc aagagctttc cttgaacctg gcatgtttta gggttttgga tggagcccag
     4261 agaccttcaa gcctcagctg ttgctttgtt tcccaacaag gtcacctggg aagggagagt
     4321 tctgcaattc tcagaagact gtcctggcct gagaccacag acatgagcca gaagaacctt
     4381 ctggaggttt cttttagcct ttccagatac ccactgaatt cctggggctc agttttggtt
     4441 ggcaatactt taagcatttg gaagatctgg ttcccatcat caagaactta atgtggggtg
     4501 tttttccaca gtcaagtatg ttaagtgctg caggaaccat ggtgctgtcc tttcctctgc
     4561 tgtcctgggc tctgctgttt agggcctaga cagggtgcag gatactcctg ggtgcactac
     4621 actaggctgg gtggagtata cacacagtgt gcatgccttt aatcccagaa ctcaggaggc
     4681 agatgcaagc agacatctgt gagtctgagg ccagccaagg ctccataatt tttcaaatga
     4741 aaaatatttg catgctatag cctggacaga tcttccaaat cctggtcaca atgacctcct
     4801 tgattacatg tcaccttgat tacatgttgc ccatgagaat tcagcttccc tagaatgcca
     4861 gaccaggcct tcaggtcagc ccctcctttg ctttgtatgg ttggctgaga tttctgtaaa
     4921 actcctggag gagttggctc ccaacgttat gcagttttag gtagcatttc tcccgtggtt
     4981 acacagctac atctcaaagg aataaattgg tataagagga aaaggctaaa tgccattgtt
     5041 ctaaagaaaa gtatggtcct ttttttttag gaagaggggg ttaacatttg gatacaaatg
     5101 gtcaggtgac ttgtccttgc tgaaattgta atttgtttgt cacacacatc ccattcactt
     5161 tactatctgc catagatgct gaaatctgca ctgtattatt tatatgagtt taaatttgat
     5221 ttttatatgt gtttgaatat agttcagttg tggcc
//
