LOCUS       NM_001037997            3066 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus FER tyrosine kinase (Fer), transcript variant 1, mRNA.
ACCESSION   NM_001037997
VERSION     NM_001037997.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3066)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3066)
  AUTHORS   Sluimer,L.M., Bullock,E., Ratze,M.A.K., Enserink,L., Overbeeke,C.,
            Hornsveld,M., Brunton,V.G., Derksen,P.W.B. and Tavares,S.
  TITLE     SKOR1 mediates FER kinase-dependent invasive growth of breast
            cancer cells
  JOURNAL   J Cell Sci 136 (3) (2023)
   PUBMED   36620935
  REMARK    GeneRIF: SKOR1 mediates FER kinase-dependent invasive growth of
            breast cancer cells.
REFERENCE   3  (bases 1 to 3066)
  AUTHORS   Navarrete,F.A., Aguila,L., Martin-Hidalgo,D., Tourzani,D.A.,
            Luque,G.M., Ardestani,G., Garcia-Vazquez,F.A., Levin,L.R., Buck,J.,
            Darszon,A., Buffone,M.G., Mager,J., Fissore,R.A., Salicioni,A.M.,
            Gervasi,M.G. and Visconti,P.E.
  TITLE     Transient Sperm Starvation Improves the Outcome of Assisted
            Reproductive Technologies
  JOURNAL   Front Cell Dev Biol 7, 262 (2019)
   PUBMED   31750304
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3066)
  AUTHORS   Fan,G., Zhang,S., Gao,Y., Greer,P.A. and Tonks,N.K.
  TITLE     HGF-independent regulation of MET and GAB1 by nonreceptor tyrosine
            kinase FER potentiates metastasis in ovarian cancer
  JOURNAL   Genes Dev 30 (13), 1542-1557 (2016)
   PUBMED   27401557
  REMARK    GeneRIF: levels of FER were elevated in ovarian cancer cell lines
            relative to those in immortalized normal surface epithelial cells
            and that suppression of FER attenuated the motility and invasive
            properties of these cancer cells
REFERENCE   5  (bases 1 to 3066)
  AUTHORS   Alvau,A., Battistone,M.A., Gervasi,M.G., Navarrete,F.A., Xu,X.,
            Sanchez-Cardenas,C., De la Vega-Beltran,J.L., Da Ros,V.G.,
            Greer,P.A., Darszon,A., Krapf,D., Salicioni,A.M., Cuasnicu,P.S. and
            Visconti,P.E.
  TITLE     The tyrosine kinase FER is responsible for the
            capacitation-associated increase in tyrosine phosphorylation in
            murine sperm
  JOURNAL   Development 143 (13), 2325-2333 (2016)
   PUBMED   27226326
  REMARK    GeneRIF: Sperm from mice targeted with a kinase-inactivating
            mutation in Fer failed to undergo capacitation-associated increases
            in tyrosine phosphorylation.
REFERENCE   6  (bases 1 to 3066)
  AUTHORS   Kim,L. and Wong,T.W.
  TITLE     The cytoplasmic tyrosine kinase FER is associated with the
            catenin-like substrate pp120 and is activated by growth factors
  JOURNAL   Mol Cell Biol 15 (8), 4553-4561 (1995)
   PUBMED   7623846
REFERENCE   7  (bases 1 to 3066)
  AUTHORS   Asada,Y. and Nadeau,J.H.
  TITLE     Fert is on mouse chromosome 11, not chromosome 17
  JOURNAL   Mamm Genome 5 (12), 830 (1994)
   PUBMED   7894174
REFERENCE   8  (bases 1 to 3066)
  AUTHORS   Hazan,B., Bern,O., Carmel,M., Lejbkowicz,F., Goldstein,R.S. and
            Nir,U.
  TITLE     ferT encodes a meiosis-specific nuclear tyrosine kinase
  JOURNAL   Cell Growth Differ 4 (6), 443-449 (1993)
   PUBMED   8373729
REFERENCE   9  (bases 1 to 3066)
  AUTHORS   Ben-David,Y., Letwin,K., Tannock,L., Bernstein,A. and Pawson,T.
  TITLE     A mammalian protein kinase with potential for serine/threonine and
            tyrosine phosphorylation is related to cell cycle regulators
  JOURNAL   EMBO J 10 (2), 317-325 (1991)
   PUBMED   1825055
REFERENCE   10 (bases 1 to 3066)
  AUTHORS   Fischman,K., Edman,J.C., Shackleford,G.M., Turner,J.A., Rutter,W.J.
            and Nir,U.
  TITLE     A murine fer testis-specific transcript (ferT) encodes a truncated
            Fer protein
  JOURNAL   Mol Cell Biol 10 (1), 146-153 (1990)
   PUBMED   2294399
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140339.4, CT010469.16 and AC110517.9.
            
            On Mar 29, 2022 this sequence version replaced NM_001037997.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.3904657.1,
                                           SRR13948564.2341542.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC140339.4         56915-56970         c
            57-322              AC140339.4         24687-24952         c
            323-496             AC140339.4         13516-13689         c
            497-596             AC140339.4         9406-9505           c
            597-780             CT010469.16        2644-2827
            781-918             CT010469.16        4393-4530
            919-1038            CT010469.16        5090-5209
            1039-1161           CT010469.16        15321-15443
            1162-1351           CT010469.16        22322-22511
            1352-1444           CT010469.16        54096-54188
            1445-1651           CT010469.16        62511-62717
            1652-1774           CT010469.16        72625-72747
            1775-1831           CT010469.16        110321-110377
            1832-1947           CT010469.16        116478-116593
            1948-2042           CT010469.16        118601-118695
            2043-2166           AC110517.9         30083-30206
            2167-2321           AC110517.9         84672-84826
            2322-2444           AC110517.9         88941-89063
            2445-3066           AC110517.9         90106-90727
FEATURES             Location/Qualifiers
     source          1..3066
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 33.06 cM"
     gene            1..3066
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /note="FER tyrosine kinase"
                     /db_xref="GeneID:14158"
                     /db_xref="MGI:MGI:105917"
     exon            1..56
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     exon            57..322
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..2587
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /EC_number="2.7.10.2"
                     /note="isoform a is encoded by transcript variant 1;
                     proto-oncogene tyrosine-protein kinase Fer; p94-Fer;
                     proto-oncogene c-Fer; fer (fms/fps related) protein
                     kinase, testis specific 2"
                     /codon_start=1
                     /product="tyrosine-protein kinase Fer isoform a"
                     /protein_id="NP_001033086.2"
                     /db_xref="CCDS:CCDS28936.1"
                     /db_xref="GeneID:14158"
                     /db_xref="MGI:MGI:105917"
                     /translation="MGFGSDLKNSQEAVLKLQDWELRLLETVKKFMALRIKSDKEYAY
                     TLQNLCNQVDKESTVQVNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTM
                     MIKDKQQVKKSYVGIHQQIEAEMIKVTKTELEKLKSSYRQLIKEMNSAKEKYKEALAK
                     GKETEKAKERYDKATMKLHMLHNQYVLALKGAQLHQSQYYDTTLPLLLDSVQKMQEEM
                     IKALKGIFDDYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQE
                     IEFDTSLLEENENLQANEIMWNNLTADSLQVMLKTLAEELTQTQQMLLHKEAAVLELE
                     KRIEESFETCEKKSDIVLLLGQKQALEELKQSVQQLRCTEAKCAAQKALLEQKVQEND
                     GKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIKSPKSVLGSSTQVCDVIS
                     VGERPLAEHDWYHGAIPRIEAQELLKQQGDFLVRESHGKPGEYVLSVYSDGQRRHFII
                     QFVDNLYRFEGTGFSNIPQLIDHHFNTKQVITKKSGVVLLNPIPKDKKWVLNHEDVSL
                     GELLGKGNFGEVYKGTLKDKTPVAIKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKL
                     IGVCTQRQPVYIIMELVPGGDFLTFLRKRKDELKLKQLVRFSLDVAAGMLYLESKNCI
                     HRDLAARNCLVGENNTLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSS
                     ESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQNCPEEVFTIMMKCW
                     DYKPENRPKFNDLHKELTVIKKMIT"
     exon            323..496
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     exon            497..596
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     exon            597..780
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     exon            781..918
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1038
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1161
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1351
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1444
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1651
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1774
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1831
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1947
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2042
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2166
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2321
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2444
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..3066
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2748..2753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /note="hexamer: AATAAA"
     polyA_site      2781
                     /gene="Fer"
                     /gene_synonym="C330004K01Rik; Fert; Fert2"
                     /note="major polyA site"
ORIGIN      
        1 acgccgggtg gcgactggct cccgggtctg aggggcttct gcttgtcagg ttctagatat
       61 gtgctgacta gcaggctcac gtgcacagtg tggaggataa gctatatctt acaaaatggg
      121 atttgggagt gacctgaaga actcacagga agctgtgtta aagttgcaag actgggaact
      181 acggttgctg gagacagtga agaaatttat ggctctgaga ataaagagtg ataaagaata
      241 tgcatatact ctacagaatc tttgtaatca agttgataaa gaaagcactg tgcaagtgaa
      301 ttatgtcagc aacgtgtcca agtcttggct actgatgatt cagcagacag aacagcttag
      361 taggataatg aagacacatg cagaggactt gaactctgga cccttgcaca ggctcaccat
      421 gatgatcaag gacaagcagc aagtgaagaa gagctatgta ggcattcatc aacagataga
      481 ggcagagatg atcaaggtca caaagacaga attggagaaa ttaaaatcca gctatcgaca
      541 attaataaaa gaaatgaatt ctgccaaaga gaaatataaa gaagccttag cgaaagggaa
      601 ggaaacagaa aaggccaagg agcgctatga caaagctaca atgaagcttc atatgctgca
      661 taatcagtat gtgttggcac tgaagggggc acagctccat cagagccagt actatgatac
      721 cacacttcct ctgctgctgg actccgtgca aaagatgcaa gaagaaatga taaaagcact
      781 aaaaggtata tttgatgact atagccagat aaccagcctt gttacagagg aaatagtgaa
      841 tgtccataaa gagattcaaa tgtctgttga acagatagac cctagcaccg aatataataa
      901 tttcatagat gttcacagaa caacagctgc taaagaacaa gaaatcgaat ttgatacttc
      961 cctattagaa gaaaatgaaa atcttcaggc aaatgagatc atgtggaata atttaacagc
     1021 agacagtttg caagtcatgt tgaagacttt agcggaagag ctcacacaga cccagcagat
     1081 gcttttacac aaggaggcgg ccgtcctgga gctagagaag aggattgaag aatcttttga
     1141 gacctgtgaa aagaagtctg acattgtgct tcttctgggc caaaaacagg cacttgaaga
     1201 gttgaaacag tcagtccagc agttgcgatg cactgaggca aagtgtgcag cacagaaagc
     1261 tttgctggag caaaaagtac aggaaaatga tgggaaagaa ccacctcctg tggtgaatta
     1321 cgaagaagac gcgcggtcag tcacatccat ggaaagaaag gagaggctat ccaaatttga
     1381 gtctattcgt cattcaattg ctgggataat taagtctcca aagtcggtac tcggatcttc
     1441 aacacaggtg tgtgatgtga tctctgtggg tgagaggccc ctggcggagc atgactggta
     1501 ccatggtgcc atccccagga tagaggcaca ggaactgctg aagcagcaag gagacttcct
     1561 ggtgcgggag agccatggga aacctggtga atatgtcctt tctgtatatt ctgacggaca
     1621 aaggaggcac tttatcatac aatttgtcga taatctgtat cgattcgagg gcaccgggtt
     1681 ttcaaacatt ccccagctta tagatcacca cttcaataca aagcaagtca tcaccaagaa
     1741 gtctggggtg gttctgctca accccatccc aaaggataag aaatgggttc tcaatcatga
     1801 agatgtttca ttgggagaat tactgggcaa ggggaatttt ggtgaagtgt ataagggcac
     1861 actaaaggat aaaactcctg ttgccattaa aacgtgcaag gaagaccttc ctcaggaatt
     1921 aaaaataaag tttctacagg aagccaaaat tctgaagcaa tatgatcatc ccaatattgt
     1981 caaactgata ggcgtgtgca cacaaagaca gcctgtctac atcattatgg aactggtccc
     2041 agggggtgat tttctgacct tcctgaggaa gaggaaggac gagctgaagc tgaagcagtt
     2101 ggtgagattt tccttggacg ttgctgctgg catgttgtat ctcgagagca agaactgcat
     2161 tcacagggac ctggctgcac ggaactgcct ggtgggtgaa aataatactc tgaaaatcag
     2221 tgactttgga atgtctcggc aagaagacgg tggagtgtat tcatcttctg gcttaaagca
     2281 gattcctatt aaatggacag caccggaagc tcttaattat gggagataca gttctgaaag
     2341 tgacgtgtgg agcttcggca tcctcctctg ggagaccttc agcctaggag tctgcccgta
     2401 ccctggaatg acaaaccagc aagcgcgaga gcaagtggag agaggatacc ggatgtcagc
     2461 cccacagaac tgtccagagg aggtttttac aatcatgatg aagtgttggg attacaagcc
     2521 tgaaaaccgc cctaagttca acgaccttca caaagagctc actgtcatca agaagatgat
     2581 cacatagtgc cagccagggc tggatgccac ctgtaggact ctgtcctcag tcacccccac
     2641 tttataccac cttactgcaa ccatctttga aggttatgtt tttttattaa ctgggttttt
     2701 aaagtatgtt ccactttaaa ctatgttaaa ggcaaatcta ttcaagaaat aaatagtcct
     2761 acccagagcc gtattagcta accacagcaa ccctgccatt tgataccgct gtaaagagaa
     2821 aagcacagga ctaatggtaa aggccaaaga aaaaggcctg cctttaatac ctaggtccat
     2881 tggtgatctc caaggttttc tactctaggc acagcctgtg ggctgctgtc ttctgccaca
     2941 ggccctcctc ggttggtgct ataaacagcc ttggtagcgc atgcttgcag gacacgtgcc
     3001 caccacagtt gctctccact ctgccaaggc gagattatat ctataaatat aatcatatat
     3061 tgggaa
//
