LOCUS       NM_010193               6505 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus fem 1 homolog b (Fem1b), mRNA.
ACCESSION   NM_010193
VERSION     NM_010193.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6505)
  AUTHORS   Manford,A.G., Mena,E.L., Shih,K.Y., Gee,C.L., McMinimy,R.,
            Martinez-Gonzalez,B., Sherriff,R., Lew,B., Zoltek,M.,
            Rodriguez-Perez,F., Woldesenbet,M., Kuriyan,J. and Rape,M.
  TITLE     Structural basis and regulation of the reductive stress response
  JOURNAL   Cell 184 (21), 5375-5390 (2021)
   PUBMED   34562363
REFERENCE   2  (bases 1 to 6505)
  AUTHORS   Shi,Y.Q., Liao,S.Y., Zhuang,X.J. and Han,C.S.
  TITLE     Mouse Fem1b interacts with and induces ubiquitin-mediated
            degradation of Ankrd37
  JOURNAL   Gene 485 (2), 153-159 (2011)
   PUBMED   21723927
  REMARK    GeneRIF: Fem1b is a binding partner of Ankrd37, and their
            interaction resulted in Ankrd37 degradation through the
            ubiquitin-mediated proteolysis pathway.
REFERENCE   3  (bases 1 to 6505)
  AUTHORS   Subauste,M.C., Ventura-Holman,T., Lu,D., Du,L., Sansom,O.J. and
            Maher,J.F.
  TITLE     Fem1b antigen in the stool of ApcMin mice as a biomarker of early
            Wnt signaling activation in intestinal neoplasia
  JOURNAL   Cancer Epidemiol 35 (1), 97-100 (2011)
   PUBMED   20952268
  REMARK    GeneRIF: Increased Fem1b is associated with intestinal neoplasia.
REFERENCE   4  (bases 1 to 6505)
  AUTHORS   Shimogori,T., Lee,D.A., Miranda-Angulo,A., Yang,Y., Wang,H.,
            Jiang,L., Yoshida,A.C., Kataoka,A., Mashiko,H., Avetisyan,M.,
            Qi,L., Qian,J. and Blackshaw,S.
  TITLE     A genomic atlas of mouse hypothalamic development
  JOURNAL   Nat Neurosci 13 (6), 767-775 (2010)
   PUBMED   20436479
REFERENCE   5  (bases 1 to 6505)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 6505)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 6505)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   8  (bases 1 to 6505)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 6505)
  AUTHORS   Chan,S.L., Tan,K.O., Zhang,L., Yee,K.S., Ronca,F., Chan,M.Y. and
            Yu,V.C.
  TITLE     F1Aalpha, a death receptor-binding protein homologous to the
            Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase
            substrate that mediates apoptosis
  JOURNAL   J Biol Chem 274 (45), 32461-32468 (1999)
   PUBMED   10542291
REFERENCE   10 (bases 1 to 6505)
  AUTHORS   Ventura-Holman,T., Seldin,M.F., Li,W. and Maher,J.F.
  TITLE     The murine fem1 gene family: homologs of the Caenorhabditis elegans
            sex-determination protein FEM-1
  JOURNAL   Genomics 54 (2), 221-230 (1998)
   PUBMED   9828124
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ047815.1, AK149329.1, AK160393.1, AK122272.1 and AI854655.1.
            
            On Nov 15, 2007 this sequence version replaced NM_010193.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068236.1, SRR1660813.2592.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                CJ047815.1         3-40
            39-2627             AK149329.1         2-2590
            2628-3853           AK160393.1         564-1789
            3854-6464           AK122272.1         3050-5660
            6465-6505           AI854655.1         1-41                c
FEATURES             Location/Qualifiers
     source          1..6505
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 33.87 cM"
     gene            1..6505
                     /gene="Fem1b"
                     /gene_synonym="mKIAA0396"
                     /note="fem 1 homolog b"
                     /db_xref="GeneID:14155"
                     /db_xref="MGI:MGI:1335087"
     exon            1..591
                     /gene="Fem1b"
                     /gene_synonym="mKIAA0396"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..2227
                     /gene="Fem1b"
                     /gene_synonym="mKIAA0396"
                     /note="mt-Fem; F1A-alpha; FEM1-beta; fem-1-like death
                     receptor-binding protein alpha; fem-1-like in apoptotic
                     pathway protein alpha; feminization 1 homolog b"
                     /codon_start=1
                     /product="protein fem-1 homolog B"
                     /protein_id="NP_034323.1"
                     /db_xref="CCDS:CCDS23266.1"
                     /db_xref="GeneID:14155"
                     /db_xref="MGI:MGI:1335087"
                     /translation="MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGG
                     QRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFE
                     VVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMI
                     AAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGH
                     GMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENYDIMKTYHYL
                     YLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELEAIRQDRDALHMEGLIVRER
                     ILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVF
                     SQMIHLNEAVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHSAMDNYECNLYTFLYL
                     VCISTKTQCSEEDQCRINKQIYNLIHLDPRTREGFSLLHLAVNSNTPVDDFHTNDVCS
                     FPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHT
                     DMTNKQNKTPLDKSTTGVSEILLKTQMKMSLKCLAARAVRANDINYQDQIPRTLEEFV
                     GFH"
     exon            592..6496
                     /gene="Fem1b"
                     /gene_synonym="mKIAA0396"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2267..2272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fem1b"
                     /gene_synonym="mKIAA0396"
                     /note="hexamer: AGTAAA"
     polyA_site      2286
                     /gene="Fem1b"
                     /gene_synonym="mKIAA0396"
                     /note="major polyA site"
     polyA_site      3026
                     /gene="Fem1b"
                     /gene_synonym="mKIAA0396"
     regulatory      4454..4459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fem1b"
                     /gene_synonym="mKIAA0396"
                     /note="hexamer: TATAAA"
     polyA_site      4484
                     /gene="Fem1b"
                     /gene_synonym="mKIAA0396"
     regulatory      4741..4746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fem1b"
                     /gene_synonym="mKIAA0396"
                     /note="hexamer: CATAAA"
     polyA_site      4762
                     /gene="Fem1b"
                     /gene_synonym="mKIAA0396"
     regulatory      5740..5745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fem1b"
                     /gene_synonym="mKIAA0396"
                     /note="hexamer: AGTAAA"
     polyA_site      5762
                     /gene="Fem1b"
                     /gene_synonym="mKIAA0396"
ORIGIN      
        1 gggcgcgcgc ctgtcgcagc ccgcaggaag gaggcggcct gagacccggg gcggcggccg
       61 ccatggagat cccctcggcc cagggccggt gcctggggcc tcgggggcgg ccctgaccgt
      121 ccttctcccc gcccgggccg ggtcccactt gtgcctccgg cggtgctcgg ccacctctgc
      181 gtctccgccc tccctgggtc gcgctgctgc ctggacacgg cggcggcgcc ctgttgaatg
      241 ggctgtgagg gcccgggtct gaagtgctgg tggacgcggc ctccgggggc gcaaggcagc
      301 agcagcggtg gcgaccaaac gggtgttgga gttggcggcg gccatggagg gcctggctgg
      361 ctatgtgtac aaggcggcca gcgagggcaa ggtgctcact ctggctgcct tgctccttaa
      421 ccggtcagag agcgatatcc gctacctgct gggctatgtc agtcagcagg gaggacagcg
      481 ctccacaccc ctcatcatcg cagcccgcaa tgggcacgcc aaggtggtgc gcttgctgtt
      541 agaacactac cgtgtgcaga cccagcagac cggcaccgtc cgcttcgacg ggtatgtcat
      601 tgacggtgcc actgctcttt ggtgtgctgc gggagccgga cattttgaag ttgttaaact
      661 tctagtcagc catggagcca acgtgaacca caccacagtc actaactcaa ctccattgcg
      721 ggcagcatgc tttgatggca gactggacat tgtgaaatat ttggttgaaa ataatgccaa
      781 tatcagcatt gccaacaagt atgacaacac ctgcctaatg atcgcagcat ataaagggca
      841 cactgatgtg gtcagatacc tcttagaaca acgtgctgat cccaatgcta aagcacactg
      901 tggagccaca gctttgcact ttgcagccga agctggtcac attgacattg tgaaagaact
      961 gataaaatgg agagctgcaa tagtggtgaa tggccatggg atgacaccat tgaaggtggc
     1021 cgctgaaagc tgtaaagctg atgtcgttga actgttgctc tctcatgctg attgtgaccg
     1081 cagaagtcgg attgaagcct tggagctctt gggtgcctcc tttgcaaatg atcgtgagaa
     1141 ctatgacatc atgaagacat accactattt atatttagct atgttggaga gatttcagga
     1201 tggtgacaac attcttgaaa aagaggttct cccacccatc catgcttatg ggaacagaac
     1261 tgagtgtagg aacccacagg aattggaggc tattcggcaa gacagagatg ctcttcacat
     1321 ggagggcctt atagttcggg aacggatttt aggtgctgac aacattgatg tttcccaccc
     1381 catcatttac agaggggctg tctatgctga taacatggag ttcgagcagt gcatcaaatt
     1441 gtggctccac gcactacacc tgaggcagaa aggtaacagg aatacccaca aagatctgct
     1501 tcggtttgct caagtcttct ctcagatgat acacctcaat gaagctgtga aggccccaga
     1561 catagagtgc gttttgagat gcagtgtctt ggaaatagag cagagcatga acagagttaa
     1621 aaatatctcc gatgccgacg tccacagtgc catggataac tatgagtgta acctctatac
     1681 ctttctgtac ctcgtgtgca tctccaccaa gacacagtgt agcgaagaag atcagtgcag
     1741 aattaacaag cagatctaca acctgattca cctggacccc agaacacggg aaggtttttc
     1801 cttgctacac ctggctgtca actcgaacac accagttgat gatttccata ctaacgatgt
     1861 ctgcagcttt cccaacgctc tggtcacaaa gctcctgctg gactgtggcg ctgaggtaaa
     1921 tgcagtggac aatgagggga acagtgccct ccacattatc gtccagtaca acaggcccat
     1981 cagtgatttt ctgaccttgc actccatcat catcagcctt gtggaggctg gagctcacac
     2041 cgacatgaca aacaagcaga ataaaactcc gctagacaaa agtacaactg gggtgtctga
     2101 aatactactt aaaactcaga tgaagatgag cctcaagtgc ctggctgccc gagcagttcg
     2161 ggctaatgac attaactacc aagaccagat cccccggact cttgaagagt ttgttggatt
     2221 tcattaagtg actggatgtg taaaatcgtt taatgtggtg ctaaaaagta aaggacttta
     2281 atcacagaca atagaattct gtgtttgtaa attctccttt tctttccact atcctttcag
     2341 ccatcgtcct tggttccgtg tgcctctttt ctcacgtggt attgagctca gcacactaaa
     2401 cagagcagcg ctgttcaggt gtaactggaa ggtgtatgga catttgtttg tttccttttc
     2461 tttttctttt tttaaaagaa tgaatgtaag ccttttgtgt aataggggca tttgtgattt
     2521 aaaattggtg atgttttaaa cagctgccta caaaagtatt tctgttaagc tgatgtcagc
     2581 atgtcatctg tgcagcagtt ttgaggattt catgaagaaa atgaactaaa aaggaacact
     2641 gggagcactg ggagatgctc aagccctgca tggatggttc tcacttcact gtgtgtgtgc
     2701 agtgatacag cacattttac atcaggagga cttgaaacac ttagctactg attaataatc
     2761 tgaaaattat gtgcagttat tgttggaaag ttgaattcct gaaaatcatt gtgttctgtt
     2821 agtgtcttct aactggtgat cttagcccaa ccttgcggac cttgctagat tccaccctta
     2881 ggcttgaatt cttctggtct ctgatgtaat gatgaatcta aattgcattt atgcattgga
     2941 tttggctcac agacctacgt aaggagcaca ctgtattatg aaacattgtc acagtatagc
     3001 tagacattgt acttcgtcct tttctagccc tgtccttgtg tgttgtatct ttaaaaattg
     3061 gaaactgcct ttccataggg cattggtgtc tccctaatta ggtgtaagat gaaaaggaat
     3121 gaggacacat atgtgatgtt tttacttagt ccattgtaag atgtaggaaa accaggagta
     3181 aggtatagga aatgaagtat ttgatgagga aaatgattct cagtgccaca tgaaaggtgt
     3241 atctcagagc tgtagacttt tctaccacag aatgtggtac tgaggtcttt gggttttttg
     3301 cttttttttt tttaaatcaa gcaacatttc aactcttaag agtattctgt gatttttttt
     3361 tttttctctt aagcatcaca gaaattcaag ttgaaggaac aacagtgtct gctgatgcta
     3421 gggatgagaa tgaaagtgaa actagttcct gtaatttcct ctagtgccaa atgaatgctg
     3481 cctaagctac ccctagtgca tggaaccgta cgtggagacc cgcagctttg tgttttcctt
     3541 tagtgaaaag cattgtcatg atacaacatc agatataaac tttaaacaac ctgtaagatt
     3601 tcacaaatac tttacctgtg gatattgctt ttaaaacata ggagaatggt tgtagttgga
     3661 gtagtacaaa gtgaccaagc caaaatcagc acctagggcc ttaaacagag ataccccata
     3721 aaatgaaata ccaggagagg gcaggaaagg agacttaaag tttcctgctc caagggtgca
     3781 agatgcagtt gctgtagttg tgcttcgtgt gtgtccttgt gttagttatt ttcctaactt
     3841 gagagtttac atggaagact tttctgatgg cttaaaggga ggtgttggaa tgccctaatt
     3901 tgggaacttc tgacctagac cctcttggtg tgacttaagg cgatattgat tcaccttgct
     3961 ctggcagctc tcagtggcct ggaagagatg acacactgca caaggtgagt cagccctgcc
     4021 tcttctcagg ctcaggtcag gtcttttcgg acactaaggc ccaatgagga cagtgaggaa
     4081 tagctgtgaa acttagtatt cagttggttc cattttttta atgtatatga tttttaagca
     4141 cccaaactga aagtatctat cagataatac tgcatgtttt aaaaacattt ttcctccttc
     4201 actacccagg accaacactg ttctaagaca ttatttatat atgagaataa taataatata
     4261 catattcaga tgtagaatta aaggacagct tttgaaggag ggaagacagt gctgaggagg
     4321 gtggagggaa cggaacggtg ctggtggtgg actaactaga gttgtttagt tgtgtagttg
     4381 cacactatgt actcttgctg aggatctaat tctgtctgta ccatcactcc agatttgcat
     4441 tgtggaacac ctgtataaat ccattatagg agcaagtgtc ctcatgcctg gccttcccgt
     4501 tatttgtttt tggtaaaatt ctttgaaagt atgctcagcc aaatgttcca tgaacttttg
     4561 tttttaaaga aaaataggtg tgaaaggtgg tagcattgta gctagctcac taggctgtcg
     4621 tgtgttgcag ccatgtctgt catttgatgt ttgttattgg tagaatcatg ctttgaattg
     4681 taacccttcc ttgatagtgt tagtgatttc cccagaacat gtcacttgtg taaattgtca
     4741 cataaatttg catgagccag gagtgcagga gggtgctttt cacttttcat gcagttagga
     4801 attaaaacct tacacttcag tgactgaccc cagtctgggc agcaaagcta tctatccatc
     4861 ctcttgttga agaagaaggg gtagctgact ctgacactgg ctttttccag tccactcttg
     4921 attataatca cagcacaacc acccagaggt tcttcactgt gggaacttta aacatgcaaa
     4981 ccaaaacaac ctggcccatc tgccatgctt tggttttgct agtttctgaa aggagttttg
     5041 atttcattac actaatagtt gctaaatggt gattatgaag acttaggcat gatagcattg
     5101 tttgacataa actgtggtta agggattaaa acctccctaa agccaacact gttttagaca
     5161 aacatttctg aaaactcaag tcctagagag gagttactca ttgtaattga ggcatcaggt
     5221 taaaatgagg ttgctttgga taatccaagc agcagaatac ccgtgttctg ggaatatgga
     5281 agccaaagga cgcgtgctac ttgaactctg tgggctgaga agaagccagt ggctgaactt
     5341 gagtgggcgg gttaaagtat ctgtgcctca tgacaattgt aaaaatccga agtgtacttt
     5401 ctcagctacc cagatgtcag tgcacgcaga agtgcaccct tctcatgact taactgcagc
     5461 agaaataggg aagagtaaaa ccctcaactc tgcctttggc tctgaactga tttcagtcag
     5521 attctaagct gtgctcactc ttactctgaa agtgcacagc tccattctgg atatcatctg
     5581 acagcccctc aatatgtaca tacactgagg ggctttcttt gaagtttctg gcaaacctgc
     5641 cagagatggg ccaggcatac agcagcccct ttctcaagcc tgggatctgg aacaaattct
     5701 atagtgacaa tgctgattgg ttgactacta caaatgtaaa gtaaatgtgg tctctagtcc
     5761 taggtttgtg gagtgtacct ttgtgttaat gtgtagggaa gggacagcgg tttgatggtt
     5821 atggggagca cgtcactgat aaatctgcag ggctgaatac tgctaaatta cagctttaca
     5881 gctttccttt aggggtgaat catgggatga gtagcctcat cagaaaaatg aaggcatgaa
     5941 gatgcaggtc tgccaggtga ggacacaggc aggctttgca cctatttcct atcaggtatt
     6001 gtaaaatgtg tgcatggctt tttttgttgt tgctcagtaa tcggtagaga agagatgagg
     6061 ggacctctcc ctgcaagctt tcctaaccag tcttttcaga agtacatagc tgggaagtaa
     6121 aatctggcct taacctactg gcaggaccct gtcctttgta atgttcaccg caccctgcag
     6181 tccttggtgc agaggagcta catagttgta gtctagtaat tcaccgtggt ttactgcgag
     6241 ccagtgatgt cattctatcg tgcgctcttg tcaagccatt tatgtgactt taataagctt
     6301 agtaactttg ctgactgcac cggggcctat cagtgactta tatattgcat gatgtcttca
     6361 acttgagttt gacatgtaga atcacctttg atttcatggc aattgacagt cctaatggct
     6421 cagctaattt gaaactaaca actttgctgt gtaaaaggaa aaatggtgtt gtgttcagta
     6481 aatgtttgaa aaaaaaaaaa aaaaa
//
